Lijing Xin

Nationality: P.R. China

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

Expertise

Magnetic resonance spectroscopy (1H, 13C and 31P)
Spin physics
Brain energy metabolism
Schizophrenia
Mood disorders
MRI instrumentation
Lijing Xin is an assistant professor at the Institute of Physics (IPHYS) and research staff scientist at the Center for Biomedical Imaging (CIBM), Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland. Her research interests focus on developing cutting-edge magnetic resonance spectroscopy and imaging methods for better understanding the brain function and the pathophysiology of neurological diseases. Her journey on magnetic resonance imaging (MRI) started from her master project during 2002-2005, where she developed a gradient unit with eddy current compensation and a pulse sequence generator for MRI spectrometer, which enhanced her knowledge in MR instrumentation. Later, she obtained her PhD in physics from Ecole polytechnique fédérale de Lausanne (EPFL) in 2010, where she focused on developing various novel 1H and 13C magnetic resonance spectroscopy (MRS) acquisition and quantification methods as well as RF coils on high field preclinical MR scanners. Afterwards, she started working on the clinical MR platforms including both 3 and 7T and continued to improve and develop novel acquisition and quantification methods for 1H, 13C and 31P nuclei. She carries on interdisciplinary collaborations with different partners, particularly with clinical partners where translational strategies are performed to explore the pathophysiology of psychiatric disorders and disease biomarkers for early diagnosis and intervention.

Main Publications from infoscience

Research

Profile on

Selected peer-reviewed conference proceedings

ISMRM 2022
M. Widmaier, S-I. Lim, L. Xin. Super-fast and accurate estimation of relaxation and chemical exchange rate using 31P-MT-MR fingerprinting at 7T in the human brain. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
M. Widmaier, S-I. Lim, L. Xin. Time-efficient and reproducible relaxation measurements by 31P MR fingerprinting in human brain at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
S-I. Lim, M. Widmaier, L. Xin. Frequency sweep 31P MR spectroscopic imaging at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Z Huang, B. Cuenoud, M. Hartweg, D. Wenz, L. Xin. Effect of circadian rhythm on brain NAD:
an MRS study at 7 T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Xiao, I. Tkac, L. Xin. Investigating the influences of spectral lineshape and linewidth in LCModel basis-sets on 1H MRS quantification at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Xiao, D. Wenz, L. Xin. STEAM-based proton observed carbon edited (POCE) 13C magnetic resonance Spectroscopy without decoupling at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Wen, C. Zhou, L. Chen, Y. Deng, M. Cleusix, R. Jenni, P. Conus, K. Do, L. Xin. Bridging Structural MRI with Cognitive Function for Individual Level Classification of Early Psychosis via Deep Learning. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Z. Wang, M. Cleusix, R. Jenni, P. Conus, K. Do, L. Xin. Structural abnormalities in patients with early psychosis: a MP2RAGE-based morphometric study at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
ISMRM 2021M. Widmaier, S-I. Lim, L. Xin. Fast acquisition of 31-P creatin kinease chemical exchange rate and relaxation rates of g-ATP and PCr in vivo human brain at 7T using MRS-FP. ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
S-I. Lim, L. Xin. GABA measurement at 7T: short-TE or MEGA editing? ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
S-I. Lim, M. Widmaier, Y. Jiang,
L. Xin. Rapid T1, T2 measurements and SNR evaluation by 31P MR fingerprinting in human brain at 7T. ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
ISMRM 2020
B. Lanz, R. Skupienski, K. Q. Do, L. Xin. Cerebral energy metabolism and neurotransmission in a schizophrenia mouse model: a combined 1H-[13C] MRS and 13C MRS study at 14.1T. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.
S-I. Lim, L. Xin. Improved GABA editing and macromolecule suppression with adiabatic and highly selective Gaussian pulses at 7T. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.
R. Skupienski, K. Q. Do, L. Xin. NAD /NADH dysregulation and brain homeostasis in the gclm-KO mouse: towards biomarker identification for schizophrenia. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.

Teaching & PhD

PhD Students

Rafael Ignacio De la Sotta Vargas, Yang Gao

Past EPFL PhD Students as codirector

Songi Lim, Mark Stephan Widmaier, Zhiwei Huang, Ying Xiao, Xinyu Liu

Courses

CIBM translational MR neuroimaging & spectroscopy

PHYS-770

Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.

Fundamentals of biomedical imaging

PHYS-438

The goal of this course is to illustrate how modern principles of basic science approaches are integrated into the major biomedical imaging modalities of importance to biology and medicine, with an emphasis on those of interest to in vivo.