We use fabrication methods borrowed from the MEMS and microelectronics industries and adapt them to soft substrates like elastomers. We develop novel characterization tools adapted to mechanically compliant bioelectronic circuits. We evaluate in vitro, in animal models and ultimately on humans our soft bioelectronic interfaces
She received her PhD in Electrical Engineering from INSA de Lyon, France, and completed postdoctoral research at Princeton University and the University of Cambridge. She is the recipient of the 2006 MIT TR35, a University Research Fellowship of the Royal Society, European Research Council ERC Starting and POC Grants, and a SNSF-ERC Consolidator Grant. She was elected a 2015 Young Global Leader by the World Economic Forum.
Outman Akouassi (co-advised by S. Micera)
INSA, Lyon, France
Integrated Electronic Devices
INSA, Lyon France
Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrationsBiofabrication. 2021-04-01. DOI : 10.1088/1758-5090/abca80.
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injuryNature. 2021-01-27. DOI : 10.1038/s41586-020-03180-w.
Guidelines to Study and Develop Soft Electrode Systems for Neural StimulationNeuron. 2020-10-28. DOI : 10.1016/j.neuron.2020.10.010.
Nanoscale Controlled Oxidation of Liquid Metals for Stretchable Electronics and PhotonicsAdvanced Functional Materials. 2020-10-07. DOI : 10.1002/adfm.202006711.
Structured nanoscale metallic glass fibres with extreme aspect ratiosNature Nanotechnology. 2020-08-03. DOI : 10.1038/s41565-020-0747-9.
Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant SurgeryOtology & Neurotology. 2020-04-01. DOI : 10.1097/MAO.0000000000002565.
Stretchable cuff deviceWO2020254915 . 2020.
Biomedical device comprising a mechanically adaptive memberCN111450409 ; US2020230401 ; EP3682941 . 2020.
Thin Hydrogel-Elastomer Multilayer Encapsulation for Soft ElectronicsAdvanced Materials Technologies. 2019-07-01. DOI : 10.1002/admt.201900331.
When and why performance goals predict exploitation behaviors: An achievement goal complex analysis of the selection function of assessmentMotivation And Emotion. 2019-04-01. DOI : 10.1007/s11031-018-9742-y.
Materials chemistry in flexible electronicsChemical Society Reviews. 2019-03-21. DOI : 10.1039/c9cs90019e.
First Biopotential Recordings from a Liquid Crystal Optrode2019-01-01. Symposium on Clinical and Translational Neurophotonics 2020 held at SPIE BiO Conference, San Francisco, CA, Feb 01, 2020. p. UNSP 1122505. DOI : 10.1117/12.2544087.
Soft And Wearable Transducers: Opportunities And Challenges For Daily Use2019-01-01. 32nd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS), Seoul, SOUTH KOREA, Jan 27-31, 2019. p. 65-65.
Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates2019. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, July 23-27, 2019.
Patterned biphasic electrical conductor and methods for producing thereofEP3462462 . 2019.
Method for manufacturing hybrid soft-rigid electronic devicesWO2019219487 . 2019.
Bi-Modal Control of Vacuum-Powered Soft Pneumatic Actuators with Embedded Liquid Metal-Based Strain Sensitive Skin2019. Robosoft 2019, Seoul, South Korea, April 14-18, 2019.
Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized componentsHearing Research. 2019. DOI : 10.1016/j.heares.2019.02.010.
Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model2018-10-29. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, 18-21 July 2018. p. 1432-1435. DOI : 10.1109/EMBC.2018.8512584.
Equilibrium and Out-of-Equilibrium Adherence of Hydrogels against Polymer BrushesMacromolecules. 2018-10-09. DOI : 10.1021/acs.macromol.8b01063.
Soft implantable neurotechnology: a translational perspectiveGRC Neuroelectronic interfaces, Galveston, Texas, USA, 25-30 March 2018.
Efficient transdifferentiation of human dermal fibroblasts into skeletal muscleJournal Of Tissue Engineering And Regenerative Medicine. 2018-02-01. DOI : 10.1002/term.2568.
Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord2018. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, July 18-21, 21018. p. 1424-1427. DOI : 10.1109/EMBC.2018.8512554.
Engineering reversible elasticity in ductile or brittle thin films and products resulting from said engineeringUS2020094466 ; CN110382216 ; EP3548264 ; WO2018100005 . 2018.
Uniaxial strain of cardiac tissue parallel to impulse propagation slows conduction more than in the perpendicular direction: untangling the effects of stretch on tissue resistance2017. p. 114-114.
Method for manufacturing electrical conductors, and electrical conductors manufactured according to sameUS10828486 ; US2018289946 ; EP3368145 ; WO2017072347 . 2017.
Method for the electrical passivation of electrode arrays and/or conductive paths in general, and a method for producing stretchable electrode arrays and/or stretchable conductive paths in generalUS10448514 ; US2017086301 ; EP3142550 ; WO2015172894 . 2017.
A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents2016-10-18. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, USA, August 16-20, 2016.
Synthetic skin for recording and modulating physiological activitiesUS10695555 ; EP3242720 ; US2018001081 ; EP3242720 ; WO2016110564 . 2016.
Design and Functional Evaluation of an Epidermal Strain Sensing System for Hand Tracking2016. 2016 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Daejeon, Korea, October 9-14, 2016. p. 3186-3191.
Stretchable electronic structures formed of thin films integrated with soft heterogeneous substrateUS9826625 ; US2015143925 ; EP2859314 ; WO2013186693 ; WO2013186693 . 2015.
Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve RegenerationJove-Journal Of Visualized Experiments. 2015. DOI : 10.3791/52543.
Fibrin Gels as Degradable Matrices for Adipose Stem Cells Encapsulation in Peripheral Nerve Repair2015. 4th TERMIS World Congress, Boston, MA, SEP 08-11, 2015. p. S336-S337.
Soft flexion sensors integrating strechable metal conductors on a silicone substrate for smart glove applications2015. 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Estoril, Portugal, 18-22 January 2015. p. 760-763. DOI : 10.1109/MEMSYS.2015.7051069.
Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?Neural Regeneration Research. 2014. DOI : 10.4103/1673-5374.145366.
Stretchable capacitive tactile skin on humanoid robot fingers - first experiments and results2014. 2014 IEEE-RAS International Conference on Humanoid Robots, Madrid, Spain, November 18-20th 2014.
Electrical stimulation of the cochlear nucleus with a thin polymer microelectrode array: Designing the next generation auditory brainstem implant2014. 37th Midwinter meeting Association for Research in Otolaryngology, San Diego, USA, February 22-26, 2014.
Implementing MEMS technology for soft, (bio)electronics interfaces.2014. SPIE Defense Sensing & Security, Baltimore, Maryland, USA, May 5-9, 2014. DOI : 10.1117/12.2051173.
Auditory responses to electric and infrared neural stimulation of the rat cochlear nucleusHearing Research. 2014. DOI : 10.1016/j.heares.2014.01.008.
Corticospinal neuroprostheses to restore locomotion after spinal cord injuryNeuroscience Research. 2014. DOI : 10.1016/j.neures.2013.10.001.
Microfabricated auditory brainstem implants on polyimide film2013. EMBS Conference in Neural Engineering, San Diego, USA, November 6-8, 2013.
Substrate Design Guidelines for Stretchable Thin-film Electronics2013. MRS Spring Meeting, San Francisco, California, USA, April 1-5, 2013.
PDMS Microchannel Regenerative Peripheral Nerve Interface2013. 6th International IEEE EMBS Conference on Neural Engineering (NER). p. 649-652.
Interaction of glia with a compliant, microstructured silicone surfaceActa Biomaterialia. 2013. DOI : 10.1016/j.actbio.2013.02.048.
Use of an Implanted Sacral Nerve Stimulator to Restore Urine Voiding in Chronically Paraplegic DogsJournal Of Veterinary Internal Medicine. 2013. DOI : 10.1111/jvim.12011.
HYPER-FLEXIBLE 1-D SHAPE SENSOR2013. The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Barcelona, Spain, June 16-20, 2013.
An interconnection method for ultra-compliant electrodes2012. International Functional Electrical Stimulation Society, Alberta, USA, September 9-12, 2012.
Stretchable Electrodes for Neuroprosthetic Interfaces2012. 11th IEEE Sensors Conference. p. 893-896.
Teaching & PhD
Life Sciences Engineering