Cristina Ramona Cudalbu

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Deputy

cristina.cudalbu@epfl.ch +41 21 693 76 85 https://www.epfl.ch/labs/mrs4brain/

Linkedin ID

https://orcid.org/0000-0003-4582-2465

Google Scholar ID

Position @ CIBM MRI AIT (EPFL)

Senior Research Staff Scientist & 9.4T MRI Operational Manager, CIBM MRI AIT (EPFL)

Field of Expertise

In vivo proton, phosphorus, carbon and nitrogen MR Spectroscopy
Chronic Hepatic Encephalopathy, Hyperammonemia - https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/
Brain metabolites quantification and macromolecules
In vivo proton Spectroscopic Imaging
Diffusion weighted Spectroscopy
Brain tumors
Dynamic nuclear polarization

PubMed

https://www.ncbi.nlm.nih.gov/pubmed/?term=cudalbu

Scholar google

‪Cristina Cudalbu‬ - ‪Google Scholar‬

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Office: CH F0 582
EPFL > VPA-AVP-CP > CIBM > CIBM-AIT

Web site: Web site: https://www.cibm.ch/

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Office: CH F0 582
EPFL > VPA-AVP-PGE > AVP-PGE-EDOC > EDPY-ENS

EPFL CIBM-AIT
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 76 85
Office: CH F0 582
EPFL > SB > SB-SPH > SPH-ENS

Web site: Web site: https://sph.epfl.ch/

vCard
Administrative data

Biography

Cristina Cudalbu obtained her Bachelors of Science degree in Medical Physics in 2002 and Masters of Science degree in Biophysics and Medical Physics in 2003, both from University Babes-Bolyai, Cluj-Napoca, Romania. In 2006 she obtained her PhD degree in Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T at University Lyon 1, RMN Laboratory, Villeurbanne, France.In 2007, she joined, as a Scientist, the Laboratory for Functional and Metabolic Imaging at EPFL, where she implemented new acquisition and quantification techniques for in vivo nitrogen, proton and carbon MRS for preclinical studies. Starting 2012, Cristina Cudalbu was appointed as Research Staff Scientist and 9.4T MRI Operational Manager at Centre d’Imagerie Biomédicale (CIBM) at EPFL. In 2021, Cristina Cudalbu was promoted to Research and Teaching Associate in the Faculty of Basic Sciences at EPFL and is leading the MRS4Brain Group. In 2023 Cristina Cudalbu was promoted to Deputy Head at CIBM MRI EPFL AIT and in 2024 to Maître d'enseignement et de recherche (MER) at School of Basic Sciences at EPFL.
Over the last decade, she has been developing new research lines at CIBM which are oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM (https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/), and on different collaborative projects with researchers from the five partner institutions of CIBM.

Professional course

Maître d'enseignement et de recherche (MER)

School of Basic Sciences

EPFL

2024-now

Deputy

Centre d’Imagerie Biomedicale (CIBM), Animal Imaging and Technology (AIT) section

EPFL

2023-now

Research and Teaching Associate

School of Basic Sciences

EPFL

2022-2024

Senior Research Staff Scientist and 9.4T MRI Operational Manager

Centre d’Imagerie Biomedicale (CIBM), Animal Imaging and Technology (AIT) section

EPFL

2012-now

Postdoctoral researcher

Laboratory for Functional and Metabolic Imaging (LIFMET)

EPFL

2007-2012

Education

PhD

RMN Laboratory MIB

University Claude-Bernard Lyon 1, France

2003-2006

Master of Science

Biophysics and Medical Physics

University Babes-Bolyai, Cluj Napoca, Romania

2002-2003

Publications

Infoscience publications

2024

[1] Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency

G. Fernandes-Pires; M. D. Azevedo; M. Lanzillo; C. Roux-Petronelli; P.-A. Binz et al.

Molecular Therapy Methods & Clinical Development. 2024-06-13. DOI : 10.1016/j.omtm.2024.101251.

Detailed record: https://infoscience.epfl.ch/record/311724?ln=en

[2] Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

J. Mosso; G. Briand; K. Pierzchala; D. Simicic; A. Sierra et al.

Frontiers In Neuroscience. 2024-03-20. DOI : 10.3389/fnins.2024.1344076.

Detailed record: https://infoscience.epfl.ch/record/310566?ln=en
Full text: https://infoscience.epfl.ch/record/310566/files/fnins-18-1344076.pdf

[3] Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

D. Evstafeva; F. Ilievski; Y. Bao; Z. Luo; B. Abramovic et al.

Nature Communications. 2024-03-12. DOI : 10.1038/s41467-024-46481-8.

Detailed record: https://infoscience.epfl.ch/record/310471?ln=en
Full text: https://infoscience.epfl.ch/record/310471/files/document.pdf

2023

[4] Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

J. Mosso; D. Simicic; B. Lanz; R. Gruetter; C. Cudalbu

Magnetic Resonance In Medicine. 2023-09-28. DOI : 10.1002/mrm.29805.

Detailed record: https://infoscience.epfl.ch/record/306053?ln=en
Full text: https://infoscience.epfl.ch/record/306053/files/Magnetic%20Resonance%20in%20Med%20-%202023%20-%20Mosso%20-%20Diffusion%E2%80%90weighted%20SPECIAL%20improves%20the%20detection%20of%20J%E2%80%90coupled%20metabolites%20at.pdf

[5] New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12-S12. DOI : 10.14309/01.ajg.0000948348.20966.21.

Detailed record: https://infoscience.epfl.ch/record/307750?ln=en

[6] Automated segmentation and labeling of subcutaneous mouse implants at 14.1T

J. Adda; G. Bioley; D. van de Ville; C. Cudalbu; M. G. Preti et al.

Frontiers In Signal Processing. 2023-08-21. DOI : 10.3389/frsip.2023.1155618.

Detailed record: https://infoscience.epfl.ch/record/305880?ln=en

[7] Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

D. Evstafeva; J.-C. Leroux; C. R. Cudalbu; D. Simicic

2023.

Detailed record: https://infoscience.epfl.ch/record/309960?ln=en

[8] Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

C. Ligneul; C. Najac; A. Doring; C. Beaulieu; F. Branzoli et al.

Magnetic Resonance In Medicine. 2023-11-09. DOI : 10.1002/mrm.29877.

Detailed record: https://infoscience.epfl.ch/record/308192?ln=en

[9] Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

D. Evstafeva; F. Ilievski; Y. Bao; Z. Luo; B. Abramovic et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S30-S31. DOI : 10.14309/01.ajg.0000948468.55577.45.

Detailed record: https://infoscience.epfl.ch/record/307754?ln=en

[10] Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

D. Simicic; K. Pierzchala; O. Braissant; C. Toso; G. Oldani et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24-S25. DOI : 10.14309/01.ajg.0000948428.52697.c3.

Detailed record: https://infoscience.epfl.ch/record/307753?ln=en

[11] Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

D. Simicic; V. Rackayova; O. Braissant; C. Toso; G. Oldani et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24-S24. DOI : 10.14309/01.ajg.0000948424.84976.19.

Detailed record: https://infoscience.epfl.ch/record/307752?ln=en

[12] The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

D. Simicic; O. Braissant; K. Pierzchala; S. Mitrea; D. Sessa et al.

2023-09-01. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. P17. DOI : 10.14309/01.ajg.0000948352.71525.d3.

Detailed record: https://infoscience.epfl.ch/record/307751?ln=en

[13] New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

J. J. Mosso

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10502.

Detailed record: https://infoscience.epfl.ch/record/306779?ln=en
Full text: https://infoscience.epfl.ch/record/306779/files/EPFL_TH10502.pdf

[14] Lessons on brain edema in HE: from cellular to animal models and clinical studies

K. Pierzchala; A. Hadjihambi; J. Mosso; R. Jalan; C. F. F. Rose et al.

Metabolic Brain Disease. 2023-08-22. DOI : 10.1007/s11011-023-01269-5.

Detailed record: https://infoscience.epfl.ch/record/304908?ln=en
Full text: https://infoscience.epfl.ch/record/304908/files/document.pdf

[15] Editorial for the special issue on Brain Biochemistry in Liver Disease

C. Cudalbu; A. J. L. Cooper

Analytical Biochemistry. 2023-09-15. DOI : 10.1016/j.ab.2023.115248.

Detailed record: https://infoscience.epfl.ch/record/304876?ln=en

[16] High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

C. Cudalbu; L. Xin; B. Marechal; S. Lachat; F. Zangas-Gheri et al.

Analytical Biochemistry. 2023-07-04. DOI : 10.1016/j.ab.2023.115212.

Detailed record: https://infoscience.epfl.ch/record/304161?ln=en
Full text: https://infoscience.epfl.ch/record/304161/files/1-s2.0-S000326972300177X-main.pdf

[17] Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

2023-03-01. 1st international conference on the Future of Redox Biology, ITALY, Jun 17-19, 2022. p. S15-S15. DOI : 10.1016/j.freeradbiomed.2022.12.056.

Detailed record: https://infoscience.epfl.ch/record/303114?ln=en

[18] Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

D. Simicic; V. Rackayova; O. Braissant; C. Toso; G. Oldani et al.

Metabolic Brain Disease. 2023-05-06. DOI : 10.1007/s11011-023-01210-w.

Detailed record: https://infoscience.epfl.ch/record/302792?ln=en

[19] Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

A. D. Harris; H. Amiri; M. Bento; R. Cohen; C. R. K. Ching et al.

Frontiers In Neurology. 2023-01-04. DOI : 10.3389/fneur.2022.1045678.

Detailed record: https://infoscience.epfl.ch/record/300533?ln=en
Full text: https://infoscience.epfl.ch/record/300533/files/fneur_2022_1045678.pdf

2022

[20] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

Free Radical Biology And Medicine. 2022-03-01. DOI : 10.1016/j.freeradbiomed.2022.01.016.

Detailed record: https://infoscience.epfl.ch/record/294217?ln=en

[21] MP-PCA denoising for diffusion MRS data: promises and pitfalls

J. Mosso; D. Simicic; K. Simsek; R. Kreis; C. Cudalbu et al.

Neuroimage. 2022-11-01. DOI : 10.1016/j.neuroimage.2022.119634.

Detailed record: https://infoscience.epfl.ch/record/298715?ln=en

[22] Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

D. Simicic; C. Cudalbu; K. Pierzchala

Analytical Biochemistry. 2022-10-01. DOI : 10.1016/j.ab.2022.114795.

Detailed record: https://infoscience.epfl.ch/record/297214?ln=en

[23] Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

P. Katarzyna; S. Dunja; S. Dario; M. Stefanita; B. Olivier et al.

2022-08-20. p. 40-40.

Detailed record: https://infoscience.epfl.ch/record/296871?ln=en

[24] Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

D. Simicic

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9422.

Detailed record: https://infoscience.epfl.ch/record/296066?ln=en
Full text: https://infoscience.epfl.ch/record/296066/files/EPFL_TH9422.pdf

[25] Abnormal brain oxygen homeostasis in an animal model of liver disease

A. Hadjihambi; C. Cudalbu; K. Pierzchala; D. Simicic; C. Donnelly et al.

Jhep Reports. 2022-08-01. DOI : 10.1016/j.jhepr.2022.100509.

Detailed record: https://infoscience.epfl.ch/record/295962?ln=en

[26] PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

Analytical Biochemistry. 2022-06-15. DOI : 10.1016/j.ab.2022.114606.

Detailed record: https://infoscience.epfl.ch/record/295944?ln=en

[27] Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al.

2022-06-01. p. 57-58.

Detailed record: https://infoscience.epfl.ch/record/294990?ln=en

[28] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

K. Pierzchala; D. Simicic; A. Sienkiewicz; D. Sessa; S. Mitrea et al.

Free Radical Biology And Medicine. 2022-01-01. DOI : 10.1016/j.freeradbiomed.2021.12.011.

Detailed record: https://infoscience.epfl.ch/record/291657?ln=en

[29] Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

L. Duran-Trio; G. Fernandes-Pires; J. Grosse; I. Soro-Arnaiz; C. Roux-Petronelli et al.

Journal Of Inherited Metabolic Disease. 2022. DOI : 10.1002/jimd.12470.

Detailed record: https://infoscience.epfl.ch/record/291317?ln=en

2021

[30] Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

E. Flatt; V. A. McLin; O. Braissant; K. Pierzchala; P. Mastromarino et al.

Scientific Reports. 2021-09-09. DOI : 10.1038/s41598-021-97018-8.

Detailed record: https://infoscience.epfl.ch/record/288857?ln=en
Full text: https://infoscience.epfl.ch/record/288857/files/s41598-021-97018-8.pdf

[31] Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

M. Mishkovsky; O. Gusyatiner; B. Lanz; C. Cudalbu; I. Vassallo et al.

Scientific Reports. 2021-03-11. DOI : 10.1038/s41598-021-85339-7.

Detailed record: https://infoscience.epfl.ch/record/285246?ln=en
Full text: https://infoscience.epfl.ch/record/285246/files/Mishkovsky_HPGlucGliom_SciRep_2021.pdf

[32] Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

V. Rackayova; E. Flatt; O. Braissant; J. Grosse; D. Capobianco et al.

Scientific Reports. 2021-01-26. DOI : 10.1038/s41598-021-81871-8.

Detailed record: https://infoscience.epfl.ch/record/287400?ln=en
Full text: https://infoscience.epfl.ch/record/287400/files/articles-s41598-021-81871-8.pdf

[33] Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

C. Cudalbu; P. Bady; M. Lai; L. Xin; O. Gusyatiner et al.

Acta Neuropathologica Communications. 2021-08-04. DOI : 10.1186/s40478-021-01232-4.

Detailed record: https://infoscience.epfl.ch/record/287868?ln=en
Full text: https://infoscience.epfl.ch/record/287868/files/s40478-021-01232-4.pdf

[34] In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

D. Simicic; V. Rackayová; L. Xin; I. Tkáč; T. Borbath et al.

Magnetic Resonance in Medicine. 2021-07-15. DOI : 10.1002/mrm.28910.

Detailed record: https://infoscience.epfl.ch/record/287462?ln=en
Full text: https://infoscience.epfl.ch/record/287462/files/mrm.28910.pdf

[35] The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

M. G. Melo; N. Remacle; H.-P. Cudre-Cung; C. Roux; M. Poms et al.

Molecular Genetics And Metabolism. 2021-06-01. DOI : 10.1016/j.ymgme.2021.03.017.

Detailed record: https://infoscience.epfl.ch/record/287041?ln=en

[36] 2021 ISHEN guidelines on animal models of hepatic encephalopathy

S. DeMorrow; C. Cudalbu; N. Davies; A. R. Jayakumar; C. F. Rose

Liver International. 2021-05-11. DOI : 10.1111/liv.14911.

Detailed record: https://infoscience.epfl.ch/record/285853?ln=en

[37] Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

A. Lin; O. Andronesi; W. Bogner; I.-Y. Choi; E. Coello et al.

Nmr In Biomedicine. 2021-02-09. DOI : 10.1002/nbm.4484.

Detailed record: https://infoscience.epfl.ch/record/284600?ln=en

[38] A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

L. Duran-Trio; G. Fernandes-Pires; D. Simicic; J. Grosse; C. Roux-Petronelli et al.

Scientific Reports. 2021. DOI : 10.1038/s41598-020-80824-x.

Detailed record: https://infoscience.epfl.ch/record/283911?ln=en
Full text: https://infoscience.epfl.ch/record/283911/files/s41598-020-80824-x.pdf

[39] Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

V. Račkayová; D. Simicic; G. Donati; O. Braissant; R. Gruetter et al.

Journal of Neurochemistry. 2021. DOI : 10.1111/jnc.15294.

Detailed record: https://infoscience.epfl.ch/record/282869?ln=en

2020

[40] Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

C. Cudalbu; K. L. Behar; P. K. Bhattacharyya; W. Bogner; T. Borbath et al.

Nmr In Biomedicine. 2020-11-25. DOI : 10.1002/nbm.4393.

Detailed record: https://infoscience.epfl.ch/record/282171?ln=en

[41] Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

B. Lanz; A. Abaei; O. Braissant; I.-Y. Choi; C. Cudalbu et al.

Nmr In Biomedicine. 2020-08-26. DOI : 10.1002/nbm.4325.

Detailed record: https://infoscience.epfl.ch/record/279961?ln=en

[42] B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

C. Juchem; C. Cudalbu; R. A. de Graaf; R. Gruetter; A. Henning et al.

Nmr In Biomedicine. 2020-06-28. DOI : 10.1002/nbm.4350.

Detailed record: https://infoscience.epfl.ch/record/278608?ln=en

[43] Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

R. Kreis; V. Boer; I.-Y. Choi; C. Cudalbu; R. A. de Graaf et al.

Nmr In Biomedicine. 2020-08-17. DOI : 10.1002/nbm.4347.

Detailed record: https://infoscience.epfl.ch/record/279668?ln=en

[44] Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

V. Rackayova; O. Braissant; A.-L. Rougemont; C. Cudalbu; V. A. McLin

Scientific Reports. 2020. DOI : 10.1038/s41598-020-64416-3.

Detailed record: https://infoscience.epfl.ch/record/277495?ln=en
Full text: https://infoscience.epfl.ch/record/277495/files/s41598-020-64416-3.pdf

[45] MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRS

I. Jelescu; J. Veraart; C. R. Cudalbu

ISMRM 28th Annual Meeting & Exhibition, Paris, France, August 8-13, 2020.

Detailed record: https://infoscience.epfl.ch/record/277018?ln=en
Full text: https://infoscience.epfl.ch/record/277018/files/https_submissions2.mirasmart.com_ISMRM2020_ViewSubmissionPublic.aspx_sei%3DSjjxlmRCQ.pdf

2019

[46] Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats

E. Flatt; O. Braissant; S. Mitrea; D. Sessa; P. Mastromarino et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S19-S19. DOI : 10.14309/01.ajg.0000582124.67482.93.

Detailed record: https://infoscience.epfl.ch/record/274297?ln=en

[47] Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings

K. Pierzchala; D. Simicic; V. Rackayova; D. Sessa; A. Sienkiewicz et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S36. DOI : 10.14309/01.ajg.0000582248.03815.eb.

Detailed record: https://infoscience.epfl.ch/record/274296?ln=en

[48] Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats

E. Flatt; O. Braissant; S. Mitrea; D. Sessa; R. Gruetter et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S18-S19. DOI : 10.14309/01.ajg.0000582120.59858.08.

Detailed record: https://infoscience.epfl.ch/record/274294?ln=en

[49] In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy

D. Simicic; K. Pierzchala; V. Rackayova; O. Braissant; S.-O. Mitrea et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S17-S17. DOI : 10.14309/01.ajg.0000582108.29364.13.

Detailed record: https://infoscience.epfl.ch/record/274295?ln=en

[50] Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture

L. Giovannoni; M. De Roo; O. Braissant; H. Henry; C. Cudalbu et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S37-S38. DOI : 10.14309/01.ajg.0000582272.41932.fe.

Detailed record: https://infoscience.epfl.ch/record/274293?ln=en

[51] Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy

K. Pierzchala; D. Simicic; O. Braissant; V. A. McLin; C. Cudalbu

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S33.

Detailed record: https://infoscience.epfl.ch/record/274292?ln=en

[52] Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T

C. Cudalbu; L. Xin; S. Lachat; N. Valenza; F. Zangas-Gehri et al.

2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S31-S32. DOI : 10.14309/01.ajg.0000582224.88567.2a.

Detailed record: https://infoscience.epfl.ch/record/274290?ln=en

[53] Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''

V. A. Mclin; O. Braissant; C. Cudalbu

Journal of Hepatology. 2019-11-01. DOI : 10.1016/j.jhep.2019.08.003.

Detailed record: https://infoscience.epfl.ch/record/271622?ln=en

[54] Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus

L. Giovannoni; M. Deroo; O. Braissant; H. Henry; C. R. Cudalbu et al.

2019-10-01. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA, Nov 08-12, 2019. p. 471A-472A.

Detailed record: https://infoscience.epfl.ch/record/271553?ln=en

[55] Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

O. Braissant; V. Rackayova; K. Pierzchala; J. Grosse; V. A. McLin et al.

Journal Of Hepatology. 2019-09-01. DOI : 10.1016/j.jhep.2019.05.022.

Detailed record: https://infoscience.epfl.ch/record/269843?ln=en
Full text: https://infoscience.epfl.ch/record/269843/files/1-s2.0-S0168827819303083-main.pdf

[56] Brain Edema in Chronic Hepatic Encephalopathy

C. Cudalbu; S. D. Taylor-Robinson

Journal Of Clinical And Experimental Hepatology. 2019-05-01. DOI : 10.1016/j.jceh.2019.02.003.

Detailed record: https://infoscience.epfl.ch/record/268492?ln=en

[57] Methodological consensus on clinical proton MRS of the brain: Review and recommendations

M. Wilson; O. Andronesi; P. B. Barker; R. Bartha; A. Bizzi et al.

Magnetic Resonance in Medicine. 2019. DOI : 10.1002/mrm.27742.

Detailed record: https://infoscience.epfl.ch/record/265150?ln=en
Full text: https://infoscience.epfl.ch/record/265150/files/Wilson_consensusPaper_MRM_2019.pdf

2018

[58] Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing

M. Hegi; C. Cudalbu; P. Bady; M. Lai; L. Xin et al.

2018-11-01. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA, Nov 14-18, 2018. p. 35-35.

Detailed record: https://infoscience.epfl.ch/record/266707?ln=en

[59] Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

H. A. I. Yoshihara; D. Firsov; C. R. Cudalbu; R. Gruetter

ISMRM 2018, Paris, France, June16-21, 2018.

Detailed record: https://infoscience.epfl.ch/record/279675?ln=en

[60] Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS

V. Rackayová

Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8612.

Detailed record: https://infoscience.epfl.ch/record/256956?ln=en
Full text: https://infoscience.epfl.ch/record/256956/files/EPFL_TH8612.pdf

[61] In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

M. Lai; I. Vassallo; B. Lanz; C. Poitry-Yamate; M.-F. Hamou et al.

International Journal of Cancer. 2018. DOI : 10.1002/ijc.31299.

Detailed record: https://infoscience.epfl.ch/record/255355?ln=en
Full text: https://infoscience.epfl.ch/record/255355/files/Lai_Glioma_IntlJCanc_2018.pdf

[62] In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

M. Lai; B. Lanz; C. Poitry-Yamate; J. F. Romero; C. M. Berset et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018. DOI : 10.1177/0271678X17734101.

Detailed record: https://infoscience.epfl.ch/record/231906?ln=en
Full text: https://infoscience.epfl.ch/record/231906/files/Lai_13Cmouse_JCBFM_2018.pdf

2017

[63] Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolism

C. Cudalbu; A. J. L. Cooper

Analytical Biochemistry. 2017. DOI : 10.1016/j.ab.2017.05.014.

Detailed record: https://infoscience.epfl.ch/record/229510?ln=en

[64] Metabolic changes in developing brain due to chronic liver disease: an in vivo longitudinal and multiparametric study using P-31-MRS (magnetic resonance spectroscopy), P-31-Magnetization transfer and H-1-MRS

V. Rackayova; V. Mlynarik; C. Cudalbu

2017. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY, APR 01-04, 2017. p. 496-497.

Detailed record: https://infoscience.epfl.ch/record/228760?ln=en

[65] MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

B. Lanz; V. Rackayova; O. Braissant; C. Cudalbu

Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.

Detailed record: https://infoscience.epfl.ch/record/224080?ln=en

[66] Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies

V. Rackayova; C. Cudalbu; P. J. W. Pouwels; O. Braissant

Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.007.

Detailed record: https://infoscience.epfl.ch/record/222972?ln=en

2016

[67] Brain edema: a valid endpoint for measuring hepatic encephalopathy?

C. Bémeur; C. Cudalbu; G. Dam; A. S. Thrane; A. J. L. Cooper et al.

Metabolic brain disease. 2016. DOI : 10.1007/s11011-016-9843-9.

Detailed record: https://infoscience.epfl.ch/record/218756?ln=en

[68] (1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism

V. Rackayova; O. Braissant; V. A. McLin; C. Berset; B. Lanz et al.

Metabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.

Detailed record: https://infoscience.epfl.ch/record/210870?ln=en

2015

[69] In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T

C. Cudalbu; M. Craveiro; V. Mlynárik; J. Bremer; A. Aguzzi et al.

Neurochemical research. 2015. DOI : 10.1007/s11064-015-1643-9.

Detailed record: https://infoscience.epfl.ch/record/210871?ln=en
Full text: https://infoscience.epfl.ch/record/210871/files/Cudalbu_NChemRes_Prion_2015.pdf

2014

[70] Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T

M. Lai; C. R. Cudalbu; B. Lanz; I. Vassallo; M.-F. Hamou et al.

2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.

Detailed record: https://infoscience.epfl.ch/record/203435?ln=en
Full text: https://infoscience.epfl.ch/record/203435/files/LongitudinalStudy_ISMRMabstract_Final.pdf

[71] In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose

M. Lai; B. Lanz; C. J. d. C. Romero; C. R. Cudalbu; R. Gruetter

2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.

Detailed record: https://infoscience.epfl.ch/record/203434?ln=en
Full text: https://infoscience.epfl.ch/record/203434/files/13CMRS_abstractISMRM2014.pdf

[72] Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T

M. Craveiro; C. Cudalbu; V. Mlynárik; R. Gruetter

NMR in Biomedicine. 2014. DOI : 10.1002/nbm.3168.

Detailed record: https://infoscience.epfl.ch/record/200499?ln=en
Full text: https://infoscience.epfl.ch/record/200499/files/Craveiro_MEGA_SPECIAL_2014.pdf

[73] Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI

M. Mishkovsky; C. R. Cudalbu; E. Can; D. Mario; I. Radovanovic et al.

2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.

Detailed record: https://infoscience.epfl.ch/record/198965?ln=en

[74] Clinical Proton MR Spectroscopy in Central Nervous System Disorders

G. Öz; J. R. Alger; P. B. Barker; R. Bartha; A. Bizzi et al.

Radiology. 2014. DOI : 10.1148/radiol.13130531.

Detailed record: https://infoscience.epfl.ch/record/197156?ln=en
Full text: https://infoscience.epfl.ch/record/197156/files

[75] In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

M. Craveiro; V. Clément-Schatlo; D. Marino; R. Gruetter; C. Cudalbu

Journal of Neurochemistry. 2014. DOI : 10.1111/jnc.12673.

Detailed record: https://infoscience.epfl.ch/record/196648?ln=en
Full text: https://infoscience.epfl.ch/record/196648/files/MC_MM_JNeurochem_2014.pdf

2013

[76] Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study

C. Cudalbu; O. Braissant; V. A. Mclin

2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases. p. 803A-803A.

Detailed record: https://infoscience.epfl.ch/record/199195?ln=en

[77] In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS

C. Cudalbu; O. Braissant; A. Jayaswal; R. Gruetter; V. A. Mclin

2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases', u'64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases'. p. 393A-393A.

Detailed record: https://infoscience.epfl.ch/record/199194?ln=en

[78] In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS

C. Cudalbu; O. Braissant; A. Jayaswal; R. Gruetter; V. A. McLin

2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 379.

Detailed record: https://infoscience.epfl.ch/record/189926?ln=en

[79] Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study

C. Cudalbu; O. Braissant; V. A. Mclin

2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 1219.

Detailed record: https://infoscience.epfl.ch/record/189925?ln=en

[80] The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

C. Cudalbu; V. A. Mclin; H. Lei; J. M. N. Duarte; A.-L. Rougemont et al.

PLoS ONE. 2013. DOI : 10.1371/journal.pone.0069782.

Detailed record: https://infoscience.epfl.ch/record/187954?ln=en
Full text: https://infoscience.epfl.ch/record/187954/files/cudalbu_C57%202013.pdf

[81] Brain metabolism in rat model of human glioma initiating cells

M. Mishkovsky; C. R. Cudalbu; A. Comment; D. Mario; I. Radovanovic et al.

2013. International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, April 2013.

Detailed record: https://infoscience.epfl.ch/record/187399?ln=en

[82] The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts

C. R. Cudalbu; V. McLin; H. Lei; J. das Neves Duarte; A.-L. Rougemont et al.

ISMRM.

Detailed record: https://infoscience.epfl.ch/record/186417?ln=en
Full text: https://infoscience.epfl.ch/record/186417/files/The%20C57BL6%20mouse%20exhibits%20sporadic%20congenital%20portosystemic%20shunts_0111.pdf

[83] In vivo and longitudinal assessment of brain metabolism in Hepatic Encephalopathy using 1H MRS

C. R. Cudalbu; V. McLin; O. Braissant; R. Gruetter

ISMRM.

Detailed record: https://infoscience.epfl.ch/record/186416?ln=en
Full text: https://infoscience.epfl.ch/record/186416/files/In%20vivo%20and%20longitudinal%20assessment%20of%20brain%20metabolism%20in%20Hepatic%20Encephalopathy%20using%201H%20MRS_3993.pdf

[84] Hepatic encephalopathy and brain metabolism: a longitudinal in vivo study

C. Cudalbu; V. McLin; O. Braissant

2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 178-179.

Detailed record: https://infoscience.epfl.ch/record/186361?ln=en

[85] The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts

C. Cudalbu; V. McLin; H. Lei; J. Duarte; A. Rougemont et al.

2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 107-108.

Detailed record: https://infoscience.epfl.ch/record/186351?ln=en

[86] In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy

C. Cudalbu

Metabolic brain disease. 2013. DOI : 10.1007/s11011-012-9368-9.

Detailed record: https://infoscience.epfl.ch/record/186170?ln=en
Full text: https://infoscience.epfl.ch/record/186170/files/11011_2012_Article_9368.pdf

[87] Ammonia toxicity to the brain

O. Braissant; V. A. McLin; C. Cudalbu

Journal of inherited metabolic disease. 2013. DOI : 10.1007/s10545-012-9546-2.

Detailed record: https://infoscience.epfl.ch/record/186169?ln=en

[88] Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

L. Xin; G. Gambarota; C. Cudalbu; V. Mlynárik; R. Gruetter

Magma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.

Detailed record: https://infoscience.epfl.ch/record/186164?ln=en
Full text: https://infoscience.epfl.ch/record/186164/files/Xin_Magma_14T_T2_2013.pdf

[89] Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

B. Schaller; L. Xin; C. Cudalbu; R. Gruetter

NMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.

Detailed record: https://infoscience.epfl.ch/record/183890?ln=en
Full text: https://infoscience.epfl.ch/record/183890/files/Schaller_MM3T_NBM_2013.pdf

[90] Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

B. Lanz; J. M. N. Duarte; N. Kunz; V. Mlynárik; R. Gruetter et al.

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.

Detailed record: https://infoscience.epfl.ch/record/180912?ln=en
Full text: https://infoscience.epfl.ch/record/180912/files/Lanz_Amares_2013.pdf

2012

[91] In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure

C. R. Cudalbu; V. McLin; O. Braissant; N. Kunz; Y. Van de Looij et al.

ISMRM 20th Annual Scientific Meeting, 5-11 May 2012, Melbourne, Australia.

Detailed record: https://infoscience.epfl.ch/record/186419?ln=en

[92] Brain osmolytes and brain edema in a rat model of chronic liver failure: in vivo longitudinal 1H Spectroscopic imaging and Diffusion tensor imaging studies at 9.4T

C. R. Cudalbu; O. Braissant; M. Lepore; R. Gruetter; V. McLin

The 15th International Society of Hepatic Encephalopathy and Nitrogen Metabolism, Symposium May 29 - June 2, 2012, Denmark.

Detailed record: https://infoscience.epfl.ch/record/186418?ln=en

[93] Handling macromolecule signals in the quantification of the neurochemical profile

C. Cudalbu; V. Mlynárik; R. Gruetter

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-120100.

Detailed record: https://infoscience.epfl.ch/record/181513?ln=en
Full text: https://infoscience.epfl.ch/record/181513/files/Cudalbu_MM_JAD.pdf

[94] Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu et al.

Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.

Detailed record: https://infoscience.epfl.ch/record/181512?ln=en
Full text: https://infoscience.epfl.ch/record/181512/files/Mlynarik_JAD.pdf

[95] Phosphorus MRS Study of a Murine Model of Peripheral Arterial Disease

V. Mlynárik; M. Pellegrin; C. R. Cudalbu; L. Mazzolai; R. Gruetter

2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.

Detailed record: https://infoscience.epfl.ch/record/178177?ln=en

[96] In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure

C. R. Cudalbu; V. McLin; O. Braissant; N. Kunz; Y. van de Looij et al.

2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.

Detailed record: https://infoscience.epfl.ch/record/177993?ln=en
Full text: https://infoscience.epfl.ch/record/177993/files/CLD_ISMRM2012.pdf

[97] Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy

V. A. McLin; O. Braissant; Y. van de Looij; N. Kunz; R. Gruetter et al.

2012. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, SPAIN, Apr 18-22, 2012. p. S231-S232.

Detailed record: https://infoscience.epfl.ch/record/177240?ln=en

[98] Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

C. R. Cudalbu; B. Lanz; J. M. N. Duarte; F. D. Morgenthaler; Y. Pilloud et al.

Journal Of Cerebral Blood Flow And Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.

Detailed record: https://infoscience.epfl.ch/record/176834?ln=en

[99] In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

V. Mlynarik; C. R. Cudalbu; V. Clement; D. Marino; I. Radovanovic et al.

Nmr In Biomedicine. 2012. DOI : 10.1002/nbm.1763.

Detailed record: https://infoscience.epfl.ch/record/176445?ln=en

2011

[100] In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

V. Clement-Schatlo; V. Mlynarik; C. Cudalbu; D. Marino; I. Radovanovic et al.

2011. p. S15-S15.

Detailed record: https://infoscience.epfl.ch/record/186253?ln=en

[101] In vivo longitudinal 1H MRS study of transgenic mouse models of prion disease in the hippocampus and cerebellum at 14.1T

C. R. Cudalbu; M. Craveiro; V. Mlynárik; J. Bremer; A. Aguzzi et al.

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177997?ln=en
Full text: https://infoscience.epfl.ch/record/177997/files/696_final%20abstract_prion_cudalbu.pdf

[102] In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain

C. R. Cudalbu; A. Comment; T. Cheng; M. Mishkovsky; R. Gruetter

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177996?ln=en
Full text: https://infoscience.epfl.ch/record/177996/files/Cudalbu_choline_ISMRM2011.pdf

[103] Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES

C. R. Cudalbu; B. Lanz; J. M. Duarte; N. Kunz; R. Gruetter

2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177995?ln=en
Full text: https://infoscience.epfl.ch/record/177995/files/Cudalbu_ISMRM-2011_1388.pdf

[104] Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study

C. R. Cudalbu; N. Kunz; B. Lanz; Y. van de Looij; V. Mlynárik et al.

2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.

Detailed record: https://infoscience.epfl.ch/record/177994?ln=en
Full text: https://infoscience.epfl.ch/record/177994/files/Cudalbu_Brain2011.pdf

[105] Effect of manganese chloride on the neurochemical profile of the rat hypothalamus

N. Just; C. R. Cudalbu; H. Lei; R. Gruetter

Journal of Cerebral Blood Flow and Metabolism. 2011. DOI : 10.1038/jcbfm.2011.92.

Detailed record: https://infoscience.epfl.ch/record/177439?ln=en
Full text: https://infoscience.epfl.ch/record/177439/files/Just_Mn_JCBFM_2011.pdf

[106] Assessing The Importance Of An Astrocyte Specific Anaplerotic Enzyme In The Central Nervous System Of Rat

S. Lengacher; C. R. Cudalbu; N. Aznavour; R. Gruetter; P. Magistretti

2011. 10th European Meeting on Glial Cells in Health and Disease, Prague, CZECH REPUBLIC, Sep 13-17, 2011. p. S109-S110.

Detailed record: https://infoscience.epfl.ch/record/171014?ln=en

2010

[107] Investigation of spatial distribution of metabolites in rat brain at elevated plasma glucose levels

V. Mlynarik; C. R. Cudalbu; H. Frenkel; N. Costers; R. Gruetter

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178176?ln=en

[108] Localized 31P saturation transfer in rat brain

V. Mlynarik; C. R. Cudalbu; Y. Pilloud; R. Gruetter

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178174?ln=en

[109] In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS

C. R. Cudalbu; B. Lanz; P. R. Vasos; Y. Pilloud; V. Mlynárik et al.

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/178001?ln=en
Full text: https://infoscience.epfl.ch/record/178001/files/radC6175_15N.pdf

[110] Imaging glutamine synthesis rates in the hyperammonemic rat brain

C. R. Cudalbu; V. Mlynárik; B. Lanz; H. Frenkel; N. Costers et al.

2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.

Detailed record: https://infoscience.epfl.ch/record/177999?ln=en
Full text: https://infoscience.epfl.ch/record/177999/files/radC3AE9_csi_ammonia.pdf

[111] In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion

C. R. Cudalbu; B. Lanz; H. Frenkel; V. Mlynárik; R. Gruetter

2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.

Detailed record: https://infoscience.epfl.ch/record/177998?ln=en
Full text: https://infoscience.epfl.ch/record/177998/files/Cudalbu_abstract.pdf

[112] Marker-independent identification of glioma-initiating cells

V. Clement; D. Marino; C. R. Cudalbu; M.-F. Hamou; V. Mlynarik et al.

Nature Methods. 2010. DOI : 10.1038/NMETH.1430.

Detailed record: https://infoscience.epfl.ch/record/172836?ln=en
Full text: https://infoscience.epfl.ch/record/172836/files/Nature%20Methods%202010.pdf

[113] Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

N. Kunz; C. R. Cudalbu; V. Mlynarik; P. S. Hueppi; S. V. Sizonenko et al.

Magnetic Resonance In Medicine. 2010. DOI : 10.1002/mrm.22490.

Detailed record: https://infoscience.epfl.ch/record/172318?ln=en
Full text: https://infoscience.epfl.ch/record/172318/files/Kunz_DW_MM.pdf

[114] Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

C. R. Cudalbu; A. Comment; F. Kurdzesau; R. van Heeswijk; K. Uffmann et al.

Physical Chemistry Chemical Physics. 2010. DOI : 10.1039/c002309b.

Detailed record: https://infoscience.epfl.ch/record/166970?ln=en
Full text: https://infoscience.epfl.ch/record/166970/files/cudalbu_15N_DNP.pdf

2009

[115] Proton MRS investigation of human glioma models in nude mice at 14.1 T

V. Mlynarik; C. R. Cudalbu; V. Clément; D. Marino; I. Radovanovic et al.

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178173?ln=en
Full text: https://infoscience.epfl.ch/record/178173/files/Mlyn_1969gliomas.pdf

[116] Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging

V. Mlynarik; C. R. Cudalbu; H. Frenkel; R. Gruetter

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178172?ln=en
Full text: https://infoscience.epfl.ch/record/178172/files/Mlyn_1962CSI.pdf

[117] Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain

C. R. Cudalbu; B. Lanz; F. D. Morgenthaler; Y. Pilloud; V. Mlynárik et al.

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.

Detailed record: https://infoscience.epfl.ch/record/178164?ln=en
Full text: https://infoscience.epfl.ch/record/178164/files/15N_ammonia_cudalbu.pdf

[118] Short-echo-time 1H MRS of the mouse lacking prion protein (Prnp-/-) at 14.1T

C. R. Cudalbu; V. Mlynárik; J. Bremer; A. Aguzzi; R. Gruetter

2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.

Detailed record: https://infoscience.epfl.ch/record/178163?ln=en
Full text: https://infoscience.epfl.ch/record/178163/files/prion%20abstract_ISMRM2009.pdf

[119] In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T

C. R. Cudalbu; B. Lanz; F. Morgenthaler; Y. Pilloud; V. Mlynarik et al.

2009. ESMRMB, Antalya, TR, October 1-3.

Detailed record: https://infoscience.epfl.ch/record/178161?ln=en
Full text: https://infoscience.epfl.ch/record/178161/files/ESMRMB2009-115%5B1%5D_eposter.pdf

[120] MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS

C. R. Cudalbu; B. Lanz; F. Morgenthaler; V. Mlynárik; R. Gruetter

2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.

Detailed record: https://infoscience.epfl.ch/record/178160?ln=en
Full text: https://infoscience.epfl.ch/record/178160/files/HE_cudalbu.pdf

[121] Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

R. van Heeswijk; K. Uffmann; A. Comment; F. Kurdzesau; C. Perazzolo et al.

Magnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.21952.

Detailed record: https://infoscience.epfl.ch/record/159787?ln=en
Full text: https://infoscience.epfl.ch/record/159787/files/6Li.pdf

[122] Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

Measurement Science & Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.

Detailed record: https://infoscience.epfl.ch/record/159432?ln=en
Full text: https://infoscience.epfl.ch/record/159432/files/cudalbu_measscitechn_2009.pdf

[123] Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

Magnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.22022.

Detailed record: https://infoscience.epfl.ch/record/159323?ln=en
Full text: https://infoscience.epfl.ch/record/159323/files/cudalbu_T1.pdf

[124] Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS

C. R. Cudalbu; B. Lanz; F. Morgenthaler; Y. Pilloud; V. Mlynarik et al.

2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609-S610.

Detailed record: https://infoscience.epfl.ch/record/159181?ln=en
Full text: https://infoscience.epfl.ch/record/159181/files/cudalbu_brain%26brainpet2009.pdf

2008

[125] In Vivo Detection of Hyperpolarized 15N Choline in the Rat

C. R. Cudalbu; A. Comment; K. Uffmann; R. van Heeswijk; C. Perazzolo et al.

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178170?ln=en
Full text: https://infoscience.epfl.ch/record/178170/files/In%20vivo%20detection%20of%20hyperpolarized%2015N%20Choline%20in%20the%20rat_ISMRM2008_Cudalbu_3195.pdf

[126] Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla

V. Mlynárik; C. R. Cudalbu; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178169?ln=en
Full text: https://infoscience.epfl.ch/record/178169/files/1461_14T.pdf

[127] Comparison of Two Approaches to Model the Macromolecule Spectrum for the Quantification of Short TE 1H MRS Spectra at 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178168?ln=en
Full text: https://infoscience.epfl.ch/record/178168/files/Comparison%20of%20two%20approaches%20to%20model%20the%20macromolecule%20spectrum%20for%20the%20quantification%20of%20short%20TE%201H%20MRS%20spectra%20at%2014T_Cudalbu_ismrm08_3174.pdf

[128] 1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 16th Annual ISMRM Meeting, Toronto, May 2008.

Detailed record: https://infoscience.epfl.ch/record/178167?ln=en
Full text: https://infoscience.epfl.ch/record/178167/files/1H%20NMR%20T1%20relaxation%20times%20of%20the%20neurochemical%20profiles%20in%20rat%20brain%20at%2014.1T_cudalbu_ismrm08_1594.pdf

[129] Comparison of the T1 of the neurochemical profile in rat brain at 9.4T and 14.1T

C. R. Cudalbu; V. Mlynárik; L. Xin; R. Gruetter

2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain, 2008.

Detailed record: https://infoscience.epfl.ch/record/178166?ln=en
Full text: https://infoscience.epfl.ch/record/178166/files/SubmitPrinterFriendlyVers_T1_emsrmb2008.pdf

[130] MRS study of human glioma-initiating cells grown in the brain of nude Mice

V. Mlynarik; C. R. Cudalbu; V. Clément; I. Radovanovic; R. Gruetter

2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain.

Detailed record: https://infoscience.epfl.ch/record/178165?ln=en
Full text: https://infoscience.epfl.ch/record/178165/files/SubmitPrinterFriendlyVers_glioma%20esmrmb%202008.pdf

[131] Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain

L. Xin; G. Gambarota; C. R. Cudalbu; V. Mlynarik; R. Gruetter

2008. ISMRM 16th Scientific Meeting & Exhibition, Toronto, Ontario, Canada, May 3-9, 2008.

Detailed record: https://infoscience.epfl.ch/record/177663?ln=en
Full text: https://infoscience.epfl.ch/record/177663/files/00694.pdf

[132] H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

V. Mlynarik; C. R. Cudalbu; L. Xin; R. Gruetter

Journal Of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.

Detailed record: https://infoscience.epfl.ch/record/160558?ln=en
Full text: https://infoscience.epfl.ch/record/160558/files/14T_MRS.pdf

[133] Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE H-1 MRS spectra

C. R. Cudalbu; V. Mlynarik; L. Xin; R. Gruetter

2008. IEEE International Workshop on Imaging Systems and Techniques, Chania, GREECE, Sep 10-12, 2008. p. 309-312. DOI : 10.1109/IST.2008.4659991.

Detailed record: https://infoscience.epfl.ch/record/160247?ln=en

2007

[134] MR study of a mouse model of implanted human glioma cells at 14.1T

C. R. Cudalbu; V. Mlynárik; V. Clement; I. Radovanovic; R. Gruetter

2007. Changins “Neuroscience” meeting, Switzerland, 21 November 2007.

Detailed record: https://infoscience.epfl.ch/record/178171?ln=en

Research

Current work

Development: implement/validate new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS

Implement new acquisition techniques for fast spectroscopic imaging and diffusion spectroscopy
Implement new techniques for brain macromolecules quantification

Animal models:

Chronic liver failure/chronic hepatic encephalopathy - https://www.youtube.com/watch?v=SYkzgkbJGiY - characterize the developing brain under chronic hepatic encephalopathy

- mechanistic understanding of chronological event involved in chronic hepatic encephalopathy and targeted treatments using a multi-modal approach

Brain tumors
Creatine deficiencies, etc

Grants

2022-2026 - PI in the Swiss National Science Foundation, n° 205321L_207935, "Developments of innovative fast acquisition and metabolic modelling strategies for clinical and preclinical deuterium MR imaging in the brain at ultra-high field", Co-PI: B Lanz (CIBM) B Strasser (University of Vienna)
2022 - PI in the Swiss National Science Foundation, n° 213184, "The International Magnetic Resonance Spectroscopy Workshop “MRS 2022: Overcoming the Barriers to Clinical Use”", Co-PI: B Alves, A Klauser, R Kreis, H Lajous, B Lanz, J Mosso, K Pierzchala, D Simicic, D Van de Ville, D Wenz, L Xin
2021-2025 - PI in the Swiss National Science Foundation, n° 310030_201218 "Enhanced MR Spectroscopic mapping of brain regional changes in type C hepatic encephalopathy of juvenile rats to develop novel combinatorial treatments," Co-PI: O Braissant (CHUV) V McLin (HUG)
2019-2021 - Co-applicant in the Innosuisse - Suisse Innovation Agency application "Pearl injectable implants, a solution for the reconstruction of ultra-large volumes of soft tissues post-injury"
2018-2022 - Vice-coordinator in the H2020-MSCA-ITN-2018 application " INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine" (INSPiRE-MED, 813120)
2017-2021: Swiss National Science Foundation; grant n° 31003A-175778/1 to Braissant&Cudalbu. “Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.”
2017-2021: Swiss National Science Foundation; grant n° 310030_173222/1 to Cudalbu&Braissant&McLin. “Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.”
2017-2018: Co-applicant in the Swiss Cancer League application “Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project”, (PI Monika Hegi)
2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)
2014: PI for the Industrial grant VSL Pharmaceuticals Inc.
2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project "Transforming Magnetic Resonance Spectroscopy into a Clinical Tool" (TRANSACT)

Teaching & PhD

Teaching

Physics

PhD Students

Alves Brayan,

Past EPFL PhD Students

Mosso Jessie Julie , Rackayová Veronika , Simicic Dunja ,

Teaching

Courses

MRI Practicals on CIBM preclinical imaging systems

The goal of this course is to teach students how to perform basic MRI and MRS experiments in-vivo and ex-vivo directly on preclinical horizontal ultra-high field MRI systems.

CIBM translational MR neuroimaging & spectroscopy

Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.

Cristina Ramona Cudalbu

Deputy

Position @ CIBM MRI AIT (EPFL)

Field of Expertise

PubMed

Scholar google

Biography

Professional course

Education

Publications

Infoscience publications

2024

[1] Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency

[2] Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

[3] Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

2023

[4] Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

[5] New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual <SUP>18</SUP>F-FDG PET and 9.4T <SUP>1</SUP>H MRS Preclinical Study

[6] Automated segmentation and labeling of subcutaneous mouse implants at 14.1T

[7] Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

[8] Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

[9] Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

[10] Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

[11] Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

[12] The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: <i>In Vivo</i> Longitudinal <SUP>1</SUP>H and <SUP>31</SUP>P Magnetic Resonance Spectroscopy Study

[13] New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

[14] Lessons on brain edema in HE: from cellular to animal models and clinical studies

[15] Editorial for the special issue on Brain Biochemistry in Liver Disease

[16] High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

[17] Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

[18] Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

[19] Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

2022

[20] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

[21] MP-PCA denoising for diffusion MRS data: promises and pitfalls

[22] Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

[23] Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

[24] Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

[25] Abnormal brain oxygen homeostasis in an animal model of liver disease

[26] PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

[27] Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

[28] Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

[29] Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

2021

[30] Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

[31] Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

[32] Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

[33] Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

[34] In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

[35] The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

[36] 2021 ISHEN guidelines on animal models of hepatic encephalopathy

[37] Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

[38] A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

[39] Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

2020

[40] Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

[41] Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

[42] B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

[43] Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

[44] Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

[45] MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRS

2019

[46] Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats

[47] Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings

[48] Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats

[49] In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy

[50] Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture

[51] Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy

[52] Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T

[53] Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''

[54] Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus

[55] Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

[56] Brain Edema in Chronic Hepatic Encephalopathy

[57] Methodological consensus on clinical proton MRS of the brain: Review and recommendations

2018

[58] Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing

[59] Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

[60] Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS

[61] In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

[62] In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose