Mor-Miri Mishkovsky
EPFL SB IPHYS LIFMET
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 67 50
Office:
CH F1 622
EPFL › SB › IPHYS › LIFMET
Site web: https://lifmet.epfl.ch/
Expertise
Spectroscopie par résonance magnétique in vivo (SRM)
Résonance magnétique nucléaire à haute résolution (RMN)
RMN multidimensionnelle ultra-rapide
Polarisation nucléaire dynamique (PDN)
Résonance magnétique nucléaire à haute résolution (RMN)
RMN multidimensionnelle ultra-rapide
Polarisation nucléaire dynamique (PDN)
I am a chemist, graduated Cum Laude in 2002 from Tel Aviv University in Israel. I obtained a PhD in Physical Chemistry from the Weizmann Institute of Science in Israel on the development of new technology for rapid detection of nuclear magnetic resonance (NMR) spectroscopic data aiming at reducing the measurement time from hour to a fraction of seconds. My thesis «Methodological Developments in Ultrafast Multidimensional NMR» granted me the Auto Swartz excellence award in 2007. Since 2009 I am working with the Laboratory of Functional and Metabolic Imaging at the école Polytechnique Fédérale de Lausanne (EPFL), Switzerland,
on the development of hyperpolarized (HP) magnetic resonance spectroscopy (MRS) methodologies for monitoring biochemical processes in real-time.
My research is focused on the development of Magnetic Resonance (MR) Molecular Imaging by dissolution dynamic nuclear polarization (dDNP). HP agents to interrogate biochemical processes in real-time are applied in vivo in the healthy brain and disease models, aiming at improving our understanding of cerebral function and metabolism toward better clinical diagnostics and therapy.
on the development of hyperpolarized (HP) magnetic resonance spectroscopy (MRS) methodologies for monitoring biochemical processes in real-time.
My research is focused on the development of Magnetic Resonance (MR) Molecular Imaging by dissolution dynamic nuclear polarization (dDNP). HP agents to interrogate biochemical processes in real-time are applied in vivo in the healthy brain and disease models, aiming at improving our understanding of cerebral function and metabolism toward better clinical diagnostics and therapy.
Publications représentatives
Localized in vivo hyperpolarization transfer sequences.
M. Mishkovsky, T. Cheng, A. Comment, R Gruetter
Published in Magn. Res. Med. Available on line (2011) doi: 10.1002/mrm.23231 in
Scavenging free radicals to preserve enhancement and extend relaxation times in NMR using dynamic nuclear polarization.
Mi�ville P, Ahuja P, Sarkar R, Jannin S, Vasos PR, Gerber-Lemaire S, Mishkovsky M, Comment A, Gruetter R, Ouari O, Tordo P, Bodenhausen G.
Published in Angew Chem Int Ed 49:6182-6185 (2010) in
Perfect state transfers by selective quantum interferences within complex spin networks
G. A. Alvarez, M. Mishkovsky, E. P. Danieli, P. R. Levstein, H. M. Pastawski, and L. Frydman
Published in Phys. Rev. A., Phys. Rev. A. 81:060302 (2010) in
Nearly 10(6)-fold enhancements in intermolecular (1)H double-quantum NMR experiments by nuclear hyperpolarization
M. Mishkovsky, U. Eliav, G. Navon, L. Frydman
Published in J. Magn. Reson., 200: 142-146 (2009) in
Principles and Progress in Ultrafast Multidimensional Nuclear Magnetic Resonance
M. Mishkovsky, L. Frydman
Published in Annu. Rev. Phys. Chem., 60:429-448 (2009). in
Progress in Hyperpolarized Ultrafast 2D NMR Spectroscopy
M. Mishkovsky, L. Frydman
Published in Chem. Phys. Chem., 9: 2340-2348 (2008). � Cover paper in
Spatially-Encoded Strategies and the Execution of Biomolecule-Oriented 3D NMR Experiments
M. Mishkovsky, M. Gal and L. Frydman
Published in J. Biomol. NMR., 39: 291-301, (2007). in
Ultrafast-Based Projection Reconstruction 3D Nuclear Magnetic Resonance Spectroscopy
M. Mishkovsky, E. Kupce and L. Frydman
Published in J. Chem. Phys., 127, 034507, (2007) in
Real-Time Monitoring of Chemical Transformations by Ultrafast 2D NMR Spectroscopy
M. Gal, M. Mishkovsky and L. Frydman
Published in J. Am. Chem. Soc., 128, 951-956 (2006). in
Interlaced Fourier Transformation of Ultrafast 2D NMR Data
M. Mishkovsky and L. Frydman
Published in J. Magn. Reson., 173:344-350 (2005). in
Sensitivity Enhancement in 1D Heteronuclear NMR Spectroscopy via Single-Scan Inverse Experiments
M. Mishkovsky and L. Frydman
Published in Chem. Phys. Chem, 5:779-786 (2004). in