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Marion Leleu

marion.leleu@epfl.ch +41 21 693 16 70 https://bix.epfl.ch/

Nationalité: French

EPFL SV PTECH PTBB
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

Expertise

Bioinformatics Genomics Hight-Throughput Sequencing Data Mining

Formation

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2004 – 2004 INSA, Lyon, France & Caisse des d�p�ts et consignation, Paris, France
Dirigée par Jean-Francois Boulicaut

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2000 – 2000 IRESTE, Nantes, France

Expériences professionnelles

2007–2009

MRC, Imperial College, London

2004–2007

Thrombosis Research Institute, London, UK

2001–2004

Paris, France

2025

Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model

E. Skoufa; J. Zhong; K. Hu; O. Kahre; G. Tsissios  et al.

Science Advances. 2025. DOI : 10.1126/sciadv.ady7682.

Detailed record

2024

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

G. Santoni; S. Astori; M. Leleu; L. Glauser; S. A. Zamora  et al.

Science. 2024. DOI : 10.1126/science.adg9982.

Detailed record

2023

ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

G. Snieckute; L. Ryder; A. C. Vind; Z. Wu; F. S. Arendrup  et al.

Science. 2023. DOI : 10.1126/science.adf3208.

Detailed record

Chromosome-level organization of the regulatory genome in the Drosophila nervous system

G. Mohana; J. Dorier; X. Li; M. Mouginot; R. C. Smith  et al.

Cell. 2023. DOI : 10.1016/j.cell.2023.07.008.

Detailed record

2022

The Transcriptional Regulator Prdm1 Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal

P. G. Manti; F. Darbellay; M. Leleu; A. Y. Coughlan; B. Moret  et al.

Biomedicines. 2022. DOI : 10.3390/biomedicines10102647.

Detailed record

2020

Multicenter analysis of sputum microbiota in tuberculosis patients

C. Sala; A. Benjak; D. Goletti; S. Banu; J. Mazza-Stadler  et al.

Plos One. 2020. DOI : 10.1371/journal.pone.0240250.

Detailed record

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion

G. A. R. Buendia; M. Leleu; F. Marzetta; L. Vanzan; J. Y. Tan  et al.

Science Advances. 2020. DOI : 10.1126/sciadv.aaz4012.

Detailed record

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

C. Chong; M. Müller; H. Pak; D. Harnett; F. Huber  et al.

Nature Communications. 2020. DOI : 10.1038/s41467-020-14968-9.

Detailed record

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

A.-L. Mahul-Mellier; J. Burtscher; N. Maharjan; L. Weerens; M. Croisier  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2020. DOI : 10.1073/pnas.1913904117.

Detailed record

2019

Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Q. Lo Giudice; M. Leleu; G. La Manno; P. J. Fabre

Development. 2019. DOI : 10.1242/dev.178103.

Detailed record

Differential regulation of RNA polymerase III genes during liver regeneration

M. Yeganeh; V. Praz; C. Carmeli; D. Villeneuve; L. Rib  et al.

Nucleic Acids Research. 2019. DOI : 10.1093/nar/gky1282.

Detailed record

2018

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

P. J. Fabre; M. Leleu; B. Mascrez; Q. Lo Giudice; J. Cobb  et al.

Bmc Biology. 2018. DOI : 10.1186/s12915-018-0570-z.

Detailed record

AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress

A. Kfoury; M. Armaro; C. Collodet; J. Sordet-Dessimoz; M. Giner  et al.

EMBO Journal. 2018. DOI : 10.15252/embj.201797673.

Detailed record

2017

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

M. N. Loviglio; M. Leleu; K. Männik; M. Passeggeri; G. Giannuzzi  et al.

Molecular Psychiatry. 2017. DOI : 10.1038/mp.2016.84.

Detailed record

Large scale genomic reorganization of topological domains at the HoxD locus

P. J. Fabre; M. Leleu; B. H. Mormann; L. Lopez-Delisle; D. Noordermeer  et al.

Genome Biology. 2017. DOI : 10.1186/s13059-017-1278-z.

Detailed record

2016

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

C. Deluz; E. T. Friman; D. Strebinger; A. Benke; M. Raccaud  et al.

Genes & Development. 2016. DOI : 10.1101/gad.289256.116.

Detailed record

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

L. A. Bultet; J. Aguilar Rodriguez; C. H. Ahrens; E. L. Ahrne; N. Ai  et al.

Nucleic Acids Research. 2016. DOI : 10.1093/nar/gkv1310.

Detailed record

2015

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

M. Vieux-Rochas; P. J. Fabre; M. Leleu; D. Duboule; D. Noordermeer

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2015. DOI : 10.1073/pnas.1504783112.

Detailed record

2014

Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy

A. Cerase; D. Smeets; Y. A. Tang; M. Gdula; F. Kraus  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2014. DOI : 10.1073/pnas.1312951111.

Detailed record

HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis

F. P. A. David; J. Delafontaine; S. Carat; F. J. Ross; G. Lefebvre  et al.

PLoS ONE. 2014. DOI : 10.1371/journal.pone.0085879.

Detailed record

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

J. M. Woltering; D. Noordermeer; M. Leleu; D. Duboule

PLoS Biology. 2014. DOI : 10.1371/journal.pbio.1001773.

Detailed record

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

D. Noordermeer; M. Leleu; P. Schorderet; E. Joye; F. Chabaud  et al.

eLife. 2014. DOI : 10.7554/eLife.02557.

Detailed record

2013

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

G. Andrey; T. Montavon; B. Mascrez; F. Gonzalez; D. Noordermeer  et al.

Science. 2013. DOI : 10.1126/science.1234167.

Detailed record

Structural Variation-Associated Expression Changes Are Paralleled by Chromatin Architecture Modifications

N. Gheldof; R. M. Witwicki; E. Migliavacca; M. Leleu; G. Didelot  et al.

Plos One. 2013. DOI : 10.1371/journal.pone.0079973.

Detailed record

Multiple Enhancers Regulate Hoxd Genes and the Hotdog LncRNA during Cecum Budding

S. Delpretti; T. Montavon; M. Leleu; E. Joye; A. Tzika  et al.

Cell reports. 2013. DOI : 10.1016/j.celrep.2013.09.002.

Detailed record

2011

The dynamic architecture of Hox gene clusters

D. Noordermeer; M. Leleu; E. Splinter; J. Rougemont; W. De Laat  et al.

Science. 2011. DOI : 10.1126/science.1207194.

Detailed record

Detecting long-range chromatin interactions using the chromosome conformation capture sequencing (4C-seq) method

N. Gheldof; M. Leleu; D. Noordermeer; J. Rougemont; A. Reymond

Methods in molecular biology (Clifton, N.J.); Springer Science+Business Media, 2011. p. 211 - 25.

Detailed record

2010

Processing and analyzing ChIP-seq data: from short reads to regulatory interactions

M. Leleu; G. Lefebvre; J. Rougemont

Briefings In Functional Genomics. 2010. DOI : 10.1093/bfgp/elq022.

Detailed record

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

D. Landeira; S. Sauer; R. Poot; M. Dvorkina; L. Mazzarella  et al.

Nature Cell Biology. 2010. DOI : 10.1038/ncb2065.

Detailed record

Epigenetic Priming of a Pre-B Cell-Specific Enhancer through Binding of Sox2 and Foxd3 at the ESC Stage

D. Liber; R. Domaschenz; P.-H. Holmqvist; L. Mazzarella; A. Georgiou  et al.

Cell Stem Cell. 2010. DOI : 10.1016/j.stem.2010.05.020.

Detailed record

Functional analysis of CTCF during mammalian limb development

N. Soshnikova; T. Montavon; M. Leleu; N. Galjart; D. Duboule

Developmental Cell. 2010. DOI : 10.1016/j.devcel.2010.11.009.

Detailed record

2009

Runx proteins regulate Foxp3 expression

L. Bruno; L. Mazzarella; M. Hoogenkamp; A. Hertweck; B. S. Cobb  et al.

The Journal of Experimental Medicine. 2009. DOI : 10.1084/jem.20090226.

Detailed record

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells

H. F. Jorgensen; A. Terry; C. Beretta; C. F. Pereira; M. Leleu  et al.

Development. 2009. DOI : 10.1242/dev.028548.

Detailed record

2008

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

V. Parelho; S. Hadjur; M. Spivakov; M. Leleu; S. Sauer  et al.

Cell. 2008. DOI : 10.1016/j.cell.2008.01.011.

Detailed record

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

S. Sauer; L. Bruno; A. Hertweck; D. Finlay; M. Leleu  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2008. DOI : 10.1073/pnas.0800928105.

Detailed record

2003

Constraint-Based Mining of Sequential Patterns over Datasets with Consecutive Repetitions

M. Leleu; C. Rigotti; J.-F. Boulicaut; G. Euvrard

2003. 7th European Conference on Principles and Practice of Knowledge Discovery in Databases, Cavtat-Dubrovnik, Croatia, September 22-26, 2003. p. 303 - 314. DOI : 10.1007/978-3-540-39804-2_28.

Detailed record