Stéphanie Lacour

Bioelectronics integrates principles of electrical engineering to biology, medicine and ultimately health. My lab challenges and seeks to advance our fundamental concepts in man-made electronic systems applied to biology. Specifically, the focus is on designing and manufacturing electronic devices with mechanical properties close to those of the host biological tissue so that long-term reliability and minimal perturbation are induced in vivo and/or truly wearable systems become possible.
We use fabrication methods borrowed from the MEMS and microelectronics industries and adapt them to soft substrates like elastomers. We develop novel characterization tools adapted to mechanically compliant bioelectronic circuits. We evaluate in vitro, in animal models and ultimately on humans our soft bioelectronic interfaces

Biography

Stéphanie P. Lacour holds the Bertarelli Foundation Chair in Neuroprosthetic Technology in the School of Engineering at EPFL and leads the Laboratory for Soft Bioelectronic Interfaces.
She received her PhD in Electrical Engineering from INSA de Lyon, France, and completed postdoctoral research at Princeton University and the University of Cambridge. She is the recipient of the 2006 MIT TR35, a University Research Fellowship of the Royal Society, European Research Council ERC Starting and POC Grants, and a SNSF-ERC Consolidator Grant. She was elected a 2015 Young Global Leader by the World Economic Forum.

Post-docs

Alix Trouillet
Haotian Chen
Florian Fallegger
Sukho Song
Kyungjin Kim

PhD students

Noaf Alwahab
Outman Akouassi (co-advised by S. Micera)
Florent-Valery Coen
Eleonora Martinelli
Valentina Paggi
Emilie Revol
Michael Shur
Yash Vyza
Kanglin Wu

Education

Ph.D.

INSA, Lyon, France

1998-2001

M.Sc.

Integrated Electronic Devices

INSA, Lyon France

1998

Publications

Infoscience publications

LSBI

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

F. Fallegger; A. Trouillet; F.-V. Coen; G. Schiavone; S. P. Lacour

Apl Bioengineering. 2023-09-01. DOI : 10.1063/5.0152509.

Stéphanie Lacour

Full Professor

Mission

Biography

Post-docs

PhD students

Education

Publications

Infoscience publications

LSBI

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Radiation Patterns of RF Wireless Devices Implanted in Small Animals: Unexpected Deformations Due to Body Resonance

Unraveling the Electrochemical Electrode Coupling in Integrated Organic Electrochemical Transistors

Radiation Performance of Antennas Implanted in Small Animals for Neuroengineering

Hydrogels and conductive hydrogels for implantable bioelectronics

Deployment of an electrocorticography system with a soft robotic actuator

Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI)

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

In Liquido Computation with Electrochemical Transistors and Mixed Conductors for Intelligent Bioelectronics

Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

The neurons that restore walking after paralysis

NeuralTree: A 256-Channel 0.227-mu J/Class Versatile Neural Activity Classification and Closed-Loop Neuromodulation SoC

Thermodynamics of organic electrochemical transistors

A finite element model of the mechanical interactions between peripheral nerves and intrafascicular implants

Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization Methods

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Chronic recording of cortical activit y underlying vocalization in awake minipigs

A stretchable sensor for force estimation in soft wearable robots

On the Modeling of Organic Electrochemical Transistors

An All-Digital 1.25 Mbps 5-Subcarrier OFDM Backscatter Uplink with Delta-Sigma Modulation for Improved Spurious-Free Dynamic Range

An All-Digital 1 Mbps, 57 pJ/bit Bluetooth Low Energy (BLE) Backscatter ASIC in 65 nm CMOS

Conformable neural interfaces : from engineering stretchability at the micro-scale to translational applications

Method for labelling a device and devices obtanaible therefrom

Adaptive Wireless Power Transfer and Backscatter Communication for Perpetual Operation of Wireless Brain-Computer Interfaces

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Editorial overview: Tissue, cell and pathway engineering: bioinspired, biomimetic and hybrid neural interfaces

Reactive Exercises with Interactive Objects: Interim Analysis of a Randomized Trial on Task-Driven NMES Grasp Rehabilitation for Subacute and Early Chronic Stroke Patients

Extended Barrier Lifetime of Partially Cracked Organic/Inorganic Multilayers for Compliant Implantable Electronics

CMOS-Inspired Complementary Fluidic Circuits for Soft Robots

Microscale Liquid Metal Conductors for Stretchable and Transparent Electronics

Dimensional scaling of thin-film stimulation electrode systems in translational research

Adaptive Self-Sealing Suction-Based Soft Robotic Gripper

Viscoelastic surface electrode arrays to interface with viscoelastic tissues

Compliant peripheral nerve interfaces

A 16-Channel Wireless Neural Recording System-on-Chip with CHT Feature Extraction Processor in 65nm CMOS

Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrations

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Soliton microcomb based spectral domain optical coherence tomography

Soft materials and technologies for neural interfaces

Bioinspired Liquid Metal Based Sensing System For Compliance Detection

Electronic Skins for Healthcare Monitoring and Smart Prostheses

Hybrid soft-rigid electrical interconnection system

Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Nanoscale Controlled Oxidation of Liquid Metals for Stretchable Electronics and Photonics

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Structured nanoscale metallic glass fibres with extreme aspect ratios

A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity

Soft Printable Electrode Coating for Neural Interfaces

Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant Surgery

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

Development and Evaluation of a Sensor Glove to Detect Grasp Intention for a Wearable Robotic Hand Exoskeleton

Stretchable cuff device

Integration of hybrid material systems in conformable neural interfaces

Biomedical device comprising a mechanically adaptive member

Soft, Implantable Bioelectronic Interfaces for Translational Research

Gallium-Based Thin Films for Wearable Sensors and Electronic Skins

Closed-Loop Haptic Feedback Control Using a Self-Sensing Soft Pneumatic Actuator Skin

Three-Dimensional Surface Reconstruction of the Human Cochlear Nucleus: Implications for Auditory Brain Stem Implant Design

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Gallium‐Based Thin Films for Wearable Human Motion Sensors

Conformable bioelectronic interfaces: Mapping the road ahead