Ruud Hovius

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Maître d'enseignement et de recherche +41 21 693 31 34

CH B3 424 (Bâtiment CH)
Station 6
CH-1015 Lausanne


Données administratives


Protein structure, expression & purification

•Molecular interaction & receptor activation

•Fluorescence imaging & spectroscopy

Signalling & sensing



Autres publications

Schreiter, C.; M. Gjoni, R. Hovius, K. L. Martinez, J.-M. Segura, and H. Vogel.
ChemBioChem (accepted)
Reversible Sequential Binding Assays Probe Receptor Function in Single Cells
Geissbuehler, I.; R. Hovius, K. L. Martinez, M. Adrian, K. R. Thampi and H. Vogel.
Angew. Chem., 44,2005
Lipid-coated Nanocrystals as Multi-functionalized Luminescent Scaffolds for Supramolecular Biological Assemblies.
Guignet, E. G.; R. Hovius and H. Vogel.
Nature Biotechnology, 22, 2004
Reversible site-selective labelling of proteins in live cells: The structure of the 5HT3 serotonin receptor.
B�umle, M.; D. Stamou, J.-M. Segura, R. Hovius and H. Vogel
Langmuir, 2004
Highly fluorescent streptavidin-coated CdSe nanoparticles: Preparation in water, characterization, micropatterning
Martinez, K. L.; B. H. Meyer, R. Hovius, K. Lundstrom and H. Vogel
Langmui, 19/26, 2003
Probing the function of G-protein coupled receptors in tethered cell membranes.
Schreiter, C.; R. Hovius, M. Costioli, H. Pick, S. Kellenberger, L. Schild, and H. Vogel
J. Biol. Chem, 278, 2003
Characterization of the ligand-binding site of the serotonin 5-HT3 receptor: The role of glutamate residues 97, 224, and 235
Milon S, Hovius R, Vogel H, Wohland T
Chemical Physics, 288, Issues 2-3, 2003
Factors influencing fluorescence correlation spectroscopy measurements on membranes: simulations and experiments
Vallotton, P; A.P. Tairi, T. Wohland, K. Friedrich-B�net, H. Pick, R. Hovius and H. Vogel
Biochemistry, 40, 2001
Mapping the antagonist binding site of the serotonin type 3 receptor by fluorescence resonance energy transfer.
Hovius, R.; P. Vallotton, T. Wohland and H. Vogel
Trends Pharmacol Sci , 21, 2000
Fluorescence techniques. Shedding light on ligand-receptor interactions.
Wohland, T.; K. Friedrich, R. Hovius and H. Vogel
Biochemistry, 38, 1999
Study of ligand-receptor interactions by fluorescence correlation spectroscopy with different fluorophores: evidence that the homopentameric 5-hydroxytryptamine type 3As receptor binds only one ligand.
Schmid, E.L.; A.P. Tairi, R. Hovius and H. Vogel
Anal Chem, 70, 1998
Screening ligands for membrane protein receptors by total internal reflection fluorescence: the 5-HT3 serotonin receptor.
Tairi, A.P.; R. Hovius, H. Pick, H. Blasey, A. Bernard, A. Surprenant, K. Lundstr�m and H. Vogel,
Biochemistry, 37, 1998
Ligand binding to the serotonin 5-HT3 receptor studied with a novel fluorescent ligand.
Stora, T.; R. Hovius, Z. Dienes, M. Pachoud and H. Vogel,
Langmuir, 13, 1997
Metal ion trace detection by a chelator-modified gold electrode: A comparison of surface to bulk affinity.
Hovius, R.; J. Thijssen, P. van der Linden, K. Nicolay and B. de Kruijff,
FEBS Lett, 330, 1993
Phospholipid asymmetry of the outer membrane of rat liver mitochondria. Evidence for the presence of cardiolipin on the outside of the outer membrane


Current interests

Structure and function DNA-protein macromolecular complexes

Real-time monitoring of structural dynamics and molecular interactions

Single molecule techniques & cellular signalling