Research in the Lutolf lab is at the interface of stem cell biology and bioengineering to gain fundamental insight into how complex three-dimensional (3D) microenvironments, termed niches, control the behavior of stem cells. We exploit this know-how to develop novel technologies for maintaining stem cells in vitro and for controlling their differentiation and self-organization into 3D functional tissues (organoids).
Professor Matthias Lutolf is Head of the Laboratory of Stem Cell Bioengineering. He was trained as a Materials Engineer at ETH Zurich where he also carried out his Ph.D. studies on the development of a novel class of biomaterials for tissue engineering (awarded with ETH medal). Lutolf carried out postdoctoral studies at the Baxter Laboratory in Stem Cell Biology at Stanford University. He started up his independent research group at EPFL in 2007 with a European Young Investigator (EURYI) award. By interfacing advanced biomaterials engineering, microtechnology and stem cell biology, a major goal in his lab is to uncover mechanisms of stem cell fate regulation; knowledge that will contribute to better ways to grow stem cells in culture and use them for various new applications.