Stéphanie Lacour

EPFL STI IMT LSBI
B3 2 229.134 (Campus Biotech bâtiment B3)
Ch. des Mines 9
CH-1202 Genève
+41 21 693 11 81
+41 21 693 11 82
Office: B3 2 229.134
EPFL > STI > IMT > LSBI
Web site: Web site: https://lsbi.epfl.ch
+41 21 693 11 81
EPFL > STI > STI-SMT > SMT-ENS
EPFL STI IBI-GE
B3 2 229.134 (Campus Biotech bâtiment B3)
Ch. des Mines 9
CH-1202 Genève
+41 21 693 11 81
Office: B3 2 229.134
EPFL > STI > IBI-STI > IBI-STI-GE
Web site: Web site: https://bioengineering.epfl.ch/
+41 21 693 11 81
EPFL > SV > SV-SSV > SSV-ENS
Web site: Web site: https://sv.epfl.ch/education
+41 21 693 11 81
EPFL > E > E-DOC > EDMI-ENS
EPFL ENT-R CNP
Campus Biotech B3
Ch. des Mines 9
CH-1202 Genève
+41 21 693 11 81
+41 21 693 18 42
Office: BM 5131
EPFL > ENT-R > CNP > CNP-GE
Web site: Web site: https://cnp.epfl.ch/
Mission
Bioelectronics integrates principles of electrical engineering to biology, medicine and ultimately health. My lab challenges and seeks to advance our fundamental concepts in man-made electronic systems applied to biology. Specifically, the focus is on designing and manufacturing electronic devices with mechanical properties close to those of the host biological tissue so that long-term reliability and minimal perturbation are induced in vivo and/or truly wearable systems become possible.We use fabrication methods borrowed from the MEMS and microelectronics industries and adapt them to soft substrates like elastomers. We develop novel characterization tools adapted to mechanically compliant bioelectronic circuits. We evaluate in vitro, in animal models and ultimately on humans our soft bioelectronic interfaces
Biography
Stéphanie P. Lacour holds the Bertarelli Foundation Chair in Neuroprosthetic Technology in the School of Engineering at EPFL and leads the Laboratory for Soft Bioelectronic Interfaces.She received her PhD in Electrical Engineering from INSA de Lyon, France, and completed postdoctoral research at Princeton University and the University of Cambridge. She is the recipient of the 2006 MIT TR35, a University Research Fellowship of the Royal Society, European Research Council ERC Starting and POC Grants, and a SNSF-ERC Consolidator Grant. She was elected a 2015 Young Global Leader by the World Economic Forum.
Post-docs
Clemetine BoutryLiz Canovic
Aaron Gerratt
Xiaoyang Kang
Jennifer Macron
Hadrien Michaud
Giuseppe Schiavone
PhD students
Florent-Valery CoenLaurent Dejace
Florian Fallegger
Sandra Gribi
Arthur Hirsch
Frédéric Michoud
Nicolas Vachicouras
Michael Shur
Education
Ph.D.
INSA, Lyon, France
1998-2001
M.Sc.
Integrated Electronic Devices
INSA, Lyon France
1998
Publications
Infoscience publications
LSBI
Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation
Neuron. 2020-10-28. DOI : 10.1016/j.neuron.2020.10.010.Nanoscale Controlled Oxidation of Liquid Metals for Stretchable Electronics and Photonics
Advanced Functional Materials. 2020-10-07. DOI : 10.1002/adfm.202006711.Structured nanoscale metallic glass fibres with extreme aspect ratios
Nature Nanotechnology. 2020-08-03. DOI : 10.1038/s41565-020-0747-9.A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity
Journal Of Neural Engineering. 2020-08-01. DOI : 10.1088/1741-2552/aba4fc.Soft Printable Electrode Coating for Neural Interfaces
ACS Applied Bio Materials. 2020-06-26. DOI : 10.1021/acsabm.0c00401.Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant Surgery
Otology & Neurotology. 2020-04-01. DOI : 10.1097/MAO.0000000000002565.Conformable Hybrid Systems for Implantable Bioelectronic Interfaces
Advanced Materials. 2020-04-01. DOI : 10.1002/adma.201903904.Integration of hybrid material systems in conformable neural interfaces
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-8096.Biomedical device comprising a mechanically adaptive member
CN111450409 ; US2020230401 ; EP3682941 . 2020.Soft, Implantable Bioelectronic Interfaces for Translational Research
Advanced Materials. 2020. DOI : 10.1002/adma.201906512.Gallium-Based Thin Films for Wearable Sensors and Electronic Skins
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7486.Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants
Science Translational Medicine. 2019-10-16. DOI : 10.1126/scitranslmed.aax9487.Closed-Loop Haptic Feedback Control Using a Self-Sensing Soft Pneumatic Actuator Skin
Soft Robotics. 2019-09-23. DOI : 10.1089/soro.2019.0013.Gallium‐Based Thin Films for Wearable Human Motion Sensors
Advanced Intelligent Systems. 2019-08-06. DOI : 10.1002/aisy.201900079.Conformable bioelectronic interfaces: Mapping the road ahead
Science Translational Medicine. 2019-07-31. DOI : 10.1126/scitranslmed.aaw5858.Thin Hydrogel-Elastomer Multilayer Encapsulation for Soft Electronics
Advanced Materials Technologies. 2019-07-01. DOI : 10.1002/admt.201900331.When and why performance goals predict exploitation behaviors: An achievement goal complex analysis of the selection function of assessment
Motivation And Emotion. 2019-04-01. DOI : 10.1007/s11031-018-9742-y.Materials chemistry in flexible electronics
Chemical Society Reviews. 2019-03-21. DOI : 10.1039/c9cs90019e.Liquid electromigration in gallium-based biphasic thin films
Apl Materials. 2019-03-01. DOI : 10.1063/1.5059380.Harnessing the Rheological Properties of Liquid Metals To Shape Soft Electronic Conductors for Wearable Applications
Accounts of Chemical Research. 2019-02-04. DOI : 10.1021/acs.accounts.8b00489.First Biopotential Recordings from a Liquid Crystal Optrode
2019-01-01. Symposium on Clinical and Translational Neurophotonics 2020 held at SPIE BiO Conference, San Francisco, CA, Feb 01, 2020. p. UNSP 1122505. DOI : 10.1117/12.2544087.Soft And Wearable Transducers: Opportunities And Challenges For Daily Use
2019-01-01. 32nd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS), Seoul, SOUTH KOREA, Jan 27-31, 2019. p. 65-65.Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates
2019. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, July 23-27, 2019.Patterned biphasic electrical conductor and methods for producing thereof
EP3462462 . 2019.Method for manufacturing hybrid soft-rigid electronic devices
WO2019219487 . 2019.Bi-Modal Control of Vacuum-Powered Soft Pneumatic Actuators with Embedded Liquid Metal-Based Strain Sensitive Skin
2019. Robosoft 2019, Seoul, South Korea, April 14-18, 2019.Microchannel-based technologies for nerve interfacing
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9425.Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized components
Hearing Research. 2019. DOI : 10.1016/j.heares.2019.02.010.Three-Dimensional Surface Reconstruction of the Human Cochlear Nucleus: Implications for Auditory Brain Stem Implant Design
Journal of Neurological Surgery Part B: Skull Base. 2019. DOI : 10.1055/s-0039-1677863.Soft microfabricated neural implants: a path towards translational implementation
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9181.Soft multimodal neural interfaces for unravelling sensory neurological circuits
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9046.Auditory Brainstem Implants: Recent Progress and Future Perspectives
Frontiers in Neuroscience. 2019. DOI : 10.3389/fnins.2019.00010.Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model
2018-10-29. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, 18-21 July 2018. p. 1432-1435. DOI : 10.1109/EMBC.2018.8512584.A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers
Nature Communications. 2018-10-23. DOI : 10.1038/s41467-018-06895-7.Equilibrium and Out-of-Equilibrium Adherence of Hydrogels against Polymer Brushes
Macromolecules. 2018-10-09. DOI : 10.1021/acs.macromol.8b01063.A Method to Form Smooth Films of Liquid Metal Supported by Elastomeric Substrate
Advanced Science. 2018-10-01. DOI : 10.1002/advs.201800256.Soft implantable neurotechnology: a translational perspective
GRC Neuroelectronic interfaces, Galveston, Texas, USA, 25-30 March 2018.Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle
Journal Of Tissue Engineering And Regenerative Medicine. 2018-02-01. DOI : 10.1002/term.2568.Optical cuff for optogenetic control of the peripheral nervous system
Journal of Neural Engineering. 2018-01-10. DOI : 10.1088/1741-2552/aa9126.Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model
2018. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI : 10.1109/EMBC.2018.8512584.Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord
2018. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, July 18-21, 21018. p. 1424-1427. DOI : 10.1109/EMBC.2018.8512554.Engineering reversible elasticity in ductile or brittle thin films and products resulting from said engineering
US2020094466 ; CN110382216 ; EP3548264 ; WO2018100005 . 2018.Uniaxial strain of cultured mouse and rat cardiomyocyte strands slows conduction more when its axis is parallel to impulse propagation than when it is perpendicular
Acta Physiologica. 2018. DOI : 10.1111/apha.13026.Electronic dura mater soft, multimodal neural interfaces
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8112.Controlled Sub-Micrometer Hierarchical Textures Engineered in Polymeric Fibers and Microchannels via Thermal Drawing
Advanced Functional Materials. 2017-01-24. DOI : 10.1002/adfm.201605935.Engineering reversible elasticity in ductile and brittle thin films supported by a plastic foil
Extreme Mechanics Letters. 2017. DOI : 10.1016/j.eml.2017.05.005.Stretchable metallization technologies for skin-like transducers
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7848.Uniaxial strain of cardiac tissue parallel to impulse propagation slows conduction more than in the perpendicular direction: untangling the effects of stretch on tissue resistance
2017. p. 114-114.Method for manufacturing electrical conductors, and electrical conductors manufactured according to same
US10828486 ; US2018289946 ; EP3368145 ; WO2017072347 . 2017.Method for the electrical passivation of electrode arrays and/or conductive paths in general, and a method for producing stretchable electrode arrays and/or stretchable conductive paths in general
US10448514 ; US2017086301 ; EP3142550 ; WO2015172894 . 2017.Electronic Dura Mater Meddling in the Central Nervous System
Jama Neurology. 2017. DOI : 10.1001/jamaneurol.2016.5767.Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7628.A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents
2016-10-18. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, USA, August 16-20, 2016.Synthetic skin for recording and modulating physiological activities
US10695555 ; EP3242720 ; US2018001081 ; EP3242720 ; WO2016110564 . 2016.Design and Functional Evaluation of an Epidermal Strain Sensing System for Hand Tracking
2016. 2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Daejeon, Korea, October 9-14, 2016. p. 3186-3191.Materials and technologies for soft implantable neuroprostheses
Nature Reviews Materials. 2016. DOI : 10.1038/natrevmats.2016.63.Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures
Biomaterials. 2016. DOI : 10.1016/j.biomaterials.2016.02.041.Performance of Indium Gallium Zinc Oxide Thin-Film Transistors in Saline Solution
Journal Of Electronic Materials. 2016. DOI : 10.1007/s11664-016-4449-x.A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals
European Journal Of Neuroscience. 2016. DOI : 10.1111/ejn.13080.Intrinsically Stretchable Biphasic (Solid–Liquid) Thin Metal Films
Advanced Materials. 2016. DOI : 10.1002/adma.201506234.Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury
Nature Medicine. 2016. DOI : 10.1038/nm.4025.Stretchable electronic structures formed of thin films integrated with soft heterogeneous substrate
US9826625 ; US2015143925 ; EP2859314 ; WO2013186693 ; WO2013186693 . 2015.Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
Jove-Journal Of Visualized Experiments. 2015. DOI : 10.3791/52543.Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait
Scientific Reports. 2015. DOI : 10.1038/srep14363.Fibrin Gels as Degradable Matrices for Adipose Stem Cells Encapsulation in Peripheral Nerve Repair
2015. 4th TERMIS World Congress, Boston, MA, SEP 08-11, 2015. p. S336-S337.Engineered substrates with embedded strain relief for stretchable thin-film electronics
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6798.Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6705.Skin health monitoring
Nature Materials. 2015. DOI : 10.1038/nmat4328.Vestibular contribution to bodily self-consciousness and multisensory cortical processing
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6365.Soft flexion sensors integrating strechable metal conductors on a silicone substrate for smart glove applications
2015. 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Estoril, Portugal, 18-22 January 2015. p. 760-763. DOI : 10.1109/MEMSYS.2015.7051069.Soft metal constructs for large strain sensor membrane
Smart Materials and Structures. 2015. DOI : 10.1088/0964-1726/24/3/035020.Elastomeric Electronic Skin for Prosthetic Tactile Sensation
Advanced Functional Materials. 2015. DOI : 10.1002/adfm.201404365.Conducting polymer electrodes for auditory brainstem implants
Journal of Materials Chemistry B. 2015. DOI : 10.1039/c5tb00099h.Research Update: Platinum-elastomer mesocomposite as neural electrode coating
APL Materials. 2015. DOI : 10.1063/1.4906502.Optogenetic stimulation of the cochlear nucleus using channelrhodopsin-2 evokes activity in the central auditory pathways
Brain Research. 2015. DOI : 10.1016/j.brainres.2014.11.044.Biomaterials. Electronic dura mater for long-term multimodal neural interfaces
Science (New York, N.Y.). 2015. DOI : 10.1126/science.1260318.Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?
Neural Regeneration Research. 2014. DOI : 10.4103/1673-5374.145366.Stretchable capacitive tactile skin on humanoid robot fingers - first experiments and results
2014. 2014 IEEE-RAS International Conference on Humanoid Robots, Madrid, Spain, November 18-20th 2014.Electrical stimulation of the cochlear nucleus with a thin polymer microelectrode array: Designing the next generation auditory brainstem implant
2014. 37th Midwinter meeting Association for Research in Otolaryngology, San Diego, USA, February 22-26, 2014.Implementing MEMS technology for soft, (bio)electronics interfaces.
2014. SPIE Defense Sensing & Security, Baltimore, Maryland, USA, May 5-9, 2014. DOI : 10.1117/12.2051173.Hybrid stretchable circuits on silicone substrate
Journal Of Applied Physics. 2014. DOI : 10.1063/1.4871279.Auditory responses to electric and infrared neural stimulation of the rat cochlear nucleus
Hearing Research. 2014. DOI : 10.1016/j.heares.2014.01.008.Corticospinal neuroprostheses to restore locomotion after spinal cord injury
Neuroscience Research. 2014. DOI : 10.1016/j.neures.2013.10.001.Microfabricated auditory brainstem implants on polyimide film
2013. EMBS Conference in Neural Engineering, San Diego, USA, November 6-8, 2013.Substrate Design Guidelines for Stretchable Thin-film Electronics
2013. MRS Spring Meeting, San Francisco, California, USA, April 1-5, 2013.PDMS Microchannel Regenerative Peripheral Nerve Interface
2013. 6th International IEEE EMBS Conference on Neural Engineering (NER). p. 649-652.Extremely robust and conformable capacitive pressure sensors based on flexible polyurethane foams and stretchable metallization
Applied Physics Letters. 2013. DOI : 10.1063/1.4832416.A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat
Science Translational Medicine. 2013. DOI : 10.1126/scitranslmed.3007186.Interaction of glia with a compliant, microstructured silicone surface
Acta Biomaterialia. 2013. DOI : 10.1016/j.actbio.2013.02.048.Localization of Folds and Cracks in Thin Metal Films Coated on Flexible Elastomer Foams
Advanced Materials. 2013. DOI : 10.1002/adma.201300587.Elastomeric substrates with embedded stiff platforms for stretchable electronics
Applied Physics Letters. 2013. DOI : 10.1063/1.4799653.Use of an Implanted Sacral Nerve Stimulator to Restore Urine Voiding in Chronically Paraplegic Dogs
Journal Of Veterinary Internal Medicine. 2013. DOI : 10.1111/jvim.12011.HYPER-FLEXIBLE 1-D SHAPE SENSOR
2013. The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Barcelona, Spain, June 16-20, 2013.An interconnection method for ultra-compliant electrodes
2012. International Functional Electrical Stimulation Society, Alberta, USA, September 9-12, 2012.Stretchable Electrodes for Neuroprosthetic Interfaces
2012. 11th IEEE Sensors Conference. p. 893-896.The Spiral Peripheral Nerve Interface: Design, Fabrication and Performance
2012. p. 1338-1341. DOI : 10.1007/978-3-642-23508-5_345.High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute in vivo validation
Journal of Neural Engineering. 2012. DOI : 10.1088/1741-2560/9/2/026005.Fabrication and electromechanical characterization of near-field electrospun composite fibers
Nanotechnology. 2012. DOI : 10.1088/0957-4484/23/10/105305.Erratum: A regenerative microchannel neural interface for recording from and stimulating peripheral axons in vivo
Journal of Neural Engineering. 2012. DOI : 10.1088/1741-2552/9/2/029601.A regenerative microchannel neural interface for recording from and stimulating peripheral axons in vivo
Journal of Neural Engineering. 2012. DOI : 10.1088/1741-2560/9/1/016010.Teaching & PhD
Teaching
Microengineering
Life Sciences Engineering