Domaines de compétences
Protein Production
Parcours professionnel
Head of Protein Crystallography Core Facility
SV-EPFL
2011-2017
Staff scientist
Chair of Microbial Pathogenesis, Prof. Stewart Cole
EPFL
2007-2018
Post-doc
Structural Biology lab, Prof. Joseph Noel
The Salk Institute (La Jolla, USA)
2004-2007
Formation
PhD thesis
Antibiotic research
Tuebingen (Germany)
1999-2003
Pharm D
Pharmacy School
Besancon (France)
1992-1998
Publications
Publications Infoscience
A highly potent antibody effective against SARS-CoV-2 variants of concern C. Fenwick ; P. Turelli ; L. Perez ; C. Pellaton ; L. Esteves-Leuenberger
et al.
Cell Reports . 2021-10-12 . DOI : 10.1016/j.celrep.2021.109814. A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma C. Fenwick ; P. Turelli ; C. Pellaton ; A. Farina ; J. Campos
et al.
Science Translational Medicine . 2021-08-04 . DOI : 10.1126/scitranslmed.abi8452. A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response D. Lainšček ; T. Fink ; V. Forstnerič ; I. Hafner-Bratkovič ; S. Orehek
et al.
Vaccines . 2021-04-27 . DOI : 10.3390/vaccines9050431. Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains L. Abrami ; M. Audagnotto ; S. Ho ; M. J. Marcaida ; F. S. Mesquita
et al.
Nature Chemical Biology . 2021-04-01 . DOI : 10.1038/s41589-021-00753-2. Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors U. F. Rohrig ; S. R. Majjigapu ; A. Reynaud ; F. Pojer ; N. Dilek
et al.
Journal Of Medicinal Chemistry . 2021-02-25 . DOI : 10.1021/acs.jmedchem.0c01968. Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies C. Fenwick ; A. Croxatto ; A. T. Coste ; F. Pojer ; C. Andre
et al.
Journal Of Virology . 2021-02-01 . DOI : 10.1128/JVI.01828-20. Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein D. Ni ; K. Lau ; F. Lehmann ; A. Fränkl ; D. Hacker
et al.
bioRxiv . 2020-10-12 . DOI : 10.1101/2020.10.12.336016. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains G. La Sala ; C. Michiels ; T. Kuekenshoener ; T. Brandstoetter ; B. Maurer
et al.
Nature Communications . 2020-08-17 . DOI : 10.1038/s41467-020-17920-z. High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis J. Piton ; F. Pojer ; S. Wakatsuki ; C. Gati ; S. Cole
Journal of Structural Biology: X . 2020-07-02 . DOI : 10.1016/j.yjsbx.2020.100029. De novo development of proteolytically resistant therapeutic peptides for oral administration X.-D. Kong ; J. Moriya ; V. Carle ; F. Pojer ; L. A. Abriata
et al.
Nature Biomedical Engineering . 2020-05-11 . DOI : 10.1038/s41551-020-0556-3. Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms D. P. Duarte ; A. J. Lamontanara ; G. La Sala ; S. Jeong ; Y.-K. Sohn
et al.
Nature Communications . 2020-05-08 . DOI : 10.1038/s41467-020-16128-5. Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1) U. F. Rohrig ; A. Reynaud ; S. R. Majjigapu ; P. Vogel ; F. Pojer
et al.
Journal Of Medicinal Chemistry . 2019-10-10 . DOI : 10.1021/acs.jmedchem.9b00942. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase S. Reckel ; C. Gehin ; D. Tardivon ; S. Georgeon ; T. Kukenshoner
et al.
Nature Communications . 2017 . DOI : 10.1038/s41467-017-02313-6. Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies T. Kükenshöner ; N. E. Schmit ; E. Bouda ; F. Sha ; F. Pojer
et al.
Journal of Molecular Biology . 2017 . DOI : 10.1016/j.jmb.2017.03.023. A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria P. Murima ; M. Zimmermann ; T. Chopra ; F. Pojer ; G. Fonti
et al.
Nature Communications . 2016 . DOI : 10.1038/ncomms12527. Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-beta-D-ribose 2 '-oxidase S. Landge ; A. B. Mullick ; K. Nagalapur ; J. Neres ; V. Subbulakshmi
et al.
Bioorganic & Medicinal Chemistry . 2015 . DOI : 10.1016/j.bmc.2015.11.017. Lansoprazole is an antituberculous prodrug targeting cytochrome bc1 J. Rybniker ; A. Vocat ; C. Sala ; P. Busso ; F. Pojer
et al.
Nature Communications . 2015 . DOI : 10.1038/ncomms8659. Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis N. Korotkova ; J. Piton ; J. M. Wagner ; S. Boy-Roettger ; A. Japaridze
et al.
Journal Of Structural Biology . 2015 . DOI : 10.1016/j.jsb.2015.06.003. 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 J. Neres ; R. C. Hartkoorn ; L. R. Chiarelli ; R. Gadupudi ; M. R. Pasca
et al.
Acs Chemical Biology . 2015 . DOI : 10.1021/cb5007163. Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination S. Martins ; E. M. N. Dohmann ; A. Cayrel ; A. Johnson ; W. Fischer
et al.
Nature Communications . 2015 . DOI : 10.1038/ncomms7151. The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors P. D. Townsend ; B. Jungwirth ; F. Pojer ; M. Bussmann ; V. A. Money
et al.
Plos One . 2014 . DOI : 10.1371/journal.pone.0113265. Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides S. Chen ; R. Gopalakrishnan ; T. Schaer ; F. Marger ; R. Hovius
et al.
Nature Chemistry . 2014 . DOI : 10.1038/nchem.2043. The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron sulfur cluster biogenesis and oxidative stress defence J. Rybniker ; F. Pojer ; J. Marienhagen ; G. S. Kolly ; J. M. Chen
et al.
Biochemical Journal . 2014 . DOI : 10.1042/Bj20130732. Functional Dissection of Intersubunit Interactions in the EspR Virulence Regulator of Mycobacterium tuberculosis B. Blasco ; A. Japaridze ; M. Stenta ; B. I. M. Wicky ; G. Dietler
et al.
Journal Of Bacteriology . 2014 . DOI : 10.1128/Jb.00039-1. Towards a new combination therapy for tuberculosis with next generation benzothiazinones V. Makarov ; B. Lechartier ; M. Zhang ; J. de Almeida Neres ; J. Pedro
et al.
Embo Molecular Medicine . 2014 . DOI : 10.1002/emmm.201303575. Pyridomycin bridges the NADH- and substratebinding pockets of the enoyl reductase InhA R. C. Hartkoorn ; F. Pojer ; J. A. Read ; H. Gingell ; J. Neres
et al.
Nature Chemical Biology . 2014 . DOI : 10.1038/nchembio.1405. Peptide ligands stabilized by small molecules S. Chen ; D. Bertoldo ; A. Angelini ; F. Pojer ; C. Heinis
Angewandte Chemie (International ed. in English) . 2014 . DOI : 10.1002/anie.201309459. Structure and Function of Essential Components of Contractile Injection Systems S. Buth
Lausanne , EPFL , 2014 . DOI : 10.5075/epfl-thesis-5939. Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence J. M. Chen ; M. Zhang ; J. Rybniker ; L. Basterra ; N. Dhar
et al.
Journal Of Bacteriology . 2013 . DOI : 10.1128/Jb.00967-13. Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence J. M. Chen ; M. Zhang ; J. Rybniker ; S. Boy-Röttger ; N. Dhar
et al.
Molecular Microbiology . 2013 . DOI : 10.1111/mmi.12336. Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs H. Haruki ; M. G. Pedersen ; K. I. Gorska ; F. Pojer ; K. Johnsson
Science . 2013 . DOI : 10.1126/science.1232972. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis J. Neres ; F. Pojer ; E. Molteni ; L. R. Chiarelli ; N. Dhar
et al.
Science Translational Medicine . 2012 . DOI : 10.1126/scitranslmed.3004395. Towards a new tuberculosis drug: pyridomycin - nature's isoniazid R. C. Hartkoorn ; C. Sala ; J. Neres ; F. Pojer ; S. Magnet
et al.
Embo Molecular Medicine . 2012 . DOI : 10.1002/emmm.201201689. Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket F. El-Turk ; B. Fauvet ; A. Ashrafi ; H. Ouertatani-Sakouhi ; M.-K. Cho
et al.
PLoS ONE . 2012 . DOI : 10.1371/journal.pone.0045024. Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein B. Blasco ; J. M. Chen ; R. Hartkoorn ; C. Sala ; S. Uplekar
et al.
Plos Pathogens . 2012 . DOI : 10.1371/journal.ppat.1002621. Directed evolution of the suicide protein O⁶-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability B. Mollwitz ; E. Brunk ; S. Schmitt ; F. Pojer ; M. Bannwarth
et al.
Biochemistry . 2012 . DOI : 10.1021/bi2016537. Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme E. Fullam ; F. Pojer ; T. Bergfors ; T. A. Jones ; S. T. Cole
Open Biology . 2012 . DOI : 10.1098/rsob.110026. Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β- C. Trefzer ; H. Škovierová ; S. Buroni ; A. Bobovská ; S. Nenci
et al.
Journal of the American Chemical Society . 2012 . DOI : 10.1021/ja211042r. EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis J. M. Chen ; S. Boy-Röttger ; N. Dhar ; N. Sweeney ; R. S. Buxton
et al.
Journal of bacteriology . 2011 . DOI : 10.1128/JB.06417-11. Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis B. Blasco ; M. Stenta ; L. Alonso-Sarduy ; G. Dietler ; M. Dal Peraro
et al.
Molecular Microbiology . 2011 . DOI : 10.1111/j.1365-2958.2011.07813.x. Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis J. M. Chen ; F. Pojer ; B. Blasco ; S. T. Cole
Drug Discovery Today: Disease Mechanisms . 2010 . DOI : 10.1016/j.ddmec.2010.09.002. Sigma Factor F does not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis R. C. Hartkoorn ; C. Sala ; S. J. Magnet ; J. M. Chen ; F. Pojer
et al.
Journal of bacteriology . 2010 . DOI : 10.1128/JB.00687-10. A finite element model of the LHC dipole cold mass with hysteretic, non-linear behavior and single turn description M. Pojer
Lausanne , EPFL , 2009 . DOI : 10.5075/epfl-thesis-4259.
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Enseignement & Phd
Cours
Ce cours décrira les méthodes qui sont à la base des approches translationnelles depuis la génération et la caractérisation des modèles des maladies jusqu'aux applications thérapeutiques. Les bases théoriques seront complétées par des rotations pratiques dans les plateformes technologiques.
Les méthodologies à haut débit, appelées "Omiques", permettent de caractériser la complexité et la dynamique de tout système biologique. Ce cours fournira une description générale des méthodes liées au domaine des "Omiques", suivie de rotations pratiques dans les plateformes participantes.
