Priscilla Turelli

priscilla.turelli@epfl.ch +41 21 693 06 49

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Nationality: Française/French

+41 21 693 06 49
Office: SV 3533
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Website: https://go.epfl.ch/edms

+41 21 693 06 49
Office: SV 3533
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Website: https://sv-in.epfl.ch

+41 21 693 06 49
Office: SV 3533
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Website: https://www.epfl.ch/labs/antanasijevic-lab/

Biography Publications Teaching & PhD

________________________________________________________________________ Positions
2024-now: Senior scientist, Federal School of Life Sciences, laboratory of Virology and Structural immunology and faculty representative for P3-related scientific activities, Lausanne, Switzerland
2005-2024: Research associate, Federal School of Life Sciences, Laboratory of Virology and Genetics, Lausanne, Switzerland
2001-2004: Research associate, Department of Microbiology, Geneva School of Medicine, Switzerland
1997-2001: Post-doctoral research fellow in Pr D. Trono's laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland
________________________________________________________________________ Honors and fellowships
2023: Award Innosuisse Business concept training
2004: Bristol-Myers Squibb AIDS AWARD
1997-1999: Human Frontier Science Program fellowship
________________________________________________________________________ Education
June 1997: PhD in cellular biology. Final mark:jury congratulations. Université de la Méditerranée, France.
June 1993: Post-graduate diploma in cellular biology and microbiology. INSERM U372, Marseille-Luminy, université de Provence, France.
June 1992: Master in cellular biology – Specialty: genetic. Final mark: Best master student of this year. Université de la Méditerranée, France.
June 1987: Scientific baccalaureate, France.
_______________________________________________________________________ Teaching experience
2009-now: phD thesis co-director, School of Life Sciences, Lausanne, Switzerland.
2002: Tutor in virology for medical students, 2nd year, Geneva School of Medicine, Switzerland.
1996-1997: Tutor in molecular biology and biochemistry for under-graduate students, Université de la Méditerranée, Aix Marseille II, France.

Publications

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

R. Forey; C. Raclot; C. Pulver; O. Rosspopoff; S. Offner et al.

Proceedings of the National Academy of Sciences. 2025. DOI : 10.1073/pnas.2505021122.

Priscilla Turelli

Publications

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

De novo design of protein interactions with learned surface fingerprints

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Cryo-EM structures and binding of mouse ACE2 to SARS-CoV-2 variants of concern

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Genetic features and genomic targets of human KRAB-zinc finger proteins

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Cell-free method for the quantitative measurement of virus neutralizing antibodies

Krab-containing zinc finger protein and cancer

SARS-CoV-2 S Omicron Spike B.1.1.529

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

A highly potent antibody effective against SARS-CoV-2 variants of concern

A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

ZNF445 is a primary regulator of genomic imprinting

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks

DNA repair protein Rad18 restricts LINE-1 mobility

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

KRAB'n'KAP, DNA methylation and epigenetic memory

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

Evolutionally dynamic L1 regulation in embryonic stem cells

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Editing at the crossroad of innate and adaptive immunity

DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

Inhibition of hepatitis B virus replication by APOBEC3G

Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action

The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Teaching & PhD

Past EPFL PhD Students as codirector