Sandrine Gerber

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Membre - Corps enseignant

sandrine.gerber@epfl.ch +41 21 693 93 72 http://gbf.epfl.ch

Nationalité : Swiss and French

Date de naissance : 21.05.1971

Site web: https://sb.epfl.ch/conseil
Unité: CF-SB

EPFL VPRHO DSPS COSEC-SB
CH B1 425 (Bâtiment CH)
Station 6
CH-1015 Lausanne

EPFL SB ISIC-GE
CH B1 425 (Bâtiment CH)
Station 6
CH-1015 Lausanne

Unité: SCGC-ENS

EPFL Valais Wallis
EPFL ISIC-GE-VS
Rue de l'Industrie 17
Case postale 440
CH-1951 Sion

EPFL SB ISIC SCI-SB-SG
CH B1 425 (Bâtiment CH)
Station 6
CH-1015 Lausanne

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Données administratives

Compétences

Organic synthesis
Engineering of polymeric hydrogels
Surface functionalization of nanomaterials

Publications

Autres publications

Rogov, A.; Irondelle, M.; Ramos-Gomes, F.; Bode, J.; Staedler, D.; Passemard, S.; Courvoisier, S.; Yamamoto, Y.;Waharte, F.; Ciepielewski, D.; Rideau, P.; Gerber-Lemaire, S.; Alves, F.; Salamero, J.; Bonacina, L.; Wolf, J.-P.
ACS Photonics, 2015, 2, 1416-1422
Simultaneous Multi-Harmonic Imaging of Nanoparticles in Tissues for Increased Selectivity
Staedler, D.; Magouroux, T.; Passemard, S.; Schwung, S.; Dubled, M.; Schneiter, G. S.; Rytz, D.; Gerber-Lemaire, S.; Bonacina, L.; Wolf, J.-P.
Nanoscale, 2014, 6, 2929-2936
Deep UV Generation and Direct DNA Photo-Interaction by Harmonic Nanoparticles in Labelled Samples
Glauser, M.; Metrailler, M.; Gerber-Lemaire, S.; Centeno, C.; Seghezzi, C.; Dunand, M.; Abid, K.; Herren, A.; Grouzmann, E.
Clinica Chim. Acta 2014, 430, 125-128
Enzyme and Acid Deconjugation of Plasma Sulfated Metanephrines
Frei, R.; Raja, A.; Franke, R.; Sasse, F.; Staedler, D.; Gerber-Lemaire, S.; Waser, J.
Angew. Chem. Int. Ed. 2013, 52, 13373-13376
Total Synthesis and Biological Evaluation of Jeriantinine E
Grouzmann, E.; Gualtierotti, J.- B.; Gerber-Lemaire, S.; Abid, K.; Brakch, N.; Pedretti, A.; Testa, B.; Vistoli, G.
Chirality 2013, 25, 28-34
Lack of Enantioselectivity in the SULT1A3-Catalyzed Sulfoconjugation of Normetanephrine Enantiomers: an in Vitro and Computational Study
Borcard, F.; Kong, P.; Journot, C.; Staedler, D.; Sturzenegger, P. N.; Krauss Juillerat, F., Gonzenbach, U. T.; Juillerat-Jeanneret, L.; Gerber-Lemaire, S.
Chimia 2013, 67, 213-217
Surface modification of biomaterials for conjugation to human fetal osteoblasts
Passemard, S.; Staedler, D.; U??ov�, L.; Schneiter, G. S.; Kong, P.; Bonacina, L.; Juillerat-Jeanneret, L.; Gerber-Lemaire, S.
Bioorg. Med. Chem. Lett. 2013, 23, 5006-5010
Convenient synthesis of bifunctional azido and amino-silanized poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications
Krauss Juillerat, F.; Engeli, R.; Jerjen, I.; Sturzenegger, P. N.; Borcard, F.; Juillerat-Jeanneret, L.; Gerber-Lemaire, S.; Gauckler, L. J.; Gonzenbach, U. T.
J. Eur. Ceram. Soc. 2013, 2013, 33, 1497-1505
Synthesis of bone-like structured foams
Krauss Juillerat, F.; Borcard, F.; Staedler, D.; Scaletta, C.; Applegate, L. A.; Comas, H.; Gauckler, L.J.; Gerber-Lemaire, S.; Juillerat-Jeanneret, L; Gonzenbach, U.
Bioconjugate Chem. 2012, 23, 2278-2290
Functionalization of microstructured open-porous bio-ceramic scaffolds with human fetal cells
Borcard, F.; Staedler, D.; Comas, H.; Krauss Juillerat, F.; Sturzenegger, P. N.; Heuberger, R. Gonzenbach, U. T.; Juillerat-Jeanneret, L.; Gerber-Lemaire, S.
J. Med. Chem. 2012, 55, 7988-7997
Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering
Staedler, D.; Magouroux, T.; Hadli, R.; Joulaud, C.; Extermann, J.; Schwung, S.; Passemard, S.; Kasparian, C.; Clarke, G.; Gerrmann, M.; Le Dantec, R.; Mugnier, Y.; Rytz, D.; Ciepielewski, D.; Galez, C.; Gerber-Lemaire, S.; Juillerat-Jeanneret, L.; Bonacina, L.; Wolf., J.-P.
ACS Nano 2012, 6, 2542-2549
Harmonic Nanocrystals for Bio-Labeling: a Survey of Optical Properties and Biocompatibility
Comas, H.; Laporte, V.; Borcard, F.; Mi�ville, P.; Krauss Juillerat, F.; Caporini, M. A.; Gonzenbach, U. T.; Juillerat-Jeanneret, L.; Gerber-Lemaire, S.
ACS Appl. Mater. Interfaces 2012, 4, 573-576
Surface Functionalisation of Alumina Ceramic Foams with Organic Ligands
Simonin, J.; Gerber-Lemaire, S.; Centeno, C.; Seghezzi, C.; Iglesias, K.; Abid, K.; Grouzmann, E.
Clinica Chim. Acta, 2012, 413, 998-1003
Synthetic calibrators for the analysis of total metanephrines in urine: hydrolysis conditions revisited

Recherche

Cancer imaging and diagnosis

Development of functionalized second harmonic nanoparticles for cancer diagnosis and imaging

In vivo imaging has huge potential as diagnostic and prognostic tools in human diseases. We are pursuing the development of a novel generation of multimodal nanodevices capable of acting simultaneously as contrast agents for different imaging techniques (optical microscopy, magnetic resonance) and of complementing these imaging capabilities with other functions such as drug delivery, electric and pH sensing, etc.

To achieve multi-modal probes for long-term imaging, we develop chemical functionalizations of Second Harmonic Generation nanoparticles (SHG-NPs) for the selective binding to human disease biomarkers (cancer biomarkers and cellular structures reporting the presence of tumour cells or tumour-associated cells with defined characteristics of the tumour environment). These nanomaterials are also designed to display the possibility to be internalized by tumour cells or tumour-associated cells, in order to report over time of the loss, or maintenance, of these cells in a defined location in response to a therapy. Several efficient synthetic routes have been implemented for the preparation of PEG-based coating polymers and their covalent conjugation to targeting for specific association with cancer cells biomarkers.In addition, we recently disclosed the possibility to use SHG-NPs as photo-therapeutic agents for in situ generation of UV. These results highlighted, for the first time, the use of up conversion NPs for on-demand and localized induction of direct damages on cancer cells nuclear DNA, paving the way for the development of theranostic devices based on SHG-NPs.

Cell therapy products

Development of functionalized polymeric hydrogels for cell immobilization

The increasing incidence of age-related diseases and the low availability of human donor material to replace dysfunctional cells and damaged tissues in patients have prompted the search for alternative transplantation therapies. Hydrogels, presenting a three dimensional (3D) structure, can serve as scaffolds for tissue engineering and as carrier for cell encapsulation and drug delivery. The transplantation of encapsulated cells/tissues prevents adverse immunological response while allowing the crossing of oxygen, nutrients and secreted factors. Despite the highly promising studies that have been directed toward the development of hydrogel microcapsules for the treatment of human diseases including liver failure, diabetes mellitus, Parkinson's disease and anemia, routine clinical application of cell microcapsules still remains a challenge.
We develop synthetic routes for the production of PEG-grafted alginate hydrogels which are further conjugated to anti-inflammatory agents and drug scaffolds targeting fibrotic pathways to provide highly biocompatible materials for the encapsulation of islets and hepatocytes.