Bruno Correia
Nationality: Portuguese
+41 21 693 61 66
EPFL › SV › SV-SSV › SSV-ENS
Website: https://sv.epfl.ch/education
+41 21 693 61 66
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDBB-GE
Website: https://go.epfl.ch/phd-edbb
+41 21 693 61 66
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › CDOCT
Expertise
Current work
- Featuring molecular surface fingerprints to decipher protein functional properties
- Bottom-up de novo design of functional proteins
- Computational design of synthetic components for CAR T-cells
- Computational Design of Precision Vaccines
Education
PhD
| Computational Biology2010 – 2010 Universidade Nova de Lisboa
B. S.
| Chemistry2004 – 2004 Universidade de Coimbra
Professionals experiences
Assistant professor
Post-doctoral researcher
Awards
PhD scholarship
Fundação para a Ciência e Tecnologia
2006
ERC Starting grant
European Research Council
2016
Visiting scientist
Radcliffe Institute - Harvard
2018
Teaching award
EPFL - SV
2019
Protein Science Young Investigator Award from Protein Society
2021
Selected publications
De novo protein design enables precise induction of functional antibodies in vivo
Sesterhenn F*, Yang C*, Cramer JT, Bonet J, Wen X, Abriata LA, Kucharska I, Chiang CI, Wang Y, Castoro G, Vollers SS, Galloux M, Dheilly E, Richard CA, Rosset S, Corthesy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Mas V, Ervin S, Eleouet JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE
Published in Science, 2020 in
Computational design of anti-CRISPR proteins with improved inhibition potency and expanded specificity
Mathony J*, Harteveld Z*, Schmelas C*, Belzen JU, Aschenbrenner S, Hoffmann MD, Stengl C, Scheck A, Rosset S, Grimm D, Eils R, Correia BE*, Niopek D*
Published in Nature Chemical Biology, 2020 in
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, Bradley P, Bystroff C, Conway P, Cooper S, Correia BE, Coventry B, Das R, De Jong RM, DiMaio F, Dsilva L, Dunbrack R, Ford AS, Frenz B, Fu DY, Geniesse C, Goldschmidt L, Gowthaman R, Gray JJ, Gront D, Guffy S, Horowitz S, Huang PS, Huber T, Jacobs TM, Jeliazkov JR, Johnson DK, Kappel K, Karanicolas J, Khakzad H, Khar KR, Khare SD, Khatib F, Khramushin A, King IC, Kleffner R, Koepnick B, Kortemme T, Kuenze G, Kuhlman B, Kuroda D, Labonte JW, Lai JK, Lapidoth G, Leaver-Fay A, Lindert S, Linsky T, London N, Lubin JH, Lyskov S, Maguire J, Malmström L, Marcos E, Marcu O, Marze NA, Meiler J, Moretti R, Mulligan VK, Nerli S, Norn C, Ó'Conchúir S, Ollikainen N, Ovchinnikov S, Pacella MS, Pan X, Park H, Pavlovicz RE, Pethe M, Pierce BG, Pilla KB, Raveh B, Renfrew PD, Burman SSR, Rubenstein A, Sauer MF, Scheck A, Schief W, Schueler-Furman O, Sedan Y, Sevy AM, Sgourakis NG, Shi L, Siegel JB, Silva DA, Smith S, Song Y, Stein A, Szegedy M, Teets FD, Thyme SB, Wang RY, Watkins A, Zimmerman L, Bonneau R
Published in Nature Methods, 2020 in
Computationally designed STOP-CAR disrupted by small molecule confers on-command regulation of T-cell therapy
Giordano-Attianese G*, Gainza P*, Gray-Gaillard E*, Cribioli E, Shui S, Kim S, Kwak M, Vollers S, Osorio A, Reichenbach P, Bonet J, Oh B, Irving M*, Coukos G*, Correia BE*
Published in Nature Biotechnology, 2020 in
Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning
Gainza P, Sverrisson F, Monti F, Rodola E, Bronstein MM, Correia BE
Published in Nature Methods, 2020 in
rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics
Bonet J, Harteveld Z, Sesterhenn F, Scheck A, Correia BE
Published in BMC Bioinformatics, 2019 in
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
Sesterhenn F, Galloux M, Vollers S, Cspregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthesy P, Chen M, Rosset S, Rameix-Welti MA, Elouet JF, Reddy ST, Graham B, Riffault S, Correia BE
Published in Plos Biology, 2019 in
Rosetta FunFolDes - a general framework for the computational design of functional proteins
Bonet J*, Wehrle S*, Schriever K*, Yang C*, Billet A, Sesterhenn F, Scheck A, Sverrisson F, Veselkova B, Vollers S, Lourman R, Villard M, Rosset S, Krey T, Correia BE
Published in Plos Computational Biology, 2018 in
Engineered anti-CRISPR proteins for optogenetic control of CRISPR/Cas9
Bubeck F, Hoffmann M, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Boerner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D
Published in Nature Methods, 2018 in
Laboratory of Protein Design and Immunoengineering
Teaching & PhD
PhD Students
Shuhao Xiao, Irina Morozova, Yangyang Miao, Pengkang Guo, Mubarak Olanrewaju Idris, Adrian Wolfgang Dobbelstein, Julius Wenckstern, Flávia Mayumi Odahara de Abreu, Marin Paul Geoffroy Marie Ollagnon, Evgenia Elizarova, Christian Schellhaas, Tian Zhu, Ekaterina Pyatova, Lennart Nickel, Petra Elisabeth Marilena Balbi, Nicolas Manuel Goldbach, Maddalena Elia, Rebecca Manuela Neeser
Past EPFL PhD Students
Fabian Sesterhenn, Che Yang, Andreas Scheck, Zander Harteveld, Sailan Shui, Sarah Wehrle, Alexandra Krina Van Hall-Beauvais, Anthony Marchand, Freyr Sverrisson, Karla Montserrat Castro Gilabert, Ahmed Sadek, Casper Goverde, Stephen Michael Buckley, Ilia Igashov, Arne Schneuing
Past EPFL PhD Students as codirector
Mathieu Girardin, Lucia Bonati
Courses
Bio-organic chemistry
BIO-110
The aim of the course is to provide a chemical understanding and intuition to decipher and predict chemical processes in living systems.
Monthly IBI-EDBB Mini-symposia
BIOENG-600
To expose EDBB students to research in Bioengineering through attendance of lecture series given by EDBB students and external speakers. The objectives are to broaden the knowledge of students in the field of Bioengineering and expose them to the diversity of studies in the IBI community.
Synthetic biology
BIOENG-320
This advanced Bachelor/Master level course will cover fundamentals and approaches at the interface of biology, chemistry, engineering and computer science for diverse fields of synthetic biology. This class requires critical and analytical thinking at the frontiers of multiple disciplines
Trends in chemical biology and drug discovery
BIOENG-510
In this course we will cover the scientific basis behind chemical biology approaches for drug development.