Mor Mishkovsky
EPFL SB IPHYS LIFMET
CH F0 612 (Bâtiment CH)
Station 6
CH-1015 Lausanne
Compétences
In vivo Magnetic Resonance Spectroscopy (MRS)
High resolution Nuclear Magnetic Resonance (NMR)
Single shot multidimensional (ultrafast) NMR
Dynamic Nuclear Polarization (DNP)
High resolution Nuclear Magnetic Resonance (NMR)
Single shot multidimensional (ultrafast) NMR
Dynamic Nuclear Polarization (DNP)
Publications
Infoscience
infoscience
Journal Articles
Y. Takado; T. Cheng; J. A. M. Bastiaansen; H. A. I. Yoshihara; B. Lanz et al. : Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo; Acs Chemical Neuroscience. 2018-11-01. DOI : 10.1021/acschemneuro.8b00066.
M. Mishkovsky; B. Anderson; M. Karlsson; M. H. Lerche; A. D. Sherry et al. : Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance; Scientific Reports. 2017. DOI : 10.1038/s41598-017-12086-z.
T. Cheng; M. Mishkovsky; M. J. N. Junk; K. Münnemann; A. Comment : Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel; Macromolecular rapid communications. 2016. DOI : 10.1002/marc.201600133.
R. Balzan; M. Mishkovsky; Y. Simonenko; R. B. van Heeswijk; R. Gruetter et al. : Hyperpolarized 6Li as a probe for hemoglobin oxygenation level; Contrast Media and Molecular Imaging. 2016. DOI : 10.1002/cmmi.1656.
R. Schmidt; M. Mishkovsky; J.-N. Hyacinthe; N. Kunz; R. Gruetter et al. : Correcting surface coil excitation inhomogeneities in single-shot SPEN MRI; Journal of Magnetic Resonance. 2015. DOI : 10.1016/j.jmr.2015.08.018.
T. R. Eichhorn; Y. Takado; N. Salameh; A. Capozzi; T. Cheng et al. : Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging; Proceedings of the National Academy of Sciences. 2013. DOI : 10.1073/pnas.1314928110.
T. Cheng; M. Mishkovsky; J. A. M. Bastiaansen; O. Ouari; P. Hautle et al. : Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR; NMR in biomedicine. 2013. DOI : 10.1002/nbm.2993.
J. Bastiaansen; T. Cheng; M. Mishkovsky; J. M. das Neves Duarte; A. Comment et al. : In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine; Biochimica et biophysica acta. 2013. DOI : 10.1016/j.bbagen.2013.03.023.
M. Mishkovsky; A. Comment; R. Gruetter : In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012. DOI : 10.1038/jcbfm.2012.136.
M. Mishkovsky; T. Cheng; A. Comment; R. Gruetter : Localized in vivo hyperpolarization transfer sequences; Magnetic Resonance in Medicine. 2012. DOI : 10.1002/mrm.23231.
P. Miéville; P. Ahuja; R. Sarkar; S. Jannin; P. R. Vasos et al. : Scavenging Free Radicals To Preserve Enhancement and Extend Relaxation Times in NMR using Dynamic Nuclear Polarization; Angewandte Chemie International Edition in English. 2010. DOI : 10.1002/anie.201000934.
M. Mishkovsky; L. Frydman : Progress in Hyperpolarized Ultrafast 2D NMR Spectroscopy; ChemPhysChem. 2008. DOI : 10.1002/cphc.200800461.
M. Mishkovsky; M. Gal; L. Frydman : Spatially encoded strategies in the execution of biomolecular-oriented 3D NMR experiments; Journal of Biomolecular NMR. 2007. DOI : 10.1007/s10858-007-9195-1.
M. Mishkovsky; E. Kupče; L. Frydman : Ultrafast-based projection-reconstruction three-dimensional nuclear magnetic resonance spectroscopy; The Journal of Chemical Physics. 2007. DOI : 10.1063/1.2748768.
M. Gal; M. Mishkovsky; L. Frydman : Real-Time Monitoring of Chemical Transformations by Ultrafast 2D NMR Spectroscopy; Journal of the American Chemical Society. 2006. DOI : 10.1021/ja0564158.
M. Mishkovsky; L. Frydman : Interlaced Fourier transformation of ultrafast 2D NMR data; Journal of Magnetic Resonance. 2005. DOI : 10.1016/j.jmr.2005.01.007.
M. Mishkovsky; L. Frydman : Sensitivity Enhancement in 1D Heteronuclear NMR Spectroscopy via Single-Scan Inverse Experiments; ChemPhysChem. 2004. DOI : 10.1002/cphc.200400005.
Conference Papers
E. Can; M. Mishkovsky; R. Gruetter; A. Comment : In vivo Hyperpolarized 13C MRS using DPPH as polarizing agent. 2014. 1st Joint Turkish-German Symposium on Human Neuroscience, Berlin, Germany, June 5-7, 2014.
E. Can; M. Mishkovsky; R. Gruetter; A. Comment : In vivo Hyperpolarized 13C MRS using DPPH as polarizing agent. 2014. Swiss Physical Society Annual Meeting 2014, Fribourg, Switzerland, June 30-July2, 2014.
E. Can; M. Mishkovsky; R. Gruetter; A. Comment : In vivo Hyperpolarized 13C MRS using DPPH as polarizing agent. 2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.
M. Mishkovsky; C. R. Cudalbu; E. Can; D. Mario; I. Radovanovic et al. : Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI. 2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.
M. Mishkovsky; E. Can; T. Eichhorn; D. Mario; I. Radovanovic et al. : Purely endogenous hyperpolarized [1-13C]Pyruvate solutions for metabolic study in glioblastoma rat models. 2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.
M. Mishkovsky; E. Can; L. Drissi Daoudi; Y. Pilloud; R. Balzan et al. : Bioreactor to simultaneously measure three parallel in vitro preparations. 2013. 4th International DNP Symposium, Copenhagen, Denmark, August 28-31, 2013.
E. Can; M. Mishkovsky; R. Gruetter; A. Comment : Automated protocol for hyperpolarized in vitro and in vivo 13C MRS using a hydrophobic radical.. 2013. 4th International DNP Symposium, Copenhagen, Denmark, August 28-31, 2013.
M. Mishkovsky; C. R. Cudalbu; A. Comment; D. Mario; I. Radovanovic et al. : Brain metabolism in rat model of human glioma initiating cells. 2013. International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, April 2013.
R. Balzan; M. Mishkovsky; Y. Solomon; R. van Heeswijk; R. Gruetter et al. : Hyperpolarized 6Li as probe for hemoglobin oxygenation level. 2012. ESMRMB 29th Annual Scientific Meeting, Lisbon, Portugal, October 4-6, 2012.
T. Cheng; M. Mishkovsky; J. Bastiaansen; O. Ouari; P. Hautle et al. : Method to minimize the polarization losses in hyperpolarized biomolecules prior to in vivo MR experiments. 2012. ESMRMB 29th Annual Scientific Meeting, Lisbon, October 4-6, 2012.
T. Cheng; M. Mishkovsky; M. Junk; D. Hinderberger; K. Münnemann et al. : Producing radical-free hyperpolarized solutions for in vivo magnetic resonance. 2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, May 5 -11, 2012. p. 1664.
J. Bastiaansen; T. Cheng; J. M. Duarte; M. Mishkovsky; A. Comment et al. : Kinetic analysis of acetylCoA synthetase activity in skeletal muscle. 2012. ESMRMB 29th Annual Scientific Meeting, Lisbon, Portugal, October 4-6, 2012..
J. Bastiaansen; T. Cheng; M. Mishkovsky; A. Comment; R. Gruetter : In vivo enzymatic assay of carnitine acetyl transferase and acetylCoA synthetase using hyperpolarized acetate. 2012. ISMRM, Melbourne, May 2012. p. 4327.
E. Can; J. Bastiaansen; T. Cheng; N. Salameh; Y. Takado et al. : BDPA as a polarizing agent for in vivo hyperpolarized MR experiment. 2012. Metaflux Meeting, May 2012.
R. Balzan; Y. Solo; M. Mishkovsky; R. Gruetter; G. Navon et al. : Effects of Blood and Plasma Oxygenation on the Spin Relaxation Times of Hyperpolarized 6Li. 2011. Joint Annual Meeting - Swiss Physical Society, Lausanne CH, 15-17/06/2011.
M. Mishkovsky; T. Cheng; A. Comment; R. Gruetter : Localized in vivo hyperpolarization transfer experiments. 2011. 19th Annual ISMRM Meeting, Montreal, Canada, May 7-13, 2011. p. 3530.
M. Mishkovsky; A. Comment; R. Gruetter : In vivo detection of brain Krebs cycle intermediate by hyperpolarized MR. 2011. 19th Annual ISMRM Meeting, Montreal, Canada, May 7-13, 2011.. p. 660.
T. Cheng; M. Mishkovsky; A. Comment : In situ polarization measurement of hyperpolarized solutions prior to in vivo 9.4T MR experiments. 2011. 18th Annual ISMRM Meeting, Montreal, Canada,, May 7-13, 2011.. p. 1504.
Y. Takado; T. Cheng; J. Bastiaansen; M. Mishkovsky; R. Gruetter et al. : In vivo real-time metabolic studies of mice brain and skeletal muscle at 9.4T. 2011. Third International Symposium on Dynamic Nuclear Polarization, Lausanne, September 2011.
J. Bastiaansen; T. Cheng; M. Mishkovsky; A. Comment; R. Gruetter : The metabolic effect of hyperpolarized [1-13C]acetate dosage in vivo. 2011. Third International Symposium on Dynamic Nuclear Polarization, Lausanne, September 2011.
J. Bastiaansen; T. Cheng; m. mishkovsky; a. comment; R. Gruetter : Study of acetylcarnitine kinetics in skeletal muscle in vivo using hyperpolarized 1-13C acetate. 2011. ISMRM, Montreal, May 2011. p. 3536.
J. Bastiaansen; T. Cheng; M. Mishkovsky; A. Comment; R. Gruetter : Hyperpolarized acetate as a metabolic tracer for skeletal and cardiac muscle energetics. 2011. Hot Topics in Molecular Imaging - TOPIM, Les Houches, January 2011.
C. R. Cudalbu; A. Comment; T. Cheng; M. Mishkovsky; R. Gruetter : In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain. 2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.
M. E. Merritt; M. Mishkovsky; T. Cheng; A. Jindal; Z. Kovacs et al. : In vivo hyperpolarized 89Y studies in a 9.4T animal scanner. 2010. 18th Annual ISMRM Meeting, May 2008., Stockholm, Sweden, May 1-7, 2010. p. 1030.
Reviews
M. Mishkovsky; A. Comment : Hyperpolarized MRS: New tool to study real-time brain function and metabolism; Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.09.020.
M. Mishkovsky; L. Frydman : Principles and Progress in Ultrafast Multidimensional Nuclear Magnetic Resonance; Annual Review of Physical Chemistry. 2009. DOI : 10.1146/annurev.physchem.040808.090420.
Posters
Y. Takado; T. Cheng; B. Lanz; J. Bastiaansen; M. Mishkovsky et al. : Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS ; 4th International DNP Symposium, Copenhagen, Denmark, August 28-31, 2013.
Y. Takado; M. Mishkovsky; T. Cheng; R. Gruetter; A. Comment : In vivo real-time metabolic studies in mice at physiological concentrations following 1-13C lactate injection ; ISMRM 20th annual meeting, Merbourne, Australia, May 5 - 11, 2012.
Autres publications
| M. Mishkovsky, T. Cheng, A. Comment, R Gruetter Magn. Res. Med. Available on line (2011) doi: 10.1002/mrm.23231 |
Localized in vivo hyperpolarization transfer sequences. |
| Mi�ville P, Ahuja P, Sarkar R, Jannin S, Vasos PR, Gerber-Lemaire S, Mishkovsky M, Comment A, Gruetter R, Ouari O, Tordo P, Bodenhausen G. Angew Chem Int Ed 49:6182-6185 (2010) |
Scavenging free radicals to preserve enhancement and extend relaxation times in NMR using dynamic nuclear polarization. |
| G. A. Alvarez, M. Mishkovsky, E. P. Danieli, P. R. Levstein, H. M. Pastawski, and L. Frydman Phys. Rev. A., Phys. Rev. A. 81:060302 (2010) |
Perfect state transfers by selective quantum interferences within complex spin networks |
| M. Mishkovsky, U. Eliav, G. Navon, L. Frydman J. Magn. Reson., 200: 142-146 (2009) |
Nearly 10(6)-fold enhancements in intermolecular (1)H double-quantum NMR experiments by nuclear hyperpolarization |
| M. Mishkovsky, L. Frydman Annu. Rev. Phys. Chem., 60:429-448 (2009). |
Principles and Progress in Ultrafast Multidimensional Nuclear Magnetic Resonance |
| M. Mishkovsky, L. Frydman Chem. Phys. Chem., 9: 2340-2348 (2008). � Cover paper |
Progress in Hyperpolarized Ultrafast 2D NMR Spectroscopy |
| M. Mishkovsky, M. Gal and L. Frydman J. Biomol. NMR., 39: 291-301, (2007). |
Spatially-Encoded Strategies and the Execution of Biomolecule-Oriented 3D NMR Experiments |
| M. Mishkovsky, E. Kupce and L. Frydman J. Chem. Phys., 127, 034507, (2007) |
Ultrafast-Based Projection Reconstruction 3D Nuclear Magnetic Resonance Spectroscopy |
| M. Gal, M. Mishkovsky and L. Frydman J. Am. Chem. Soc., 128, 951-956 (2006). |
Real-Time Monitoring of Chemical Transformations by Ultrafast 2D NMR Spectroscopy |
| M. Mishkovsky and L. Frydman J. Magn. Reson., 173:344-350 (2005). |
Interlaced Fourier Transformation of Ultrafast 2D NMR Data |
| M. Mishkovsky and L. Frydman Chem. Phys. Chem, 5:779-786 (2004). |
Sensitivity Enhancement in 1D Heteronuclear NMR Spectroscopy via Single-Scan Inverse Experiments |