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Christian Iseli

christian.iseli@epfl.ch +41 21 693 75 36 https://bix.epfl.ch

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

EPFL SV PTECH BICC
AAB 1 19 (Bâtiment AAB)
Station 19
1015 Lausanne

- Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls

A.-L. Ducrest; L. S.-J. Garcia; S. Neuenschwander; E. Schmid-Siegert; C. Simon  et al.

PIGMENT CELL & MELANOMA RESEARCH. 2025. DOI : 10.1111/pcmr.70001.

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- Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing

A. N. Glaus; M. Brechet; G. Swinnen; L. Lebeigle; J. Iwaszkiewicz  et al.

Nature Genetics. 2025. DOI : 10.1038/s41588-024-02026-9.

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- Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity

M. Pirovino; C. Iseli; J. A. Curran; B. Conrad

PLOS COMPUTATIONAL BIOLOGY. 2025. DOI : 10.1371/journal.pcbi.1012162.

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- DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen

S. Martin; F. Fournes; G. Ambrosini; C. Iseli; K. Bojkowska  et al.

NUCLEIC ACIDS RESEARCH. 2024. DOI : 10.1093/nar/gkae757.

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- tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

F. Brozzi; C. Jacovetti; C. Cosentino; V. Menoud; K. Wu  et al.

DIABETOLOGIA. 2024. DOI : 10.1007/s00125-024-06207-3.

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- Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

S. Bassani; J. Chrast; G. Ambrosini; N. Voisin; F. Schuetz  et al.

Genome Medicine. 2024. DOI : 10.1186/s13073-024-01339-y.

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- Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

K. Pinjusic; G. Ambrosini; J. Lourenco; N. Fournier; C. Iseli  et al.

Frontiers In Immunology. 2024. DOI : 10.3389/fimmu.2023.1335207.

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- A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer

S. Bobisse; V. Bianchi; J. Tanyi; A. Sarivalasis; E. Missiaglia  et al.

Nature Cancer. 2023. DOI : 10.1038/s43018-023-00623-x.

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- Chromosome-level organization of the regulatory genome in the Drosophila nervous system

G. Mohana; J. Dorier; X. Li; M. Mouginot; R. C. Smith  et al.

Cell. 2023. DOI : 10.1016/j.cell.2023.07.008.

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- Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

A. Seifinejad; M. Ramosaj; L. Shan; S. Li; M.-L. Possovre  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2023. DOI : 10.1073/pnas.2220911120.

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- DNA modifications impact natural transformation of Acinetobacter baumannii

N. Vesel; C. Iseli; N. Guex; A. Lemopoulos; M. Blokesch

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad377.

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- Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles

J. Villà-Freixa; B. Conrad; C. Iseli; M. Pirovino

PLOS ONE. 2023. DOI : 10.1371/journal.pone.0281661.

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- Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

H. A. Lashuel; A.-L. Mahul-Mellier; S. Novello; R. N. Hegde; Y. Jasiqi  et al.

Npj Parkinsons Disease. 2022. DOI : 10.1038/s41531-022-00388-7.

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- SPICA: Swiss portal for immune cell analysis

M. Andreatta; F. P. A. David; C. Iseli; N. Guex; S. J. Carmona

Nucleic Acids Research. 2022. DOI : 10.1093/nar/gkab1055.

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- Essential role of Cp190 in physical and regulatory boundary formation

A. Kaushal; J. Dorier; B. Wang; G. Mohana; M. Taschner  et al.

Science Advances. 2022. DOI : 10.1126/sciadv.abl8834.

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- Blood virosphere in febrile Tanzanian children

S. Cordey; F. Laubscher; M.-A. Hartley; T. Junier; K. Keitel  et al.

Emerging Microbes & Infections. 2021. DOI : 10.1080/22221751.2021.1925161.

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- CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

A. Kaushal; G. Mohana; J. Dorier; I. Özdemir; A. Omer  et al.

Nature Communications. 2021. DOI : 10.1038/s41467-021-21366-2.

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- Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

M. Bruand; D. Barras; M. Mina; E. Ghisoni; M. Morotti  et al.

Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109412.

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Teaching & PhD

Courses

Bioinformatic Analysis of RNA-sequencing (Fall)

BIO-693(a)

Bioinformatic Analysis of RNA-sequencing (Spring)

BIO-693(b)

This course will take place in Spring 2026, dates and place to be determined. It introduces the workflows and techniques that are used for the analysis of bulk and single-cell RNA-seq data. It empowers students to understand and analyze their own data.

Methods: omics in biomedical research

BIOENG-519

High-throughput methodologies broadly called Omics allow to characterize the complexity and dynamics of any biological system. This course will provide a general description of different methods related to the Omics field followed by hands-on rotations in participating technological platforms.