Michel Aguet

michel.aguet@epfl.ch http://aguet-lab.epfl.ch/

EPFL SV SV-DEC PH-SV
SV 3807 (Bâtiment SV)
Station 19
1015 Lausanne

Office: SV 3807
EPFL > SV > SV-DEC > PH-SV

Web site: Web site: https://sv.epfl.ch/professeurs-honoraires

Biography

Dr. Michel Aguet, MD, held positions in academia and industry (Associate Professor at the Institute of Molecular Biology, University of Zürich; Head of Molecular Oncology, Genentech, So. San Francisco) before he was appointed director of the Swiss Institute for Experimental Cancer Research (ISREC) (1996-2009). In the context of the integration of ISREC into the Swiss Federal Institute of Technology (EPFL), he was appointed as Full Professor at the newly established School of Life Sciences in 2005. From 2001-2013 he directed the National Center of Competence in Research (NCCR) in Molecular Oncology, a national program launched by the Swiss National Science Foundation to encourage translational cancer research and for which ISREC was the leading house. Dr. Aguet has been a SAB member in the pharmaceutical industry, biotech industry and venture capital industry since 1997. A large part of his scientific career was devoted to exploring the molecular biology of interferons (cloning of the interferon gamma receptor, generation of various interferon signaling mutants in the mouse) and, in collaboration with Prof. Charles Weissmann, to investigating the role of prion related protein PrP in mouse prion disease models. In recent years his research focused on characterizing the role of BCL9 proteins, which are part of the Wnt/beta-catenin transcriptional activation complex, in regulating stem cell traits in intestinal epithelium and colorectal cancer. His laboratory is now closed due to retirement.

Publications

Infoscience publications

Publications list

Ecosystem engineering by periphyton in Alpine proglacial streams

M. Roncoroni; A. Ballu; A. Selitaj; D. Mancini; F. Miesen et al.

Earth Surface Processes And Landforms. 2023-10-03. DOI : 10.1002/esp.5712.

Michel Aguet

Biography

Publications

Infoscience publications

Publications list

Ecosystem engineering by periphyton in Alpine proglacial streams

Blood pressure monitoring during anesthesia induction using PPG morphology features and machine learning

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Interbeat Interval Detection from Synthetic Photoplethysmography Signals

Feature Learning for Blood Pressure Estimation from Photoplethysmography

TBX3 acts as tissue-specific component of the Wnt/beta-catenin enhanceosome

TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling

Ultrastructural basis of strong unitary inhibition in a binaural neuron

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription

3-D PSF fitting for fluorescence microscopy: implementation and localization application

Defining new criteria for selection of cell-based intestinal models using publicly available databases

Identification of a Novel Wnt Inhibitor

Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model

The Creation of EBV Biotech

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

Rotational Features Extraction for Ridge Detection

Optical Imaging Using Binary Sensors

Pre-clinical characterization of long synthetic peptide vaccine candidates against melanoma

Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

Steerable Features for Statistical 3D Dendrite Detection

Super-resolved position and orientation from defocused images of fluorescent dipoles

Steerable filters for orientation estimation and localization of fluorescent dipoles

High-resolution imaging with simultaneous estimation of position and orientation of single molecules

Super-resolved position and orientation of fluorescent dipoles

Super-resolution orientation estimation and localization of fluorescent dipoles using 3-D steerable filters

Super-resolution fluorescence microscopy based on physical models

Parametric B-Spline Snakes on Distance Maps—Application to Segmentation of Histology Images

An accurate PSF model with few parameters for axially shift-variant deconvolution

Gene expression analysis of metastases and tumor host interactions in metastatic lesions in a multistage model of prostate carcinogenesis

Gene expression profiling of the stromal reaction to invasive human breast and prostate cancer

Model-Based 2.5-D Deconvolution for Extended Depth of Field in Brightfield Microscopy

Sub-resolution maximum-likelihood based localization of fluorescent nanoparticles in three dimensions

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike

Joint Texture and Topography Estimation for Extended Depth of Field in Brightfield Microscopy

The Colored Revolution of Bioimaging

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Sub-Resolution Axial Localization of Nanoparticles in Fluorescence Microscopy

Three-Dimensional Feature Detection Using Optimal Steerable Filters

A Maximum-Likelihood Formalism for Sub-Resolution Axial Localization of Fluorescent Nanoparticles

Notch1 is required for neuronal and glial differentiation in the cerebellum

Notch1 control of oligodendrocyte differentiation in the spinal cord

Multiple roles of mouse Numb in tuning developmental cell fates

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

The Genetics Company, Inc. - A newly founded Swiss Biotech Company

Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells

Deficient T cell fate specification in mice with an induced inactivation of Notch1

VEGF is required for growth and survival in neonatal mice

Effets électromagnétiques de manoeuvres et de la foudre dans les postes sous enveloppe métallique

The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes

The gene for the ligand binding chain of the human interferon gamma receptor

The role of antibody concentration and avidity in antiviral protection

The IFN gamma receptor: A paradigm for cytokine receptor signaling

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

A negative regulatory region in the intracellular domain of the human interferon-alpha receptor

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice

Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile

Ligand-induced assembly and activation of the gamma interferon receptor in intact cells

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

Dissection of the extracellular human interferon gamma receptor alpha-chain into two immunoglobulin-like domains. Production in an Escherichia coli thioredoxin gene fusion expression system and recognition by neutralizing antibodies

Antiviral Defense in Mice Lacking Both Alpha/Beta and Gamma-Interferon Receptors

Immune defence in mice lacking type I and/or type II interferon receptors