Henry Markram

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

S. Farina; A. Cattabiani; D. Mandge; P. Shichkova; J. B. Isbister  et al.

Seizure and redox rescue in a model of glucose transport deficiency

J. S. Coggan; P. Shichkova; H. Markram; D. Keller

Computational Generation of Long-range Axonal Morphologies

A. Berchet; R. Petkantchin; H. Markram; L. Kanari

Principles of inter-areal interactions in cortical sensory processing

S. Bolaños Puchet / H. Markram; M. Reimann (Dir.)

Cell density quantification of high resolution Nissl images of the juvenile rat brain

J. Meystre; J. Jacquemier; O. Burri; C. Zsolnai; N. Frank  et al.

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

M. Reimann; S. Bolaños Puchet; J.-D. Courcol; D. Egas Santander; A. Arnaudon  et al.

Modeling of blood flow dynamics in the rat somatosensory cortex

S. Battini; N. Cantarutti; C. Kotsalos; Y. Roussel; A. Cattabiani  et al.

Sex dimorphism in rodent brain responses to ketogenic diets: A comparative study

C. Lorin; H. Markram; M. Garcia; G. O. Diaceri; E. Logette  et al.

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

J. B. Isbister; A. Ecker; C. Pokorny; S. Bolaños Puchet; D. Egas Santander  et al.

An extended and improved CCFv3 annotation and Nissl atlas of the entire mouse brain

S. Piluso; C. Verasztó; H. Carey; E. Delattre; T. L’Yvonnet  et al.

Simplification of spiking neural network models

H. Markram; W. Gerstner; M.-O. Gewaltig; C. A. Rossert; E. B. Muller  et al.

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus.

A. Romani; A. Antonietti; D. Bella; J. M. Budd; E. Giacalone  et al.

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes

P. Shichkova; J. Coggan; H. Markram; D. Keller

Generating brain-wide connectome using synthetic axonal morphologies

R. Petkantchin; A. Berchet; H. Peng; H. Markram; L. Kanari

Deep learning for classifying neuronal morphologies: combining topological data analysis and graph neural networks

L. Kanari; S. Schmidt; F. Casalegno; E. Delattre; J. Banjac  et al.

BlueCelluLab: Biologically Detailed Neural Network Experimentation API

M. A. Tuncel; M. Gevaert; W. Van Geit; B. Torben-Nielsen; D. Mandge  et al.

Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex

C. Lorin; R. Guiet; N. Chiaruttini; G. Ambrosini; E. Boci  et al.

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

M. Abatis; R. Perin; R. Niu; E. van den Burg; C. Hegoburu  et al.

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

A. P. Buccino; T. Damart; J. Bartram; D. Mandge; X. Xue  et al.

Of mice and men: Increased dendritic complexity gives rise to unique human networks

L. Kanari; Y. Shi; A. Arnaudon; N. Barros Zulaica; R. Benavides-Piccione  et al.

Coupled Electromagnetic-Electrophysiological Modeling of Neural Circuits

J. Tharayil / H. Markram; E. Neufeld (Dir.)

A universal workflow for creation, validation and generalization of detailed neuronal models

M. Reva; C. Rössert; A. Arnaudon; T. Damart; D. Mandge  et al.

Controlling morpho-electrophysiological variability of neurons with detailed models

A. Arnaudon; M. Reva; M. M. Zbili; H. Markram; W. Van Geit  et al.

Cell-type-specific densities in mouse somatosensory cortex derived from scRNA-seq and in situ RNA hybridization

D. Keller; C. Veraszto; H. Markram

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

P. Shichkova / H. Markram; D. Keller (Dir.)

Principles of Network Plasticity in Neocortical Microcircuits

A. Ecker / H. Markram; M. Reimann (Dir.)

Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons

Y. Roussel; C. Veraszto; D. Rodarie; T. Damart; M. Reimann  et al.

A theory of memory consolidation and synaptic pruning in cortical circuits

G. Iatropoulos / H. Markram; W. Gerstner (Dir.)

Blue Brain Nexus: An open, secure, scalable system for knowledge graph management and data-driven science

M. F. Sy; B. Roman; S. Kerrien; D. Montero Mendez; H. Genet  et al.

Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience

M. Abdellah; J. J. G. Cantero; N. R. Guerrero; A. Foni; J. S. Coggan  et al.

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

E. Iavarone; J. Simko; Y. Shi; M. L. Bertschy; M. García-Amado  et al.

Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord

I. Kuras / H. Markram; M.-O. Gewaltig (Dir.)

Simulating Temporal Interference Stimulation

J. Tharayil; M. Reimann; E. Neufeld; F. Schurmann; H. Markram

Breakdown and rejuvenation of aging brain energy metabolism

P. Shichkova; J. S. Coggan; E. Boci; C. P. H. Favreau; S. M. Antonel  et al.

Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease

N. Rosenberg; M. Reva; F. Binda; L. Restivo; P. Depierre  et al.

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

D. Rodarie; C. Veraszto; Y. Roussel; M. Reimann; D. Keller  et al.

Neuromodulatory organization in the developing rat somatosensory cortex

C. Colangelo; A. Muñoz; A. Antonietti; A. Antón-Fernández; A. Romani  et al.

Optimum trajectory learning in musculoskeletal systems with model predictive control and deep reinforcement learning

B. Denizdurduran; H. Markram; M.-O. Gewaltig

Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

S. Hunt; Y. Leibner; E. J. Mertens; N. Barros-Zulaica; L. Kanari  et al.

A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex

G. Chindemi; M. Abdellah; O. Amsalem; R. Benavides-Piccione; V. Delattre  et al.

Representing stimulus information in an energy metabolism pathway

J. S. Coggan; D. Keller; H. Markram; F. Schurmann; P. J. Magistretti

Computational synthesis of cortical dendritic morphologies

L. Kanari; H. Dictus; A. Chalimourda; A. Arnaudon; W. Van Geit  et al.

Neuromodulation of neocortical microcircuitry: a multi-scale framework to model the effects of cholinergic release

C. Colangelo / H. Markram; S. Ramaswamy (Dir.)

Data-driven whole mouse brain modeling for multi-scale simulations

D. B. M. Rodarie / H. Markram; M.-O. Gewaltig (Dir.)

Reconstruction of the Hippocampus

A. Romani; F. Schürmann; H. Markram; M. Migliore

Extracellular stimulation and Local Field Potential recording in a L5 PC model with full axonal arbor

J. Tharayil; M. Zbili; A. Arnaudon; W. Van Geit; E. Neufeld  et al.

Building somatosensory cortex neuron models using a workflow for the creation, validation and generalization of biophysically detailed cell models

M. Reva; C. Roessert; D. Mandge; A. Arnaudon; T. Damart  et al.

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

E. Zisis; D. Keller; L. Kanari; A. Arnaudon; M. Gevaert  et al.

Computational modelling of a mouse layer 5 pyramidal neuron using genetic ion channels

D. Mandge; Y. Roussel; S. van Dorp; T. Damart; D. Keller  et al.

A Standardized Brain Molecular Atlas: A Resource for Systems Modeling and Simulation

P. Shichkova; J. S. Coggan; H. Markram; D. Keller

Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus

J. Simko; H. Markram

The Role of Hub Neurons in Modulating Cortical Dynamics

E. Gal; O. Amsalem; A. Schindel; M. London; F. Schuermann  et al.

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas

J. Krepl; F. Casalegno; E. Delattre; C. Ero; H. Lu  et al.

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

E. Logette; C. Lorin; C. Favreau; E. Oshurko; J. S. Coggan  et al.

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

M. Abdellah; A. Foni; E. Zisis; N. R. Guerrero; S. Lapere  et al.

In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations

T. H. Newton; M. W. Reimann; M. Abdellah; G. Chevtchenko; E. B. Muller  et al.

ARC: An Open Web-Platform for Request/Supply Matching for a Prioritized and Controlled COVID-19 Response

J.-D. Courcol; C. F. Invernizzi; Z. C. Landry; M. Minisini; D. A. Baumgartner  et al.

Synthesis of branching morphologies

L. Kanari; K. P. Bellwald; H. Markram

Structural architecture of the Neuronal-Glial-Vascular system

E. Zisis / H. Markram; D. Keller (Dir.)

Thalamic microcircuitry: neurons, synapses, and circuit motifs in receptive field structure and sensory processing

J. Yi / H. Markram; S. L. Hill (Dir.)

Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis

M. Abdellah; N. R. Guerrero; S. Lapere; J. S. Coggan; D. Keller  et al.

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

J. S. Coggan; D. Keller; H. Markram; F. Schurmann; P. J. Magistretti

A Kinetic Map of the Homomeric Voltage-gated Potassium Channel (Kv) Family

R. Ranjan; E. Logette; M. Marani; M. Herzog; V. Tache  et al.

Neuron Geometry Underlies Universal Network Features in Cortical Microcircuits

E. Gal; R. Perin; H. Markram; M. London; I. Segev

Data driven building of realistic neuron model using IBEA and CMA evolution strategies

T. P. L. Damart; W. Van Geit; H. Markram

Impact of higher order network structure on emergent cortical activity

M. Nolte; E. Gal; H. Markram; M. W. Reimann

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

N. Barros-Zulaica; J. Rahmon; G. Chindemi; R. Perin; H. Markram  et al.

A null model of the mouse whole-neocortex micro-connectome

M. W. Reimann; M. Geyaert; Y. Shi; H. Lu; H. Markram  et al.

Caries Detection with Near-Infrared Transillumination Using Deep Learning

F. Casalegno; T. Newton; R. Daher; M. Abdelaziz; A. Lodi-Rizzini  et al.

Cortical reliability amid noise and chaos

M. Nolte; M. W. Reimann; J. G. King; H. Markram; E. B. Muller

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

R. Ranjan; E. Logette; M. Marani; M. Herzog; V. Tache  et al.

A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex

D. Keller; J. Meystre; R. V. Veettil; O. Burri; R. Guiet  et al.

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

E. Iavarone; J. Yi; Y. Shi; B.-J. Zandt; C. O'Reilly  et al.

A Brief History of Simulation Neuroscience

X. Fan; H. Markram

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

C. Colangelo; P. Shichkova; D. Keller; H. Markram; S. Ramaswamy

Objective Morphological Classification of Neocortical Pyramidal Cells

L. Kanari; S. Ramaswamy; Y. Shi; S. Morand; J. Meystre  et al.

Individual differences in sensory sensitivity: Further lessons from an Autism model

M. R. Favre; H. Markram; K. Markram

Corrigendum: A Cell Atlas for the Mouse Brain

C. Ero; M.-O. Gewaltig; D. Keller; H. Markram

In Silico Voltage-Sensitive Dye Imaging: A Model-Based Approach for Bridging Scales of Cortical Activity

T. H. Newton / H. Markram (Dir.)

Reverse engineering the motor control system

B. Denizdurduran / H. Markram; M.-O. Gewaltig (Dir.)

Untangling emergent cortical dynamics: neurons from networks, noise from chaos

M. C. Nolte / H. Markram; E. B. Muller (Dir.)

A Cell Atlas for the Mouse Brain

C. Eroe; M.-O. Gewaltig; D. Keller; H. Markram

Cell Densities in the Mouse Brain: A Systematic Review

D. Keller; C. Ero; H. Markram

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

S. Ramaswamy; C. Colangelo; H. Markram

A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble

J. S. Coggan; C. Cali; D. Keller; M. Agus; D. Boges  et al.

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

R. Migliore; C. A. Lupascu; L. L. Bologna; A. Romani; J.-D. Courcol  et al.

Generating and identifying functional subnetworks within structural networks

M. W. Reimann; M. C. Nolte; H. Markram; K. P. Hess Bellwald; R. Levi

Microcircuitry of the neocortex

S. Ramaswamy; E. B. Muller; M. Reimann; H. Markram

Neuronal morphologies: the shapes of thoughts

L. Kanari / H. Markram; J. C. Shillcock (Dir.)

Simplification of neural network models

H. Markram; W. Gerstner; M.-O. Gewaltig; C. Rössert; E. B. Muller  et al.

Data-driven reconstruction of a point neuron mouse brain

C. Erö / H. Markram; M.-O. Gewaltig (Dir.)

Towards a unified understanding of synaptic plasticity : parsimonious modeling and simulation of the glutamatergic synapse life-cycle

G. Chindemi / H. Markram; E. B. Muller (Dir.)

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

J. S. Coggan; D. Keller; C. Calì; H. Lehväslaiho; H. Markram  et al.

Reconstruction and simulation of neocortical microcircuitry

H. Markram; E. B. Muller; S. L. Hill; F. Schuermann

Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation

M. Abdellah; A. Bilgili; S. Eilemann; J. Shillcock; H. Markram  et al.

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function

M. W. Reimann; M. Nolte; M. Scolamiero; K. Turner; R. Perin  et al.

A Physically Plausible Model for Rendering Highly Scattering Fluorescent Participating Media

M. Abdellah; A. Bilgili; S. Eilemann; H. Markram; F. Schürmann

Modeling the metabolic response of astrocytes to neuronal activity

J. Coggan; D. Keller; C. Cal; H. Lehvaslaiho; F. Schurmann  et al.

Reconstruction and visualization of large-scale volumetric models of neocortical circuits for physically-plausible in silico optical studies

M. Abdellah; J. Hernando; N. Antille; S. Eilemann; H. Markram  et al.

Rich cell-type-specific network topology in neocortical microcircuitry

E. Gal; M. London; A. Globerson; S. Ramaswamy; M. W. Reimann  et al.

In Silico Brain Imaging Physically-plausible Methods for Visualizing Neocortical Microcircuitry

M. Abdellah / H. Markram; F. Schürmann (Dir.)

Using the Green's function to simplify and understand dendrites

W. A. M. Wybo / H. Markram; M.-O. Gewaltig (Dir.)

Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity

M. W. Reimann; A.-L. Horlemann; S. Ramaswamy; E. B. Muller; H. Markram

From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells

O. Amsalem; W. Van Geit; E. Muller; H. Markram; I. Segev

Agile in-litero experiments : how can semi-automated information extraction from neuroscientific literature help neuroscience model building?

R. L. Richardet / H. Markram; J.-C. Chappelier (Dir.)

Automated point-neuron simplification of data-driven microcircuit models

C. Rössert; C. Pozzorini; G. Chindemi; A. P. Davison; C. Eroe  et al.

Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors

J. V. Raimondo; H. Tomes; A. Irkle; L. Kay; L. Kellaway  et al.

Cell-type- and activity-dependent extracellular correlates of intracellular spiking

C. Anastassiou; R. d. C. Perin; G. Buzsaki; H. Markram; C. Koch

Network-timing-dependent plasticity

V. Delattre; D. Keller; M. Perich; H. Markram; E. B. Muller

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

S. Camacho; S. Michlig; C. De Senarclens-Bezencon; J. Meylan; J. Meystre  et al.

An algorithm to predict the connectome of neural microcircuits

M. W. Reimann; J. G. King; E. B. Muller; S. Ramaswamy; H. Markram

Reconstruction and Simulation of Neocortical Microcircuitry

H. Markram; E. Muller; S. Ramaswamy; M. W. Reimann; M. Abdellah  et al.

Large Volume Imaging of Rodent Brain Anatomy with Emphasis on Selective Plane Illumination Microscopy

J. P. Ghobril / H. Markram; F. S. Pavone (Dir.)

An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse

D. Keller; N. Babai; O. Kochubey; Y. Han; H. Markram  et al.

Structural to functional synaptic conversion

M. Reimann; H. Markram; F. Schürmann; E. B. Muller; S. Hill  et al.

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

S. Ramaswamy; H. Markram

Physically-based in silico light sheet microscopy for visualizing fluorescent brain models

M. Abdellah; A. Bilgili; S. Eilemann; H. Markram; F. Schürmann

A versatile clearing agent for multi-modal brain imaging

I. Costantini; J.-P. Ghobril; A. P. Di Giovanna; A. L. A. Mascaro; L. Silvestri  et al.

Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism

M. R. Favre; D. La Mendola; J. Meystre; D. Christodoulou; M. Cochrane  et al.

The future of human cerebral cartography: a novel approach

R. Frackowiak; H. Markram

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

S. Ramaswamy; J.-D. Courcol; M. Abdellah; S. R. Adaszewski; N. Antille  et al.

Scalable Exploration of Spatial Data in Large-Scale Scientific Simulations

F. Tauheed / A. Ailamaki; H. Markram (Dir.)

OCTOPUS: Efficient Query Execution on Dynamic Mesh Datasets

F. Tauheed; T. Heinis; F. Schürmann; H. Markram; A. Ailamaki

Visualizing the similarity and pedigree of NEURON ion channel models available on ModelDB

W. F. Podlaski; A. Seeholzer; R. Rajnish; T. Vogels

The death of Cajal and the end of scientific romanticism and individualism

J. Defelipe; E. Garrido; H. Markram

Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity

M. Toledo-Rodriguez; H. Markram

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

S. Muralidhar; Y. Wang; H. Markram

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

M. Pezzoli; A. Elhamdani; S. Camacho; J. Meystre; S. M. Gonzalez  et al.

The In-Silico Neocortical Microcircuit : From Structure to Dynamics

M. Reimann / H. Markram; S. Hill (Dir.)

Distributor of neurons in a neocortical column

G. Khazen; H. Markram; F. Schürmann; M. Telefont

Computing the size and number of neuronal clusters in local circuits

R. Perin; M. Telefont; H. Markram

Preserving axosomatic spiking features despite diverse dendritic morphology

E. Hay; F. Schuermann; H. Markram; I. Segev

Hyper-emotional neurophysiology in a rat model of autism

M. R. Favre / H. Markram; K. Markram (Dir.)

New insights into the classification and nomenclature of cortical GABAergic interneurons

J. Defelipe; P. L. Lopez-Cruz; R. Benavides-Piccione; C. Bielza; P. Larranaga  et al.

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

S. Druckmann; S. Hill; F. Schuermann; H. Markram; I. Segev

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro

V. Delattre; D. La Mendola; J. Meystre; H. Markram; K. Markram

A computer-assisted multi-electrode patch-clamp system

R. Perin; H. Markram

General developmental health in the VPA-rat model of autism

M. R. Favre; T. R. Barkat; D. Lamendola; G. Khazen; H. Markram  et al.

Synaptic and Cellular Organization of Layer 1 of the Developing Rat Somatosensory Cortex

S. Muralidhar / H. Markram (Dir.)

Seven challenges for neuroscience

H. Markram

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

M. W. Reimann; C. A. Anastassiou; R. Perin; S. L. Hill; H. Markram  et al.

Correction: Effective Stimuli for Constructing Reliable Neuron Models

S. Druckmann; T. K. Berger; F. Schuermann; S. Hill; H. Markram  et al.

Neuroscience thinks big (and collaboratively)

E. R. Kandel; H. Markram; P. M. Matthews; R. Yuste; C. Koch

Network Activity and Plasticity

V. Delattre / H. Markram (Dir.)

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

A. Loebel; J.-V. Le Be; M. J. E. Richardson; H. Markram; A. V. M. Herz

One minute with ... Henry Markram

J. Griggs; H. Markram

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

G. Khazen; S. L. Hill; F. Schürmann; H. Markram

Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections

S. Ramaswamy; S. L. Hill; J. G. King; F. Schürmann; Y. Wang  et al.

The neocortical column

J. DeFelipe; H. Markram; K. S. Rockland

A neuron membrane mesh representation for visualization of electrophysiological simulations

S. Lasserre; J. Hernando; S. Hill; F. Schürmann; P. d. M. Anasagasti  et al.

Short-term ionic plasticity at GABAergic synapses

J. V. Raimondo; H. Markram; C. J. Akerman

SCOUT: Prefetching for Latent Structure Following Queries

F. Tauheed; T. Heinis; F. Schürmann; H. Markram; A. Ailamaki

The human brain project

H. Markram

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

S. L. Hill; Y. Wang; I. Riachi; F. Schürmann; H. Markram

Spike-timing-dependent plasticity: a comprehensive overview

H. Markram; W. Gerstner; P. J. Sjöström

Frontiers research : seek, share & create

H. Markram; K. Markram

Augmenting cognition

Channelpedia: an integrative and interactive database for ion channels

R. Ranjan; G. Khazen; L. Gambazzi; S. Ramaswamy; S. L. Hill  et al.

Ephaptic coupling of cortical neurons

C. A. Anastassiou; R. Perin; H. Markram; C. Koch

Introducing the Human Brain Project

H. Markram; K. Meier; T. Lippert; S. Grillner; R. Frackowiak  et al.

Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex

S. Romand; Y. Wang; M. Toledo-Rodriguez; H. Markram

Engineering Neuron Models : from Ion Channels to Electrical Behavior

R. Ranjan / H. Markram (Dir.)

Effective Stimuli for Constructing Reliable Neuron Models

S. Druckmann; T. K. Berger; F. Schuermann; S. Hill; H. Markram  et al.

Innate neural assemblies for lego memory

H. Markram; R. Perin

A synaptic organizing principle for cortical neuronal groups

R. Perin; T. K. Berger; H. Markram

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

E. Hay; S. Hill; F. Schürmann; H. Markram; I. Segev

A history of spike-timing-dependent plasticity

H. Markram; W. Gerstner; P. J. Sjöström

Organizing neural networks

H. Markram; R. d. C. Perin; T. Berger

Encoding and decoding of information

H. Markram

A Pipeline Based Approach for Experimental Neuroscience Data Management

M. A. Jan / H. Markram; F. Schürmann (Dir.)

Predictive Engineering the Membrane Composition of Neocortical Neurons

G. Khazen / H. Markram (Dir.)

Emergent Properties of in silico Synaptic Transmission in a Model of the Rat Neocortical Column

S. Ramaswamy / H. Markram; S. L. Hill (Dir.)

Newsmaker interview: Heny Markram Blue Brain founder responds to critics, clarifies his goals

G. Miller; H. Markram

Emergent Connectivity Principles in the Neocortex

I. Riachi / H. Markram (Dir.)

The intense world theory - a unifying theory of the neurobiology of autism

K. Markram; H. Markram

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

L. Gambazzi; O. Gokce; T. Seredenina; E. Katsyuba; H. Runne  et al.

Emergent Dynamics in Neocortical Microcircuits

R. d. C. Perin / H. Markram (Dir.)

Impact of Carbon-Nanotube Substrate Coating in Neuronal Networks

L. Gambazzi / H. Markram (Dir.)

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

T. K. Berger; G. Silberberg; R. Perin; H. Markram

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

J. G. King; M. Hines; S. Hill; P. H. Goodman; H. Markram  et al.

Properties of neocortical microcircuits

T. Berger / H. Markram (Dir.)

Structure and function of the olfactory bulb microcircuit

M. Pignatelli / H. Markram; A. Carleton (Dir.)

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

A. Loebel; G. Silberberg; D. Helbig; H. Markram; M. Tsodyks  et al.

Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

T. K. Berger; R. Perin; G. Silberberg; H. Markram

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

G. T. Silva; J.-V. Le Bé; I. Riachi; T. Rinaldi; K. Markram  et al.

Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts

G. Cellot; E. Cilia; S. Cipollone; V. Rancic; A. Sucapane  et al.

Slow oscillations in neural networks with facilitating synapses

O. Melamed; O. Barak; G. Silberberg; H. Markram; M. Tsodyks

Fixing the location and dimensions of functional neocortical columns

H. Markram

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

C. Cali; T. K. Berger; M. Pignatelli; A. Carleton; H. Markram  et al.

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

G. A. Ascoli; L. Alonso-Nanclares; S. A. Anderson; G. Barrionuevo; R. Benavides-Piccione  et al.

Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons

M. Pospischil; M. Toledo-Rodriguez; C. Monier; Z. Piwkowska; T. Bal  et al.

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

T. Rinaldi; C. Perrodin; H. Markram

Fully implicit parallel simulation of single neurons

M. L. Hines; H. Markram; F. Schürmann

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

S. Druckmann; T. K. Berger; S. Hill; F. Schürmann; H. Markram  et al.

Identifying, tabulating, and analyzing contacts between branched neuron morphologies

J. Kozloski; K. Sfyrakis; S. Hill; F. Schürmann; C. Peck  et al.

Abnormal fear conditioning and amygdala processing in an animal model of autism

K. Markram; T. Rinaldi; D. La Mendola; C. Sandi; H. Markram

Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex

J. V. Le Be; G. Silberberg; Y. Wang; H. Markram

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

T. Rinaldi; G. Silberberg; H. Markram

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells

G. Silberberg; H. Markram

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

A. Mazzatenta; M. Giugliano; S. Campidelli; L. Gambazzi; L. Businaro  et al.

Methods For Treating And/Or Preventing Pervasive Developmental Disorders In A Subject

H. Markram; T. Rinaldi; T. Markram; M. Rodriguez Bravo; B. Mattson  et al.

The intense world syndrome – an alternative hypothesis for autism

H. Markram; T. Rinaldi; K. Markram

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

T. Rinaldi; K. Kulangara; K. Antoniello; H. Markram

A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data

S. Druckmann; Y. Banitt; A. Gidon; F. Schürmann; H. Markram  et al.

Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity

M. Toledo-Rodriguez; H. Markram

Industrializing neuroscience

H. Markram

Structure and dynamics of the neocortical microcircuit connectivity

J.-V. Le Bé / H. Markram (Dir.)

Heterogeneity in the pyramidal network of the medial prefrontal cortex

Y. Wang; H. Markram; P. H. Goodman; T. K. Berger; J. Ma  et al.

Un nouveau mécanisme de mémoire : connexions et déconnexions de neurones dans le néocortex de jeunes rats [A new mechanism for memory: neuronal networks rewiring in the young rat neocortex]

J. V. Le Be; H. Markram

Parallel network simulations with NEURON

M. Migliore; C. Cannia; W. W. Lytton; H. Markram; M. L. Hines

Altered neocortical microcircuitry in the valproic acid rat model of autism

T. Rinaldi / H. Markram (Dir.)

Spontaneous and evoked synaptic rewiring in the neonatal neocortex

J. V. Le Be; H. Markram

Dynamical principles for neuroscience and intelligent biomimetic devices

A. Ijspeert; J. Buchli; A. Selverston; M. Rabinovich; M. Hasler  et al.

The blue brain project

H. Markram

The neocortical microcircuit as a tabula rasa

N. Kalisman; G. Silberberg; H. Markram

Microcircuits in action--from CPGs to neocortex

S. Grillner; H. Markram; E. De Schutter; G. Silberberg; F. E. LeBeau

Subthreshold cross-correlations between cortical neurons: A reference model with static synapses

O. Melamed; G. Silberberg; H. Markram; W. Gerstner; M. J. E. Richardson

Neuropeptide and calcium-binding protein gene expression profiles predict neuronal anatomical type in the juvenile rat

M. Toledo-Rodriguez; P. Goodman; M. Illic; C. Wu; H. Markram

The Neocortical Microcircuit Database (NMDB)

H. Markram; X. Luo; G. Silberberg; M. Toledo-Rodriguez; A. Gupta

Synaptic pathways in neural microcircuits

G. Silberberg; S. Grillner; F. E. LeBeau; R. Maex; H. Markram

Short-term-plasticity orchestrates the response of pyramidal cells and interneurons to population bursts

M. J. E. Richardson; O. Melamed; G. Silberberg; W. Gerstner; H. Markram

NEOBASE: databasing the neocortical microcircuit

A. J. Muhammad; H. Markram

Interneuron Diversity series: Molecular and genetic tools to study GABAergic interneuron diversity and function

H. Monyer; H. Markram

Fading memory and kernel properties of generic cortical microcircuit models

W. Maass; T. Natschlager; H. Markram

Dynamics of population rate codes in ensembles of neocortical neurons

G. Silberberg; M. Bethge; H. Markram; K. Pawelzik; M. Tsodyks

Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex

M. Toledo-Rodriguez; B. Blumenfeld; C. Wu; J. Luo; B. Attali  et al.

Coding and Learning of behavioral sequences

O. Melamed; W. Gerstner; W. Maass; M. Tsodyks; H. Markram

Computational Models for Generic Cortical Microcircuits

W. Maass; T. Natschläger; H. Markram

Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit

G. Silberberg; C. Wu; H. Markram

Interneuron Heterogeneity in the Neocortex

A. Gupta; M. Toledo-Rodriguez; G. Silberberg; H. Markram

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Y. Wang; M. Toledo-Rodriguez; A. Gupta; C. Wu; G. Silberberg  et al.

Interneurons of the neocortical inhibitory system

H. Markram; M. Toledo-Rodriguez; Y. Wang; A. Gupta; G. Silberberg  et al.

Deriving physical connectivity from neuronal morphology

N. Kalisman; G. Silberberg; H. Markram

A Model for Real-Time Computation in Generic Neural Microcircuits

W. Maass; T. Natschläger; H. Markram; S. Becker; S. Thrun  et al.

Temporal integration in recurrent microcircuits

W. Maass; H. Markram

Input prediction and autonomous movement analysis in recurrent circuits of spiking neurons

R. Legenstein; H. Markram; W. Maass

Computer models and analysis tools for neural microcircuits

T. Natschläger; H. Markram; W. Maass

Preface to the Special Issue

J. F. Linden; H. Markram

Perspectives of the high-dimensional dynamics of neural microcircuits from the point of view of low-dimensional readouts

S. Häusler; H. Markram; W. Maass

Synapses as dynamic memory buffers

W. Maass; H. Markram

Spike frequency adaptation and neocortical rhythms

G. Fuhrmann; H. Markram; M. Tsodyks

Real-time computing without stable states: a new framework for neural computation based on perturbations

W. Maass; T. Natschlager; H. Markram

Stereotypy in neocortical microcircuits

G. Silberberg; A. Gupta; H. Markram

The "Liquid Computer": A Novel Strategy for Real-Time Computing on Time Series

T. Natschläger; W. Maass; H. Markram

Coding of temporal information by activity-dependent synapses

G. Fuhrmann; I. Segev; H. Markram; M. Tsodyks

A New Approach towards Vision Suggested by Biologically Realistic Neural Microcircuit Models

W. Maass; R. A. Legenstein; H. Markram; H. H. Buelthoff; S. W. Lee  et al.

Anatomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex

Y. Wang; A. Gupta; M. Toledo-Rodriguez; C. Z. Wu; H. Markram

An algorithm for modifying neurotransmitter release probability based on pre- and postsynaptic spike timing

W. Senn; H. Markram; M. Tsodyks

Synchrony generation in recurrent networks with frequency-dependent synapses

M. Tsodyks; A. Uziel; H. Markram

Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex

A. Gupta; Y. Wang; H. Markram

Anatomical and functional differentiation of glutamatergic synaptic innervation in the neocortex

Y. Wang; A. Gupta; H. Markram

Competitive calcium binding: implications for dendritic calcium signaling

H. Markram; A. Roth; F. Helmchen

Neural networks with dynamic synapses

M. Tsodyks; K. Pawelzik; H. Markram

Differential signaling via the same axon of neocortical pyramidal neurons

H. Markram; Y. Wang; M. Tsodyks

Potential for multiple mechanisms, phenomena and algorithms for synaptic plasticity at single synapses

H. Markram; D. Pikus; A. Gupta; M. Tsodyks

Information processing with frequency-dependent synaptic connections

H. Markram; A. Gupta; A. Uziel; Y. Wang; M. Tsodyks

The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability

M. V. Tsodyks; H. Markram

Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex

H. Markram; J. Lübke; M. Frotscher; A. Roth; B. Sakmann

A network of tufted layer 5 pyramidal neurons

H. Markram

Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs

H. Markram; J. Lübke; M. Frotscher; B. Sakmann

Neural codes: firing rates and beyond

W. Gerstner; A. K. Kreiter; H. Markram; A. V. M. Herz

Frequency and dendritic distribution of autapses established by layer 5 pyramidal neurons in the developing rat neocortex: comparison with synaptic innervation of adjacent neurons of the same class

J. Lübke; H. Markram; M. Frotscher; B. Sakmann

Redistribution of synaptic efficacy: a mechanism to generate infinite synaptic input diversity from a homogeneous population of neurons without changing absolute synaptic efficacies

H. Markram; M. Tsodyks

Redistribution of synaptic efficacy between neocortical pyramidal neurons

H. Markram; M. Tsodyks

Dendritic calcium transients evoked by single back-propagating action potentials in rat neocortical pyramidal neurons

H. Markram; P. J. Helm; B. Sakmann

Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels

H. Markram; B. Sakmann

The inositol 1,4,5-trisphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA

H. Markram; M. Segal

Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones

H. Markram; M. Segal

Spontaneous recovery of deficits in spatial memory and cholinergic potentiation of NMDA in CA1 neurons during chronic lithium treatment

G. Richter-Levin; H. Markram; M. Segal

Actions of norepinephrine in the rat hippocampus

M. Segal; H. Markram; G. Richter-Levin

Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate

H. Markram; M. Segal

Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex

H. Markram; M. Segal

Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat

H. Markram; M. Segal

Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus

H. Markram; M. Segal

Long-lasting facilitation of excitatory postsynaptic potentials in the rat hippocampus by acetylcholine

H. Markram; M. Segal

Presynaptic cholinergic action in the hippocampus

M. Segal; V. Greenberger; H. Markram