Aleksandra Radenovic
Elle - She/her
Nationality: Croatian and Swiss
EPFL STI IBI-STI LBEN
BM 2140 (Bâtiment BM)
Station 17
1015 Lausanne
+41 21 693 73 71
+41 21 693 11 61
Office:
BM 2140
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Expertise
Single-molecule Biophysics, Nanofluidics, Biosensing, 2D Materials, Super-resolution Microscopy
Current work
My laboratory works in the research field of single-molecule biophysics, with a strong emphasis on nanofluidics, advanced microscopy, and nanoscale device engineering. Together with my students and collaborators, we have contributed to four major research directions:
(i) Nanopores and 2D materials for sensing and energy applications.
We introduced transition metal dichalcogenide (TMDC) membranes, particularly MoS₂, into nanofluidics and nanopore sensing. Our work demonstrated their potential for single-molecule detection, osmotic energy harvesting, and filtration. We established MoS₂ nanopores as platforms with high ion selectivity and surface conductivity, and showed that their properties can be tuned via light to enhance performance under neutral conditions. In parallel, we developed scalable fabrication strategies, including MOCVD growth and wafer-scale nanopore integration, enabling high-throughput device production and controlled membrane porosity.
We introduced transition metal dichalcogenide (TMDC) membranes, particularly MoS₂, into nanofluidics and nanopore sensing. Our work demonstrated their potential for single-molecule detection, osmotic energy harvesting, and filtration. We established MoS₂ nanopores as platforms with high ion selectivity and surface conductivity, and showed that their properties can be tuned via light to enhance performance under neutral conditions. In parallel, we developed scalable fabrication strategies, including MOCVD growth and wafer-scale nanopore integration, enabling high-throughput device production and controlled membrane porosity.
(ii) Microscopy innovations for materials and biological interfaces.
We develop experimental and computational methods for single-molecule localisation microscopy (SMLM) and related super-resolution approaches. Our work applies SMLM to characterise optically active defects in 2D materials, resolve nanoscale emitter distributions, and probe interfacial dynamics such as proton transport and liquid–solid interactions. We also introduced parameter-free image analysis tools and combine SMLM with complementary techniques (e.g., SOFI, AFM, SICM) to extract quantitative, high-resolution information across complex nanoscale systems.
We develop experimental and computational methods for single-molecule localisation microscopy (SMLM) and related super-resolution approaches. Our work applies SMLM to characterise optically active defects in 2D materials, resolve nanoscale emitter distributions, and probe interfacial dynamics such as proton transport and liquid–solid interactions. We also introduced parameter-free image analysis tools and combine SMLM with complementary techniques (e.g., SOFI, AFM, SICM) to extract quantitative, high-resolution information across complex nanoscale systems.
(iii) Nanocapillary-based single-molecule characterisation.
We established approaches combining nanocapillaries with force-based manipulation techniques to study DNA–protein interactions at the single-molecule level. These methods enable precise measurements of binding kinetics, molecular charge, and hydrodynamic properties, while detecting rare events with high sensitivity. Recent advances include the development of scanning ion conductance spectroscopy (SICS), which enables repeated, label-free measurements of the same molecule and opens new possibilities for biomarker detection and future sequencing technologies.
We established approaches combining nanocapillaries with force-based manipulation techniques to study DNA–protein interactions at the single-molecule level. These methods enable precise measurements of binding kinetics, molecular charge, and hydrodynamic properties, while detecting rare events with high sensitivity. Recent advances include the development of scanning ion conductance spectroscopy (SICS), which enables repeated, label-free measurements of the same molecule and opens new possibilities for biomarker detection and future sequencing technologies.
(iv) Neuromorphic iontronics and nanopore-based computing.
Our research explores ionic analogues of electronic computation using nanopores and nanofluidic systems. We demonstrated nanofluidic logic based on mechano–ionic memristive switches and identified memristive behaviour in biological nanopores governed by lumen charge. These efforts bridge solid-state and biological systems, establishing a framework for neuromorphic iontronic devices and scalable nanopore-based computing architectures.
Our research explores ionic analogues of electronic computation using nanopores and nanofluidic systems. We demonstrated nanofluidic logic based on mechano–ionic memristive switches and identified memristive behaviour in biological nanopores governed by lumen charge. These efforts bridge solid-state and biological systems, establishing a framework for neuromorphic iontronic devices and scalable nanopore-based computing architectures.
Mission
Our mission is to uncover and control the complex behaviour of biomolecules at the single-molecule level by developing and integrating advanced nanoscale technologies. Biological function often arises from rare, transient molecular states that remain hidden in ensemble-averaged measurements; capturing these dynamics requires tools capable of probing, manipulating, and engineering matter at the ultimate limit of resolution.
We therefore focus on the development of next-generation experimental platforms that combine nanopores, nanofluidics, super-resolution optical microscopy, and force-based manipulation. By leveraging solid-state and biological nanopores, low-dimensional materials, and nanocapillary-based approaches, we aim not only to sense and analyse single molecules with high precision, but also to control their transport, interactions, and functionality in real time.
We therefore focus on the development of next-generation experimental platforms that combine nanopores, nanofluidics, super-resolution optical microscopy, and force-based manipulation. By leveraging solid-state and biological nanopores, low-dimensional materials, and nanocapillary-based approaches, we aim not only to sense and analyse single molecules with high precision, but also to control their transport, interactions, and functionality in real time.
A central goal of our work is to bridge disciplines—linking biophysics, materials science, and nanoelectronics—to enable new paradigms such as high-throughput molecular sensing, quantitative imaging of dynamic processes at interfaces, and iontronic systems inspired by biological function. Through continuous innovation in instrumentation and methodology, we seek to transform our ability to observe, understand, and ultimately harness molecular behaviour for applications in biology, energy, and information processing.
Prof. Aleksandra Radenovic is a full professor of bioengineering at the École Polytechnique Fédérale de Lausanne (EPFL) and head of the Laboratory of Nanoscale Biology. She has received her Ph.D. in Biophysics from the University of Lausanne (Switzerland.) in 2003 and a graduated Physics at the University of Zagreb (Croatia) in 2000.
Curriculum vitae
Link to 2 page pdf CV (update March 2026)
Education
The H.I.T. Program
| (High Potential University Leaders Identity & Skills Training Program – Inclusive Leadership in Academia2025 – 2026 Center for Higher Education and Science Studies (CHESS) at the University of Zurich
Advanced Academic Leadership Program for ETH domain Professors
|2023 – 2023 International Institute for Management Development - IMD, Switzerland
Biophysics
| Development of low-temperature atomic force microscope for biological application
2000 – 2003
University of Lausanne, Switzerland
Directed by
Prof. Giovanni Dietler, Laboratory of Physics of Living Matter
Master of Science in Physics
| Experimental Physics-Biophysics
1994 – 1999
Department of Physics, Faculty of Science, University of Zagreb Croatia Research advi-sors:
Directed by
Prof. Selma Supek and Dr. Goran Baranovic
Latin & Ancient Greek (Focused on languages, humanities, and strong general education)
| Gymnasium1990 – 1994 Classical Gymnasium in Zagreb (Croatian: Klasična gimnazija)
Professionals experiences
Associate Dean of Research
Co-Director of Bioengineering institute
Professor
2021 Full Professor
2015-2021 Associate Professor
2008 Tenure-Track Assistant Professor
2015-2021 Associate Professor
2008 Tenure-Track Assistant Professor
Postdoctoral Fellow,
Prof. Jan Liphardt’s research group, Department of Physics, University of California
Visiting Scientist,
Patents
Patent Number: WO07079411 ALIGNMENT, TRANSPORTATION AND INTEGRATION OF NANOWIRES USING OPTICAL TRAPPING Publication date: 2007-07-12.
Patent Number: WO2014141168 A1 MANUFACTURING OF ORIFICES IN GLASS LIKE MATERIALS, E.G. NANOCAPILLARIES AND OBJECT OBTAINED ACCORDING TO THIS PROCESS Publication date: 2014-25-03
Patent Number: WO2015121394 MOLECULAR SENSING DEVICE- Publication date: 2015-20-08
Patent Number: WO2016142925 NANOPORE FORMING METHOD AND USES THERE OF- Publication date: 2016-15-09 LICENSED TO ROCHE
Patent Number: WO2018002099 OSMOTIC POWER GENERATOR Publication date: 2018-04-01
Patent Number: WO2023233345 4532109. NANOPORE-BASED SCANNING SYSTEM AND METHOD Publication date: 09.04.2025. EPFL Ref. 6.2333-PCT_EP ARSA Ref. P3722EP00 / 0013-569 / db-lm
Patent application filed NATURE-INSPIRED STALACTITE NANOPORES FOR BIOSENSING AND ENERGY HARVESTING
Patent application filed BENCHMARKING OF SINGLE IMAGING DATASETS PCT / 19 180 900.3 - Your ref.: 6.1943 - Our ref.: 34623EP; Publication date: Pending
Patent Number: WO2023233345 4532109. NANOPORE-BASED SCANNING SYSTEM AND METHOD Publication date: 09.04.2025. EPFL Ref. 6.2333-PCT_EP ARSA Ref. P3722EP00 / 0013-569 / db-lm
Patent application filed NATURE-INSPIRED STALACTITE NANOPORES FOR BIOSENSING AND ENERGY HARVESTING
Patent application filed BENCHMARKING OF SINGLE IMAGING DATASETS PCT / 19 180 900.3 - Your ref.: 6.1943 - Our ref.: 34623EP; Publication date: Pending
Awards
Full career Emmy Noether Distinction
European Physical Society
2025
Elected Member, Elected Member, Swiss Academy of Engineering Sciences (SATW)
Swiss Academy of Engineering Sciences (SATW)
2025
Optica Fellow
Optica
2021
ERC Advanced Grant
2021
SNSF-ERC Consolidator Grant
2015
CCMX Materials challenge award
2016
ERC Starting Grant
European Research Council
2010
SNSF Fellowship
Swiss National Science Foundation
2003
Selected publications
Single-Layer MoS2 Nanopores as Nanopower Generators.
Jiandong Feng, Michael Graf, Ke Liu, Dmitry Ovchinnikov, Dumitru Dumcenco, Mohammad Heiranian, Vishal Nandigana, Narayana R. Aluru, Andras Kis and Aleksandra Radenovic
Published in Nature in 2016
Identification of Single Nucleotides in MoS2 Nanopores
Jiandong Feng, Ke Liu, Roman D. Bulushev, Sergey Khlybov, Dumitru Dumcenco, Andras Kis & Aleksandra Radenovic
Published in Nature Nanotechnology in 2015
Charge and slip-length optimization in lipid-bilayer-coated nanofluidics for enhanced osmotic energy harvesting
Yunfei Teng, Tzu-Heng Chen, Nianduo Cai, Pratik Saud, Peiyue Li, Akhil Sai Naidu, Victor Boureau and Aleksandra Radenovic
Published in Nature Energy in 2026
LBEN Thesis
[16] 2D MoS2 Nanopores: Wafer-scale Fabrication and Monolayer Stability for Long-term Single-Molecule Sensing
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9538.[15] Molybdenum disulphide nanoporous membranes as nanofluidic platforms - large-area engineering and study
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8787.[14] Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8532.[13] Exploring optically active defects in wide-bandgap materials using fluorescence microscopy
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8204.[12] Biophysical applications of correlative scanning probe and super-resolution microscopy
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-9021.[11] Fundamental Applications of Nanopores: Controlled DNA Translocations to Nanofluidics
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7693.[10] Electrochemical and morphological engineering of 2D materials for nanopore sensing
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7588.[9] Development of novel experimental and computational methods for three-dimensional coherent and super-resolution microscopy
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7942.[8] 2D nanopores: fabrication, energy harvesting and field-effect sensing
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9516.[7] Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7608.[6] Probing chemical structures and physical processes with nanopores
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7082.[5] Nanoscale Magnetometry with Single Fluorescent Nanodiamonds Manipulated in an Anti-Brownian Electrokinetic Trap
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6972.[4] Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6726.[3] Alkaline niobate nanostructures as opto-mechanical probes
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6214.[2] Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5570.[1] Investigating the Impact of Single Molecule Fluorescence Dynamics on Photo Activated Localization Microscopy Experiments
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5517.Peer reviewed journal articles
2024
[159] Fluorescence microscopy: A statistics-optics perspective
Reviews Of Modern Physics. 2024-06-05. DOI : 10.1103/RevModPhys.96.025003.[158] CVD graphene contacts for lateral heterostructure MoS2 field effect transistors
Npj 2D Materials And Applications. 2024-05-10. DOI : 10.1038/s41699-024-00471-y.[157] Label-Free Techniques for Probing Biomolecular Condensates
Acs Nano. 2024-04-12. DOI : 10.1021/acsnano.4c01534.[156] Nanofluidic logic with mechano-ionic memristive switches
Nature Electronics. 2024-03-19. DOI : 10.1038/s41928-024-01137-9.[155] Open-source microscope add-on for structured illumination microscopy
Nature Communications. 2024-02-20. DOI : 10.1038/s41467-024-45567-7.[154] AI-driven detection and analysis of label-free protein aggregates
Nature Reviews Molecular Cell Biology. 2024-02-08. DOI : 10.1038/s41580-024-00708-0.2023
[153] Liquid-activated quantum emission from native hBN defects for nanofluidic sensing
Nature Materials. 2023-08-31. DOI : 10.1038/s41563-023-01658-2.[152] Confinement-Controlled Water Engenders Unusually High Electrochemical Capacitance
Journal Of Physical Chemistry Letters. 2023-07-17. DOI : 10.1021/acs.jpclett.3c01498.[151] Selective Growth of van der Waals Heterostructures Enabled by Electron-Beam Irradiation
Acs Applied Materials & Interfaces. 2023-07-07. DOI : 10.1021/acsami.3c02892.[150] Nature-Inspired Stalactite Nanopores for Biosensing and Energy Harvesting
Advanced Materials. 2023-07-06. DOI : 10.1002/adma.202302827.[149] Spatially multiplexed single-molecule translocations through a nanopore at controlled speeds
Nature Nanotechnology. 2023-06-19. DOI : 10.1038/s41565-023-01412-4.[148] Nanoscale thermal control of a single living cell enabled by diamond heater-thermometer
Scientific Reports. 2023-05-26. DOI : 10.1038/s41598-023-35141-4.[147] The Three-Phase Contact Potential Difference Modulates the Water Surface Charge
Journal Of Physical Chemistry Letters. 2023-05-16. DOI : 10.1021/acs.jpclett.3c00479.[146] The Three-Phase Contact Potential Difference Modulates the Water Surface Charge
Journal Of Physical Chemistry Letters. 2023-05-16. DOI : 10.1021/acs.jpclett.3c00479.[145] Optical imaging of the small intestine immune compartment across scales
Communications Biology. 2023-03-31. DOI : 10.1038/s42003-023-04642-3.[144] High durability and stability of 2D nanofluidic devices for long-term single-molecule sensing
Npj 2D Materials And Applications. 2023-02-23. DOI : 10.1038/s41699-023-00373-5.[143] Defect engineering of 2D material for biosensing applications
2023-02-10. p. 278A-278A. DOI : 10.1016/j.bpj.2022.11.1584.[142] Imaging of interactions of biomolecules with nanomaterials with interferometric scattering microscopy
2023-02-10. p. 153A-153A.[141] Substitutional p‐type Doping in NbS2‐MoS2 Lateral Heterostructures Grown by MOCVD
Advanced Materials. 2023-01-16. DOI : 10.1002/adma.202209371.[140] Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization
Journal of the American Chemical Society. 2023. DOI : 10.1021/jacs.3c09261.[139] A large-scale integrated vector–matrix multiplication processor based on monolayer molybdenum disulfide memories
Nature Electronics. 2023. DOI : 10.1038/s41928-023-01064-1.[138] How to Achieve Large-Area Ultra-Fast Operation of MoS 2 Monolayer Flash Memories?
IEEE Nanotechnology Magazine. 2023. DOI : 10.1109/MNANO.2023.3297118.2022
[137] High-Throughput Nanopore Fabrication and Classification Using Xe-Ion Irradiation and Automated Pore-Edge Analysis
Acs Nano. 2022-09-26. DOI : 10.1021/acsnano.2c05201.[136] Wafer-scale MoS2 with water-vapor assisted showerhead MOCVD
Nanoscale Advances. 2022-09-02. DOI : 10.1039/d2na00409g.[135] Stress induced delamination of suspended MoS2 in aqueous environments
Physical Chemistry Chemical Physics. 2022-07-29. DOI : 10.1039/d2cp02094g.[134] Stable Al2O3 Encapsulation of MoS2 ‐FETs Enabled by CVD Grown h‐BN
Advanced Electronic Materials. 2022-04-29. DOI : 10.1002/aelm.202200123.[133] Three-step, transfer-free growth of MoS2/WS2/graphene vertical van der Waals heterostructure
2D Materials. 2022-04-01. DOI : 10.1088/2053-1583/ac5f6d.[132] Engineering Optically Active Defects in Hexagonal Boron Nitride Using Focused Ion Beam and Water
Acs Nano. 2022-03-22. DOI : 10.1021/acsnano.1c07086.[131] High Performance Semiconducting Nanosheets via a Scalable Powder-Based Electrochemical Exfoliation Technique
Acs Nano. 2022-03-15. DOI : 10.1021/acsnano.1c10739.[130] Statistical distortion of supervised learning predictions in optical microscopy induced by image compression
Scientific Reports. 2022-03-02. DOI : 10.1038/s41598-022-07445-4.[129] Zero-Bias Power-Detector Circuits based on MoS<sub>2</sub> Field-Effect Transistors on Wafer-Scale Flexible Substrates
Advanced Materials. 2022-02-17. DOI : 10.1002/adma.202108469.[128] Low-Power Artificial Neural Network Perceptron Based on Monolayer MoS2
ACS Nano. 2022-02-16. DOI : 10.1021/acsnano.1c07065.[127] Bacterial nanopores open the future of data storage
2022-01-01. International Electron Devices Meeting (IEDM), San Francisco, CA, Dec 03-07, 2022. DOI : 10.1109/IEDM45625.2022.10019421.[126] Flat-Band-Induced Many-Body Interactions and Exciton Complexes in a Layered Semiconductor
Nano Letters. 2022-11-08. DOI : 10.1021/acs.nanolett.2c02965.2021
[125] Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics
Acs Nano. 2021-11-23. DOI : 10.1021/acsnano.1c05202.[124] Rhesus Blood Typing within a Few Seconds by Packing-Enhanced Nanoscattering on Individual Erythrocytes
Analytical Chemistry. 2021-11-16. DOI : 10.1021/acs.analchem.1c03590.[123] Superconducting 2D NbS2 Grown Epitaxially by Chemical Vapor Deposition
ACS Nano. 2021-11-10. DOI : 10.1021/acsnano.1c07956.[122] Anomalous interfacial dynamics of single proton charges in binary aqueous solutions
Science Advances. 2021-10-01. DOI : 10.1126/sciadv.abg8568.[121] Bio-orthogonal Red and Far-Red Fluorogenic Probes for Wash-Free Live-Cell and Super-resolution Microscopy
Acs Central Science. 2021-09-22. DOI : 10.1021/acscentsci.1c00703.[120] Experimental Combination of Super-Resolution Optical Fluctuation Imaging with Structured Illumination Microscopy for Large Fields-of-View
Acs Photonics. 2021-08-18. DOI : 10.1021/acsphotonics.1c00668.[119] Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy
Nature Communications. 2021-07-27. DOI : 10.1038/s41467-021-24901-3.[118] Direct Growth of Hexagonal Boron Nitride on Photonic Chips for High-Throughput Characterization
Acs Photonics. 2021-07-21. DOI : 10.1021/acsphotonics.1c00165.[117] Adaptive optics enables multimode 3D super-resolution microscopy via remote focusing
Nanophotonics. 2021-06-10. DOI : 10.1515/nanoph-2021-0108.[116] High resolution optical projection tomography platform for multispectral imaging of the mouse gut
Biomedical Optics Express. 2021-06-01. DOI : 10.1364/BOE.423284.[115] Parameter-free rendering of single-molecule localization microscopy data for parameter-free resolution estimation
Communications Biology. 2021-05-11. DOI : 10.1038/s42003-021-02086-1.[114] From Water Solutions to Ionic Liquids with Solid State Nanopores as a Perspective to Study Transport and Translocation Phenomena
Small. 2021-05-06. DOI : 10.1002/smll.202100777.[113] Super-resolved Optical Mapping of Reactive Sulfur-Vacancies in Two-Dimensional Transition Metal Dichalcogenides
Acs Nano. 2021-04-27. DOI : 10.1021/acsnano.1c00373.[112] Wetting of nanopores probed with pressure
Physical Chemistry Chemical Physics. 2021-02-28. DOI : 10.1039/d1cp00253h.[111] Electrochemical Functionalization of Selectively Addressed MoS2 Nanoribbons for Sensor Device Fabrication
Acs Applied Nano Materials. 2021-02-26. DOI : 10.1021/acsanm.0c02628.[110] Decoding Digital Information Stored in Polymer by Nanopore
2021-02-12. p. 98A-98A. DOI : 10.1016/j.bpj.2020.11.802.2020
[109] Aerolysin nanopores decode digital information stored in tailored macromolecular analytes
Science Advances. 2020-12-09. DOI : 10.1126/sciadv.abc2661.[108] Recent Advances and Prospects in the Research of Nascent Adhesions
Frontiers In Physiology. 2020-12-04. DOI : 10.3389/fphys.2020.574371.[107] Prospects of Observing Ionic Coulomb Blockade in Artificial Ion Confinements
Entropy. 2020-12-01. DOI : 10.3390/e22121430.[106] Pressure-Induced Enlargement and Ionic Current Rectification in Symmetric Nanopores
Nano Letters. 2020-11-11. DOI : 10.1021/acs.nanolett.0c03083.[105] Microscopic Detection Analysis of Single Molecules in MoS2 Membrane Nanopores
ACS Nano. 2020-11-06. DOI : 10.1021/acsnano.0c08382.[104] Logic-in-memory based on an atomically thin semiconductor
Nature. 2020-11-05. DOI : 10.1038/s41586-020-2861-0.[103] Towards artificial mechanosensing
Nature Materials. 2020-10-01. DOI : 10.1038/s41563-020-00811-5.[102] Self-Blinking Dyes Unlock High-Order and Multiplane Super-Resolution Optical Fluctuation Imaging
Acs Nano. 2020-07-28. DOI : 10.1021/acsnano.0c04602.[101] Polymer Coatings to Minimize Protein Adsorption in Solid-State Nanopores
Small Methods. 2020-07-16. DOI : 10.1002/smtd.202000177.[100] High-Throughput Nanocapillary Filling Enabled by Microwave Radiation for Scanning Ion Conductance Microscopy Imaging
ACS Applied Nano Materials. 2020-07-02. DOI : 10.1021/acsanm.0c01345.[99] Spectral cross-cumulants for multicolor super-resolved SOFI imaging
Nature Communications. 2020-06-15. DOI : 10.1038/s41467-020-16841-1.[98] Direct observation of water-mediated single-proton transport between hBN surface defects
Nature Nanotechnology. 2020-05-25. DOI : 10.1038/s41565-020-0695-4.[97] Wafer-Scale Fabrication of Nanopore Devices for Single-Molecule DNA Biosensing using MoS2
Small Methods. 2020-05-11. DOI : 10.1002/smtd.202000072.[96] Nanocapillary confinement of imidazolium based ionic liquids
Nanoscale. 2020-04-28. DOI : 10.1039/d0nr01164a.[95] High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism
Nanophotonics. 2020-01-01. DOI : 10.1515/nanoph-2019-0346.2019
[94] Nanoscale Selective Passivation of Electrodes Contacting a 2D Semiconductor
Advanced Functional Materials. 2019-12-11. DOI : 10.1002/adfm.201907860.[93] Waveguide-Based Platform for Large-FOV Imaging of Optically Active Defects in 2D Materials
Acs Photonics. 2019-12-01. DOI : 10.1021/acsphotonics.9b01103.[92] Transverse Detection of DNA Using a MoS2 Nanopore
Nano Letters. 2019-12-01. DOI : 10.1021/acs.nanolett.9b04180.[91] Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores
Nature Communications. 2019-10-29. DOI : 10.1038/s41467-019-12690-9.[90] Wafer-scale MOCVD growth of monolayer MoS2 on sapphire and SiO2
Nano Research. 2019-10-01. DOI : 10.1007/s12274-019-2502-9.[89] 2D MoS2 nanopores: ionic current blockade height for clustering DNA events
2D Materials. 2019-10-01. DOI : 10.1088/2053-1583/ab2c38.[88] 2D materials as an emerging platform for nanopore-based power generation
Nature Reviews Materials. 2019-09-01. DOI : 10.1038/s41578-019-0126-z.[87] Parameter-free image resolution estimation based on decorrelation analysis
Nature Methods. 2019-08-26. DOI : 10.1038/s41592-019-0515-7.[86] Facile Production of Hexagonal Boron Nitride Nanoparticles by Cryogenic Exfoliation
Nano Letters. 2019-08-01. DOI : 10.1021/acs.nanolett.9b01913.[85] Light-Enhanced Blue Energy Generation Using MoS2 Nanopores
Joule. 2019-06-19. DOI : 10.1016/j.joule.2019.04.011.[84] Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography
Biomedical Optics Express. 2019-06-01. DOI : 10.1364/BOE.10.003041.[83] Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging
Nature Communications. 2019-03-20. DOI : 10.1038/s41467-019-09247-1.[82] Wide-Field Spectral Super-Resolution Mapping of Optically Active Defects in Hexagonal Boron Nitride
Nano Letters. 2019-03-13. DOI : 10.1021/acs.nanolett.9b00178.[81] Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions
Nano Letters. 2019-10-03. DOI : 10.1021/acs.nanolett.9b02024.[80] Identifying microbial species by single-molecule DNA optical mapping and resampling statistics
NAR Genomics and Bioinformatics. 2019-10-05. DOI : 10.1093/nargab/lqz007.[79] Fluorescent Nanodiamonds as Versatile Intracellular Temperature Sensors
CHIMIA International Journal for Chemistry. 2019-02-01. DOI : 10.2533/chimia.2019.73.[78] Fabrication and practical applications of molybdenum disulfide nanopores
Nature Protocols. 2019-03-22. DOI : 10.1038/s41596-019-0131-0.[77] Detecting topological variations of DNA at single-molecule level
Nature Communications. 2019. DOI : 10.1038/s41467-018-07924-1.2018
[76] Transverse Detection of DNA in a MoS2 Nanopore
Biophysical Journal. 2018. DOI : 10.1016/j.bpj.2017.11.1005.[75] Single step synthesis of Schottky-like hybrid graphene - titania interfaces for efficient photocatalysis
Scientific Reports. 2018-05-25. DOI : 10.1038/s41598-018-26447-9.[74] Orthogonal Tip-to-Tip Nanocapillary Alignment Allows for Easy Detection of Fluorescent Emitters in Femtomolar Concentrations
Nano Letters. 2018-04-04. DOI : 10.1021/acs.nanolett.8b00831.[73] Imaging of Optically Active Defects with Nanometer Resolution
Nano Letters. 2018-02-02. DOI : 10.1021/acs.nanolett.7b04819.[72] Centimeter-Sized Single-Orientation Monolayer Hexagonal Boron Nitride With or Without Nanovoids
Nano Letters. 2018-01-09. DOI : 10.1021/acs.nanolett.7b04752.2017
[71] Investigating Focal Adhesion Substructures by Localization Microscopy
Biophysical Journal. 2017. DOI : 10.1016/j.bpj.2017.09.032.[70] Combining PALM and SOFI for quantitative imaging of focal adhesions in living cells
2017. SPIE Photonics West, San Francisco, 27 January-2 February 2017. DOI : 10.1117/12.2252865.[69] Geometrical Effect in 2D Nanopores
Nano Letters. 2017. DOI : 10.1021/acs.nanolett.7b01091.2016
[68] Fluorescent Nanodiamonds in Biological and Biomedical Imaging and Sensing
Super-Resolution Imaging in Biomedicine; Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2016.[67] Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions
Nature Communications. 2016. DOI : 10.1038/ncomms13693.[66] Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries
Nano Letters. 2016. DOI : 10.1021/acs.nanolett.6b04165.[65] On characterizing protein spatial clusters with correlation approaches
Scientific Reports. 2016. DOI : 10.1038/srep31164.[64] Single-layer MoS2 nanopores as nanopower generators
Nature. 2016. DOI : 10.1038/nature18593.[63] Observation of ionic Coulomb blockade in nanopores
Nature Materials. 2016. DOI : 10.1038/nmat4607.2015
[62] Molybdenum Disulfide Nanopores: Why 3 Atoms are Better than One?
2015. 59th Annual Meeting of the Biophysical-Society, Baltimore, MD, FEB 07-11, 2015. p. 489A-489A. DOI : 10.1016/j.bpj.2014.11.2677.[61] Investigating Cellular Focal Adhesions on Nano-Patterned Substrates with Dual Color Photo-Activated Localization Microscopy
2015. 59th Annual Meeting of the Biophysical-Society, Baltimore, MD, FEB 07-11, 2015. p. 359A-359A. DOI : 10.1016/j.bpj.2014.11.1971.[60] Single florescent nanodiamond in a three dimensional ABEL trap
Scientific Reports. 2015. DOI : 10.1038/srep16669.[59] Revealing GPCR oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function
FEBS Journal. 2015. DOI : 10.1111/febs.13577.[58] Large-area MoS2 grown using H2S as the sulphur source
2D Materials. 2015. DOI : 10.1088/2053-1583/2/4/044005.[57] Relevance of the Drag Force during Controlled Translocation of a DNA–Protein Complex through a Glass Nanocapillary
Nano Letters. 2015. DOI : 10.1021/acs.nanolett.5b03264.[56] Identification of single nucleotides in MoS2 nanopores
Nature Nanotechnology. 2015. DOI : 10.1038/nnano.2015.219.[55] Preface for a special issue of Microelectronic Engineering Micro/Nano Biotechnologies & Systems 2014
2015. p. vi-vii. DOI : 10.1016/S0167-9317(15)00341-X.[54] High-Resolution Correlative Microscopy: Bridging the Gap between Single Molecule Localization Microscopy and Atomic Force Microscopy
Nano Letters. 2015. DOI : 10.1021/acs.nanolett.5b00572.[53] Electrochemical Reaction in Single Layer MoS2: nanopores opened atom by atom
Nano Letters. 2015. DOI : 10.1021/acs.nanolett.5b00768.[52] Large-Area Epitaxial Monolayer MoS2
ACS Nano. 2015. DOI : 10.1021/acsnano.5b01281.[51] Accounting for Limited Detection Efficiency and Localization Precision in Cluster Analysis in Single Molecule Localization Microscopy
PLOS ONE. 2015. DOI : 10.1371/journal.pone.0118767.[50] The emergence of nanopores in next-generation sequencing
Nanotechnology. 2015. DOI : 10.1088/0957-4484/26/7/074003.2014
[49] Measurement of the Position-Dependent Electrophoretic Force on DNA in a Glass Nanocapillary
Nano Letters. 2014. DOI : 10.1021/nl503272r.[48] High throughput second harmonic imaging for label-free biological applications
Optics Express. 2014. DOI : 10.1364/OE.22.031102.[47] Probing the size of proteins with glass nanopores
Nanoscale. 2014. DOI : 10.1039/C4NR05001K.[46] Electron Spin Resonance of Nitrogen-Vacancy Defects Embedded in Single Nanodiamonds in an ABEL Trap
Nano Letters. 2014. DOI : 10.1021/nl5023964.[45] Shrinking Nanocapillaries to Low Noise Nanopores for Single Molecule Detection
2014. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 633A-633A. DOI : 10.1016/j.bpj.2013.11.3499.[44] Combination of Optical Tweezers with Nanocapillaries as System for Estimation of DNA/Ligand Interactions
2014. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 15-19, 2014. p. 393A-393A. DOI : 10.1016/j.bpj.2013.11.2221.[43] Challenges in quantitative single molecule localization microscopy
FEBS Letters. 2014. DOI : 10.1016/j.febslet.2014.06.014.[42] Progress in quantitative single-molecule localization microscopy
Histochemistry and Cell Biology. 2014. DOI : 10.1007/s00418-014-1217-y.[41] Probing Rotational and Translational Diffusion of Nanodoublers in Living Cells on Microsecond Time Scales
Nano Letters. 2014. DOI : 10.1021/nl500356u.[40] Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation
ACS Nano. 2014. DOI : 10.1021/nn406102h.[39] Light Generation and Harvesting in a van der Waals Heterostructure
ACS Nano. 2014. DOI : 10.1021/nn500480u.[38] Nanopore Integrated Nanogaps for DNA Detection
Nano Letters. 2014. DOI : 10.1021/nl403849g.[37] ComEA Is Essential for the Transfer of External DNA into the Periplasm in Naturally Transformable Vibrio cholerae Cells
PLoS Genetics. 2014. DOI : 10.1371/journal.pgen.1004066.2013
[36] Detection of RNAP-DNA complexes using solid state nanopores
2013. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Osaka, Japan, 3-7 07 2013. p. 4106-4109. DOI : 10.1109/EMBC.2013.6610448.[35] DNA Trans location through Low-Noise Glass Nanopores
Acs Nano. 2013. DOI : 10.1021/nn405029j.[34] MosaicIA: an ImageJ/Fiji plugin for spatial pattern and interaction analysis
Bmc Bioinformatics. 2013. DOI : 10.1186/1471-2105-14-349.[33] Enhancement of Second Harmonic Signal in Nanofabricated Cones
Nano Letters. 2013. DOI : 10.1021/nl403279y.[32] Detecting the translocation of DNA through a nanopore using graphene nanoribbons
Nature Nanotechnology. 2013. DOI : 10.1038/Nnano.2013.240.[31] Controllable Shrinking and Shaping of Glass Nanocapillaries under Electron Irradiation
Nano Letters. 2013. DOI : 10.1021/nl400304y.[30] Enlightening G-protein-coupled receptors on the plasma membrane using super-resolution photoactivated localization microscopy
Biochemical Society Transactions. 2013. DOI : 10.1042/Bst20120250.[29] Ultrasensitive photodetectors based on monolayer MoS2
Nature Nanotechnology. 2013. DOI : 10.1038/nnano.2013.100.2012
[28] Identification of the factors affecting co-localization precision for quantitative multicolor localization microscopy
Optical Nanoscopy. 2012. DOI : 10.1186/2192-2853-1-9.[27] Alkaline niobate nanowires as opto-mechanical probes
2012. Conference on Optical Trapping and Optical Micromanipulation IX. DOI : 10.1117/12.929466.[26] Fast and automatic processing of multi-level events in nanopore translocation experiments
Nanoscale. 2012. DOI : 10.1039/c2nr30951c.[25] Cell-type-specific 2 adrenergic receptor clusters identified using photo-activated localization microscopy are not lipid raft related, but depend on actin cytoskeleton integrity
Journal of Biological Chemistry. 2012. DOI : 10.1074/jbc.M111.329912.[24] Nanopore Detection of Single Molecule RNAP–DNA Transcription Complex
Nano Letters. 2012. DOI : 10.1021/nl3002827.[23] Micro-fabrication process for small transport devices of layered manganite
2012. THE 56TH ANNUAL CONFERENCE ON MAGNETISM AND MAGNETIC MATERIALS, Phoenix, Arizona, USA, October, 30- November 3, 2011. DOI : 10.1063/1.3675995.2011
[22] Niobates Nanowires: Synthesis, Characterization and Applications
Nanowires - Implementations and Applications; In Tech, 2011. p. 509-524.[21] Nonlinear Optical Response in Single Alkaline Niobate Nanowires
Nano Letters. 2011. DOI : 10.1021/nl201085b.[20] Quantitative Photo Activated Localization Microscopy: Unraveling the Effects of Photoblinking
PLoS ONE. 2011. DOI : 10.1371/journal.pone.0022678.[19] Identification of clustering artifacts in photoactivated localization microscopy
Nature Methods. 2011. DOI : 10.1038/nmeth.1627.[18] Single-layer MoS2 transistors
Nature Nanotechnology. 2011. DOI : 10.1038/nnano.2010.279.2010
[17] ssDNA Binding Reveals the Atomic Structure of Graphene
Langmuir. 2010. DOI : 10.1021/la102518t.[16] Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
Neurobiology of Aging. 2010. DOI : 10.1016/j.neurobiolaging.2008.08.019.[15] Photoactivatable Fluorescent Protein mEos2 Displays Repeated Photoactivation after a Long-Lived Dark State in the Red Photoconverted Form
The Journal of Physical Chemistry Letters. 2010. DOI : 10.1021/jz1003523.2008
[14] Fabrication of 10 nm diameter hydrocarbon nanopores
Applied Physics Letters. 2008. DOI : 10.1063/1.3012376.2007
[13] Controlling DNA capture and propagation through artificial nanopores
Nano Letters. 2007. DOI : 10.1021/nl0714334.[12] Electrophoretic threading kinetics of optically trapped DNA through synthetic nanopores
Biophysical Journal. 2007.[11] Tunable nanowire nonlinear optical probe
Nature. 2007. DOI : 10.1038/nature05921.2006
[10] EFTEM Imaging of ZnO-TiO2 Core-Shell Nanowires and TiO2 Nanotubes
2006. p. 474. DOI : 10.1017/S1431927606069261.[9] Optical trapping and integration of semiconductor nanowire assemblies in water
Nature Materials. 2006. DOI : 10.1038/nmat1563.[8] Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
Neurobiology of Aging. 2006. DOI : 10.1016/j.neurobiolaging.2005.01.018.[7] ZnO-Al2O3 and ZnO-TiO2 core-shell nanowire dye-sensitized solar cells
Journal of Physical Chemistry B. 2006. DOI : 10.1021/jp0648644.[6] Study of DNA in "glasslike state" by atomic force microscopy: Importance of substrates
Japanese Journal of Applied Physics Part 1-Regular Papers Brief Communications & Review Papers. 2006. DOI : 10.1143/JJAP.45.2345.2004
[5] Complex characterization of physiology solution based magnetic fluid
Indian Journal of Engineering and Materials Sciences. 2004.2003
[4] Study of probes and substrates for low temperature atomic force microscopy and biological applications
Acta Physica Polonica A. 2003. DOI : 10.12693/APhysPolA.104.373.[3] A low-temperature ultrahigh vacuum atomic force microscope for biological applications
Review of Scientific Instruments. 2003. DOI : 10.1063/1.1532840.[2] Low noise current-to-voltage converter and vibration damping system for a low-temperature ultrahigh vacuum scanning tunneling microscope
Review of Scientific Instruments. 2003. DOI : 10.1063/1.1533100.[1] Characterization of atomic force microscope probes at low temperatures
Journal of Applied Physics. 2003. DOI : 10.1063/1.1604952.Teaching & PhD
PhD Students
Helena Miljkovic, Akhil Sai Naidu, Karl Rufus Pang Yeo, Wei Guo, Eveline Simone Mayner, Nianduo Cai, Marianna Mitsioni
Past EPFL PhD Students
Paolo Annibale, Camille Alice Raillon, Fabrizia Dutto, Arun Shivanandan, Metin Kayci, Jiandong Feng, Roman Bulushev, Michael Graf, Adrien Charles Descloux, Sebastian James Davis, Martina Lihter, Evgenii Glushkov, Vytautas Navikas, Arielle Louise Planchette, Michal Daniel Macha, Mukeshchand Thakur, Nathan Ronceray, Khalid Ibrahim, Yunfei Teng
Past EPFL PhD Students as codirector
Hossein Babashah, Simon Finn Mayer
Courses
Fundamentals of biophotonics
BIO-443
This module serves as an introduction to the area of biophotonics. The approach is multidisciplinary .The course is mainly knowledge-based but students will benefit from the skills learned by carrying out problem solving and by completing the assignment.
Seminar in physiology and instrumentation
MICRO-568
To get familiar with the state-of-the-art in medical and bio-instrumentation. To acquire basic understanding of related physiology associated to these instruments.
Fundamentals of biophotonics BIOE -443
This module serves as an introduction to the area of biophotonics. The approach is multidisciplinary .The course is mainly knowledge-based but students will benefit from the skills learned by carrying out problem solving and by completing the assignment.
https://people.epfl.ch/profiles/5002/edit?lang=en
https://people.epfl.ch/profiles/5002/edit?lang=en
Seminar in physiology and instrumentation MICO-568
This course aims to provide a comprehensive understanding of the state of the art in biomedical instrumentation. It focuses on the principles, design, and application of biomedical devices and measurement methods used in relation to human health. Students will learn how these technologies are used to monitor, diagnose, and support physiological functions, while gaining insight into the underlying biological and medical concepts.
https://edu.epfl.ch/coursebook/en/seminar-in-physiology-and-instrumentation-MICRO-568
https://edu.epfl.ch/coursebook/en/seminar-in-physiology-and-instrumentation-MICRO-568