Cristina Ramona Cudalbu Moldovan
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office:
CH F0 582
EPFL › VPA › VPA-AVP-CP › CIBM › CIBM-PCI
Website: https://www.cibm.ch/
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office:
CH F0 582
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDPY-ENS
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office:
CH F0 582
EPFL › SB › SB-SPH › SPH-ENS
Website: https://sph.epfl.ch/
Expertise
- In vivo proton, phosphorus, carbon and nitrogen MR Spectroscopy
- Chronic Hepatic Encephalopathy, Hyperammonemia - https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/
- Brain metabolites quantification and macromolecules
- In vivo proton Spectroscopic Imaging
- Magnetic Resonance Imaging, Diffusion Weighted Imaging
- Brain tumors
- Dynamic nuclear polarization
Scholar google
Current work
- Implement new acquisition techniques for fast spectroscopic imaging and diffusion spectroscopy
- Implement new techniques for brain macromolecules quantification
- Chronic liver failure/chronic hepatic encephalopathy
- https://www.youtube.com/watch?v=SYkzgkbJGiY
- characterize the developing brain under chronic hepatic encephalopathy
- Brain tumors
- Creatine deficiencies, etc
PubMed
Over the last decade, she has been developing new research lines at CIBM which are oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM (https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/), and on different collaborative projects with researchers from the five partner institutions of CIBM.
Education
PhD
| RMN Laboratory MIB2003 – 2006 University Claude-Bernard Lyon 1, France
Master of Science
| Biophysics and Medical Physics2002 – 2003 University Babes-Bolyai, Cluj Napoca, Romania
Professionals experiences
Head
MER
Deputy
Research and Teaching Associate
Senior Research Staff Scientist and 9.4T MRI Operational Manager
Postdoctoral researcher
Selected publications
Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.
Just N, Cudalbu C, Lei H, Gruetter R.
Published in J Cereb Blood Flow Metab. 2011 Dec;31(12):2324-33. in
Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.
Xin L, Gambarota G, Cudalbu C, Mlyn�rik V, Gruetter R.
Published in MAGMA. 2013 Dec;26(6):549-54. in
Quantitation for in vivo and ex vivo NMR Spectroscopy
H. Rabeson, H. Ratiney, F. Fauvelle, C. Cudalbu, S. Cavassila, A. Bernard, P. Giraudon, D. van Ormondt, D. Graveron-Demilly.
Published in Journal of Optoelectronics and Advanced Materials, 2007, 9 (3): 505-511. in
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents
RB. van Heeswijk, K Uffmann, A Comment, F Kurdzesau, C Perazzolo, C Cudalbu, S Jannin, JA. Konter, P Hautle, B van den Brandt, G Navon, JJ. van der Klink and R Gruetter.
Published in Magn Reson Med. 2009 Jun;61(6):1489-93 in
Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T.
Schaller B, Xin L, Cudalbu C, Gruetter R.
Published in NMR Biomed. 2013 May;26(5):593-9. in
1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
V Mlynarik, C Cudalbu, L Xin, R Gruetter.
Published in J Magn Reson. 2008 Oct;194(2):163-8 in
In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla
Vladim�r Mlyn�rik, Cristina Cudalbu, Virginie Cl�ment, Denis Marino, Ivan Radovanovic, Rolf Gruetter
Published in NMR Biomed. 2012 Apr;25(4):506-13. in
Handling macromolecule signals in the quantification of the neurochemical profile
C Cudalbu, V. Mlyn�rik, R. Gruetter
Published in J Alzheimers Dis. 2012;31 Suppl 3:S101-15. Review. in
Marker-independent identification of glioma-initiating cells
Cl�ment V, Marino D, Cudalbu C, Hamou MF, Mlynarik V, de Tribolet N, Dietrich PY, Gruetter R, Hegi ME, Radovanovic I.
Published in Nat Methods, 2010 Mar;7(3):224-8. in
Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE 1H MRS spectra.
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Published in Meas. Sci. Technol. 20:104034 (2009) in
In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1 H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T.
Craveiro M, Cl�ment-Schatlo V, Marino D, Gruetter R, Cudalbu C.
Published in J Neurochem. 2014 Feb 7. doi: 10.1111/jnc.12673. [Epub ahead of print] in
Rat brain metabolite relaxation time estimates using Magnetic Resonance Spectroscopy at two different field strengths
C. Cudalbu, A. Rengle, O. Beuf, S. Cavassila.
Published in C.R. Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 442-447 in
Influence of Measured and Simulated Basis-Sets on the Metabolite Concentration Estimates
C. Cudalbu, S. Cavassila, H. Rabeson, D. van Ormondt, D. Graveron-Demilly.
Published in NMR Biomed, 2008, 21: 627-636. in
Cerebral Glutamine metabolism under hyperamonemia determined in vivo by localized 1H and 15N NMR spectroscopy
C. Cudalbu, B. Lanz, J.M.N. Duarte, FD Morgenthaler, Y. Pilloud, V. Mlyn�rik and R. Gruetter.
Published in J Cereb Blood Flow Metab. 2012 Apr;32(4):696-708 in
Brain metabolite concentration estimates using MRS in a chronic model of temporal lobe epilepsy
C. Cudalbu, A. Montavont, P. Ryvlin, S. Cavassila.
Published in CR Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 434-441. in
In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy
Cudalbu C
Published in Metab Brain Dis. 2013 Jun;28(2):167-74. in
In vivo short echo time localized 1H MRS of the rat brain at 7T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST
C. Cudalbu, O. Beuf, S. Cavassilla.
Published in Journal of VLSI Signal Processing Systems, 55 (1-3) , pp. 25-34, DOI: 10.1007/s11265-008-0187-5. in
Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS
Kunz N, Cudalbu C, Mlynarik V, H�ppi PS, Sizonenko SV, Gruetter R.
Published in Magn Reson Med. 2010 Oct;64(4):939-46. in
Clinical proton MR spectroscopy in central nervous system disorders.
Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Din�er A, Dydak U, Emir UE, Frahm J, Gonz�lez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, H�ppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marja?ska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tk�? I, Vigneron DB, Kauppinen RA; MRS Consensus Group.
Published in Radiology. 2014 Mar;270(3):658-79. doi: 10.1148/radiol.13130531. in
Ammonia toxicity to the brain
Braissant O, McLin VA, Cudalbu C.
Published in J Inherit Metab Dis. 2013 Jul;36(4):595-612 in
Dose distribution in the irradiation of medulloblastoma with two adjacent fields,
C Cudalbu, A Stan, O. Cozar.
Published in Studia UBB, Physica, 2003, 48(2), pp 3-11 in
Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES.
Lanz B, Duarte JM, Kunz N, Mlyn�rik V, Gruetter R, Cudalbu C.
Published in Magn Reson Med. 2013 Jun;69(6):1512-22. in
Estimation of metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla
C. Cudalbu, S. Cavassila, H. Ratiney, D. Grenier, A. Briguet, D. Graveron-Demilly.
Published in C. R. Chimie, 9, 2006, pp 534-538. in
The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts.
Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R
Published in PLoS One. 2013 Jul 23;8(7):e69782. in
Feasibility of in vivo(15)N MRS detection of hyperpolarized (15)N labeled choline in rats
Cudalbu C, Comment A, Kurdzesau F, van Heeswijk RB, Uffmann K, Jannin S, Denisov V, Kirik D, Gruetter R.
Published in Phys Chem Chem Phys. 2010 Jun 14;12(22):5818-23 in
Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease.
Mlyn�rik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R.
Published in J Alzheimers Dis. 2012;31 Suppl 3:S87-99. in
Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Published in Magn Reson Med. 2009 Oct;62(4):862-7 in
Infoscience
Research
Grants
- 2022-2026 - PI in the Swiss National Science Foundation, n° 205321L_207935,
"Developments of innovative fast acquisition and metabolic modelling strategies for clinical and preclinical deuterium MR imaging in the brain at ultra-high field", Co-PI: B Lanz (CIBM) B Strasser (University of Vienna) - 2022 - PI in the Swiss National Science Foundation,
n° 213184, "The International Magnetic Resonance Spectroscopy Workshop «MRS 2022: Overcoming the Barriers to Clinical Use»", Co-PI: B Alves, A Klauser, R Kreis, H Lajous, B Lanz, J Mosso, K Pierzchala, D Simicic, D Van de Ville, D Wenz, L Xin - 2021-2025 - PI in the Swiss National Science Foundation, n° 310030_201218
"Enhanced MR Spectroscopic mapping of brain regional changes in type C hepatic encephalopathy of juvenile rats to develop novel combinatorial treatments," Co-PI: O Braissant (CHUV) V McLin (HUG) - 2019-2021 - Co-applicant in the Innosuisse - Suisse Innovation Agency application "Pearl injectable implants, a solution for the reconstruction of ultra-large volumes of soft tissues post-injury"
- 2018-2022 - Vice-coordinator in the H2020-MSCA-ITN-2018 application " INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine" (INSPiRE-MED, 813120)
- 2017-2021: Swiss National Science Foundation; grant n° 31003A-175778/1 to Braissant&Cudalbu. «Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.»
- 2017-2021: Swiss National Science Foundation; grant n° 310030_173222/1 to Cudalbu&Braissant&McLin. «Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.»
- 2017-2018: Co-applicant in the Swiss Cancer League application «Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project», (PI Monika Hegi)
- 2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)
- 2014: PI for the Industrial grant VSL Pharmaceuticals Inc.
- 2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project "Transforming Magnetic Resonance Spectroscopy into a Clinical Tool" (TRANSACT)
Teaching & PhD
PhD Students
Past EPFL PhD Students as codirector
Veronika Rackayová, Dunja Simicic, Jessie Mosso, Brayan Alves
Courses
CIBM translational MR neuroimaging & spectroscopy
PHYS-770
Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.
MRI Practicals on CIBM preclinical imaging systems
PHYS-473
The goal of this course is to teach students how to perform basic MRI and MRS experiments in-vivo and ex-vivo directly on preclinical horizontal ultra-high field MRI systems.