Michel Aguet

michel.aguet@epfl.ch http://aguet-lab.epfl.ch/

EPFL SV SV-DEC PH-SV
SV 3807 (Bâtiment SV)
Station 19
1015 Lausanne

Office: SV 3807
EPFL › SV › SV-DEC › PH-SV

Website: https://sv.epfl.ch/professeurs-honoraires

Biography Publications Teaching & PhD

Dr. Michel Aguet, MD, held positions in academia and industry (Associate Professor at the Institute of Molecular Biology, University of Zürich; Head of Molecular Oncology, Genentech, So. San Francisco) before he was appointed director of the Swiss Institute for Experimental Cancer Research (ISREC) (1996-2009). In the context of the integration of ISREC into the Swiss Federal Institute of Technology (EPFL), he was appointed as Full Professor at the newly established School of Life Sciences in 2005. From 2001-2013 he directed the National Center of Competence in Research (NCCR) in Molecular Oncology, a national program launched by the Swiss National Science Foundation to encourage translational cancer research and for which ISREC was the leading house. Dr. Aguet has been a SAB member in the pharmaceutical industry, biotech industry and venture capital industry since 1997. A large part of his scientific career was devoted to exploring the molecular biology of interferons (cloning of the interferon gamma receptor, generation of various interferon signaling mutants in the mouse) and, in collaboration with Prof. Charles Weissmann, to investigating the role of prion related protein PrP in mouse prion disease models. In recent years his research focused on characterizing the role of BCL9 proteins, which are part of the Wnt/beta-catenin transcriptional activation complex, in regulating stem cell traits in intestinal epithelium and colorectal cancer. His laboratory is now closed due to retirement.

Publications list

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

B. Degirmenci; C. Dincer; H. C. Demirel; L. Berkova; A. E. Moor et al.

Iscience. 2021. DOI : 10.1016/j.isci.2021.103369.

Michel Aguet

Publications list

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

TBX3 acts as tissue-specific component of the Wnt/beta-catenin enhanceosome

TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription

Defining new criteria for selection of cell-based intestinal models using publicly available databases

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model

The Creation of EBV Biotech

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Notch1 control of oligodendrocyte differentiation in the spinal cord

Notch1 is required for neuronal and glial differentiation in the cerebellum

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

Multiple roles of mouse Numb in tuning developmental cell fates

Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells

The Genetics Company, Inc. - A newly founded Swiss Biotech Company

VEGF is required for growth and survival in neonatal mice

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor

The role of antibody concentration and avidity in antiviral protection

The IFN gamma receptor: A paradigm for cytokine receptor signaling

The gene for the ligand binding chain of the human interferon gamma receptor

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice

Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

A negative regulatory region in the intracellular domain of the human interferon-alpha receptor

Ligand-induced assembly and activation of the gamma interferon receptor in intact cells

Role of Interferon-Gamma in Contact Hypersensitivity Assessed in Interferon-Gamma Receptor-Deficient Mice

MHC antigens in interferon gamma (IFN gamma) receptor deficient mice: IFN gamma-dependent up-regulation of MHC class II in renal tubules

Role of Interferon-Gamma in Interleukin 12-Induced Pathology in Mice

Immune defence in mice lacking type I and/or type II interferon receptors

Variable region cDNA sequences and characterization of murine anti-human interferon gamma receptor monoclonal antibodies that inhibit receptor binding by interferon gamma

Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets

The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo

Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor

Dissection of the extracellular human interferon gamma receptor alpha-chain into two immunoglobulin-like domains. Production in an Escherichia coli thioredoxin gene fusion expression system and recognition by neutralizing antibodies

Cd40 Ligand Has Potent Antiviral Activity

Generation of nitric oxide and clearance of interferon-gamma after BCG infection are impaired in mice that lack the interferon-gamma receptor

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response

Inducible gene targeting in mice

Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells

Development of Antimalaria Immunity in Mice Lacking Ifn-Gamma Receptor

IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors

Antiviral Protection by Vesicular Stomatitis Virus-Specific Antibodies in Alpha/Beta Interferon Receptor-Deficient Mice

Involvement of Ifn-Gamma in Bacillus Calmette-Guerin-Induced but Not in Tumor-Induced Sensitization to Tnf-Induced Lethality

Antiviral Defense in Mice Lacking Both Alpha/Beta and Gamma-Interferon Receptors

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

Susceptibility to Scrapie in Mice Is Dependent on Prpc

Functional role of type I and type II interferons in antiviral defense

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

Interferon gamma receptor deficient mice are resistant to endotoxic shock

A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells

PrP-deficient mice are resistant to scrapie

IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression

The Transcription Factor Mtf-1 Is Essential for Basal and Heavy Metal-Induced Metallothionein-I Gene-Expression

Signaling Steps Involving the Cytoplasmic Domain of the Interferon-Gamma Receptor Alpha-Subunit Are Not Species-Specific

Molecular biology of prion diseases

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide

Role of Prp in Prion Diseases

Immune response in mice that lack the interferon-gamma receptor