MissionBioelectronics integrates principles of electrical engineering to biology, medicine and ultimately health. My lab challenges and seeks to advance our fundamental concepts in man-made electronic systems applied to biology. Specifically, the focus is on designing and manufacturing electronic devices with mechanical properties close to those of the host biological tissue so that long-term reliability and minimal perturbation are induced in vivo and/or truly wearable systems become possible.
We use fabrication methods borrowed from the MEMS and microelectronics industries and adapt them to soft substrates like elastomers. We develop novel characterization tools adapted to mechanically compliant bioelectronic circuits. We evaluate in vitro, in animal models and ultimately on humans our soft bioelectronic interfaces
BiographyStéphanie P. Lacour holds the Bertarelli Foundation Chair in Neuroprosthetic Technology in the School of Engineering at EPFL and leads the Laboratory for Soft Bioelectronic Interfaces.
She received her PhD in Electrical Engineering from INSA de Lyon, France, and completed postdoctoral research at Princeton University and the University of Cambridge. She is the recipient of the 2006 MIT TR35, a University Research Fellowship of the Royal Society, European Research Council ERC Starting and POC Grants, and a SNSF-ERC Consolidator Grant. She was elected a 2015 Young Global Leader by the World Economic Forum.
PhD studentsNoaf Alwahab
Outman Akouassi (co-advised by S. Micera)
INSA, Lyon, France
Integrated Electronic Devices
INSA, Lyon France
NeuralTree: A 256-Channel 0.227-mu J/Class Versatile Neural Activity Classification and Closed-Loop Neuromodulation SoCIeee Journal Of Solid-State Circuits. 2022-09-29. DOI : 10.1109/JSSC.2022.3204508.
A finite element model of the mechanical interactions between peripheral nerves and intrafascicular implantsJournal Of Neural Engineering. 2022-08-01. DOI : 10.1088/1741-2552/ac7d0e.
Recent Advances in Encapsulation of Flexible Bioelectronic Implants: Materials, Technologies, and Characterization MethodsAdvanced Materials. 2022-07-20. DOI : 10.1002/adma.202201129.
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeysNature Neuroscience. 2022-06-30. DOI : 10.1038/s41593-022-01106-5.
Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte culturesJournal Of Physiology-London. 2022-06-23. DOI : 10.1113/JP283083.
Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)Jaro-Journal Of The Association For Research In Otolaryngology. 2022-04-05. DOI : 10.1007/s10162-022-00840-8.
Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapiesScience Robotics. 2022-03-30. DOI : 10.1126/scirobotics.abk2378.
Prevention of the foreign body response to implantable medical devices by inflammasome inhibitionProceedings Of The National Academy Of Sciences Of The United States Of America. 2022-03-22. DOI : 10.1073/pnas.2115857119.
Chronic recording of cortical activit y underlying vocalization in awake minipigsJournal Of Neuroscience Methods. 2022-01-15. DOI : 10.1016/j.jneumeth.2021.109427.
A stretchable sensor for force estimation in soft wearable robots2022-01-01. International Conference on Rehabilitation Robotics (ICORR), Rotterdam, NETHERLANDS, Jul 25-29, 2022. DOI : 10.1109/ICORR55369.2022.9896479.
On the Modeling of Organic Electrochemical Transistors2022-01-01. Conference on Organic and Hybrid Sensors and Bioelectronics XV, San Diego, CA, Aug 21-22, 2022. p. 1221005. DOI : 10.1117/12.2633291.
An All-Digital 1.25 Mbps 5-Subcarrier OFDM Backscatter Uplink with Delta-Sigma Modulation for Improved Spurious-Free Dynamic Range2022-01-01. IEEE International Conference on RFID (IEEE RFID), Las Vegas, NV, May 17-19, 2022. p. 103-108. DOI : 10.1109/RFID54732.2022.9795980.
An All-Digital 1 Mbps, 57 pJ/bit Bluetooth Low Energy (BLE) Backscatter ASIC in 65 nm CMOS2022-01-01. IEEE International Conference on RFID (IEEE RFID), Las Vegas, NV, May 17-19, 2022. p. 109-113. DOI : 10.1109/RFID54732.2022.9795961.
Conformable neural interfaces : from engineering stretchability at the micro-scale to translational applicationsLausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8968.
Method for labelling a device and devices obtanaible therefromWO2022017655 ; EP3943008 . 2022.
Adaptive Wireless Power Transfer and Backscatter Communication for Perpetual Operation of Wireless Brain-Computer InterfacesProceedings Of The Ieee. 2022. DOI : 10.1109/JPROC.2021.3130059.
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in miceNature Biotechnology. 2022. DOI : 10.1038/s41587-021-01019-x.
Editorial overview: Tissue, cell and pathway engineering: bioinspired, biomimetic and hybrid neural interfacesCurrent Opinion In Biotechnology. 2021-12-01. DOI : 10.1016/j.copbio.2021.11.008.
Extended Barrier Lifetime of Partially Cracked Organic/Inorganic Multilayers for Compliant Implantable ElectronicsSmall. 2021-09-03. DOI : 10.1002/smll.202103039.
Dimensional scaling of thin-film stimulation electrode systems in translational researchJournal Of Neural Engineering. 2021-08-01. DOI : 10.1088/1741-2552/abf607.
Viscoelastic surface electrode arrays to interface with viscoelastic tissuesNature Nanotechnology. 2021-06-17. DOI : 10.1038/s41565-021-00926-z.
Compliant peripheral nerve interfacesJournal Of Neural Engineering. 2021-06-01. DOI : 10.1088/1741-2552/abcdbe.
Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrationsBiofabrication. 2021-04-01. DOI : 10.1088/1758-5090/abca80.
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injuryNature. 2021-01-27. DOI : 10.1038/s41586-020-03180-w.
Bioinspired Liquid Metal Based Sensing System For Compliance Detection2021-01-01. 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), ELECTR NETWORK, Jan 25-29, 2021. p. 51-54. DOI : 10.1109/MEMS51782.2021.9375380.
Electronic Skins for Healthcare Monitoring and Smart ProsthesesAnnual Review Of Control, Robotics, And Autonomous Systems. 2021-01-01. DOI : 10.1146/annurev-control-071320-101023.
Hybrid soft-rigid electrical interconnection systemJP2022552636 ; EP4045135 ; CN114585413 ; AU2020368576 ; CA3151549 ; WO2021073828 . 2021.
Guidelines to Study and Develop Soft Electrode Systems for Neural StimulationNeuron. 2020-10-28. DOI : 10.1016/j.neuron.2020.10.010.
Nanoscale Controlled Oxidation of Liquid Metals for Stretchable Electronics and PhotonicsAdvanced Functional Materials. 2020-10-07. DOI : 10.1002/adfm.202006711.
Epineural optogenetic activation of nociceptors initiates and amplifies inflammationNature Biotechnology. 2020-09-21. DOI : 10.1038/s41587-020-0673-2.
Structured nanoscale metallic glass fibres with extreme aspect ratiosNature Nanotechnology. 2020-08-03. DOI : 10.1038/s41565-020-0747-9.
Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant SurgeryOtology & Neurotology. 2020-04-01. DOI : 10.1097/MAO.0000000000002565.
Development and Evaluation of a Sensor Glove to Detect Grasp Intention for a Wearable Robotic Hand Exoskeleton2020-01-01. 8th IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob), New York City, NY, Nov 29-Dec 01, 2020. p. 19-24. DOI : 10.1109/BioRob49111.2020.9224463.
Stretchable cuff deviceUS2022249834 ; EP3986534 ; WO2020254915 . 2020.
Biomedical device comprising a mechanically adaptive memberEP3682941 ; CN111450409 ; US2020230401 ; EP3682941 . 2020.
Thin Hydrogel-Elastomer Multilayer Encapsulation for Soft ElectronicsAdvanced Materials Technologies. 2019-07-01. DOI : 10.1002/admt.201900331.
When and why performance goals predict exploitation behaviors: An achievement goal complex analysis of the selection function of assessmentMotivation And Emotion. 2019-04-01. DOI : 10.1007/s11031-018-9742-y.
Materials chemistry in flexible electronicsChemical Society Reviews. 2019-03-21. DOI : 10.1039/c9cs90019e.
First Biopotential Recordings from a Liquid Crystal Optrode2019-01-01. Symposium on Clinical and Translational Neurophotonics 2020 held at SPIE BiO Conference, San Francisco, CA, Feb 01, 2020. p. 1122505. DOI : 10.1117/12.2544087.
Soft And Wearable Transducers: Opportunities And Challenges For Daily Use2019-01-01. 32nd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS), Seoul, SOUTH KOREA, Jan 27-31, 2019. p. 65-65. DOI : 10.1109/MEMSYS.2019.8870770.
Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates2019. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, July 23-27, 2019.
Patterned biphasic electrical conductor and methods for producing thereofEP3462462 . 2019.
Method for manufacturing hybrid soft-rigid electronic devicesWO2019219487 . 2019.
Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized componentsHearing Research. 2019. DOI : 10.1016/j.heares.2019.02.010.
Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model2018-10-29. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, 18-21 July 2018. p. 1432-1435. DOI : 10.1109/EMBC.2018.8512584.
Equilibrium and Out-of-Equilibrium Adherence of Hydrogels against Polymer BrushesMacromolecules. 2018-10-09. DOI : 10.1021/acs.macromol.8b01063.
Soft implantable neurotechnology: a translational perspectiveGRC Neuroelectronic interfaces, Galveston, Texas, USA, 25-30 March 2018.
Efficient transdifferentiation of human dermal fibroblasts into skeletal muscleJournal Of Tissue Engineering And Regenerative Medicine. 2018-02-01. DOI : 10.1002/term.2568.
Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord2018. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA, July 18-21, 21018. p. 1424-1427. DOI : 10.1109/EMBC.2018.8512554.
Engineering reversible elasticity in ductile or brittle thin films and products resulting from said engineeringCN110382216 ; US2020094466 ; CN110382216 ; EP3548264 ; WO2018100005 . 2018.
Uniaxial strain of cardiac tissue parallel to impulse propagation slows conduction more than in the perpendicular direction: untangling the effects of stretch on tissue resistance2017. p. 114-114.
Method for manufacturing electrical conductors, and electrical conductors manufactured according to sameUS10828486 ; US2018289946 ; EP3368145 ; WO2017072347 . 2017.
Method for the electrical passivation of electrode arrays and/or conductive paths in general, and a method for producing stretchable electrode arrays and/or stretchable conductive paths in generalEP3142550 ; US10448514 ; US2017086301 ; EP3142550 ; WO2015172894 . 2017.
A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents2016-10-18. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, USA, August 16-20, 2016. p. 4439-4442. DOI : 10.1109/EMBC.2016.7591712.
Synthetic skin for recording and modulating physiological activitiesUS10695555 ; EP3242720 ; US2018001081 ; EP3242720 ; WO2016110564 . 2016.
Teaching & PhD
Life Sciences Engineering