Bernard Lanz
+41 21 693 79 95
Office: CH F0 572
EPFL › VPA › VPA-AVP-CP › CIBM › CIBM-MRI
Website: https://www.cibm.ch/
+41 21 693 79 95
EPFL › SB › SB-SPH › SPH-ENS
Website: https://sph.epfl.ch/
Expertise
Magnetic resonance spectroscopy
Dynamic in vivo 1H, 2H, 13C, 15N MR spectroscopy and spectroscopic imaging
Positron emission tomography
Mathematical models of metabolism
Dynamic in vivo 1H, 2H, 13C, 15N MR spectroscopy and spectroscopic imaging
Positron emission tomography
Mathematical models of metabolism
Google Scholar
Pubmed
Infoscience
Advanced methods in deuterium metabolic imaging
Magnetic Resonance Materials in Physics, Biology and Medicine. 2026. DOI : 10.1007/s10334-026-01322-1.MRS4Brain: a processing toolbox for preclinical MR spectroscopy and spectroscopic imaging data
2025Towards harmonized spectral quantification in MRSI: Comparative analysis of Backward-Linear-Predicted and original ¹H-FID-MRSI dephased data
2025Metabolic modelling and time-resolved mapping of glucose oxidative metabolism in rats brain by indirect deuterium detection with <sup>1</sup> H-FID-MRSI at 9.4T
2025Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences
Molecular Psychiatry. 2025. DOI : 10.1038/s41380-025-03337-x.Comparison of Low‐Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T
NMR in Biomedicine. 2025. DOI : 10.1002/nbm.70125.Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain
NMR in Biomedicine. 2025. DOI : 10.1002/nbm.70094.Ex vivo brain MRI to assess conventional and FLASH brain irradiation effects
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2025. DOI : 10.1016/j.radonc.2025.110894.Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI
2025Fast High-Resolution Metabolite Mapping in the rat Brain Using <sup>1</sup>H-FID-MRSI at 14.1 T
NMR in biomedicine. 2025. DOI : 10.1002/nbm.5304.Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application
NMR in Biomedicine. 2024. DOI : 10.1002/nbm.5211.Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences
2024Subject Classification and Cross-time Prediction Based on Functional Connectivity and White Matter Microstructure Features in a Rat Model of Alzheimer's Using Machine Learning
ALZHEIMERS RESEARCH & THERAPY. 2023. DOI : 10.1186/s13195-023-01328-0.Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel
Nmr In Biomedicine. 2023. DOI : 10.1002/nbm.5056.Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field
Magnetic Resonance in Medicine. 2023. DOI : 10.1002/mrm.29805.New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual <SUP>18</SUP>F-FDG PET and 9.4T <SUP>1</SUP>H MRS Preclinical Study
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12 - S12. DOI : 10.14309/01.ajg.0000948348.20966.21.Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior
Molecular Psychiatry. 2022. DOI : 10.1038/s41380-022-01791-5.PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats
Analytical Biochemistry. 2022. DOI : 10.1016/j.ab.2022.114606.Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats
2022. p. 57 - 58.In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times
Magnetic Resonance in Medicine. 2021. DOI : 10.1002/mrm.28910.Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions
Metabolites. 2021. DOI : 10.3390/metabo11070413.Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
Scientific Reports. 2021. DOI : 10.1038/s41598-021-85339-7.In Vivo Metabolism of [1,6-C-13(2)]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus
Metabolites. 2021. DOI : 10.3390/metabo11010050.Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose
Journal of Cerebral Blood Flow & Metabolism. 2021. DOI : 10.1177/0271678X20910535.Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease
NeuroImage. 2020. DOI : 10.1016/j.neuroimage.2020.117498.Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4325.Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4347.Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
Elife. 2020. DOI : 10.7554/eLife.53618.Neuronal energy metabolism in the mouse brain measured by H-1-[C-13] MRS at 14.1T under [3-C-13]-Lactate infusion: a feasibility study
2019. 29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama, JAPAN, Jul 04-07, 2019. p. 208 - 209.Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo
Acs Chemical Neuroscience. 2018. DOI : 10.1021/acschemneuro.8b00066.In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose
Journal of Cerebral Blood Flow & Metabolism. 2018. DOI : 10.1177/0271678X17734101.Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T
Magnetic Resonance in Medicine. 2018. DOI : 10.1002/mrm.27129.Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2017.01.019.Diffusion-weighted MRS of acetate in the rat brain
NMR in biomedicine. 2017. DOI : 10.1002/nbm.3768.MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism
Metabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.New technologies – new insights into the pathogenesis of hepatic encephalopathy
Metabolic Brain Disease. 2016. DOI : 10.1007/s11011-016-9906-y.Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets
ASN neuro. 2016. DOI : 10.1177/1759091416632342.Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla
Journal of Cerebral Blood Flow & Metabolism. 2015. DOI : 10.1038/jcbfm.2014.251.Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T
Journal of Neurochemistry (JNC). 2014. DOI : 10.1111/jnc.12479.Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014. DOI : 10.2967/jnumed.113.127381.Metabolic Flux and Compartmentation Analysis in the Brain In vivo
Frontiers in Endocrinology. 2013. DOI : 10.3389/fendo.2013.00156.Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS
4th International DNP Symposium, Copenhagen, Denmark, August 28-31, 2013.Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES
Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.Hepatic glucose sensing is required to preserve β cell glucose competence
The Journal of clinical investigation. 2013. DOI : 10.1172/JCI65538.Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy
Journal of Cerebral Blood Flow & Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5468.A two-compartment mathematical model of neuroglial metabolism using [1-C-11] acetate
Journal of Cerebral Blood Flow & Metabolism. 2012. DOI : 10.1038/jcbfm.2011.162.GLIAL GLYCOLYTIC GAPDH ACTIVITY MODULATES THE RESTING CEREBRAL METABOLIC RATE OF GLUCOSE AND CA+2- DEPENDENT EXCITATORY NEUROTRANSMITTER RELEASE
2011. Brain 2011, Barcelona, Spain, 25-28 May, 2011.Cerebral metabolic compartmentation determined by high resolution in vivo 13C NMR spectroscopy
Swiss Society for Neuroscience Annual Meeting 2011, Basel, Switzerland, March 26, 2011.Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study
2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
Molecular Imaging And Biology. 2011. DOI : 10.1007/s11307-010-0368-z.Evaluation of glial metabolic fluxes in vivo with [2-13C] acetate infusion in mouse brain by 1H-[13C] NMR spectroscopy
2011. ESMRMB CONGRESS 2011 28th Annual Scientific Meeting, Leipzig,Germany, October 6-8, 2011.Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES
2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T
Frontiers in neuroenergetics. 2011. DOI : 10.3389/fnene.2011.00003.In Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by 1H-[13C] NMR Spectroscopy
2011. ISMRM 19th Annual Meeting & Exhibition, Montréal, Québec, Canada, May 7-13, 2011.Brain metabolism by in vivo 13C NMR spectroscopy
25th International Symposium on Cerebral Blood Flow, Metabolism and Function & 10th International Conference on Quantification of Brain Function with PET, Barcelona, Spain, May 25-28, 2011..In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion
2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T
Magnetic Resonance in Medicine. 2010. DOI : 10.1002/mrm.22359.In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Imaging glutamine synthesis rates in the hyperammonemic rat brain
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Measurements of glial metabolic fluxes with C-11-acetate using positron emission and an adapted NMR-based metabolic modeling approach
2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S460 - S461.Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS
2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609 - S610.MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS
2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness
Neurochemistry International: The Journal of Cellular and Molecular Neuroscience (NCI). 2009. DOI : 10.1016/j.neuint.2009.02.023.Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.BISEP-based, Ultra-short TE 1H–[13C] NMR Spectroscopy of the Rat Brain at 14.1 T
2009. ISMRM 17th Scientific Meeting & Exhibition, Honolulu, Hawai’i, USA, April 18-24, 2009.In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T
2009. ESMRMB, Antalya, TR, October 1-3.Teaching & PhD
PhD Students
Courses
CIBM translational MR neuroimaging & spectroscopy
PHYS-770
Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.
MRI Practicals on CIBM preclinical imaging systems
PHYS-473
The goal of this course is to teach students how to perform basic MRI and MRS experiments in-vivo and ex-vivo directly on preclinical horizontal ultra-high field MRI systems.