Didier Trono
EPFL SV GHI LVG
SV 3512 (Bâtiment SV)
Station 19
1015 Lausanne
+41 21 693 17 51
+41 21 693 17 61
Office: SV 3512
EPFL › SV › GHI › LVG
Site web: https://tronolab.epfl.ch/
+41 21 693 17 51
EPFL › SV › SV-SSV › SSV-ENS
Site web: https://sv.epfl.ch/education
Mission
Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. Depuis une quinzaine d'année, sa recherche porte sur l'épigénétique, où il explore l'impact des rétroéléments et de leurs mécanismes de contrôle sur le développement et la physiologie des organismes supérieurs, dont les humains, et utilise cette information pour mettre au point de nouvelles approches pour le diagnostic et la thérapie du cancer.
Après des études de médecine à l'Université de Genève et une formation clinique en pathologie, médecine interne et maladies infectieuses à Genève et au Massachusetts General Hospital de Boston, Didier Trono s'engage dans une carrière scientifique au Whitehead Institute du MIT. En 1990, il est recruté par le Salk Institute de San Diego pour lancer un centre de recherche sur le SIDA. Il rentre en Europe sept ans plus tard, avant de prendre en 2004 les rênes de la toute nouvelle faculté des Sciences de la Vie de l'EPFL, dont il orchestre le développement et qu'il dirige jusqu'en 2012. Il participe aujourd'hui activement à la coordination des efforts de la Suisse en vue de l'intégration des nouvelles technologies dans le domaine de la médecine de précision et de la santé personnalisée.
Publications représentatives
Editing at the crossroad between innate and adaptive immunity
1. P. Turelli and D. Trono
Published in Science, 307: 1061-1065, 2005 in
2026
* Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity
Cell Reports. 2026. DOI : 10.1016/j.celrep.2025.116817.2025
* Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation
Current opinion in genetics & development. 2025. DOI : 10.1016/j.gde.2025.102414.* The ‘mono‐side’ of cutaneous adverse drug reactions
Journal of the European Academy of Dermatology and Venereology. 2025. DOI : 10.1111/jdv.70128.* Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
Proceedings of the National Academy of Sciences. 2025. DOI : 10.1073/pnas.2505021122.* Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control
2025* Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity
2025* Zinc-finger proteins with a co-opted capsid domain anchor nucleosomes over transposon sequences
2025* Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification
Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-10580.* Evolutionarily recent transcription factors partake in human cell cycle regulation
Cell Genomics. 2025. DOI : 10.1016/j.xgen.2025.100923.2024
* Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset
JOURNAL OF LEUKOCYTE BIOLOGY. 2024. DOI : 10.1093/jleuko/qiae229.* Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments
Science Advances. 2024. DOI : 10.1126/sciadv.ado1662.* A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies
Infectious Diseases and Therapy. 2024. DOI : 10.1007/s40121-023-00908-9.* A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Cancer Research. 2024. DOI : 10.1158/0008-5472.CAN-23-1237.* Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning
Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10774.* Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer
Nature Communications. 2024. DOI : 10.1038/s41467-023-42405-0.* Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants
Cell Genomics. 2024. DOI : 10.1016/j.xgen.2024.100497.2023
* ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys
2023* De novo design of protein interactions with learned surface fingerprints
Nature. 2023. DOI : 10.1038/s41586-023-05993-x.* Cryo-EM structures and binding of mouse ACE2 to SARS-CoV-2 variants of concern
PLOS Pathogens. 2023. DOI : 10.1371/journal.ppat.1011206.* Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
PLOS Pathogens. 2023. DOI : 10.1371/journal.ppat.1011206.* Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10665.* Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints
2023. 36th Annual Symposium of the Protein-Society, San Francisco, CA, Jul 07-10, 2022.* Statistical learning quantifies transposable element-mediated cis-regulation
Genome Biology. 2023. DOI : 10.1186/s13059-023-03085-7.* Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys
Journal of Infection. 2023. DOI : 10.1016/j.jinf.2023.10.008.* SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
Nature Communications. 2023. DOI : 10.1038/s41467-023-43027-2.* The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer
Nature Cancer. 2023. DOI : 10.1038/s43018-023-00548-5.* Take a walk on the KRAB side
Trends in Genetics. 2023. DOI : 10.1016/j.tig.2023.08.003.* Genetic features and genomic targets of human KRAB-zinc finger proteins
Genome Research. 2023. DOI : 10.1101/gr.277722.123.* New ingredients for old recipes
Nature Genetics. 2023. DOI : 10.1038/s41588-023-01591-9.* Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad466.* KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10272.2022
* Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study
The Lancet Regional Health - Europe. 2022. DOI : 10.1016/j.lanepe.2022.100547.* Primate-specific transposable elements shape transcriptional networks during human development
Nature Communications. 2022. DOI : 10.1038/s41467-022-34800-w.* A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819
Science Advances. 2022. DOI : 10.1126/sciadv.abp8085.* Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis
Nature Communications. 2022. DOI : 10.1038/s41467-022-32649-7.* Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys
Nature Microbiology. 2022. DOI : 10.1038/s41564-022-01198-6.* Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development
RNA. 2022. DOI : 10.1261/rna.079100.122.* The interplay between regulatory variants, transposable elements and gene expression in the context of colorectal cancer
2022. p. 387 - 388.* Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients
Jama Oncology. 2022. DOI : 10.1001/jamaoncol.2022.0446.* Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Life Science Alliance. 2022. DOI : 10.26508/lsa.202101270.* Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Nature Communications. 2022. DOI : 10.1038/s41467-022-28105-1.* KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences
Mobile Dna. 2022. DOI : 10.1186/s13100-021-00260-0.* A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
Cell Stem Cell. 2022. DOI : 10.1016/j.stem.2021.09.008.* KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9450.* Integrative transcriptome analyses of Transposable Elements (TEs) and genes contribute to a better understanding of colorectal cancer
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9602.* Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study
Occupational And Environmental Medicine. 2022. DOI : 10.1136/oemed-2021-107924.2021
* S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity
Developmental Cell. 2021. DOI : 10.1016/j.devcel.2021.09.016.* A highly potent antibody effective against SARS-CoV-2 variants of concern
Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109814.* Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain
Genome Research. 2021. DOI : 10.1101/gr.275133.120.* A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
Science Translational Medicine. 2021. DOI : 10.1126/scitranslmed.abi8452.* Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
2021. DOI : 10.1158/1538-7445.AM2021-2853.* Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland
Nature Communications. 2021. DOI : 10.1038/s41467-021-23796-4.* Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies
Journal of Virology. 2021. DOI : 10.1128/JVI.01828-20.* Changes in SARS-CoV-2 Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies
Journal of Virology. 2021. DOI : 10.1128/jvi.01828-20.* KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-10621.2020
* The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity
iScience. 2020. DOI : 10.1016/j.isci.2020.101811.* Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression
Science Advances. 2020. DOI : 10.1126/sciadv.abc3020.* Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
Science Advances. 2020. DOI : 10.1126/sciadv.aba3200.* Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
The Lancet. 2020. DOI : 10.1016/S0140-6736(20)31304-0.* KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
eLife. 2020. DOI : 10.7554/eLife.56337.* Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Nature Communications. 2020. DOI : 10.1038/s41467-020-14968-9.* KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity
Philosophical Transactions of the Royal Society B: Biological Sciences. 2020. DOI : 10.1098/rstb.2019.0334.* HIV host genomics in the era of effective antiretroviral therapy
Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-10132.2019
* DUX is a non-essential synchronizer of zygotic genome activation
Development. 2019. DOI : 10.1242/dev.177725.* The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
The EMBO Journal. 2019. DOI : 10.15252/embj.2018101220.* KAP1 is an antiparallel dimer with a functional asymmetry
Life Science Alliance. 2019. DOI : 10.26508/lsa.201900349.* A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family
Journal of Molecular Biology. 2019. DOI : 10.1016/j.jmb.2019.05.002.* PAX5 as a model to study the evolution of transcription factors' regulatory networks
2019. p. 30S - 31S.* ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
Nature Communications. 2019. DOI : 10.1038/s41467-019-09803-9.* Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9388.* ZNF445 is a primary regulator of genomic imprinting
Genes & Development. 2019. DOI : 10.1101/gad.320069.118.2018
* Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
Mobile Dna. 2018. DOI : 10.1186/s13100-018-0138-z.* DPPA2 and DPPA4 regulate expression of Dux in mouse embryonic stem cells
2018. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A29 - A29.* Retroelements, their polydactyl controllers and the specificity of human biology
2018. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A6 - A7.* Transposable element-driven transcripts as new cancer biomarkers
2018. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A52 - A52.* KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks
2018. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, October 16-19, 2018. p. A150 - A150.* Evolutionarily recent transposable elements and their controllers regulate human early embryonic transcriptional networks
2018. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A25 - A25.* Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells
Epigenetics & Chromatin. 2018. DOI : 10.1186/s13072-018-0177-1.2017
* DUX-family transcription factors regulate zygotic genome activation in placental mammals
Nature Genetics. 2017. DOI : 10.1038/ng.3858.* Polyphenic trait promotes liver cancer in a model of epigenetic instability
Hepatology. 2017. DOI : 10.1002/hep.29182.* KRAB zinc finger proteins
Development. 2017. DOI : 10.1242/dev.132605.* SMiLE-seq identifies binding motifs of single and dimeric transcription factors
Nature methods. 2017. DOI : 10.1038/nmeth.4143.* Genomic targets and molecular partners of the chromatin regulator KAP1
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7373.* A KRABsody for Embryo-Placental Development
Developmental Cell. 2017. DOI : 10.1016/j.devcel.2017.06.005.* KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks
Nature. 2017. DOI : 10.1038/nature21683.* KRAB'n'KAP, DNA methylation and epigenetic memory
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8070.* The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units
PLoS One. 2017. DOI : 10.1371/journal.pone.0173746.2016
* Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues
Developmental Cell. 2016. DOI : 10.1016/j.devcel.2016.02.024.* Switzerland and the Digital Health Revolution
Chimia. 2016. DOI : 10.2533/chimia.2016.851.* The evolution of gene expression and binding specificity of the largest transcription factor family in primates
Evolution. 2016. DOI : 10.1111/evo.12819.* Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7020.* Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks
Cold Spring Harbor symposia on quantitative biology. 2016. DOI : 10.1101/sqb.2015.80.027573.* A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression
Methods in molecular biology (Clifton, N.J.). 2016. DOI : 10.1007/978-1-4939-3372-3_25.* Molecular Criteria for Defining the Naive Human Pluripotent State
Cell stem cell. 2016. DOI : 10.1016/j.stem.2016.06.011.* Lentiviral vectors, two decades later
Science. 2016. DOI : 10.1126/science.aah6192.2015
* TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
Cell Reports. 2015. DOI : 10.1016/j.celrep.2014.12.004.* Evolutionally dynamic control of LINE-1 elements in embryonic stem cells
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6511.* Drawing a fine line on endogenous retroelement activity
Mobile genetic elements. 2015. DOI : 10.1080/2159256X.2015.1006109.* Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
eLife. 2015. DOI : 10.7554/eLife.06068.* The Developmental Control of Transposable Elements and the Evolution of Higher Species
Annual review of cell and developmental biology. 2015. DOI : 10.1146/annurev-cellbio-100814-125514.* Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages
EMBO Reports. 2015. DOI : 10.15252/embr.201540162.* Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease
2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S115 - S116.* Dual-regulated lentiviral vector for gene therapy of x-linked chronic granulomatous disease
2015. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy (ESGCT) and Finnish-Society-of-Gene-Therapy (FSGT), Helsinki, FINLAND, SEP 17-20, 2015. p. A51 - A51.* Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6842.* A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation
Genes & Development. 2015. DOI : 10.1101/gad.254532.114.* Potential Of Induced Pluripotent Stem Cells For The Treatment Of Crigler-Najjar Liver Disease
2015. 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Vienna, AUSTRIA, APR 22-26, 2015. p. S818 - S818. DOI : 10.1016/S0168-8278(15)31427-6.2014
* Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
Genome research. 2014. DOI : 10.1101/gr.172833.114.* Evolutionally dynamic L1 regulation in embryonic stem cells
Genes & Development. 2014. DOI : 10.1101/gad.241661.114.* As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements
Developmental Cell. 2014. DOI : 10.1016/j.devcel.2014.10.019.* Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency
Genome research. 2014. DOI : 10.1101/gr.172809.114.* Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease
2014. 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, MAY 21-24, 2014. p. S261 - S261.* Transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in pluripotent stem cells
2014. ESGCT and NVGCT Collaborative Congress, The Hague, NETHERLANDS, OCT 23-26, 2014. p. A11 - A11.* Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis
Molecular Therapy. 2014. DOI : 10.1038/mt.2014.87.* Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network
Elife. 2014. DOI : 10.7554/eLife.03346.* Dual-Regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatous Disease
2014. ESGCT and NVGCT Collaborative Congress, The Hague, NETHERLANDS, OCT 23-26, 2014. p. A26 - A26.* Control of mitophagie by microRNAs - A key step of erythropoiesis
M S-Medecine Sciences. 2014. DOI : 10.1051/medsci/20143001003.2013
* A switch between topological domains underlies HoxD genes collinearity in mouse limbs
Science. 2013. DOI : 10.1126/science.1234167.* A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy
Science. 2013. DOI : 10.1126/science.1232398.* Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
Transl Psychiatry. 2013. DOI : 10.1038/tp.2012.144.* De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET
Development. 2013. DOI : 10.1242/dev.087585.* TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Genome research. 2013. DOI : 10.1101/gr.147678.112.* VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy
American Journal Of Pathology. 2013. DOI : 10.1016/j.ajpath.2013.07.031.* Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G
Journal of Virology. 2013. DOI : 10.1128/JVI.03385-12.* Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells
PloS One. 2013. DOI : 10.1371/journal.pone.0056721.2012
* The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation
Molecular cancer research : MCR. 2012. DOI : 10.1158/1541-7786.MCR-11-0134.* Gene therapy: too much splice can spoil the dish
The Journal of clinical investigation. 2012. DOI : 10.1172/JCI63066.* KAP1 regulates gene networks controlling T-cell development and responsiveness
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012. DOI : 10.1096/fj.12-206177.* The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo
Journal of Biological Chemistry. 2012. DOI : 10.1074/jbc.M112.350884.* KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function
Blood. 2012. DOI : 10.1182/blood-2011-12-401117.* MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. DOI : 10.1523/JNEUROSCI.0558-12.2012.* Embryonic stem cell potency fluctuates with endogenous retrovirus activity
Nature. 2012. DOI : 10.1038/nature11244.* KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5436.* The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development
Cell Reports. 2012. DOI : 10.1016/j.celrep.2012.08.043.* Regulated Lentiviral Vector Gene Transfer For X-Cgd
2012. 15th Biennial Meeting European-Society-for-Immunodeficiency (ESID), Florence, ITALY, OCT 03-06, 2012. p. 126 - 127.* Regulated lentiviral vector gene transfer for X-CGD
2012. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Versailles, FRANCE, OCT 25-29, 2012. p. A52 - A52.* Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma
Hepatology. 2012. DOI : 10.1002/hep.25767.2011
* Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences
PloS One. 2011. DOI : 10.1371/journal.pone.0017634.* A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing
BMC genomics. 2011. DOI : 10.1186/1471-2164-12-378.* Measuring In Vivo Protein Half-Life
Chemistry & Biology. 2011. DOI : 10.1016/j.chembiol.2011.03.014.* A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice
Blood. 2011. DOI : 10.1182/blood-2011-04-346619.* 3D-structure of the immunoblobulin heavy chain locus
2011* In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions
Molecular Cell. 2011. DOI : 10.1016/j.molcel.2011.08.032.* Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease
Gene therapy. 2011. DOI : 10.1038/gt.2011.65.* Dynamic control of endogenous retroviruses during development
Virology. 2011. DOI : 10.1016/j.virol.2010.12.007.* In Vivo Studies on the Control of Gene Expression and Protein Degradation
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5119.* Lentiviral Vector Mediated Transgenesis
Current Protocols in Mouse Biology 1. 2011. DOI : 10.1002/9780470942390.mo100169.* Studies on KRAB/KAP1-Mediated Transcriptional Repression
Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-4972.* Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells
Cell host & microbe. 2011. DOI : 10.1016/j.chom.2011.03.001.* Genomic instability in induced stem cells
Cell death and differentiation. 2011. DOI : 10.1038/cdd.2011.9.2010
* The specificity of TRIM5{alpha}-mediated restriction is influenced by its coiled-coil domain
Journal of Virology. 2010. DOI : 10.1128/JVI.02413-09.* Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction
Journal of Biological Chemistry. 2010. DOI : 10.1074/jbc.M110.187609.* Innate Barriers to Genome Invasion : how TRIM5a Restricts Retroelements
Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4630.* Genomic Context and KRAB/KAP1-mediated Transcriptional Repression
Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4678.* Production and titration of lentiviral vectors
Current protocols in neuroscience; John Wiley & Sons, 2010.* KRAB-Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000869.* Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities
Journal of Virology. 2010. DOI : 10.1128/JVI.01651-10.* A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the olig1 and olig2 locus
PloS One. 2010. DOI : 10.1371/journal.pone.0015741.* Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa
Science. 2010. DOI : 10.1126/science.1190897.* Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo
Stem cells (Dayton, Ohio). 2010. DOI : 10.1002/stem.460.* HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals
Science. 2010. DOI : 10.1126/science.1191047.* The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites
Lausanne, EPFL, 2010. DOI : 10.5075/epfl-thesis-4759.* KAP1 controls endogenous retroviruses in embryonic stem cells
Nature. 2010. DOI : 10.1038/nature08674.2009
* Studies on lentiviral-mediated transgenesis
Lausanne, EPFL, 2009. DOI : 10.5075/epfl-thesis-4281.* Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications
Journal of Virology. 2009. DOI : 10.1128/JVI.00001-09.* Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates
Molecular therapy : the journal of the American Society of Gene Therapy. 2009. DOI : 10.1038/mt.2009.143.* Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition
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Doctorant·es actuel·les
A dirigé les thèses EPFL de
Stéphanie Jost, Marc-Olivier Sauvain, Pierre Maillard, Yannick Bulliard, Sylvain Meylan, Anna Claire Groner, Andrea Corsinotti, Nathaly Castro Diaz, Flavia Marzetta, Gabriela Ecco, Annamaria Kauzlaric, Andrea Coluccio, Pierre-Yves Helleboid, Alexandra Iouranova, Jonas De Tribolet-Hardy, Eunji Shin, Alexandre Coudray, Filipe Martins, Cyril Pulver, Danica Milovanovic
A co-dirigé les thèses EPFL de
Karolina Bojkowska, Guillaume Andrey, Christian Axel Wandall Thorball