Pierre Magistretti

EPFL SV SV-DEC PH-SV
AAB 1 46 (Bâtiment AAB)
Station 19
1015 Lausanne

Current work

Full Professor and Director Prof. Director, Brain Mind Institute, EPFL Director, Center for Psychiatric Neuroscience, Department of Psychiatry / CHUV
Pierre J. Magistretti is an internationally-recognized neuroscientist who has made significant contributions in the field of brain energy metabolism. His group has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by the brain. This work has considerable ramifications for the understanding of the origin of the signals detected with the current functional brain imaging techniques used in neurological and psychiatric research (see for example Magistretti et al, Science, 283: 496 – 497, 1999). He is the author of over 100 articles published in peer-reviewed journals. He has given over 80 invited lectures at international meetings or at universities in Europe and North America, including the 2000 Talairach Lecture at the “Functional Mapping of the Human Brain Conference”. In November 2000 he has been a “Mc Donnel Visiting Scholar” at Washington University School of Medicine. Pierre J. Magistretti is the President-Elect (2002 – 2004) of the Federation of European Neuroscience Societies (FENS) which has a membership of over 15000 European neuroscientists. He has been first president of the Swiss Society for Neuroscience (1997-1999) and the first Chairman of the Department of Neurosciences of the University of Lausanne (1996 – 1998). Pierre J. Magistretti is Professor of Physiology (since 1988) at the University of Lausanne Medical School. He has been Vice-Dean of the University of Lausanne Medical School from 1996 to 2000. Pierre Magistretti, is Director of the Brain Mind Institute at EPFL and Director of the Center for Psychiatric Neuroscience of the University of Lausanne and CHUV. He is also Director of the NCCR SYNAPSY "the synaptic bases of mental diseases". POSITIONS AND HONORS MAIN POSITION HELD • 1988-2004 Professor of Physiology, University of Lausanne Medical School • 1996-2000 Vice-Dean for Preclinical Departments, University of Lausanne Medical School • 2001-2004 Chairman, Department of Physiology, University of Lausanne Medical School • 2004-present Professor and Director, Center for Psychiatric Neuroscience, Department of Psychiatry, University of Lausanne Medical School and Hospitals (UNIL-CHUV) (Joint appointment with EPFL) • 2005-2008 Professor and Co-Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne (Joint appointment with UNIL-CHUV) • 2007-present Chairman of the Scientific Advisory Board of Centre d’Imagerie Biomédicale (CIBM), an Imaging Consortium of the Universities, University Hospitals of Lausanne and Geneva and of Ecole Polytechnique Fédérale de Lausanne • 2008-present Professor and Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne Joint appointment with UNIL-CHUV) • 2010-present Director, National Center for Competence in Research (NCCR) “The synaptic bases of mental diseases” of the Swiss National Science Foundation • 2010-present Secretary General, International Brain Research Organization (IBRO) MAIN HONORS AND AWARDS • 1997 Recipient of the Theodore-Ott Prize of the Swiss Academy of Medical Sciences • 2001 Elected Member of Academia Europaea • 2001 Elected Member of the Swiss Academy of Medical Sciences, ad personam • 2002 Recipient of the Emil Kraepelin Guest Professorship, Max Planck Institute für Psychiatry, Münich • 2006 Elected Professor at Collège de France, Paris, International Chair 2007-2008 • 2009 Goethe Award for Psychoanalytic Scholarship, Canadian Psychological Association • 2011 Camillo Golgi Medal Award, Golgi Fondation • 2011 Elected Member of the American College of NeuroPsychopharmacology (ACNP)

Education

Doctor of Philosophy Degree in Biology (Ph.D.)

|

1982 – 1982 University of California at San Diego

Doctorat en Médecine (M.D.)

|

1979 – 1979 University of Geneva

Diplôme Fédéral de Médecin

|

1977 – 1977 University of Geneva

Awards

Fellow of the Accademia dei Lincei

Accademia dei Lincei

2021

Selected publications

Brain lactate metabolism in humans with subarachnoid haemorrhage.

Mauro Oddo, Joshua M Levine, Suzanne Frangos, Eileen Maloney-Wilensky, Emmanuel Carrera, Roy T Daniel, Marc Levivier, Pierre J Magistretti, and Peter D LeRoux
Published in Stroke, Journal of the American heart association. 2011 Dec. 29; in press in

Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia.

Lavoie S, Allaman I, Petit JM, Do KQ, Magistretti PJ.
Published in PLoS One. 2011;6(7):e22875 in

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Cotransporters KCC2 and NKCC1: A Digital Holographic Microscopy Study.

Jourdain P, Pavillon N, Moratal C, Boss D, Rappaz B, Depeursinge C, Marquet P, Magistretti PJ.
Published in J Neurosci. 2011 Aug 17;31(33):11846-54 in

Astrocyte-neuron lactate transport is required for long-term memory formation.

Akinobu Suzuki, Sarah A. Stern, Ozlem Bozdagi, George W. Huntley, Ruth H. Walker, Pierre J. Magistretti and Cristina M. Alberini.
Published in Cell, in press. in

Astrocyte-neuron metabolic relationships: for better and for worse

Allaman I, Bélanger M, Magistretti PJ.
Published in Trends Neurosci. 2011 Jan 12. [Epub ahead of print]. Review. in

Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes.

Bélanger M, Allaman I, Magistretti PJ.
Published in J Neurochem. 2010 Dec 10. doi: 10.1111/j.1471-4159.2010.07135.x. [Epub ahead of print]. in

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

Allaman I, Gavillet M, Bélanger M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ.
Published in J Neurosci. 2010 Mar 3;30(9):3326-38. in

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines.

Gavillet M, Allaman I, Magistretti PJ.
Published in 2008 56(9):975-89. in

Activity-dependent regulation of energy metabolism by astrocytes: an update

Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, Magistretti PJ.
Published in 2007 Sep; 55(12):1251-62. Review in

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

Morgenthaler FD, Kraftsik R, Catsicas S, Magistretti PJ, Chatton JY.
Published in Neuroscience 141 (1):157-65. Year: 2006 in

Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics.

Bliss, T.M., Ip, M., Cheng, E., Minami, M., Pellerin, L., Magistretti, P.J., Sapolsky, R.M.
Published in J. Neurosci. 24, 6202-6208. 2004 in

Lactate is a preferential oxidative energy substrate over glucose for neurons in culture

Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P.J. and Pellerin, L.
Published in J. Cereb. Blood Flow Metab. 23, 1298-1306. in