Cristina Ramona Cudalbu Moldovan
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office: CH F0 582
EPFL › VPA › VPA-AVP-CP › CIBM › CIBM-PCI
Site web: https://www.cibm.ch/
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office: CH F0 582
EPFL › VPA › VPA-AVP-DLE › AVP-DLE-EDOC › EDPY-ENS
EPFL CIBM-PCI
CH F0 582 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 76 85
Office: CH F0 582
EPFL › SB › SB-SPH › SPH-ENS
Site web: https://sph.epfl.ch/
Formation
PhD
| RMN Laboratory MIB2003 – 2006 University Claude-Bernard Lyon 1, France
Master of Science
| Biophysics and Medical Physics2002 – 2003 University Babes-Bolyai, Cluj Napoca, Romania
Expériences professionnelles
Head
Maître d'enseignement et de recherche (MER)
Deputy
Research and Teaching Associate
Senior Research Staff Scientist and 9.4T MRI Operational Manager
Postdoctoral researcher
Publications représentatives
Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.
Just N, Cudalbu C, Lei H, Gruetter R.
Published in J Cereb Blood Flow Metab. 2011 Dec;31(12):2324-33. in
Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.
Xin L, Gambarota G, Cudalbu C, Mlyn�rik V, Gruetter R.
Published in MAGMA. 2013 Dec;26(6):549-54. in
Quantitation for in vivo and ex vivo NMR Spectroscopy
H. Rabeson, H. Ratiney, F. Fauvelle, C. Cudalbu, S. Cavassila, A. Bernard, P. Giraudon, D. van Ormondt, D. Graveron-Demilly.
Published in Journal of Optoelectronics and Advanced Materials, 2007, 9 (3): 505-511. in
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents
RB. van Heeswijk, K Uffmann, A Comment, F Kurdzesau, C Perazzolo, C Cudalbu, S Jannin, JA. Konter, P Hautle, B van den Brandt, G Navon, JJ. van der Klink and R Gruetter.
Published in Magn Reson Med. 2009 Jun;61(6):1489-93 in
Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T.
Schaller B, Xin L, Cudalbu C, Gruetter R.
Published in NMR Biomed. 2013 May;26(5):593-9. in
1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
V Mlynarik, C Cudalbu, L Xin, R Gruetter.
Published in J Magn Reson. 2008 Oct;194(2):163-8 in
In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla
Vladim�r Mlyn�rik, Cristina Cudalbu, Virginie Cl�ment, Denis Marino, Ivan Radovanovic, Rolf Gruetter
Published in NMR Biomed. 2012 Apr;25(4):506-13. in
Handling macromolecule signals in the quantification of the neurochemical profile
C Cudalbu, V. Mlyn�rik, R. Gruetter
Published in J Alzheimers Dis. 2012;31 Suppl 3:S101-15. Review. in
Marker-independent identification of glioma-initiating cells
Cl�ment V, Marino D, Cudalbu C, Hamou MF, Mlynarik V, de Tribolet N, Dietrich PY, Gruetter R, Hegi ME, Radovanovic I.
Published in Nat Methods, 2010 Mar;7(3):224-8. in
Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE 1H MRS spectra.
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Published in Meas. Sci. Technol. 20:104034 (2009) in
In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1 H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T.
Craveiro M, Cl�ment-Schatlo V, Marino D, Gruetter R, Cudalbu C.
Published in J Neurochem. 2014 Feb 7. doi: 10.1111/jnc.12673. [Epub ahead of print] in
Rat brain metabolite relaxation time estimates using Magnetic Resonance Spectroscopy at two different field strengths
C. Cudalbu, A. Rengle, O. Beuf, S. Cavassila.
Published in C.R. Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 442-447 in
Influence of Measured and Simulated Basis-Sets on the Metabolite Concentration Estimates
C. Cudalbu, S. Cavassila, H. Rabeson, D. van Ormondt, D. Graveron-Demilly.
Published in NMR Biomed, 2008, 21: 627-636. in
Cerebral Glutamine metabolism under hyperamonemia determined in vivo by localized 1H and 15N NMR spectroscopy
C. Cudalbu, B. Lanz, J.M.N. Duarte, FD Morgenthaler, Y. Pilloud, V. Mlyn�rik and R. Gruetter.
Published in J Cereb Blood Flow Metab. 2012 Apr;32(4):696-708 in
Brain metabolite concentration estimates using MRS in a chronic model of temporal lobe epilepsy
C. Cudalbu, A. Montavont, P. Ryvlin, S. Cavassila.
Published in CR Chimie, Volume 11, Issues 4-5, April-May 2008, Pages 434-441. in
In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy
Cudalbu C
Published in Metab Brain Dis. 2013 Jun;28(2):167-74. in
In vivo short echo time localized 1H MRS of the rat brain at 7T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST
C. Cudalbu, O. Beuf, S. Cavassilla.
Published in Journal of VLSI Signal Processing Systems, 55 (1-3) , pp. 25-34, DOI: 10.1007/s11265-008-0187-5. in
Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS
Kunz N, Cudalbu C, Mlynarik V, H�ppi PS, Sizonenko SV, Gruetter R.
Published in Magn Reson Med. 2010 Oct;64(4):939-46. in
Clinical proton MR spectroscopy in central nervous system disorders.
Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Din�er A, Dydak U, Emir UE, Frahm J, Gonz�lez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, H�ppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marja?ska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tk�? I, Vigneron DB, Kauppinen RA; MRS Consensus Group.
Published in Radiology. 2014 Mar;270(3):658-79. doi: 10.1148/radiol.13130531. in
Ammonia toxicity to the brain
Braissant O, McLin VA, Cudalbu C.
Published in J Inherit Metab Dis. 2013 Jul;36(4):595-612 in
Dose distribution in the irradiation of medulloblastoma with two adjacent fields,
C Cudalbu, A Stan, O. Cozar.
Published in Studia UBB, Physica, 2003, 48(2), pp 3-11 in
Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES.
Lanz B, Duarte JM, Kunz N, Mlyn�rik V, Gruetter R, Cudalbu C.
Published in Magn Reson Med. 2013 Jun;69(6):1512-22. in
Estimation of metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla
C. Cudalbu, S. Cavassila, H. Ratiney, D. Grenier, A. Briguet, D. Graveron-Demilly.
Published in C. R. Chimie, 9, 2006, pp 534-538. in
The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts.
Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R
Published in PLoS One. 2013 Jul 23;8(7):e69782. in
Feasibility of in vivo(15)N MRS detection of hyperpolarized (15)N labeled choline in rats
Cudalbu C, Comment A, Kurdzesau F, van Heeswijk RB, Uffmann K, Jannin S, Denisov V, Kirik D, Gruetter R.
Published in Phys Chem Chem Phys. 2010 Jun 14;12(22):5818-23 in
Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease.
Mlyn�rik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R.
Published in J Alzheimers Dis. 2012;31 Suppl 3:S87-99. in
Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T
C. Cudalbu, V Mlynarik, L Xin, R Gruetter.
Published in Magn Reson Med. 2009 Oct;62(4):862-7 in
Infoscience
2025
Comparison of Low‐Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T
NMR in Biomedicine. 2025. DOI : 10.1002/nbm.70125.Heterozygous females from a rat model for creatine transporter deficiency reveal altered behavioral response to stressors, normal body weight and slight metabolic changes
Frontiers in neuroscience. 2025. DOI : 10.3389/fnins.2025.1520550.Fast High-Resolution Metabolite Mapping in the rat Brain Using <sup>1</sup>H-FID-MRSI at 14.1 T
NMR in biomedicine. 2025. DOI : 10.1002/nbm.5304.2024
Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application
NMR in Biomedicine. 2024. DOI : 10.1002/nbm.5211.Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency
Molecular Therapy Methods & Clinical Development. 2024. DOI : 10.1016/j.omtm.2024.101251.Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study
Frontiers In Neuroscience. 2024. DOI : 10.3389/fnins.2024.1344076.Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy
Nature Communications. 2024. DOI : 10.1038/s41467-024-46481-8.2023
Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling
Magnetic Resonance in Medicine. 2023. DOI : 10.1002/mrm.29877.Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field
Magnetic Resonance in Medicine. 2023. DOI : 10.1002/mrm.29805.Editorial for the special issue on Brain Biochemistry in Liver Disease
Analytical Biochemistry. 2023. DOI : 10.1016/j.ab.2023.115248.New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual <SUP>18</SUP>F-FDG PET and 9.4T <SUP>1</SUP>H MRS Preclinical Study
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12 - S12. DOI : 10.14309/01.ajg.0000948348.20966.21.Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24 - S24. DOI : 10.14309/01.ajg.0000948424.84976.19.Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S24 - S25. DOI : 10.14309/01.ajg.0000948428.52697.c3.The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: <i>In Vivo</i> Longitudinal <SUP>1</SUP>H and <SUP>31</SUP>P Magnetic Resonance Spectroscopy Study
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12 - S13. DOI : 10.14309/01.ajg.0000948352.71525.d3.Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy
2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S30 - S31. DOI : 10.14309/01.ajg.0000948468.55577.45.Lessons on brain edema in HE: from cellular to animal models and clinical studies
Metabolic Brain Disease. 2023. DOI : 10.1007/s11011-023-01269-5.Automated segmentation and labeling of subcutaneous mouse implants at 14.1T
Frontiers In Signal Processing. 2023. DOI : 10.3389/frsip.2023.1155618.High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study
Analytical Biochemistry. 2023. DOI : 10.1016/j.ab.2023.115212.Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset
Metabolic Brain Disease. 2023. DOI : 10.1007/s11011-023-01210-w.Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?
2023. 1st international conference on the Future of Redox Biology, ITALY, Jun 17-19, 2022. p. S15 - S15. DOI : 10.1016/j.freeradbiomed.2022.12.056.New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10502.Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset
2023.2022
MP-PCA denoising for diffusion MRS data: promises and pitfalls
Neuroimage. 2022. DOI : 10.1016/j.neuroimage.2022.119634.Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data
Analytical Biochemistry. 2022. DOI : 10.1016/j.ab.2022.114795.Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?
2022. p. 40 - 40.Abnormal brain oxygen homeostasis in an animal model of liver disease
Jhep Reports. 2022. DOI : 10.1016/j.jhepr.2022.100509.PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats
Analytical Biochemistry. 2022. DOI : 10.1016/j.ab.2022.114606.Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats
2022. p. 57 - 58.Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)
Free Radical Biology And Medicine. 2022. DOI : 10.1016/j.freeradbiomed.2022.01.016.Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9422.Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy
Free Radical Biology And Medicine. 2022. DOI : 10.1016/j.freeradbiomed.2021.12.011.2021
Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE
Scientific Reports. 2021. DOI : 10.1038/s41598-021-97018-8.Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
Acta Neuropathologica Communications. 2021. DOI : 10.1186/s40478-021-01232-4.In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times
Magnetic Resonance in Medicine. 2021. DOI : 10.1002/mrm.28910.The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery
Molecular Genetics And Metabolism. 2021. DOI : 10.1016/j.ymgme.2021.03.017.2021 ISHEN guidelines on animal models of hepatic encephalopathy
Liver International. 2021. DOI : 10.1111/liv.14911.Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
Scientific Reports. 2021. DOI : 10.1038/s41598-021-85339-7.Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations
Nmr In Biomedicine. 2021. DOI : 10.1002/nbm.4484.Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
Scientific Reports. 2021. DOI : 10.1038/s41598-021-81871-8.A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism
Scientific Reports. 2021. DOI : 10.1038/s41598-020-80824-x.2020
Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4393.Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4325.Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4347.B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4350.MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRS
ISMRM 28th Annual Meeting & Exhibition, Paris, France, August 8-13, 2020.Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease
Scientific Reports. 2020. DOI : 10.1038/s41598-020-64416-3.2019
Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''
Journal of Hepatology. 2019. DOI : 10.1016/j.jhep.2019.08.003.Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus
2019. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA, Nov 08-12, 2019. p. 471A - 472A.Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy
Journal Of Hepatology. 2019. DOI : 10.1016/j.jhep.2019.05.022.Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33 - S36. DOI : 10.14309/01.ajg.0000582248.03815.eb.Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33 - S33.Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S18 - S19. DOI : 10.14309/01.ajg.0000582120.59858.08.Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S37 - S38. DOI : 10.14309/01.ajg.0000582272.41932.fe.In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S17 - S17. DOI : 10.14309/01.ajg.0000582108.29364.13.Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S31 - S32. DOI : 10.14309/01.ajg.0000582224.88567.2a.Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats
2019. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S19 - S19. DOI : 10.14309/01.ajg.0000582124.67482.93.Brain Edema in Chronic Hepatic Encephalopathy
Journal Of Clinical And Experimental Hepatology. 2019. DOI : 10.1016/j.jceh.2019.02.003.2018
Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing
2018. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA, Nov 14-18, 2018. p. 35 - 35.In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose
Journal of Cerebral Blood Flow & Metabolism. 2018. DOI : 10.1177/0271678X17734101.Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine
ISMRM 2018, Paris, France, June16-21, 2018.Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8612.2017
Metabolic changes in developing brain due to chronic liver disease: an in vivo longitudinal and multiparametric study using P-31-MRS (magnetic resonance spectroscopy), P-31-Magnetization transfer and H-1-MRS
2017. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY, APR 01-04, 2017. p. 496 - 497.Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.007.Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolism
Analytical Biochemistry. 2017. DOI : 10.1016/j.ab.2017.05.014.MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.2016
Brain edema: a valid endpoint for measuring hepatic encephalopathy?
Metabolic brain disease. 2016. DOI : 10.1007/s11011-016-9843-9.(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism
Metabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.2015
In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T
Neurochemical research. 2015. DOI : 10.1007/s11064-015-1643-9.2014
Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI
2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.Clinical Proton MR Spectroscopy in Central Nervous System Disorders
Radiology. 2014. DOI : 10.1148/radiol.13130531.In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T
2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T
Journal of Neurochemistry (JNC). 2014. DOI : 10.1111/jnc.12673.Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T
NMR in Biomedicine. 2014. DOI : 10.1002/nbm.3168.2013
Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study
2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases. p. 803A - 803A.The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts
2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 107 - 108.In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS
2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases', u'64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases'. p. 393A - 393A.In vivo and longitudinal assessment of brain metabolism in Hepatic Encephalopathy using 1H MRS
ISMRM.Hepatic encephalopathy and brain metabolism: a longitudinal in vivo study
2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 178 - 179.Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T
NMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts
PLoS ONE. 2013. DOI : 10.1371/journal.pone.0069782.Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES
Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain
Magma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.Ammonia toxicity to the brain
Journal of inherited metabolic disease. 2013. DOI : 10.1007/s10545-012-9546-2.Brain metabolism in rat model of human glioma initiating cells
2013. International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, April 2013.The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts
ISMRM.In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy
Metabolic brain disease. 2013. DOI : 10.1007/s11011-012-9368-9.Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study
2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013.In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS
2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013.2012
In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla
Nmr In Biomedicine. 2012. DOI : 10.1002/nbm.1763.In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure
2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease
Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy
Journal of Cerebral Blood Flow & Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy
2012. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, SPAIN, Apr 18-22, 2012. p. S231 - S232.Brain osmolytes and brain edema in a rat model of chronic liver failure: in vivo longitudinal 1H Spectroscopic imaging and Diffusion tensor imaging studies at 9.4T
The 15th International Society of Hepatic Encephalopathy and Nitrogen Metabolism, Symposium May 29 - June 2, 2012, Denmark.In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure
ISMRM 20th Annual Scientific Meeting, 5-11 May 2012, Melbourne, Australia.Handling macromolecule signals in the quantification of the neurochemical profile
Journal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-120100.Phosphorus MRS Study of a Murine Model of Peripheral Arterial Disease
2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.2011
In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain
2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.In vivo longitudinal 1H MRS study of transgenic mouse models of prion disease in the hippocampus and cerebellum at 14.1T
2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study
2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.Effect of manganese chloride on the neurochemical profile of the rat hypothalamus
Journal of Cerebral Blood Flow & Metabolism. 2011. DOI : 10.1038/jcbfm.2011.92.Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES
2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.Assessing The Importance Of An Astrocyte Specific Anaplerotic Enzyme In The Central Nervous System Of Rat
2011. 10th European Meeting on Glial Cells in Health and Disease, Prague, CZECH REPUBLIC, Sep 13-17, 2011. p. S109 - S110.In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla
2011. p. S15 - S15.2010
RETRACTED: Marker-independent identification of glioma-initiating cells
Nature Methods. 2010. DOI : 10.1038/NMETH.1430.Imaging glutamine synthesis rates in the hyperammonemic rat brain
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion
2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.Localized 31P saturation transfer in rat brain
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS
Magnetic Resonance in Medicine. 2010. DOI : 10.1002/mrm.22490.In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Investigation of spatial distribution of metabolites in rat brain at elevated plasma glucose levels
2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats
Physical Chemistry Chemical Physics. 2010. DOI : 10.1039/c002309b.2009
Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents
Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.21952.Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum
Measurement Science and Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla
Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.22022.Proton MRS investigation of human glioma models in nude mice at 14.1 T
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS
2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS
2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609 - S610.Short-echo-time 1H MRS of the mouse lacking prion protein (Prnp-/-) at 14.1T
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T
2009. ESMRMB, Antalya, TR, October 1-3.Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging
2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.2008
Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain
2008. ISMRM 16th Scientific Meeting & Exhibition, Toronto, Ontario, Canada, May 3-9, 2008.Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE H-1 MRS spectra
2008. IEEE International Workshop on Imaging Systems and Techniques, Chania, GREECE, Sep 10-12, 2008. p. 309 - 312. DOI : 10.1109/IST.2008.4659991.Comparison of the T1 of the neurochemical profile in rat brain at 9.4T and 14.1T
2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain, 2008.Comparison of Two Approaches to Model the Macromolecule Spectrum for the Quantification of Short TE 1H MRS Spectra at 14.1T
2008. 16th Annual ISMRM Meeting, Toronto, May 2008.H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
Journal of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.MRS study of human glioma-initiating cells grown in the brain of nude Mice
2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain.Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla
2008. 16th Annual ISMRM Meeting, Toronto, May 2008.In Vivo Detection of Hyperpolarized 15N Choline in the Rat
2008. 16th Annual ISMRM Meeting, Toronto, May 2008.1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T
2008. 16th Annual ISMRM Meeting, Toronto, May 2008.2007
MR study of a mouse model of implanted human glioma cells at 14.1T
2007. Changins “Neuroscience” meeting, Switzerland, 2007-11-21.Enseignement et PhD
Current Phd
Past Phd As Codirector
Veronika Rackayová, Dunja Simicic, Jessie Mosso
Courses
CIBM translational MR neuroimaging & spectroscopy
Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners.
MRI Practicals on CIBM preclinical imaging systems
L'objectif de ce cours est d'enseigner aux étudiants comment réaliser des expériences d'IRM et de MRS (SRM) de base in-vivo et ex-vivo directement sur des systèmes d'IRM précliniques horizontaux à ultra-haut champ.