Bernard Lanz
+41 21 693 79 95
Office:
CH F0 572
EPFL
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VPA-AVP-CP
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CIBM
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CIBM-AIT
Web site: Web site: https://www.cibm.ch/
+41 21 693 79 95
EPFL
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SB
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SPH-ENS
Web site: Web site: https://sph.epfl.ch/
Fields of expertise
Magnetic resonance spectroscopy
Dynamic in vivo 1H, 13C, 15N MR spectroscopy
Positron emission tomography
Mathematical models of metabolism
Dynamic in vivo 1H, 13C, 15N MR spectroscopy
Positron emission tomography
Mathematical models of metabolism
Publications
Infoscience publications
Infoscience
Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel
Nmr In Biomedicine. 2023-10-15. DOI : 10.1002/nbm.5056.Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field
Magnetic Resonance In Medicine. 2023-09-28. DOI : 10.1002/mrm.29805.New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual <SUP>18</SUP>F-FDG PET and 9.4T <SUP>1</SUP>H MRS Preclinical Study
2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12-S12. DOI : 10.14309/01.ajg.0000948348.20966.21.Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior
Molecular Psychiatry. 2022-10-12. DOI : 10.1038/s41380-022-01791-5.PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats
Analytical Biochemistry. 2022-06-15. DOI : 10.1016/j.ab.2022.114606.Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats
2022-06-01. p. 57-58.Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions
Metabolites. 2021-06-23. DOI : 10.3390/metabo11070413.Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
Scientific Reports. 2021-03-11. DOI : 10.1038/s41598-021-85339-7.Quantitative Microstructural Imaging for Clinical Use
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-9618.In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times
Magnetic Resonance in Medicine. 2021-07-15. DOI : 10.1002/mrm.28910.In Vivo Metabolism of [1,6-C-13(2)]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus
Metabolites. 2021-01-01. DOI : 10.3390/metabo11010050.Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose
Journal Of Cerebral Blood Flow And Metabolism. 2021. DOI : 10.1177/0271678X20910535.Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations
Nmr In Biomedicine. 2020-08-26. DOI : 10.1002/nbm.4325.Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
Elife. 2020-06-23. DOI : 10.7554/eLife.53618.Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease
NeuroImage. 2020-10-24. DOI : 10.1016/j.neuroimage.2020.117498.Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations
Nmr In Biomedicine. 2020-08-17. DOI : 10.1002/nbm.4347.Neuronal energy metabolism in the mouse brain measured by H-1-[C-13] MRS at 14.1T under [3-C-13]-Lactate infusion: a feasibility study
2019-07-01. 29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama, JAPAN, Jul 04-07, 2019. p. 208-209.Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo
Acs Chemical Neuroscience. 2018-11-01. DOI : 10.1021/acschemneuro.8b00066.In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells
International Journal of Cancer. 2018. DOI : 10.1002/ijc.31299.Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T
Magnetic Resonance in Medicine. 2018. DOI : 10.1002/mrm.27129.In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018. DOI : 10.1177/0271678X17734101.Diffusion-weighted MRS of acetate in the rat brain
NMR in biomedicine. 2017. DOI : 10.1002/nbm.3768.Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2017.01.019.MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.New technologies – new insights into the pathogenesis of hepatic encephalopathy
Metabolic Brain Disease. 2016. DOI : 10.1007/s11011-016-9906-y.Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets
ASN neuro. 2016. DOI : 10.1177/1759091416632342.(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism
Metabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015. DOI : 10.1038/jcbfm.2014.251.Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014. DOI : 10.2967/jnumed.113.127381.In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T
Journal of Neurochemistry. 2014. DOI : 10.1111/jnc.12479.Metabolic Flux and Compartmentation Analysis in the Brain In vivo
Frontiers in Endocrinology. 2013. DOI : 10.3389/fendo.2013.00156.Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS
4th International DNP Symposium, Copenhagen, Denmark, August 28-31, 2013.Hepatic glucose sensing is required to preserve β cell glucose competence
The Journal of clinical investigation. 2013. DOI : 10.1172/JCI65538.Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5468.Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy
Journal Of Cerebral Blood Flow And Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.A two-compartment mathematical model of neuroglial metabolism using [1-C-11] acetate
Journal Of Cerebral Blood Flow And Metabolism. 2012. DOI : 10.1038/jcbfm.2011.162.GLIAL GLYCOLYTIC GAPDH ACTIVITY MODULATES THE RESTING CEREBRAL METABOLIC RATE OF GLUCOSE AND CA+2- DEPENDENT EXCITATORY NEUROTRANSMITTER RELEASE
2011. Brain 2011, Barcelona, Spain, 25-28 May, 2011. p. 133.Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES
2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study
2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.Evaluation of glial metabolic fluxes in vivo with [2-13C] acetate infusion in mouse brain by 1H-[13C] NMR spectroscopy
2011. ESMRMB CONGRESS 2011 28th Annual Scientific Meeting, Leipzig,Germany, October 6-8, 2011.In Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by 1H-[13C] NMR Spectroscopy
2011. ISMRM 19th Annual Meeting & Exhibition, Montréal, Québec, Canada, May 7-13, 2011.Cerebral metabolic compartmentation determined by high resolution in vivo 13C NMR spectroscopy
Swiss Society for Neuroscience Annual Meeting 2011, Basel, Switzerland, March 26, 2011.Brain metabolism by in vivo 13C NMR spectroscopy
25th International Symposium on Cerebral Blood Flow, Metabolism and Function & 10th International Conference on Quantification of Brain Function with PET, Barcelona, Spain, May 25-28, 2011..Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T
Frontiers in neuroenergetics. 2011. DOI : 10.3389/fnene.2011.00003.Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
Molecular Imaging And Biology. 2011. DOI : 10.1007/s11307-010-0368-z.In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Imaging glutamine synthesis rates in the hyperammonemic rat brain
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion
2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T
Magnetic Resonance In Medicine. 2010. DOI : 10.1002/mrm.22359.Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T
2009. ESMRMB, Antalya, TR, October 1-3.MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS
2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.BISEP-based, Ultra-short TE 1H–[13C] NMR Spectroscopy of the Rat Brain at 14.1 T
2009. ISMRM 17th Scientific Meeting & Exhibition, Honolulu, Hawai’i, USA, April 18-24, 2009.Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness
Neurochemistry international. 2009. DOI : 10.1016/j.neuint.2009.02.023.Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS
2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609-S610.Measurements of glial metabolic fluxes with C-11-acetate using positron emission and an adapted NMR-based metabolic modeling approach
2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S460-S461.Teaching & PhD
Teaching
Physics
PhD Students
Siviglia Alessio,Courses
MRI Practicals on CIBM preclinical imaging systems
The goal of this course is to teach students how to perform basic MRI and MRS experiments in-vivo and ex-vivo directly on preclinical horizontal ultra-high field MRI systems.
CIBM translational MR neuroimaging & spectroscopy
This course's purpose is to provide students with a solid theoretical and practical knowledge in magnetic resonance imaging (MRI) and spectroscopy (MRS). This course will cover all of the core aspects that a PhD candidate or a post-doc would require to design and carry out their own (neuro)imaging experiment in order to accomplish specific research goals. These include fundamentals of experimen