Cristina Ramona Cudalbu
Field of Expertise
- In vivo proton, phosphorus, carbon and nitrogen MR Spectroscopy
- Chronic Hepatic Encephalopathy, Hyperammonemia - https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/
- Brain metabolites quantification and macromolecules
- In vivo proton Spectroscopic Imaging
- Diffusion weighted Spectroscopy
- Brain tumors
- Dynamic nuclear polarization
PositionSenior Research Staff Scientist & 9.4T MRI Operational Manager, CIBM MRI AIT (EPFL)
BiographyCristina Cudalbu obtained her Bachelors of Science degree in Medical Physics in 2002 and Masters of Science degree in Biophysics and Medical Physics in 2003, both from University Babes-Bolyai, Cluj-Napoca, Romania. In 2006 she obtained her PhD degree in Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T at University Lyon 1, RMN Laboratory, Villeurbanne, France.In 2007, she joined, as a Scientist, the Laboratory for Functional and Metabolic Imaging at EPFL, where she implemented new acquisition and quantification techniques for in vivo nitrogen, proton and carbon MRS for preclinical studies. Starting 2012, Cristina Cudalbu was appointed as Research Staff Scientist and 9.4T MRI Operational Manager at Centre d’Imagerie Biomédicale (CIBM) at EPFL. She is now developing new research lines at CIBM, being oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM (https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/), and on different collaborative projects with researchers from the five partner institutions of CIBM.
Senior Research Staff Scientist and 9.4T MRI Operational Manager
Centre d’Imagerie Biomedicale (CIBM), Animal Imaging and Technology (AIT) section
Laboratory for Functional and Metabolic Imaging (LIFMET)
RMN Laboratory MIB
University Claude-Bernard Lyon 1, France
Master of Science
Biophysics and Medical Physics
University Babes-Bolyai, Cluj Napoca, Romania
 Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)Free Radical Biology And Medicine. 2022-03-01. DOI : 10.1016/j.freeradbiomed.2022.01.016.
 Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathyFree Radical Biology And Medicine. 2022-01-01. DOI : 10.1016/j.freeradbiomed.2021.12.011.
 Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophyJournal Of Inherited Metabolic Disease. 2022. DOI : 10.1002/jimd.12470.
 Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HEScientific Reports. 2021-09-09. DOI : 10.1038/s41598-021-97018-8.
Full text: https://infoscience.epfl.ch/record/288857/files/s41598-021-97018-8.pdf
 Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in miceActa Neuropathologica Communications. 2021-08-04. DOI : 10.1186/s40478-021-01232-4.
Full text: https://infoscience.epfl.ch/record/287868/files/s40478-021-01232-4.pdf
 In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation timesMagnetic Resonance in Medicine. 2021-07-15. DOI : 10.1002/mrm.28910.
Full text: https://infoscience.epfl.ch/record/287462/files/mrm.28910.pdf
 The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and peripheryMolecular Genetics And Metabolism. 2021-06-01. DOI : 10.1016/j.ymgme.2021.03.017.
 2021 ISHEN guidelines on animal models of hepatic encephalopathyLiver International. 2021-05-11. DOI : 10.1111/liv.14911.
 Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastomaScientific Reports. 2021-03-11. DOI : 10.1038/s41598-021-85339-7.
Full text: https://infoscience.epfl.ch/record/285246/files/Mishkovsky_HPGlucGliom_SciRep_2021.pdf
 Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendationsNmr In Biomedicine. 2021-02-09. DOI : 10.1002/nbm.4484.
 Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver diseaseScientific Reports. 2021-01-26. DOI : 10.1038/s41598-021-81871-8.
Full text: https://infoscience.epfl.ch/record/287400/files/articles-s41598-021-81871-8.pdf
 A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolismScientific Reports. 2021. DOI : 10.1038/s41598-020-80824-x.
Full text: https://infoscience.epfl.ch/record/283911/files/s41598-020-80824-x.pdf
 Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance SpectroscopyJournal of Neurochemistry. 2021. DOI : 10.1111/jnc.15294.
 Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendationsNmr In Biomedicine. 2020-11-25. DOI : 10.1002/nbm.4393.
 Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendationsNmr In Biomedicine. 2020-08-26. DOI : 10.1002/nbm.4325.
 Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendationsNmr In Biomedicine. 2020-08-17. DOI : 10.1002/nbm.4347.
 B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendationsNmr In Biomedicine. 2020-06-28. DOI : 10.1002/nbm.4350.
 Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver diseaseScientific Reports. 2020. DOI : 10.1038/s41598-020-64416-3.
Full text: https://infoscience.epfl.ch/record/277495/files/s41598-020-64416-3.pdf
 MP-PCA denoising dramatically improves SNR in large-sized MRS data: an illustration in diffusion-weighted MRSISMRM 28th Annual Meeting & Exhibition, Paris, France, August 8-13, 2020.
Full text: https://infoscience.epfl.ch/record/277018/files/https_submissions2.mirasmart.com_ISMRM2020_ViewSubmissionPublic.aspx_sei%3DSjjxlmRCQ.pdf
 Reply to: "Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?''Journal of Hepatology. 2019-11-01. DOI : 10.1016/j.jhep.2019.08.003.
 Bile Acids And Ammonium Contribute To Changes In Dendritic Spine Distribution In An Organotypic Culture Of Rat Hippocampus2019-10-01. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA, Nov 08-12, 2019. p. 471A-472A.
 Probiotics Combined With Rifaximin for the Treatment of Chronic Hepatic Encephalopathy: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism Using BDL Rats2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S19-S19. DOI : 10.14309/01.ajg.0000582124.67482.93.
 Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S36.
 In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S17-S17. DOI : 10.14309/01.ajg.0000582108.29364.13.
 Antibiotic Rifaximin for Treatment of Chronic Liver Disease-Induced HE: A Longitudinal In Vivo 1H-MRS Study of Brain Metabolism on BDL Rats2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S18-S19. DOI : 10.14309/01.ajg.0000582120.59858.08.
 Cholestasis Decreases Dendritic Spine Density in a Rat Hippocampal Organotypic Culture2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S37-S38. DOI : 10.14309/01.ajg.0000582272.41932.fe.
 Hippocampal and Cerebellar Astrocytes Morphological Alterations in a Rat Model of Chronic Hepatic Encephalopathy2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S33-S33.
 Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T2019-09-01. 18th International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism Meeting, Williamsburg, VA, Sep 12-15, 2019. p. S31-S32. DOI : 10.14309/01.ajg.0000582224.88567.2a.
 Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathyJournal Of Hepatology. 2019-09-01. DOI : 10.1016/j.jhep.2019.05.022.
Full text: https://infoscience.epfl.ch/record/269843/files/1-s2.0-S0168827819303083-main.pdf
 Brain Edema in Chronic Hepatic EncephalopathyJournal Of Clinical And Experimental Hepatology. 2019-05-01. DOI : 10.1016/j.jceh.2019.02.003.
 Methodological consensus on clinical proton MRS of the brain: Review and recommendationsMagnetic Resonance in Medicine. 2019. DOI : 10.1002/mrm.27742.
Full text: https://infoscience.epfl.ch/record/265150/files/Wilson_consensusPaper_MRM_2019.pdf
 Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing2018-11-01. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA, Nov 14-18, 2018. p. 35-35.
 Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginineISMRM 2018, Paris, France, June16-21, 2018.
 Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRSLausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8612.
Full text: https://infoscience.epfl.ch/record/256956/files/EPFL_TH8612.pdf
 In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cellsInternational Journal of Cancer. 2018. DOI : 10.1002/ijc.31299.
Full text: https://infoscience.epfl.ch/record/255355/files/Lai_Glioma_IntlJCanc_2018.pdf
 In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucoseJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018. DOI : 10.1177/0271678X17734101.
Full text: https://infoscience.epfl.ch/record/231906/files/Lai_13Cmouse_JCBFM_2018.pdf
 Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolismAnalytical Biochemistry. 2017. DOI : 10.1016/j.ab.2017.05.014.
 Metabolic changes in developing brain due to chronic liver disease: an in vivo longitudinal and multiparametric study using P-31-MRS (magnetic resonance spectroscopy), P-31-Magnetization transfer and H-1-MRS2017. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY, APR 01-04, 2017. p. 496-497.
 MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic modelsAnalytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.021.
 Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficienciesAnalytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.11.007.
 Brain edema: a valid endpoint for measuring hepatic encephalopathy?Metabolic brain disease. 2016. DOI : 10.1007/s11011-016-9843-9.
 (1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolismMetabolic brain disease. 2016. DOI : 10.1007/s11011-015-9715-8.
 In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 TNeurochemical research. 2015. DOI : 10.1007/s11064-015-1643-9.
Full text: https://infoscience.epfl.ch/record/210871/files/Cudalbu_NChemRes_Prion_2015.pdf
 Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.
Full text: https://infoscience.epfl.ch/record/203435/files/LongitudinalStudy_ISMRMabstract_Final.pdf
 In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose2014. International Society for Magnetic Resonance in Medicine, Milan, May 10-16, 2014.
Full text: https://infoscience.epfl.ch/record/203434/files/13CMRS_abstractISMRM2014.pdf
 Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 TNMR in Biomedicine. 2014. DOI : 10.1002/nbm.3168.
Full text: https://infoscience.epfl.ch/record/200499/files/Craveiro_MEGA_SPECIAL_2014.pdf
 Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI2014. International Society for Magnetic Resonance in Medicine, Milano, Italy, 2014.
 Clinical Proton MR Spectroscopy in Central Nervous System DisordersRadiology. 2014. DOI : 10.1148/radiol.13130531.
Full text: https://infoscience.epfl.ch/record/197156/files
 In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 TJournal of Neurochemistry. 2014. DOI : 10.1111/jnc.12673.
Full text: https://infoscience.epfl.ch/record/196648/files/MC_MM_JNeurochem_2014.pdf
 Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases. p. 803A-803A.
 In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS2013. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases', u'64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases'. p. 393A-393A.
 In vivo brain energy metabolism in a rat model of chronic Hepatic Encephalopathy using 31P MRS2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 379.
 Differences in CNS metabolism between pups and adults in an animal model of biliary cirrhosis: longitudinal, non-invasive in vivo study2013. The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013, Washington, DC, November 1 - 5, 2013. p. 1219.
 The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic ShuntsPLoS ONE. 2013. DOI : 10.1371/journal.pone.0069782.
Full text: https://infoscience.epfl.ch/record/187954/files/cudalbu_C57%202013.pdf
 Brain metabolism in rat model of human glioma initiating cells2013. International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, April 2013.
 The C57BL/6 mouse exhibits sporadic congenital portosystemic shuntsISMRM.
Full text: https://infoscience.epfl.ch/record/186417/files/The%20C57BL6%20mouse%20exhibits%20sporadic%20congenital%20portosystemic%20shunts_0111.pdf
 In vivo and longitudinal assessment of brain metabolism in Hepatic Encephalopathy using 1H MRSISMRM.
Full text: https://infoscience.epfl.ch/record/186416/files/In%20vivo%20and%20longitudinal%20assessment%20of%20brain%20metabolism%20in%20Hepatic%20Encephalopathy%20using%201H%20MRS_3993.pdf
 Hepatic encephalopathy and brain metabolism: a longitudinal in vivo study2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 178-179.
 The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts2013. 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Cancun, MEXICO, APR 20-24, 2013. p. 107-108.
 In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance SpectroscopyMetabolic brain disease. 2013. DOI : 10.1007/s11011-012-9368-9.
Full text: https://infoscience.epfl.ch/record/186170/files/11011_2012_Article_9368.pdf
 Ammonia toxicity to the brainJournal of inherited metabolic disease. 2013. DOI : 10.1007/s10545-012-9546-2.
 Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brainMagma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.
Full text: https://infoscience.epfl.ch/record/186164/files/Xin_Magma_14T_T2_2013.pdf
 Quantification of the neurochemical profile using simulated macromolecule resonances at 3 TNMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.
Full text: https://infoscience.epfl.ch/record/183890/files/Schaller_MM3T_NBM_2013.pdf
 Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARESMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24406.
Full text: https://infoscience.epfl.ch/record/180912/files/Lanz_Amares_2013.pdf
 In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failureISMRM 20th Annual Scientific Meeting, 5-11 May 2012, Melbourne, Australia.
 Brain osmolytes and brain edema in a rat model of chronic liver failure: in vivo longitudinal 1H Spectroscopic imaging and Diffusion tensor imaging studies at 9.4TThe 15th International Society of Hepatic Encephalopathy and Nitrogen Metabolism, Symposium May 29 - June 2, 2012, Denmark.
 Handling macromolecule signals in the quantification of the neurochemical profileJournal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-120100.
Full text: https://infoscience.epfl.ch/record/181513/files/Cudalbu_MM_JAD.pdf
 Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's diseaseJournal of Alzheimer's disease : JAD. 2012. DOI : 10.3233/JAD-2012-112072.
Full text: https://infoscience.epfl.ch/record/181512/files/Mlynarik_JAD.pdf
 Phosphorus MRS Study of a Murine Model of Peripheral Arterial Disease2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.
 In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure2012. ISMRM 20th Annual Scientific Meeting, Melbourne, Australia, 5-11 May 2012.
Full text: https://infoscience.epfl.ch/record/177993/files/CLD_ISMRM2012.pdf
 Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy2012. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, SPAIN, Apr 18-22, 2012. p. S231-S232.
 Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopyJournal Of Cerebral Blood Flow And Metabolism. 2012. DOI : 10.1038/jcbfm.2011.173.
 In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 TeslaNmr In Biomedicine. 2012. DOI : 10.1002/nbm.1763.
 In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla2011. p. S15-S15.
 In vivo longitudinal 1H MRS study of transgenic mouse models of prion disease in the hippocampus and cerebellum at 14.1T2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.
Full text: https://infoscience.epfl.ch/record/177997/files/696_final%20abstract_prion_cudalbu.pdf
 In vivo localized 15N MRS detection of hyperpolarized 15N labeled choline in the rat brain2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.
Full text: https://infoscience.epfl.ch/record/177996/files/Cudalbu_choline_ISMRM2011.pdf
 Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES2011. ISMRM 19th Annual Scientific Meeting, Montreal, Canada, 7-13 May 2011.
Full text: https://infoscience.epfl.ch/record/177995/files/Cudalbu_ISMRM-2011_1388.pdf
 Imaging the in vivo effect of hyperammonemia in the rat brain: a Spectroscopic Imaging and Diffusion Tensor Imaging study2011. BRAIN’11 & BRAINPET’11, Barcelona, Spain, 24-28 May 2011.
Full text: https://infoscience.epfl.ch/record/177994/files/Cudalbu_Brain2011.pdf
 Effect of manganese chloride on the neurochemical profile of the rat hypothalamusJournal of Cerebral Blood Flow and Metabolism. 2011. DOI : 10.1038/jcbfm.2011.92.
Full text: https://infoscience.epfl.ch/record/177439/files/Just_Mn_JCBFM_2011.pdf
 Assessing The Importance Of An Astrocyte Specific Anaplerotic Enzyme In The Central Nervous System Of Rat2011. 10th European Meeting on Glial Cells in Health and Disease, Prague, CZECH REPUBLIC, Sep 13-17, 2011. p. S109-S110.
 Investigation of spatial distribution of metabolites in rat brain at elevated plasma glucose levels2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.
 Localized 31P saturation transfer in rat brain2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.
 In vivo simultaneous measurement of glutamine synthetase and glutamate dehydrogenase activity in the hyperammonemic rat brain using localized 1H and 15N MRS2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.
Full text: https://infoscience.epfl.ch/record/178001/files/radC6175_15N.pdf
 Imaging glutamine synthesis rates in the hyperammonemic rat brain2010. ISMRM-ESMRMB joint Annual Meeting, Stockholm, Sweden, 1-7 May, 2010.
Full text: https://infoscience.epfl.ch/record/177999/files/radC3AE9_csi_ammonia.pdf
 In vivo Magnetic Resonance Spectroscopy (MRS) studies of brain metabolism during ammonia infusion2010. 9th International Conference on Brain Energy Metabolism, Budapest, 7-10 July 2010.
Full text: https://infoscience.epfl.ch/record/177998/files/Cudalbu_abstract.pdf
 Marker-independent identification of glioma-initiating cellsNature Methods. 2010. DOI : 10.1038/NMETH.1430.
Full text: https://infoscience.epfl.ch/record/172836/files/Nature%20Methods%202010.pdf
 Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRSMagnetic Resonance In Medicine. 2010. DOI : 10.1002/mrm.22490.
Full text: https://infoscience.epfl.ch/record/172318/files/Kunz_DW_MM.pdf
 Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in ratsPhysical Chemistry Chemical Physics. 2010. DOI : 10.1039/c002309b.
Full text: https://infoscience.epfl.ch/record/166970/files/cudalbu_15N_DNP.pdf
 Proton MRS investigation of human glioma models in nude mice at 14.1 T2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.
Full text: https://infoscience.epfl.ch/record/178173/files/Mlyn_1969gliomas.pdf
 Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.
Full text: https://infoscience.epfl.ch/record/178172/files/Mlyn_1962CSI.pdf
 Simultaneous Localized in vivo 1H and 15N MRS of Glutamine Synthesis in the hyperammonaemic rat brain2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April.
Full text: https://infoscience.epfl.ch/record/178164/files/15N_ammonia_cudalbu.pdf
 Short-echo-time 1H MRS of the mouse lacking prion protein (Prnp-/-) at 14.1T2009. ISMRM 17th Annual Scientific Meeting, Hawaii, 18-19 April 2009.
Full text: https://infoscience.epfl.ch/record/178163/files/prion%20abstract_ISMRM2009.pdf
 In vivo localized 15N and 1H MRS in the hyperammonaemic rat brain at 9.4T2009. ESMRMB, Antalya, TR, October 1-3.
Full text: https://infoscience.epfl.ch/record/178161/files/ESMRMB2009-115%5B1%5D_eposter.pdf
 MEASUREMENT OF GLUTAMINE SYNTHESIS RATE IN THE HYPERAMMONAEMIC RAT BRAIN USING IN VIVO 1H AND 15N MRS2009. INTERNATIONAL SYMPOSIUM ON HEPATIC ENCEPHALOPATHY, Valencia, Spain, September 17-19.
Full text: https://infoscience.epfl.ch/record/178160/files/HE_cudalbu.pdf
 Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast AgentsMagnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.21952.
Full text: https://infoscience.epfl.ch/record/159787/files/6Li.pdf
 Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrumMeasurement Science & Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.
Full text: https://infoscience.epfl.ch/record/159432/files/cudalbu_measscitechn_2009.pdf
 Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 TeslaMagnetic Resonance In Medicine. 2009. DOI : 10.1002/mrm.22022.
Full text: https://infoscience.epfl.ch/record/159323/files/cudalbu_T1.pdf
 Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS2009. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, Jun 29-Jul 03, 2009. p. S609-S610.
Full text: https://infoscience.epfl.ch/record/159181/files/cudalbu_brain%26brainpet2009.pdf
 In Vivo Detection of Hyperpolarized 15N Choline in the Rat2008. 16th Annual ISMRM Meeting, Toronto, May 2008.
Full text: https://infoscience.epfl.ch/record/178170/files/In%20vivo%20detection%20of%20hyperpolarized%2015N%20Choline%20in%20the%20rat_ISMRM2008_Cudalbu_3195.pdf
 Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla2008. 16th Annual ISMRM Meeting, Toronto, May 2008.
Full text: https://infoscience.epfl.ch/record/178169/files/1461_14T.pdf
 Comparison of Two Approaches to Model the Macromolecule Spectrum for the Quantification of Short TE 1H MRS Spectra at 14.1T2008. 16th Annual ISMRM Meeting, Toronto, May 2008.
Full text: https://infoscience.epfl.ch/record/178168/files/Comparison%20of%20two%20approaches%20to%20model%20the%20macromolecule%20spectrum%20for%20the%20quantification%20of%20short%20TE%201H%20MRS%20spectra%20at%2014T_Cudalbu_ismrm08_3174.pdf
 1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T2008. 16th Annual ISMRM Meeting, Toronto, May 2008.
Full text: https://infoscience.epfl.ch/record/178167/files/1H%20NMR%20T1%20relaxation%20times%20of%20the%20neurochemical%20profiles%20in%20rat%20brain%20at%2014.1T_cudalbu_ismrm08_1594.pdf
 Comparison of the T1 of the neurochemical profile in rat brain at 9.4T and 14.1T2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain, 2008.
Full text: https://infoscience.epfl.ch/record/178166/files/SubmitPrinterFriendlyVers_T1_emsrmb2008.pdf
 MRS study of human glioma-initiating cells grown in the brain of nude Mice2008. 25th Annual Scientific Meeting of ESMRMB, Valencia, Spain.
Full text: https://infoscience.epfl.ch/record/178165/files/SubmitPrinterFriendlyVers_glioma%20esmrmb%202008.pdf
 Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain2008. ISMRM 16th Scientific Meeting & Exhibition, Toronto, Ontario, Canada, May 3-9, 2008.
Full text: https://infoscience.epfl.ch/record/177663/files/00694.pdf
 H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profileJournal Of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.
Full text: https://infoscience.epfl.ch/record/160558/files/14T_MRS.pdf
 Comparison of two approaches to model the macromolecule spectrum for the quantification of short TE H-1 MRS spectra2008. IEEE International Workshop on Imaging Systems and Techniques, Chania, GREECE, Sep 10-12, 2008. p. 309-312. DOI : 10.1109/IST.2008.4659991.
 MR study of a mouse model of implanted human glioma cells at 14.1T2007. Changins “Neuroscience” meeting, Switzerland, 21 November 2007.
Current workDevelopment: implement/validate new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS
- Implement new acquisition techniques for fast spectroscopic imaging and diffusion spectroscopy
- Implement new techniques for brain macromolecules quantification
- Chronic liver failure/chronic hepatic encephalopathy - https://www.youtube.com/watch?v=SYkzgkbJGiY
- mechanistic understanding of chronological event involved in chronic hepatic encephalopathy and targeted treatments using a multi-modal approach
- Brain tumors
- Creatine deficiencies, etc
- 2019-2021 - Co-applicant in the Innosuisse - Suisse Innovation Agency application "Pearl injectable implants, a solution for the reconstruction of ultra-large volumes of soft tissues post-injury"
- 2018-2022 - Vice-coordinator in the H2020-MSCA-ITN-2018 application " INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine" (INSPiRE-MED, 813120)
- 2017-2021: Swiss National Science Foundation; grant n° 31003A-175778/1 to Braissant&Cudalbu. “Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.”
- 2017-2021: Swiss National Science Foundation; grant n° 310030_173222/1 to Cudalbu&Braissant&McLin. “Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.”
- 2017-2018: Co-applicant in the Swiss Cancer League application “Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project”, (PI Monika Hegi)
- 2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)
- 2014: PI for the Industrial grant VSL Pharmaceuticals Inc.
- 2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project "Transforming Magnetic Resonance Spectroscopy into a Clinical Tool" (TRANSACT)
Teaching & PhD
Doctoral Program in Physics
PhD StudentsAlves Brayan, Mosso Jessie Julie, Simicic Dunja,
Past EPFL PhD StudentsRackayová Veronika ,
Additional Teaching Activities2009 – 2019 Lecturer and organizer of the Doctoral course “Advanced biomedical imaging methods and instrumentation”, EPFL, Lausanne2018 –present ISMRM Education Committee, Molecular/Spectroscopy Table - https://www.ismrm.org/online-education-program/meet-your-education-committee/2016 Lecturer ESMRMB meeting, “Challenges for push-button processing and quantification of MR spectra”2019-2014 Lecturer during ISHEN meetings, 4 curses on Brain edema and brain metabolism in HE2012 Lecturer for Animal experimentation, 2 courses, CHUV, Lausanne, Switzerland2012 Lecturer ISMRM meeting, “MRS of Rodents at Ultra-High Fields” within “MR Spectroscopy & Spectroscopic Imaging–sunrise course”,2010 Lecturer for Animal experimentation, 1 course, EPFL, Lausanne, Switzerland2010 Lecturer ISMRM meeting, “Metabolite quantification” within “Potentials and challenges of high-field MRS –sunrise course”
ORGANISATION OF SCIENTIFIC MEETINGS 2018 Organizer of the MRS Workshop on Metabolic Imaging, Utrecht, the Netherlands2016 Organizer of final meeting of TRANSACT FP7-PEOPLE Marie Curie ITN, Lausanne, CH
Additional Supervised Thesis
- Master Thesis of André Rocha Morais, Universidade Nova de Lisboa (Portugal) and EPFL, 2013
- Master Thesis of Ana da Silva Santos, University of Coimbra, (Portugal) and EPFL, 2013
- PhD thesis of Marta Lei, EPFL, 2011- 2017, “In vivo cerebral metabolism of glioblastoma xenografts assessed with 1H MRS, 13C MRS and 18F-FDG PET”
- PhD thesis of Melanie Craveiro, EPFL, 2009-2013, "Development and implementation of 1H magnetic resonance techniques for an improved in vivo assessment of cerebral metabolic disorders"
- Master Thesis of Arjun Jayaswal - Imperial College, London, UK, EPFL, 2012-2013, "Brain metabolism and brain edema in a rat model of chronic liver disease: in vivo longitudinal 1H MRS, 31P MRS, Water mapping and Diffusion Tensor Imaging studies at 9.4T"
- Master Thesis of Hend Koubaji, EPFL, 2012-2013, "Brain metabolism and brain edema in chronic liver failure during brain development measured using 1H Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging"
- Master Thesis of Eleanor Berry, Imperial College (London, UK) and EPFL, 2010-2011, "MR Imaging and MR Spectroscopy in preclinical models of Parkinson disease: application to the Haloperidol model", winner of "The Gloucester Research Prize for Academic Excellence in Physics", 2010-2011
- Master Thesis of Sharon Janssens, University of Ghent and EPFL, 2010, "Creatine kinase reaction rates in rat brain measured by localized phosphorus saturation transfer spectroscopy"
- Master Thesis of Melanie Craveiro, EPFL, 2009, "Short-echo-time 1H MRS of ischemic evolution in mice lacking PPAR beta at 14.1T"
- TP-IV Project of Melanie Craveiro, EPFL, 2008: "Methodological aspects of 15N-1H-NMR in vitro and in vivo"
- TP-IV Project of Melanie Craveiro, EPFL, 2008, "Short-echo-time 1H MRS of mice lacking PPAR beta at 14.1T"