Fields of expertise
- Tissue Engineering
MissionThe Laboratory of Biomechanical Orthopedics (LBO) is dedicated to the advancement of techniques and technology for patient care in the musculo-skeletal system, through fundamental research, applied research, and teaching
Current workThrough biomechanical considerations, Dominique Pioletti's research focus on tissue engineering applications for musculoskeletal tissues. In parallel, new drug delivery solutions for these tissues are also developed by using mechanical loading as a trigger stimulus for the delivery of drugs.
- Musculoskeletal tissues engineering
- Development of hydrogels with enhanced mechanical properties
- Drug delivery system for bone and soft tissues
- Soft tissues mechanics
BiographyDominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone; development of orthopedic implant as drug delivery system. Since 2013, he has been promoted to the rank of Associate Professor.
Journal paper and review
Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signalingElife. 2022-03-08. DOI : 10.7554/eLife.72068.
An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative MedicineMacromolecular Rapid Communications. 2021-04-08. DOI : 10.1002/marc.202000660.
An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem CellsAcs Biomaterials Science & Engineering. 2021-03-08. DOI : 10.1021/acsbiomaterials.9b01863.
Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush CoatingsBiomacromolecules. 2020-01-01. DOI : 10.1021/acs.biomac.9b01196.
Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis PreventionACS Biomaterials Science & Engineering. 2019-10-01. DOI : 10.1021/acsbiomaterials.9b01041.
Patellar bone strain after total knee arthroplasty is correlated with bone mineral density and body mass indexMedical Engineering & Physics. 2019. DOI : 10.1016/j.medengphy.2019.03.017.
Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem CellsSTEM CELLS. 2018. DOI : 10.1002/stem.2765.
Energy dissipation as a mechanobiological variable inducing chondrogenesisJournal Of Tissue Engineering And Regenerative Medicine. 2014.
Response to Letter to the Editor: Comment on "injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies"Journal Of Biomechanics. 2013. DOI : 10.1016/j.jbiomech.2012.09.024.
Calcium phosphate augmentation of cancellous bone screws in impaired lapine bone (vol 40, pg S23, 2009)Injury-International Journal Of The Care Of The Injured. 2010. DOI : 10.1016/j.injury.2009.09.026.
The skeletal keyPublic Service Review: Science and Technology. 2010.
From bench to bedsideEPC Drug Discovery, Delivery & Therapeutics. 2010.
3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurementsComputer Methods In Biomechanics And Biomedical Engineering. 2009. DOI : 10.1080/10255840802178053.
Orthopedic implant used as drug delivery system: clinical situation and state of the researchCurrent Drug Delivery. 2008.
Polylactic Acid–Phosphate Glass Composite Foams as Scaffolds for Bone Tissue EngineeringJournal of Biomedical Materials Research Part B. 2006. DOI : 10.1002/jbm.b.30600.
Total joint replacement and aseptic looseningHelix Review Series Rheumatology. 2006.
Bioresorbable composites prepared by supercritical fluid foamingJournal of Biomedical Materials Research Part A. 2005. DOI : 10.1002/jbm.a.30385.
Titanium particles inhibit osteoblast adhesion to fibronectin-coated substratesJ Orthopaed Res. 2000. DOI : 10.1002/jor.1100180207.
Displacements of the tibial tuberosity - Effects of the surgical parametersClinical Orthopaedics and Related Research. 1997.
Cinématique et élongation contiue du ligament croisé antérieur [Kinematics and continuous elongation of the anterior cruciate ligament]Revue médicale de la Suisse romande. 1994.
Teaching & PhD
Doctoral Program in Biotechnology and Bioengineering
Doctoral Program in Mechanics
Doctoral Program in Materials Science and Engineering