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Lijing Xin

Nationalité: P.R. China

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

EPFL CIBM-MRI
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne

Expertise

Magnetic resonance spectroscopy (1H, 13C and 31P)
Spin physics
brain energy metabolism
Schizophrenia
Mood disorders
MRI instrumentation
Lijing Xin is an assistant professor at the Institute of Physics (IPHYS) and research staff scientist at the Center for Biomedical Imaging (CIBM), Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland. Her research interests focus on developing cutting-edge magnetic resonance spectroscopy and imaging methods for better understanding the brain function and the pathophysiology of neurological diseases. Her journey on magnetic resonance imaging (MRI) started from her master project during 2002-2005, where she developed a gradient unit with eddy current compensation and a pulse sequence generator for MRI spectrometer, which enhanced her knowledge in MR instrumentation. Later, she obtained her PhD in physics from Ecole polytechnique fédérale de Lausanne (EPFL) in 2010, where she focused on developing various novel 1H and 13C magnetic resonance spectroscopy (MRS) acquisition and quantification methods as well as RF coils on high field preclinical MR scanners. Afterwards, she started working on the clinical MR platforms including both 3 and 7T and continued to improve and develop novel acquisition and quantification methods for 1H, 13C and 31P nuclei. She carries on interdisciplinary collaborations with different partners, particularly with clinical partners where translational strategies are performed to explore the pathophysiology of psychiatric disorders and disease biomarkers for early diagnosis and intervention.

Main Publications from infoscience

Neurometabolic predictors of mental effort in the frontal cortex

A. BarakatJ. BrochardM. PessiglioneJ. GodinB. Cuenoud  et al.

Translational Psychiatry. 2025. DOI : 10.1038/s41398-025-03554-6.

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary <sup>1</sup>H MR spectroscopy study at 7 T

L. XinP. ReymondJ. BotoF. GrouillerS. Vulliemoz  et al.

European Journal of Radiology Open. 2025. DOI : 10.1016/j.ejro.2025.100640.

Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility

Z. HuangU. EmirA. DoringA. KlauserY. Xiao  et al.

Human Brain Mapping. 2025. DOI : 10.1002/hbm.70176.

Fast 3D <sup>31</sup>P B1+ mapping with a weighted stack of spiral trajectory at 7 T

M. S. WidmaierA. KaiserS. BaupD. WenzK. Pierzchała  et al.

Magnetic resonance in medicine. 2025. DOI : 10.1002/mrm.30321.

CEST imaging combined with <SUP>1</SUP>H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

Y. ShenX. ZhangS. LiuL. XinW. Xuan  et al.

ALZHEIMERS RESEARCH & THERAPY. 2025. DOI : 10.1186/s13195-025-01672-3.

A graphical pipeline platform for MRS data processing and analysis: MRSpecLAB

Y. XiaoA. KaiserM. KockischA. BackR. Carlet  et al.

Frontiers in neuroimaging. 2025. DOI : 10.3389/fnimg.2025.1610658.

Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity

X. LiuS. ScherrerS. EggerS. I. LimB. Lauber  et al.

Human Brain Mapping. 2024. DOI : 10.1002/hbm.70057.

Five percent CO<inf>2</inf> inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

Z. ZhaoX. ZhangX. ZhangS. XieY. Chen  et al.

Neuroprotection. 2024. DOI : 10.1002/nep3.53.

A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making

N. ClairisA. BarakatJ. BrochardL. XinC. Sandi

Molecular Psychiatry. 2024. DOI : 10.1038/s41380-024-02726-y.

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

S. CamporesiL. XinP. GolayC. B. EapM. Cleusix  et al.

Molecular Psychiatry. 2024. DOI : 10.1038/s41380-024-02631-4.

NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Y. ZhaoC. MaR. CaiL. XinY. Li  et al.

Nature Communications. 2024. DOI : 10.1038/s41467-024-46837-0.

Twisted pair transmission line coil - a flexible, self-decoupled and robust element for 7 T MRI

J. VliemY. XiaoD. WenzL. XinW. Teeuwise  et al.

Magnetic Resonance Imaging. 2024. DOI : 10.1016/j.mri.2024.02.007.

MRI characterization of in vitro clots at 3T and 7T: A technical note

D. D. LagrangeL. XinF. LazeyrasK. M. DoyleI. Wanke  et al.

Journal Of Neuroradiology. 2024. DOI : 10.1016/j.neurad.2023.06.003.

NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

R. CaiL. X. KeY. ZhaoJ. ZhaoH. Zhang  et al.

International Journal of Cancer. 2024. DOI : 10.1002/ijc.35273.

Effect of circadian rhythm on NAD and other metabolites in human brain

B. CuenoudZ. HuangM. HartwegM. S. WidmaierS. Lim  et al.

Frontiers In Physiology. 2023. DOI : 10.3389/fphys.2023.1285776.

Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel

Y. XiaoB. LanzS.-LimI. TkacL. Xin

Nmr In Biomedicine. 2023. DOI : 10.1002/nbm.5056.

Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia

R. SkupienskiP. SteulletK. Q. DoL. Xin

Translational Psychiatry. 2023. DOI : 10.1038/s41398-023-02568-2.

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

M. WidmaierS.-LimD. WenzL. Xin

Nmr In Biomedicine. 2023. DOI : 10.1002/nbm.4998.

High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

C. CudalbuL. XinB. MarechalS. LachatF. Zangas-Gheri  et al.

Analytical Biochemistry. 2023. DOI : 10.1016/j.ab.2023.115212.

Dipolectric antenna for high-field MRI

D. WenzL. XinT. DardanoA. Kuehne

Magnetic Resonance in Medicine. 2023. DOI : 10.1002/mrm.29719.

Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential

D. DwirI. KhadimallahL. XinM. RahmanF. Du  et al.

International Journal Of Neuropsychopharmacology. 2023. DOI : 10.1093/ijnp/pyad012.

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

K. MerrittR. McCutcheonA. AlemanS. AshleyK. Beck  et al.

Molecular Psychiatry. 2023. DOI : 10.1038/s41380-023-01991-7.

Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T

Z. HuangG. GambarotaY. XiaoD. WenzL. Xin

Magnetic Resonance Materials In Physics Biology And Medicine. 2023. DOI : 10.1007/s10334-023-01065-3.

Bridging structural MRI with cognitive function for individual level classification of early psychosis via deep learning

Y. WenC. ZhouL. ChenY. DengM. Cleusix  et al.

Frontiers In Psychiatry. 2023. DOI : 10.3389/fpsyt.2022.1075564.

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

J. SongeonS. CourvoisierL. XinT. AgiusO. Dabrowski  et al.

Magnetic Resonance in Medicine. 2022. DOI : 10.1002/mrm.29446.

gamma-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing

S.-LimL. Xin

Nmr In Biomedicine. 2022. DOI : 10.1002/nbm.4706.

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

I. ZalachorasE. Ramos-FernándezF. HollisL. TrovoJ. Rodrigues  et al.

eLife. 2022. DOI : 10.7554/eLife.77791.

Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis

D. DwirJ.-H. CabungcalL. XinB. GiangrecoE. Parietti  et al.

Schizophrenia Bulletin. 2021. DOI : 10.1093/schbul/sbab066.

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

C. CudalbuP. BadyM. LaiL. XinO. Gusyatiner  et al.

Acta Neuropathologica Communications. 2021. DOI : 10.1186/s40478-021-01232-4.

In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

D. SimicicV. RackayováL. XinI. TkáčT. Borbath  et al.

Magnetic Resonance in Medicine. 2021. DOI : 10.1002/mrm.28910.

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

B. CuenoudO. IpekM. ShevlyakovaM. BeaumontS. C. Cunnane  et al.

Frontiers In Aging Neuroscience. 2020. DOI : 10.3389/fnagi.2020.609517.

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

C. CudalbuK. L. BeharP. K. BhattacharyyaW. BognerT. Borbath  et al.

Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4393.

In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment

R. SkupienskiK. Q. DoL. Xin

Scientific Reports. 2020. DOI : 10.1038/s41598-020-72492-8.

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

B. LanzA. AbaeiO. BraissantI.-Y. ChoiC. Cudalbu  et al.

Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4325.

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

G. ÖzD. K. DeelchandJ. P. WijnenV. MlynárikL. Xin  et al.

NMR in Biomedicine. 2020. DOI : 10.1002/nbm.4236.

Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times

M. DehghaniK. Q. DoP. MagistrettiL. Xin

Magnetic Resonance in Medicine. 2020. DOI : 10.1002/mrm.28066.

Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans

A. V. I. StrasserG. LuksysL. XinM. PessiglioneR. Gruetter  et al.

Neuropsychopharmacology. 2020. DOI : 10.1038/s41386-020-0760-6.

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

D. DwirB. GiangrecoL. XinL. TenenbaumJ.-H. Cabungcal  et al.

Molecular Psychiatry. 2020. DOI : 10.1038/s41380-019-0393-5.

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

E. MullierT. RoineA. GriffaL. XinP. S. Baumann  et al.

International Journal of Neuropsychopharmacology. 2019. DOI : 10.1093/ijnp/pyz022.

Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla

Y. BoillatL. XinW. van der ZwaagR. Gruetter

Journal of Cerebral Blood Flow & Metabolism. 2019. DOI : 10.1177/0271678X19831022.

Improved off‐resonance phase behavior using a phase‐inverted adiabatic half‐passage pulse for 13 C MRS in humans at 7 T

E. Serés RoigL. XinD. GallichanV. MlynarikR. Gruetter

NMR in Biomedicine. 2019. DOI : 10.1002/nbm.4171.

Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study

A. StrasserL. XinR. GruetterC. Sandi

Eur Neuropsychopharmacol. 2019. DOI : 10.1016/j.euroneuro.2018.12.015.

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Y. TakadoN. SatoY. KanbeM. TomiyasuL. Xin  et al.

Nutrients. 2019. DOI : 10.3390/nu11071649.

Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

J. M. N. DuarteL. Xin

Neurochemical research. 2019. DOI : 10.1007/s11064-018-2521-z.

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

P. KlauserL. XinM. FournierA. GriffaM. Cleusix  et al.

Translational Psychiatry. 2018. DOI : 10.1038/s41398-018-0266-8.

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

L. XinÖ. IpekM. BeaumontM. ShevlyakovaN. Christinat  et al.

Frontiers in Nutrition. 2018. DOI : 10.3389/fnut.2018.00062.

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

S. RigucciL. XinP. KlauserP. S. BaumannL. Alameda  et al.

Psychopharmacology. 2018. DOI : 10.1007/s00213-017-4745-z.

Clinical Neuroimaging Using 7 T MRI: Challenges and Prospects

M. I. VargasP. MartelliL. XinO. IpekF. Grouiller  et al.

Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2018. DOI : 10.1111/jon.12481.

MP2RAGE and Susceptibility-Weighted Imaging in Lesional Epilepsy at 7T

F. PittauM. O. BaudJ. JorgeL. XinF. Grouiller  et al.

Journal of Neuroimaging. 2018. DOI : 10.1111/jon.12523.

A practical guide to in vivo proton magnetic resonance spectroscopy at high magnetic fields

L. XinI. Tkáč

Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.10.019.

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

L. XinR. MekleM. FournierP. S. BaumannC. Ferrari  et al.

Schizophrenia bulletin. 2016. DOI : 10.1093/schbul/sbw038.

A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T

E. Serés RoigA. W. MagillG. DonatiM. MeyerspeerL. Xin  et al.

Magnetic Resonance in Medicine. 2015. DOI : 10.1002/mrm.25171.

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

A. MoninP. BaumannA. GriffaL. XinR. Mekle  et al.

Molecular Psychiatry. 2015. DOI : 10.1038/mp.2014.88.

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

L. XinB. LanzH. LeiR. Gruetter

Journal of Cerebral Blood Flow & Metabolism. 2015. DOI : 10.1038/jcbfm.2014.251.

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

C. BerthetL. XinL. BuscemiC. BenakisR. Gruetter  et al.

Journal of Cerebral Blood Flow & Metabolism. 2014. DOI : 10.1038/jcbfm.2014.155.

Is the macromolecule signal tissue-specific in healthy human brain? A 1H MRS study at 7 tesla in the occipital lobe

B. SchallerL. XinR. Gruetter

Magnetic Resonance in Medicine. 2014. DOI : 10.1002/mrm.24995.

Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

B. SchallerL. XinK. O‘BrienA. MagillR. Gruetter

NeuroImage. 2014. DOI : 10.1016/j.neuroimage.2014.02.016.

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

B. LanzL. XinP. MilletR. Gruetter

Journal of Neurochemistry (JNC). 2014. DOI : 10.1111/jnc.12479.

Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences

N. JustL. XinH. FrenkelR. Gruetter

Neuroimage. 2013. DOI : 10.1016/j.neuroimage.2013.02.042.

Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

L. XinB. SchallerV. MlynarikH. LuR. Gruetter

Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24352.

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

B. SchallerL. XinC. CudalbuR. Gruetter

NMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla

B. SchallerR. MekleL. XinN. KunzR. Gruetter

Journal of neuroscience research. 2013. DOI : 10.1002/jnr.23194.

Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

L. XinG. GambarotaC. CudalbuV. MlynárikR. Gruetter

Magma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.

Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7 T

Y. LinM. C. StephensonL. XinA. NapolitanoP. G. Morris

Journal of Cerebral Blood Flow & Metabolism. 2012. DOI : 10.1038/jcbfm.2012.33.

Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata

L. XinG. GambarotaJ. M. N. DuarteV. MlynarikR. Gruetter

Nmr In Biomedicine. 2010. DOI : 10.1002/nbm.1537.

Quantification of brain glycogen concentration and turnover through localized C-13 NMR of both the C1 and C6 resonances

R. van HeeswijkF. D. MorgenthalerL. XinR. Gruetter

Nmr In Biomedicine. 2010. DOI : 10.1002/nbm.1460.

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

L. XinV. MlynarikB. LanzH. FrenkeR. Gruetter

Magnetic Resonance in Medicine. 2010. DOI : 10.1002/mrm.22359.

Selective Resonance Suppression H-1-[C-13] NMR Spectroscopy With Asymmetric Adiabatic RF Pulses

L. XinH. FrenkelV. MlynarikF. D. MorgenthalerR. Gruetter

Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.21829.

Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

C. R. CudalbuV. MlynarikL. XinR. Gruetter

Measurement Science and Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.

Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

C. R. CudalbuV. MlynarikL. XinR. Gruetter

Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.22022.

In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T

G. GambarotaR. MekleL. XinM. HergtW. van der Zwaag  et al.

Magnetic Resonance Materials In Physics Biology And Medicine. 2009. DOI : 10.1007/s10334-008-0152-0.

H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

V. MlynarikC. R. CudalbuL. XinR. Gruetter

Journal of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.

Non-invasive quantification of brain glycogen absolute concentration

F. D. MorgenthalerR. van HeeswijkL. XinS. LausH. Frenkel  et al.

Journal of Neurochemistry (JNC). 2008. DOI : 10.1111/j.1471-4159.2008.05717.x.

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

G. GambarotaL. XinC. PerazzoloI. KohlerV. Mlynarik  et al.

Magnetic Resonance in Medicine. 2008. DOI : 10.1002/mrm.21695.

Proton T-2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4T

L. XinG. GambarotaV. MlynarikR. Gruetter

Nmr In Biomedicine. 2008. DOI : 10.1002/nbm.1205.

Enseignement et PhD

Current Phd

Zhiwei Huang, Rafael Ignacio De la Sotta Vargas, Ying Xiao, Xinyu Liu

Past Phd As Codirector

Songi Lim, Mark Stephan Widmaier

Courses

CIBM translational MR neuroimaging & spectroscopy

PHYS-770

Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.

Fundamentals of biomedical imaging

PHYS-438

The goal of this course is to illustrate how modern principles of basic science approaches are integrated into the major biomedical imaging modalities of importance to biology and medicine, with an emphasis on those of interest to in vivo.