Pierre Vogel
Nationality: Swiss
+41 21 693 93 71
EPFL › SB › ISIC › ISIC-DIV
Mission
Senior co-workers
Selected publications
Expeditions Asymmetric Synthesis of a Stereoheptad Corresponding to the C(19)-C(27)-Ansa Chain of Rifamycins: Formal Total Synthesis of Rifamycin S.
Turks, M.; Huang, X.; Vogel, P.
Published in Chem. Eur. J. 2005, 11, 465. in
Polysulfones: solid organic catalysts for the chemoselective cleavage of methyl-substituted allyl ethers under neutral conditions.
Markovic, D.; Steunenberg, P.; Ekstrand, M.; Vogel, P.
Published in J. Chem. Soc., Chem. Commun. 2004, 2444. in
Sulfur Dioxide Mediated One-Pot, Three- and Four-Component Syntheses of Polyfunctional Sulfonamides and Sulfonic Esters: Study of the Stereoselectivity of the Ene Reaction of Sulfur Dioxide.
Bouchez, L.; Dubbaka, S. R.; Turks, M.; Vogel, P.
Published in Journal of Organic chemsitry, 2004, 69(19), 6413-6418. in
First Asymmetric Synthesis of the Cyclohexanone Subunit of Baconipyrones A and B. Revision of Its Structure.
Turks,M.; Murcia, M. C.; Scopelliti,R.; Vogel, P.
Published in Organic Letters, 2004, 6(18), 3031-3034. in
Synthesis of D- and L-2,3-trans-3,4-cis-4,5-trans-3,4-Dihydroxy-5-hydroxymethylproline and Tripeptides Containing Them.
Moreno Vargas, A. J.; Robina, I.; Petricci, E.; Vogel, P.
Published in Journal of Organic Chemistry, 2004, 69(13), 4487-4491. in
Synthesis of Long-Chain Polyketide Fragments by Reaction of 1,3-Dioxy-1,3-dienes with Allylsilanes: Umpolung with Sulfur Dioxide.
Turks, M.; Fonquerne, F.; Vogel, P.
Published in Organic Letters, 2004, 6(6), 1053-1056 in
Palladium-Catalyzed Stille Cross-Couplings of Sulfonyl Chlorides and Organostannanes.
Dubbaka, S. R.; Vogel, P.
Published in Journal of the American Chemical Society. 2004, 125(59), 15292-15293. in
An expeditous, on-iterative, and asymmetric synthesis of 3,5,7,9,11,13,15-heptahydroxypentadecanals.
Gerber, S.; Vogel, P.
Published in European Journal of Organic Chemistry, 2003, (15), 2959-2963. in
Ab Initio and Experimental Studies on the Hetero-Diels-Alder and Cheletropic Additions of Sulfur Dioxide to (E)-1-Methoxybutadiene: A Mechanism Involving Three Molecules of SO2.
Monnat, F.; Vogel, P.; Rayon, V. M.; Sordo, J. A.
Published in J. Org. Chem., 2002, 67, 1882-1889. in
Total Asymmetric Synthesis of a New 9,12-Anhydroerythronolide Aglycone.
Gerber-Lemaire, S.; Ainge, S. W.; Glanzmann, C.; Vogel, P.
Published in Helv. Chim. Acta. 2002, 85, 417-430. in
An efficient Combinatorial Method for the discovery of Glycosidase Inhibitors.
Gerber-Lemaire, S.; Poposycz, F.; Rodriguez-Garcia, E.; Carmona-Asenjo, A. T.; Robina, I.; Vogel, P.
Published in ChemBioChem, 2002, 3(5), 466-470. in
A New, Non-Iterative Asymmetric Synthesis of Long.Chain, 1,3-Polyols.
Schwenter, M.-E.; Vogel, P.
Published in Chem. Eur. J., 2000, 6, 4091-4103. in
The C-Disaccharide α-C(1→3)-Mannopyranoside of N-Acetylgalactosamine is an Inhibitor of Glycohydrolases and of Human α-1, 3-Fucosyltransferase VI. Its Epimer α- (1→3)-Mannopyranoside of N-Acetylosamine Is Not.
Pasquarello, C.; Picasso, S.; Demange, R.; Malissard, M.; Berger, E.G.; Vogel, P.
Published in The Journal of Organic Chemistry, 2000, 65(14), 4251-4260. in
Synthesis of a C29-C51 Subunit of Spongistatin 1(Altohyrtin A) Starting from (R)-3-Benzyloxy-2-methylpropan-1-ol.
Lemaire-Audoire, S.; Vogel, P.
Published in J. Org. Chem., 2000, 65, 3346-3356. in
A New Asymmetric Carbon-Carbon Bond Forming Reaaction: Four-Coponent Stereoselective Synthesis of 8Z)-4,6-Dihydroxy-3-methylalk-2-enyl Methyl Sulfones.
Narkevitch, V.; Schenk, K.; Vogel, P.
Published in Angew. Chem. Int. Ed., 2000, 39, 1806-1808. in
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity,
Borcard, Francoise; Baud, Matthias; Bello, Claudia; Dal Bello, Giovanna; Grossi, Francesco; Pronzato, Paolo; Cea, Michele; Nencioni, Alessio; Vogel, Pierre
Published in Bioorg. Med. Chem. Letters 2010, 20, 5353-5356 in 2010
Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors
Roehrig, Ute F.; Awad, Loay; Grosdidier, Aurelien; Larrieu, Pierre; Stroobant, Vincent; Colau, Didier; Cerundolo, Vincenzo; Simpson, Andrew J.; Vogel, Pierre; Van den Eynde, Benoit J.; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2010, 53, 1172-1189 in 2010
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols
Bello, Claudia; Dal Bello, Giovanna; Cea, Michele; Nahimana, Aimable; Aubry, Dominique; Garuti, Anna; Motta, Giulia; Moran, Eva; Fruscione, Floriana; Pronzato, Paolo; Grossi, Francesco; Patrone, Franco; Ballestrero, Alberto; Dupuis, Marc; Sordat, Bernard; Zimmermann, Kaspar; Loretan, Jacqueline; Wartmann, Markus; Duchosal, Michel A.; Nencioni, Alessio; Vogel, Pierre.
Published in Bioorg. Med. Chem. 2011, 19, 7720-7727. https://doi.org/10.1016/j.bmc.2011.07.053 in 2011
A C-Linked Disaccharide Analogue of Thomsen-Friedenreich Epitope Induces a Strong Immune Response in Mice.
Awad, Loay; Madani, Rime; Gillig, Annabelle; Kolympadi, Maria; Philgren, Maria; Muhs, Andreas; Gerard, Catherine; Vogel, Pierre.
Published in Chem. Eur. J. 2012, 18, 8578-8582. https://doi.org/10.1002/chem.201200364 in 2012
Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors.
Li, Hongqing; Zhang, Yongmin; Favre, Sylvain; Vogel, Pierre; Sollogoub, Matthieu; Bleriot, Yves.
Published in Carbohydrate Research 2012, 356, 110-114. https://doi.org/10.1016/j.carres.2011.10.039 in 2012
Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition
Roehrig, Ute F.; Majjigapu, Somi Reddy; Grosdidier, Aurelien; Bron, Sylvian; Stroobant, Vincent; Pilotte, Luc; Colau, Didier; Vogel, Pierre; Van den Eynde, Benoit J.; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2012, 55, 5270-5290. httpds://doi.org/10.1021/jm300260v in 2026
Synthesis of 2-(1-aminocyclopropyl)pyrrolidine-3,4-diol derivatives applying titanium-mediated reaction conditions.
Declerck, Delphine; Nhien, Albert Nguyen Van; Josse, Solen; Szymoniak, Jan; Bertus, Philippe; Bello, Claudia; Vogel, Pierre; Postel, Denis.
Published in Tetrahedron 2012, 68, 1802-1809. https://doi.org/10.1016/j.tet.2011.12.024 in 2012
Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866.
Gillig, Annabelle; Majjigapu, Somi Reddy; Sordat, Bernard; Vogel, Pierre.
Published in Helv. Chim. Acta 2012, 95, 34-42. https://doi.org/10.1002/hlca.201100415 in 2012
Amide Formation in One Pot from Carboxylic Acids and Amines via Carboxyl and Sulfinyl Mixed Anhydrides.
Zambron, Bartosz K.; Dubbaka, Srinivas R.; Markovic, Dean; Moreno-Clavijo, Elena; Vogel, Pierre.
Published in Org. Letters 2013, 15, 2550-2553. https://doi.org/10.1021/ol401053y in 2013
Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides.
Bai, Jianfei; Zambron, Bartosz K.; Vogel, Pierre.
Published in Org. Letters 2014, 16 (2), 604-607. https://doi.org/10.1021/ol403508j in 2014
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Roehrig, Ute F.; Majjigapu, Somi Reddy; Chambon, Marc; Bron, Sylvian; Pilotte, Luc; Colau, Didier; Van den Eynde, Benoit J.; Turcatti, Gerardo; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in Eur. J. Med. Chem. 2014, 84, 284-301. https://doi.org/10.1016/j.ejmech.2014.06.078 in 2014
Synthesis of pyrrolidine 3,4-diol derivatives with anticancer activity on pancreatic tumor cells.
Steimer, Frederic; Carmona, Ana T.; Moreno-Vargas, Antonio J.; Caffa, Irene; Cea, Michele; Montecucco, Fabrizio; Nencioni, Alessio;Vogel, Pierre; Robina, Inmaculada.
Published in Heterocycles 2014, 88 (2), 1445-1464. in 2014
A critical role of autophagy in antileukemia/ lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
Ginet, Vanessa; Puyal, Julien; Rummel, Coralie; Aubry, Dominique; Breton, Caroline; Cloux, Anne-Julie; Majjigapu, Somi R.; Sordat, Bernard; Vogel, Pierre; Bruzzone, Santina; Nencioni, Alessio; Duchosal, Miechel A.; Nahimana, Aimable.
Published in Autophagy, 2014, 10(4), 603–617. https://doi.org/10.4161/auto.27722 in 2014
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody
Nahimana, Aimable; Aubry, Dominique; Breton, Caroline S.; Majjigapu, Somi R.; Sordat, Bernard; Vogel, Pierre; Duchosal, Michel A.
Published in Leukemia & Lymphoma 2014, 55 (9), 2141-2150. https://doi.org/10.3109/10428194.2013.869325 in 2014
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.
Roehrig, Ute F.; Majjigapu, Somi Reddy; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2015, 58 (24), 9421-9437. https://doi.ord/10.1021/acs.jmedchem.5b00326 in 2015
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).
Roehrig, Ute F.; Majjigapu, Somi Reddy; Caldelari, Daniela; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in Bioorg. Med. Chem. Lett. 2016, 26 (17), 4330-4333. https://doi.org/10.1016/j.bmcl.2016.07.031 in 2016
Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells
Bello, Claudia; Bai, Jianfei; Zambron, Bartosz K.; Elias-Rodriguez, Pilar; Gajate, Consuelo; Robina, Inmaculada; Caffa, Irene; Cea, Michele; Montecucco, Fabrizio; Nencioni, Alessio; Nahimana, Aimable; Aubry, Dominique; Breton, Caroline; Duchosal, Michel A.; Mollinedo, Faustino; Vogel, Pierre
Published in Eur. J. Med. Chem. 2018, 150, 457-478. https://doi.org/10.1016/j.ejmech.2018.02.086 in 2018
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).
Roehrig, Ute F.; Reynaud, Aline; Majjigapu, Somi Reddy; Vogel, Pierre; Pojer, Florence; Zoete, Vincent.
Published in J. Med. Chem. 2019, 62 (19), 8784-8795. https://doi.org/10.1021/acs.jmedchem.9b00942 in 2019
Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.
Röhrig, Ute; Majjigapu, Somi Reddy; Reynaud, Aline; Pojer, Florence; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Michielin, Oliver; Zoete, Vincent.
Published in .J. Med. Chem. 2021, 64(4), 2205-2227. https://doi.org/10.1021/acs.jmedchem.0c01968 in 2021
Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.
Bai, Jianfei; Majjigapu, Sordat, Bernard; Poty, Sophie; Vogel, Pierre; Elias-Rodriguez, Pilar; Moreno-Vargas, Antonio, J.; Carmona, Ana. T.; Caffa, Irene; Ghanem, Moustafa; Khalifa, Amr; Robina, Inmaculada; Cajate, Consuelo; Mollinedo, Faustino; Nahimana, Aimable; Duchosal, Michel; Nencioni, Alessio.
Published in Eur. J. Med. Chem. 2022, 239, article no. 114504, pp. 1-11. https://doi.org/10.1016/j.ejmech.2022.114504 in 2022
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Röhrig, Ute, F.; Majjigapu, Somi, R.; Vogel, Pierre; Reynaud, Aline; Pojer, Florence; Dilek, Nahzli; Reichenbach, Patrick; Ascenção, Kelly; Irving, Melita; Coukos, George; Michielin, Olivier; Zoete, Vincent.
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1), 1773-1811, https://doi.org/10.1080/14756366.2022.2089665. in 2022
Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies.
Biniecka, P.; Matsumoto, S.; Belotti, A.; Joussot, J.; Bai, J. F.; Majjigapu, S. R.; Thoueille, P.; Spaggiari, D.; Desfontaine, V.; Piacente, F.; Bruzzone, S.; Cea, M.; Decosterd, L. A.; Vogel, P.; Nencioni, A.; Duchosal, M. A.; Nahimana, A.
Published in Molecules 2023, 28, article nb. 1897, pp. 1-23. https://doi.org/10.3390/molecules28041897 in 2023
Organocatalysis: fundamentals and comparisons to metal and enzyme catalysis,
Vogel, Pierre; Lam, Yu-hong; Simon, Adam; Houk, Kendall N.
Published in Catalysts 2016, 6 (9), article nb, 128, pp. 1-65. https://doi.org/10.3390/catal6090128 in 2016
Expeditious Asymmetric Synthesis of Polypropionates Relying on Sulfur Dioxide-Induced C-C Bond Forming Reactions
Vogel, Pierre; Sordo Gonzalo, Jose Angel.
Published in Catalysts 2021, 11(11), article nb. 1267, pp.1-20. https://doi.org/10.3390/catal11111267 in 2021
Organic Chemistry and Synthesis Rely More and More upon Catalysts.
Vogel, Pierre; Houk, Kendall N.
Published in Catalysts 2022, 12(7), article no. 758, pp. 1-31. https://doi.org/10.3390/catal12070758 in 2022
Asymmetric Bio- and Organocatalysis: Historical Aspects and Concepts.
Vogel, Pierre.
Published in Catalysts 2026, 6, article nb. 131, pp. 1-142. https://doi.org/10.3390/catal16020131. Link: https://www.mdpi.com/2073-4344/16/2/131 in 2026
Total Synthei and Determinaion f the Absolte Configuration of (-)-Dolabriferol
Laclef, S.; Turk, M.; Vogel, P.
Published in Angew. Chem. Int. Ed. 2010, 49(4), 8525-8527 in 2010
Synthesis and Applications of Silyl 2-Methylprop-2-ene-1-sulfinates in Preparative Silylation and GC-Derivatization actions of Polyols and Carbohydrates s
Markovic, D.; Tchawou, W. A.; Novosjolova, I.; LaClef, S.; Stepanovs, D.; Turks, M.; Vogel. P.
Published in Chem. Eur. J. 2016, 22(12), 4196-4205 in 2016
The norbornene mistery revealed
Steinmann, S. N.; Vogel, P.; Mo, Y.; Corminboeuf, C.
Published in Chem. Commun. 2011, 47(1), 227-229 in 2011