BiographyPositions 2005-now: Research associate, Federal School of Life Sciences, Laboratory of Virology and Genetics, Lausanne, Switzerland 2001-2004: Research associate in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland 1997-2001: Post-doctoral research fellow in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland ________________________________________________________________________ Honors and fellowships 2004: Bristol-Myers Squibb AIDS AWARD 1997-1999: Human Frontier Science Program fellowship ________________________________________________________________________ Education June 1997: PhD in cellular biology. Final mark:jury congratulations. Université de la Méditerranée, France. June 1993: Post-graduate diploma in cellular biology and microbiology. INSERM U372, Marseille-Luminy, université de Provence, France. June 1992: Master in cellular biology Specialty: genetic. Final mark: Best master student of this year. Université de la Méditerranée, France. June 1987: Scientific baccalaureate, France. _______________________________________________________________________ Teaching experience 2009-now: phD thesis co-director, School of Life Sciences, Lausanne, Switzerland. 2002: Tutor in virology for medical students, 2nd year, Geneva School of Medicine, Switzerland. 1996-1997: Tutor in molecular biology and biochemistry for under-graduate students, Université de la Méditerranée, Aix Marseille II, France. ___________________________________________
Cell-free method for the quantitative measurement of virus neutralizing antibodiesWO2022090573 . 2022.
A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP FamilyJournal of Molecular Biology. 2019-06-28. DOI : 10.1016/j.jmb.2019.05.002.
KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, October 16-19, 2018. p. A150-A150.
Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult TissuesDevelopmental Cell. 2016. DOI : 10.1016/j.devcel.2016.02.024.
Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelementsGenome research. 2014. DOI : 10.1101/gr.172833.114.
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotencyGenome research. 2014. DOI : 10.1101/gr.172809.114.
Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activitiesJournal of virology. 2010. DOI : 10.1128/JVI.01651-10.
APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic miceJournal of Virology. 2008. DOI : 10.1128/JVI.00216-08.
Interfering residues narrow the spectrum of MLV restriction by human TRIM5alphaPLOS Pathogens. 2007. DOI : 10.1371/journal.ppat.0030200.
Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferonsJournal of Virology. 2007. DOI : 10.1128/JVI.02489-06.
Editing at the crossroad of innate and adaptive immunityScience. 2005. DOI : 10.1126/science.1105964.
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integrationJournal of Virology. 2005. DOI : 10.1128/JVI.79.5.2973-2978.2005.
A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif actionJournal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400060200.
Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"Science. 2004. DOI : 10.1126/science.1101974.
Inhibition of hepatitis B virus replication by APOBEC3GScience. 2004. DOI : 10.1126/science.1092066.
The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assayJournal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400334200.
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcriptsNature. 2003. DOI : 10.1038/nature01709.
Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalizationJournal of Virology. 2002. DOI : 10.1128/JVI.76.20.10356-10364.2002.
Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replicationMolecular Cell. 2001. DOI : 10.1016/S1097-2765(01)00255-6.
Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticlesPharm Res. 2001. DOI : 10.1023/A:1010962507273.
Visna virus dUTPase is dispensable for neuropathogenicityJournal of Virology. 1998. DOI : 10.1128/JVI.72.2.1657-1661.1998.
dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.Journal of Virology. 1997. DOI : 10.1128/jvi.71.6.4522-4530.1997.
Replication properties of dUTPase-deficient mutants of caprine and ovine lentivirusesJournal of Virology. 1996. DOI : 10.1128/jvi.70.2.1213-1217.1996.
Teaching & PhD
Doctoral Program in Molecular Life Sciences
PhD StudentsBrandão Sanches Vong Martins Filipe Amândio,
Past EPFL PhD StudentsColuccio Andrea , Ecco Gabriela , Helleboid Pierre-Yves Joseph Laurent , Iouranova Alexandra , Marzetta Flavia , Pennese Natali ,
Program: Doctoral Program in Molecular Life Sciences