Henry Markram
henry.markram@epfl.ch +41 21 693 95 36
+41 21 693 95 36
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Web site: Site web: https://markram-lab.epfl.ch
+41 21 693 95 36
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Web site: Site web: https://sv.epfl.ch/education
EPFL ENT-R BBP-CORE
Campus Biotech
Bâtiment B1
Ch. des Mines 9
CH-1202 Genève
+41 21 693 95 36
Local: B1 5 282.040
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Web site: Site web: https://www.epfl.ch/research/domains/bluebrain/
Publications
Publications Infoscience
Infoscience
Thalamic microcircuitry: neurons, synapses, and circuit motifs in receptive field structure and sensory processing
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-7614.Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling
Journal Of Theoretical Biology. 2020-02-21. DOI : 10.1016/j.jtbi.2019.110123.A Kinetic Map of the Homomeric Voltage-gated Potassium Channel (Kv) Family
2020-02-07. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, Feb 15-19, 2020. p. 108A-108A.Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex
Frontiers In Synaptic Neuroscience. 2019-10-15. DOI : 10.3389/fnsyn.2019.00029.A null model of the mouse whole-neocortex micro-connectome
Nature Communications. 2019-08-29. DOI : 10.1038/s41467-019-11630-x.Caries Detection with Near-Infrared Transillumination Using Deep Learning
Journal of Dental Research. 2019-08-26. DOI : 10.1177/0022034519871884.Cortical reliability amid noise and chaos
Nature Communications. 2019-08-22. DOI : 10.1038/s41467-019-11633-8.A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
Frontiers in Cellular Neuroscience. 2019-08-20. DOI : 10.3389/fncel.2019.00358.A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex
Frontiers In Neuroanatomy. 2019-08-06. DOI : 10.3389/fnana.2019.00078.Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons
PLoS Computational Biology. 2019-05-16. DOI : 10.1371/journal.pcbi.1006753.A Brief History of Simulation Neuroscience
Frontiers In Neuroinformatics. 2019-05-07. DOI : 10.3389/fninf.2019.00032.Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Frontiers In Neural Circuits. 2019-04-12. DOI : 10.3389/fncir.2019.00024.Objective Morphological Classification of Neocortical Pyramidal Cells
Cerebral Cortex. 2019-04-01. DOI : 10.1093/cercor/bhy339.Individual differences in sensory sensitivity: Further lessons from an Autism model
Cognitive Neuroscience. 2019-03-30. DOI : 10.1080/17588928.2019.1592143.A Cell Atlas for the Mouse Brain (vol 12, 84, 2018)
Frontiers In Neuroinformatics. 2019-02-19. DOI : 10.3389/fninf.2019.00007.In Silico Voltage-Sensitive Dye Imaging: A Model-Based Approach for Bridging Scales of Cortical Activity
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9848.Reverse engineering the motor control system
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9599.Untangling emergent cortical dynamics: neurons from networks, noise from chaos
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9616.A Cell Atlas for the Mouse Brain
Frontiers In Neuroinformatics. 2018-11-28. DOI : 10.3389/fninf.2018.00084.Cell Densities in the Mouse Brain: A Systematic Review
Frontiers In Neuroanatomy. 2018-10-23. DOI : 10.3389/fnana.2018.00083.Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity
Frontiers In Neural Circuits. 2018-10-09. DOI : 10.3389/fncir.2018.00077.A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble
Frontiers In Neuroscience. 2018-09-25. DOI : 10.3389/fnins.2018.00664.The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow
Plos Computational Biology. 2018-09-01. DOI : 10.1371/journal.pcbi.1006423.Reconstruction and simulation of neocortical microcircuitry
US2018101660 . 2018.Generating and identifying functional subnetworks within structural networks
US2018197069 . 2018.Simplification of neural network models
US2018285716 . 2018.Data-driven reconstruction of a point neuron mouse brain
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8962.NeuroMorphoVis: a collaborative framework for analysis and visualization of neuronal morphology skeletons reconstructed from microscopy stacks
BIOINFORMATICS. 2018. DOI : 10.1093/bioinformatics/bty231.A Topological Representation of Branching Neuronal Morphologies
NEUROINFORMATICS. 2018. DOI : 10.1007/s12021-017-9341-1.Neuronal morphologies: the shapes of thoughts
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8255.Towards a unified understanding of synaptic plasticity
Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8186.Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons
Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.10.035.In Silico Brain Imaging Physically-plausible Methods for Visualizing Neocortical Microcircuitry
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8161.Reconstruction and visualization of large-scale volumetric models of neocortical circuits for physically-plausible in silico optical studies
Bmc Bioinformatics. 2017. DOI : 10.1186/s12859-017-1788-4.Using the Green's function to simplify and understand dendrites
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7869.Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity
Cerebral Cortex. 2017. DOI : 10.1093/cercor/bhx150.Modeling the metabolic response of astrocytes to neuronal activity
2017. 13th European Meeting on Glial Cells in Health and Disease, Edinburgh, SCOTLAND, JUL 08-11, 2017. p. E280-E280.Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
Frontiers In Computational Neuroscience. 2017. DOI : 10.3389/fncom.2017.00048.Rich cell-type-specific network topology in neocortical microcircuitry
Nature Neuroscience. 2017. DOI : 10.1038/nn.4576.Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation
Bmc Bioinformatics. 2017. DOI : 10.1186/s12859-016-1444-4.From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells
Cerebral Cortex. 2016-06-09. DOI : 10.1093/cercor/bhw166.Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors
Journal Of Neuroscience. 2016. DOI : 10.1523/Jneurosci.0664-16.2016.BluePyOpt: Leveraging Open Source Software and Cloud Infrastructure to Optimise Model Parameters in Neuroscience
Frontiers In Neuroinformatics. 2016. DOI : 10.3389/fninf.2016.00017.Agile in-litero experiments
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6809.Structural to functional synaptic conversion
US9165244 ; US2014108315 . 2015.Physically-based in silico light sheet microscopy for visualizing fluorescent brain models
BMC bioinformatics. 2015. DOI : 10.1186/1471-2105-16-S11-S8.The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex
Frontiers In Neural Circuits. 2015. DOI : 10.3389/fncir.2015.00044.An algorithm to predict the connectome of neural microcircuits
Frontiers In Computational Neuroscience. 2015. DOI : 10.3389/fncom.2015.00120.Reconstruction and Simulation of Neocortical Microcircuitry
Cell. 2015. DOI : 10.1016/j.cell.2015.09.029.Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
Frontiers In Cellular Neuroscience. 2015. DOI : 10.3389/fncel.2015.00233.An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse
PLoS computational biology. 2015. DOI : 10.1371/journal.pcbi.1004253.Network-timing-dependent plasticity
Frontiers in cellular neuroscience. 2015. DOI : 10.3389/fncel.2015.00220.Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism
Frontiers in Neuroscience. 2015. DOI : 10.3389/fnins.2015.00127.Cell-type- and activity-dependent extracellular correlates of intracellular spiking
Journal of Neurophysiology. 2015. DOI : 10.1152/jn.00628.2014.A versatile clearing agent for multi-modal brain imaging
Scientific Reports. 2015. DOI : 10.1038/srep09808.The future of human cerebral cartography: a novel approach
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 2015. DOI : 10.1098/rstb.2014.0171.Large Volume Imaging of Rodent Brain Anatomy with Emphasis on Selective Plane Illumination Microscopy
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6533.Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying
Scientific Reports. 2015. DOI : 10.1038/srep07919.Distributor of neurons in a neocortical column
US2014107992 . 2014.Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity
Methods in molecular biology (Clifton, N.J.). 2014. DOI : 10.1007/978-1-4939-1096-0_8.The death of Cajal and the end of scientific romanticism and individualism
Trends In Neurosciences. 2014. DOI : 10.1016/j.tins.2014.08.002.Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices
Scientific Reports. 2014. DOI : 10.1038/srep06825.Scalable Exploration of Spatial Data in Large-Scale Scientific Simulations
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6125.The In-Silico Neocortical Microcircuit
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6168.Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex
Frontiers In Neuroanatomy. 2014. DOI : 10.3389/fnana.2013.00052.Visualizing the similarity and pedigree of NEURON ion channel models available on ModelDB
COSYNE 2014, Salt Lake City & Snowbird, Utah, USA, February 27 - March 4, 2014.OCTOPUS: Efficient Query Execution on Dynamic Mesh Datasets
2014. 30st International Conference on Data Engineering (ICDE '14), Chicago, USA, April, 2014.Correction: Effective Stimuli for Constructing Reliable Neuron Models
PLoS Computational Biology. 2013. DOI : 10.1371/annotation/c002fbe1-712c-4608-9747-f1185f0b7cf4.Seven challenges for neuroscience
Functional neurology. 2013. DOI : 10.11138/FNeur/2013.28.3.145.A computer-assisted multi-electrode patch-clamp system
Journal of visualized experiments : JoVE. 2013. DOI : 10.3791/50630.A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis
Cerebral Cortex. 2013. DOI : 10.1093/cercor/bhs290.Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro
Scientific Reports. 2013. DOI : 10.1038/srep02897.Hyper-emotional neurophysiology in a rat model of autism
Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5996.Synaptic and Cellular Organization of Layer 1 of the Developing Rat Somatosensory Cortex
Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5902.Network Activity and Plasticity
Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5901.General developmental health in the VPA-rat model of autism
Frontiers In Behavioral Neuroscience. 2013. DOI : 10.3389/fnbeh.2013.00088.A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
Neuron. 2013. DOI : 10.1016/j.neuron.2013.05.023.Neuroscience thinks big (and collaboratively)
Nature Reviews Neuroscience. 2013. DOI : 10.1038/nrn3578.Preserving axosomatic spiking features despite diverse dendritic morphology
Journal Of Neurophysiology. 2013. DOI : 10.1152/jn.00048.2013.Computing the size and number of neuronal clusters in local circuits
Frontiers In Neuroanatomy. 2013. DOI : 10.3389/fnana.2013.00001.Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales
Journal Of Neuroscience. 2013. DOI : 10.1523/Jneurosci.3740-12.2013.One minute with ... Henry Markram
New Scientist. 2013.New insights into the classification and nomenclature of cortical GABAergic interneurons
Nature Reviews Neuroscience. 2013. DOI : 10.1038/nrn3444.Method for in-vitro monitoring of neuronal disorders and use thereof
EP2591356 ; US2013109048 ; WO2012004778 . 2012.A neuron membrane mesh representation for visualization of electrophysiological simulations
IEEE transactions on visualization and computer graphics. 2012. DOI : 10.1109/TVCG.2011.55.Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections
The Journal of physiology. 2012. DOI : 10.1113/jphysiol.2011.219576.Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons
PloS One. 2012. DOI : 10.1371/journal.pone.0034786.The human brain project
Scientific American. 2012.Spike-timing-dependent plasticity: a comprehensive overview
Frontiers in synaptic neuroscience. 2012. DOI : 10.3389/fnsyn.2012.00002.Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
Proceedings of the National Academy of Sciences of the United States of America. 2012. DOI : 10.1073/pnas.1202128109.Short-term ionic plasticity at GABAergic synapses
Frontiers in synaptic neuroscience. 2012. DOI : 10.3389/fnsyn.2012.00005.The neocortical column
Frontiers In Neuroanatomy. 2012. DOI : 10.3389/fnana.2012.00022.SCOUT: Prefetching for Latent Structure Following Queries
2012. 38th International Conference on Very Large Databases (VLDB '12), Istanbul, Turkey, August, 2012.Accelerating Range Queries For Brain Simulations
2012. 28th International Conference on Data Engineering (ICDE '12), Washington DC, USA, March, 2012. DOI : 10.1109/Icde.2012.56.Organizing neural networks
US2019354841 ; US10387767 ; US10373048 ; KR101816329 ; DK2531959 ; EP2531959 ; CN102859538 ; JP5844286 ; US2015363689 ; JP2013519140 ; CN102859538 ; US2012323833 ; EP2531959 ; KR20120123698 ; WO2011095342 . 2011.Encoding and decoding of information
EP3771103 ; EP2460276 ; CN104901702 ; KR101734596 ; JP5848414 ; CN104901702 ; CN102648582 ; US8941512 ; JP2014209794 ; JP5587412 ; JP2013500660 ; US2012313798 ; US8253607 ; CN102648582 ; EP2460276 ; US2012119926 ; KR20120046760 ; US8159373 ; WO2011012614 ; WO2011012158 ; WO2011012614 ; US2011025532 . 2011.Ephaptic coupling of cortical neurons
Nature neuroscience. 2011. DOI : 10.1038/nn.2727.Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex
Frontiers in neuroanatomy. 2011. DOI : 10.3389/fnana.2011.00005.A synaptic organizing principle for cortical neuronal groups
Proceedings of the National Academy of Sciences of the United States of America. 2011. DOI : 10.1073/pnas.1016051108.Innate neural assemblies for lego memory
Frontiers in neural circuits. 2011. DOI : 10.3389/fncir.2011.00006.Enseignement & Phd
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