MissionBIOGRAPHY RESEARCH TOPICS (more than 400 publications in referred journals) Asymmetric Synthesis of Natural Products and Analogs of Biological Interest (anti-cancer, antiviral agents, antibiotics). Actual targets: Spongistatins (anti-cancer), Aptotolidin (anti-cancer), oxopolyene RK-397 (antibiotic), Ryfamycins (antibiotics, antifungals, Erythronolides (antibiotics). Glycomimetics as New Tools for Biology and Medicine (glycomics, cell/cell communication, cell/pathogen communication: glycosidase and glycosyltransferase inhibitors, non-hydrolysable sugar epitopes). New inhibitors of α-mannosidases and α-glucosidases as potential anti-cancer and anti-HIV agents. Artificial vaccines against cancer, synthesis of C-linked disaccharides analogs of the T-epitopes. New Scaffolds for Biomolecules, for New Materials (polyfunctional systems for combinatorial chemistry, multicomponent synthesis). New Organic Chemistry of Sulfur Dioxide (new C-C bond forming reactions, synthesis of polyketides and polypropionates, new reagents, new organic catalysts for hole-catalysed reactions).
BiographyBIOGRAPHIE Professional positions: P. Vogel was born in Cully (Switzerland) Oct. 23, 1944. In 1969, he did his Ph.D under supervision of Prof. H. Prinzbach at the Institute of Organic Chemistry, University of Lausanne. He spent two years at Yale University, New Haven, Connecticut, USA with Prof. Martin Saunders, Prof. J. A. Berson, K. A. Wiberg and P.v.R. Schleyer (Princeton Universtiy). He worked then as a Research chemist at Syntex S.A., in Mexico with Prof. P.Crabbé before the return to the University of Lausanne in 1973. As of 1977 he became Professor of organic chemistry at the University of Lausanne. In 1991 he was Vice-Chairman of the Institute of organic Chemistry, University of Lausanne until 2001. He was also part-time grad.school teacher at the Universities of Rouen and Caen from 1991 to 1993 and Part-time professor at Ecole Polytechnique de Palaiseau from 1993-2000. Since 2001 he is Professor of organic chemistry at the EPFL. Degrees and distincions 1969 Ph.D, University of Lausanne 1976 Swiss Chemical Society Award, Werner Medal 1984-1989 IOCD adviser 1988-1989 Associate Professor of Organic Chemistry at Ecole Normale Supérieure, Paris 1989-2000 Member of the Swiss National Council of Research 1991-1992 Associate Professor of Organic Chemistry, University of Paris VI 1992 Pacific Coast Lecturer (USA) 1992-1993 Associate Professor at the Université de Montpellier, France 1993 Associate Professor, Université Paris Sud, Orsay 1994 (spring) Associate Professor, ESPCI, Paris 1997 President of the european COST D2 management committee 2002-2003 Novartis Lecturer 2004-2005 Boehringer Ingelheim Distinguished Lecturer
Senior co-workersDr. Sandrine Gerber-Lemaire Dr. Mariz Turks Dr. Robert Lysek
|Turks, M.; Huang, X.; Vogel, P.
Chem. Eur. J. 2005, 11, 465.
|Expeditions Asymmetric Synthesis of a Stereoheptad Corresponding to the C(19)-C(27)-Ansa Chain of Rifamycins: Formal Total Synthesis of Rifamycin S.|
|Markovic, D.; Steunenberg, P.; Ekstrand, M.; Vogel, P.
J. Chem. Soc., Chem. Commun. 2004, 2444.
|Polysulfones: solid organic catalysts for the chemoselective cleavage of methyl-substituted allyl ethers under neutral conditions.|
|Bouchez, L.; Dubbaka, S. R.; Turks, M.; Vogel, P.
Journal of Organic chemsitry, 2004, 69(19), 6413-6418.
|Sulfur Dioxide Mediated One-Pot, Three- and Four-Component Syntheses of Polyfunctional Sulfonamides and Sulfonic Esters: Study of the Stereoselectivity of the Ene Reaction of Sulfur Dioxide.|
|Turks,M.; Murcia, M. C.; Scopelliti,R.; Vogel, P.
Organic Letters, 2004, 6(18), 3031-3034.
|First Asymmetric Synthesis of the Cyclohexanone Subunit of Baconipyrones A and B. Revision of Its Structure.|
|Moreno Vargas, A. J.; Robina, I.; Petricci, E.; Vogel, P.
Journal of Organic Chemistry, 2004, 69(13), 4487-4491.
|Synthesis of D- and L-2,3-trans-3,4-cis-4,5-trans-3,4-Dihydroxy-5-hydroxymethylproline and Tripeptides Containing Them.|
|Turks, M.; Fonquerne, F.; Vogel, P.
Organic Letters, 2004, 6(6), 1053-1056
|Synthesis of Long-Chain Polyketide Fragments by Reaction of 1,3-Dioxy-1,3-dienes with Allylsilanes: Umpolung with Sulfur Dioxide.|
|Dubbaka, S. R.; Vogel, P.
Journal of the American Chemical Society. 2004, 125(59), 15292-15293.
|Palladium-Catalyzed Stille Cross-Couplings of Sulfonyl Chlorides and Organostannanes.|
|Gerber, S.; Vogel, P.
European Journal of Organic Chemistry, 2003, (15), 2959-2963.
|An expeditous, on-iterative, and asymmetric synthesis of 3,5,7,9,11,13,15-heptahydroxypentadecanals.|
|Monnat, F.; Vogel, P.; Rayon, V. M.; Sordo, J. A.
J. Org. Chem., 2002, 67, 1882-1889.
|Ab Initio and Experimental Studies on the Hetero-Diels-Alder and Cheletropic Additions of Sulfur Dioxide to (E)-1-Methoxybutadiene: A Mechanism Involving Three Molecules of SO2.|
|Gerber-Lemaire, S.; Ainge, S. W.; Glanzmann, C.; Vogel, P.
Helv. Chim. Acta. 2002, 85, 417-430.
|Total Asymmetric Synthesis of a New 9,12-Anhydroerythronolide Aglycone.|
|Gerber-Lemaire, S.; Poposycz, F.; Rodriguez-Garcia, E.; Carmona-Asenjo, A. T.; Robina, I.; Vogel, P.
ChemBioChem, 2002, 3(5), 466-470.
|An efficient Combinatorial Method for the discovery of Glycosidase Inhibitors.|
|Schwenter, M.-E.; Vogel, P.
Chem. Eur. J., 2000, 6, 4091-4103.
|A New, Non-Iterative Asymmetric Synthesis of Long.Chain, 1,3-Polyols.|
|Pasquarello, C.; Picasso, S.; Demange, R.; Malissard, M.; Berger, E.G.; Vogel, P.
The Journal of Organic Chemistry, 2000, 65(14), 4251-4260.
|The C-Disaccharide α-C(1→3)-Mannopyranoside of N-Acetylgalactosamine is an Inhibitor of Glycohydrolases and of Human α-1, 3-Fucosyltransferase VI. Its Epimer α- (1→3)-Mannopyranoside of N-Acetylosamine Is Not.|
|Lemaire-Audoire, S.; Vogel, P.
J. Org. Chem., 2000, 65, 3346-3356.
|Synthesis of a C29-C51 Subunit of Spongistatin 1(Altohyrtin A) Starting from (R)-3-Benzyloxy-2-methylpropan-1-ol.|
|Narkevitch, V.; Schenk, K.; Vogel, P.
Angew. Chem. Int. Ed., 2000, 39, 1806-1808.
|A New Asymmetric Carbon-Carbon Bond Forming Reaaction: Four-Coponent Stereoselective Synthesis of 8Z)-4,6-Dihydroxy-3-methylalk-2-enyl Methyl Sulfones.|
Teaching & PhD
Doctoral Program in Chemistry and Chemical Engineering