Andrea Capozzi
Nationality: Italian
EPFL SB IPHYS LIFMET
CH F1 633 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 05 88
Office: CH F1 633
EPFL › SB › IPHYS › LIFMET
Website: https://lifmet.epfl.ch/
Expertise
Electron Spin Resonance (ESR)
Dynamic Nuclear Polarization (DNP)
Hyperpolarization Techniques
Cryogenics
Open PhD positions
A PhD student position is available on the Physics of Xenon hyperpolarization: Spin Exchange Optical Pumping (SEOP) and Dynamic Nuclear Polarization (DNP)
The project builds on a well-established and long-standing collaboration between the Laboratory for Functional and Metabolic Imaging at EPFL (Lausanne, Switzerland) and the School of Health Science (Geneva, Switzerland).
The involved research lays across nuclear spin dynamics and biomedical imaging. The main goal of the project is to answer fundamental questions on the spin order transfer mechanisms to enhance the Xenon polarization.
The successful candidate will have a strong interest in nuclear spin Physics and Chemical Physics, be able to work independently in a multidisciplinary team and get acquainted quickly with new methods. We expect him/her to be comfortable in an experimental environment as well as for theoretical developments.
The candidate will have access to a top-notch hyperpolarization laboratory equipped with two DNP polarizers/ESR spectrometers (3.35 T and 5 T), one SEOP polarizer, a multi-nuclei 1 T benchtop NMR spectrometer, a low-field MRI scanner and a 400 MHz NMR spectrometer. Active external collaborations also provide access to clinical and pre-clinical MRI platforms.
With a master degree preferably in Physics or Chemical Physics, the candidate should have good communication skills, experience with programming (MATLAB, Python, C/C++) and experimental Physics.
French speaking proficiency and experience with NMR/ESR is a plus.
The project involves regular travels between Lausanne and Geneva.
Applicants should send by email a CV, cover letter, master final marks, publications on scientific journals if any and three references (with email address) to:
andrea.capozzi@epfl.ch
jean-noel.hyacinthe@hesge.ch
Education
PhD
| Physics2016 – 2016 EPFL
MSc
| Physics2011 – 2011 University of Pavia
BSc
| Physics2009 – 2009 University of Pavia
Awards
Hyperpolarization media study group award 2020, ISMRM conference
1st place
2020
Hyperpolarization methods & equipment study group award 2019, ISMRM conference
1st place
2020
Selected publications
13C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid-Effect
Radaelli A., Yoshihara H. A. I., Nonaki H., Sando S., Ardenkjær-Larsen J.H., Gruetter R., Capozzi A.#
Published in The Journal of Physical Chemistry Letters in
UV-Irradiated 2-Keto-(1-13C)Isocaproic Acid for High-Performance 13C Hyperpolarized MR
Patel S.#, Pinon A. C., Lerche M. H., Karlsson M., Capozzi A., Ardenkjær-Larsen J. H.;
Published in The Journal of Physical Chemistry C in
Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances
Pinon A. C., Capozzi A., Ardenkjær-Larsen J.H.#
Published in Magnetic Resonance Matererials in Physics, Biology and Medicine in
Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals
Pinon A. C., Capozzi A., Ardenkjær-Larsen J.H.#
Published in Communication Chemistry in
Gadolinium Effect at High-Magnetic-Field DNP: 70% 13C Polarization of [U-13C] Glucose Using Trityl
Capozzi A.#, Patel S, Wenckebach W.T., Karlsson M., Lerche M.H, Ardenkjær-Larsen J.H.
Published in The Journal of Physical Chemistry Letters in
Efficient Hyperpolarization of U-13C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals
Capozzi A.#, Patel S., Gunnarsson C.P., Marco-Rius I., Comment A., Karlsson M., Lerche M.H., Ouari O., Ardenkjær-Larsen J.H.
Published in Angewandte Chemie International Edition in
Optimized microwave delivery in dDNP
Albannay M.M., Vinther J.M.O., Capozzi A., Zhurbenko V., Ardenkjaer-Larsen J.H.#
Published in The Journal of Magnetic Resonance in
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates
Marco-Rius I.#, Cheng T., Gaunt A.P., Patel S., Kreis F., Capozzi A., Wright A.J., Brindle K.M., Ouari O., Comment A.
Published in Journal of the American Chemical Society (JACS) in
Liquid-State 13C Polarization of 30% through Photoinduced Nonpersistent Radicals
Capozzi A.#, Karlsson M., Petersen J. R., Lerche M. H., Ardenkjær-Larsen J. H.
Published in The Journal of Physical Chemistry C in
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced non-persistent radicals
Bastiaansen J.A.M.#, Yoshihara H.A.I., Capozzi A., Schwitter J., Gruetter R., Merritt M.E., Comment A.
Published in Magnetic Resonance in Medicine (MRM) in
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized C-13-substrates
Capozzi A., Cheng T., Boero G., Roussel C., Comment A.
Published in Nature Communications in
Photo-Induced non-Persistent Radicals as Polarizing Agents for X-Nuclei dissolution-DNP
Capozzi A.#, Hyacinthe J.-N., Cheng T., Eichhorn T.R., Boero G., Roussel C., van der Klink J.J., Comment A.#
Published in The Journal of Physical Chemistry C in
Optimal glass-forming solvent brings sublimation dynamic nuclear polarization to 129Xe hyperpolarization biomedical imaging standards
Capozzi A.#, Roussel C., Comment A.#, Hyacinthe J.-N.
Published in The Journal of Physical Chemistry C in
Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with 13C hyperpolarized NMR
Breukels V.#, Jansen K.C., van Heijster F.H., Capozzi A., van Bentum P.J.M., Schalken J.A., Comment A., Scheenen T.W.J.
Published in NMR in Biomedicine in
Spin dynamics in hybrid iron oxide-gold nanostructures
Orlando T.#, Capozzi A., Umut E., Bordonali L., Mariani M., Galinetto P., Pineider F., Innocenti C., Masala P., Tabak F., Scavini M., Santini P., Corti M., Sangregorio C., Ghigna P.l, Lascialfari A.
Published in The Journal of Physical Chemistry C in
Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging
Eichhorn T.R., Takado, Y., Salameh N., Capozzi A., Cheng T., Hyacinthe J.-N., Mishkovsky M., Roussel C., Comment A.#
Published in Proceedings of the National Academy of Science (PNAS) in
Over 35% liquid-state 13C polarization obtained via dissolution dynamic nuclear polarization at 7 T and 1 K using ubiquitous nitroxyl radicals
Cheng T.#, Capozzi A., Takado Y., Balzan R., Comment A.
Published in Physical Chemistry Chemical Physics (PCCP) in