Fields of expertise
- Tissue Engineering
MissionThe Laboratory of Biomechanical Orthopedics (LBO) is dedicated to the advancement of techniques and technology for patient care in the musculo-skeletal system, through fundamental research, applied research, and teaching
Current workThrough biomechanical considerations, Dominique Pioletti's research focus on tissue engineering applications for bone, cartilage and nucleus pulpous. In parallel, new drug delivery solutions for musculo-skeletal tissues are also developed by using mechanical loading as a trigger stimulus for the delivery of drugs.
BiographyDominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics.? His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone;? development of orthopedic implant as drug delivery system?. Since 2013, he has been promoted to the rank of Associate Professor.
Journal paper and review
Feasibility of an alternative method to estimate glenohumeral joint center from videogrammetry measurements and CT/MRI of patientsComputer Methods In Biomechanics And Biomedical Engineering. 2020-08-25. DOI : 10.1080/10255842.2020.1808889.
Hybrid granular hydrogels: combining composites and microgels for extended ranges of material propertiesSoft Matter. 2020-04-21. DOI : 10.1039/d0sm00213e.
In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial AneurysmsFrontiers In Bioengineering And Biotechnology. 2020-04-03. DOI : 10.3389/fbioe.2020.00261.
Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush CoatingsBiomacromolecules. 2020-01-01. DOI : 10.1021/acs.biomac.9b01196.
Control of Dissipation Sources: A Central Aspect for Enhancing the Mechanical and Mechanobiological Performances of HydrogelsACS Applied Materials & Interfaces. 2019-10-30. DOI : 10.1021/acsami.9b15450.
Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis PreventionACS Biomaterials Science & Engineering. 2019-10-01. DOI : 10.1021/acsbiomaterials.9b01041.
Patellar bone strain after total knee arthroplasty is correlated with bone mineral density and body mass indexMedical Engineering & Physics. 2019. DOI : 10.1016/j.medengphy.2019.03.017.
Composite Double-Network Hydrogels To Improve Adhesion on Biological SurfacesACS Applied Materials & Interfaces. 2018. DOI : 10.1021/acsami.8b10735.
Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem CellsSTEM CELLS. 2018. DOI : 10.1002/stem.2765.
Effect of a collar on subsidence and local micromotion of cementless femoral stems: in vitro comparative study based on micro-computerised tomographyInternational Orthopaedics. 2018. DOI : 10.1007/s00264-017-3524-0.
A simulation framework for humeral head translationsMedical Engineering and Physics. 2017. DOI : 10.1016/j.medengphy.2017.08.013.
Energy dissipation as a mechanobiological variable inducing chondrogenesisJournal Of Tissue Engineering And Regenerative Medicine. 2014.
Cartilage self-heating contributes to chondrogenic expressionEuropean Cells and Materials. 2013.
Response to Letter to the Editor: Comment on "injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies"Journal Of Biomechanics. 2013. DOI : 10.1016/j.jbiomech.2012.09.024.
Regulation of proliferation and differentiation of human fetal bone cellsEuropean Cells and Materials. 2011.
Calcium phosphate augmentation of cancellous bone screws in impaired lapine bone (vol 40, pg S23, 2009)Injury-International Journal Of The Care Of The Injured. 2010. DOI : 10.1016/j.injury.2009.09.026.
The skeletal keyPublic Service Review: Science and Technology. 2010.
From bench to bedsideEPC Drug Discovery, Delivery & Therapeutics. 2010.
In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffoldsEuropean Cells and Materials. 2010.
3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurementsComputer Methods In Biomechanics And Biomedical Engineering. 2009. DOI : 10.1080/10255840802178053.
Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot studye Cells and Materials. 2008.
Orthopedic implant used as drug delivery system: clinical situation and state of the researchCurrent Drug Delivery. 2008.
Consistency of fetal cell banks for research and clinical useCell Transplantation. 2007.
Polylactic Acid–Phosphate Glass Composite Foams as Scaffolds for Bone Tissue EngineeringJournal of Biomedical Materials Research Part B. 2006.
Bone tissue engineering using fetal cell therapySwiss Medical Weekly. 2006.
Total joint replacement and aseptic looseningHelix Review Series Rheumatology. 2006.
The effect of bisphosphonates and titanium particles on osteoblasts: an in vitro studyJ Bone Joint Surg Br. 2005.
Bioresorbable composites prepared by supercritical fluid foamingJournal of Biomedical Materials Research Part A. 2005. DOI : 10.1002/jbm.a.30385.
Effect of different Ti-6Al-4V surface treatments on osteoblasts behaviourBiomaterials. 2002.
Large-scale gene expression analysis of osteoblasts cultured on three different Ti-6Al-4V surface treatmentsBiomaterials. 2002.
Orthopedic implant used as a drug delivery system: a numerical studyComputer Methods in Biomechanics and Biomedical Engineering. 2001.
Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cellsJ Biomed Mater Res. 2000.
Non-linear viscoelastic laws for soft biological tissuesEuropean Journal of Mechanics a-Solids. 2000.
Titanium particles inhibit osteoblast adhesion to fibronectin-coated substratesJ Orthopaed Res. 2000. DOI : 10.1002/jor.1100180207.
Displacements of the tibial tuberosity - Effects of the surgical parametersClinical Orthopaedics and Related Research. 1997.
[Kinematics and continuous elongation of the anterior cruciate ligament]Rev Med Suisse Romande. 1994.
Teaching & PhD