Philippe Colin

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Technicienne/Technicien

philippe.colin@epfl.ch +41 21 693 95 11

Nationalité: Française

Date de naissance: 10.12.1969

EPFL SV PTECH PTBTG
B3 5 206.118 (Campus Biotech bâtiment B3)
Ch. des Mines 9
1202 Genève

+41 21 693 95 11
Local: B3 5 206.118
EPFL > SV > PTECH > PTBTG

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Mission

- Cultures de lignées cellulaires, dissection d

Biographie

A ce jour Technicien spécialisé en expérimentation animal in vivo (rongeurs) à lEPFL dans le laboratoire d

Publications

Sélection de publications

1. Horellou, P., Vigne, E., Castel, M. N., Barneoud, P., Colin, P., Perricaudet, M., Delaere, P., and Mallet, J. . Neuroreport, 6, 49-53.(1994).	). Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
2. Onteniente, B., Horellou, P., Neveu, I., Makeh, I., Suzuki, F., Bourdet, C., Grimber, G., Colin, P., Brachet, P., Mallet, J., Brachet,P., Mallet,J. and Peschanski M. (1994). Mol Brain Res, 21, 225-234.	Cell-type-specific expression and regulation of a c-fos-NGF fusion gene in neurons and astrocytes of transgenic mice.
Sabate, O., Horellou, P., Vigne, E., Colin, P., Perricaudet, M., Buc-Caron, M. H., and Mallet, J. (1995) Nat Genet, 9, 256-260.	Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses.
Corti, O., Horellou, P., Colin, P., Cattaneo, E., and Mallet, J. (1996). Neuroreport, 7, 1655-1659.	Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors.
Bilang-Bleuel, A., Revah, F., Colin, P., Locquet, I., Robert, J. J., Mallet, J., and Horellou, P. Proc Natl Acad Sci U S A, 94, 8818-8823.(1997)	Intrastriatal injection of an adenoviral vector expressing glial cell-line derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.
Corti, O., Sabate, O., Horellou, P., Colin, P., Dumas, S., Buchet, D., Buc-Caron, M. H., and Mallet, J. (1999). Nat Biotechnol, 17, 349-354.	A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors.
Corti, O., Sanchez-Capelo, A., Colin, P., Hanoun, N., Hamon, M., and Mallet, J. (1999) Proc Natl Acad Sci U S A, 96, 12120-12125.	Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.
Bemelmans, A., Horellou, P., Pradier, L., Brunet, I., Colin, P., and Mallet, J. (1999) Hum Gene Ther, 10, 2987-2997.	Brain-derived neurotrophic factor (BDNF)-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer.
Zennou V, Serguera C, Sarkis C, Colin P, Perret E, Mallet J, Charneau P (2001 May)Nat Biotechnol.;19(5):446-50	The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain.
Serguera C, Sarkis C, Ridet JL, Colin P, Moullier P, Mallet J. (2001 Jun)Mol Ther;3(6):875-81.	Primary adult human astrocytes as an ex vivo vehicle for beta-glucuronidase delivery in the brain.
Fender P, Jeanson L, Ivanov MA, Colin P, Mallet J, Dedieu JF, Latta-Mahieu M. (2002 Nov-Dec)J Gene Med;4(6):668-75.	Controlled transgene expression by E1-E4-defective adenovirus vectors harbouring a "tet-on" switch system.
Sanchez-Capelo A, Colin P, Guibert B, Biguet NF, Mallet J. (2003 Aug)Mol Cell Neurosci. (4):614-25.	Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice.
Thevenot E, Cote F, Colin P, He Y, Leblois H, Perricaudet M, Mallet J, Vodjdani G. (2003 sep)Mol Cell Neurosci.; 24 :139-47.	Targeting conditional gene modification into the serotonin neurons of the dorsal raphe nucleus by viraldelivery of the Cre recombinase.