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Domaines de compétences
Associations of genetic and infectious risk factors with coronary heart diseaseElife. 2023-02-14. DOI : 10.7554/eLife.79742.
Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal StudyClinical Infectious Diseases. 2023-01-23. DOI : 10.1093/cid/ciad033.
Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus StudyEuropean Journal Of Preventive Cardiology. 2023-01-18. DOI : 10.1093/eurjpc/zwad012.
Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotypeTranslational Psychiatry. 2022-12-31. DOI : 10.1038/s41398-022-02275-4.
Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ LocusArthritis & Rheumatology. 2022-11-02. DOI : 10.1002/art.42265.
The combined impact of persistent infections and human genetic variation on C-reactive protein levelsBmc Medicine. 2022-11-01. DOI : 10.1186/s12916-022-02607-7.
A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strandNucleic Acids Research. 2022-09-21. DOI : 10.1093/nar/gkac779.
Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort StudyClinical Infectious Diseases. 2022-09-13. DOI : 10.1093/cid/ciac758.
A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease TraitsMolecular Biology And Evolution. 2022-08-03. DOI : 10.1093/molbev/msac163.
A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913Journal Of Immunology. 2022-08-01. DOI : 10.4049/jimmunol.2100685.
Improving polygenic prediction with genetically inferred ancestryHuman Genetics And Genomics Advances. 2022-07-14. DOI : 10.1016/j.xhgg.2022.100109.
Host genomics of SARS-CoV-2 infectionEuropean Journal Of Human Genetics. 2022-06-30. DOI : 10.1038/s41431-022-01136-4.
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodiesProceedings Of The National Academy Of Sciences Of The United States Of America. 2022-05-24. DOI : 10.1073/pnas.2200413119.
Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group (vol 74, pg 1468, 2022)Clinical Infectious Diseases. 2022-04-27. DOI : 10.1093/cid/ciac242.
CD38 Expression by Antigen-Specific CD4 T Cells Is Significantly Restored 5 Months After Treatment Initiation Independently of Sputum Bacterial Load at the Time of Tuberculosis DiagnosisFrontiers In Medicine. 2022-04-15. DOI : 10.3389/fmed.2022.821776.
Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral loadVirus Evolution. 2022-04-07. DOI : 10.1093/ve/veac022.
A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease2022-04-01. p. 28-28.
Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome2022-04-01. p. 438-439.
Increased CHIP prevalence amongst people living with HIV2022-04-01. p. 75-75.
A billion-year trend of amino acid substitutions in the mitochondrial genome2022-04-01. p. 535-535.
Mitochondrial mutational spectrum in human cancers is sensitive to cellular hypoxia2022-04-01. p. 413-414.
A highly virulent variant of HIV-1 circulating in the NetherlandsScience. 2022-02-04. DOI : 10.1126/science.abk1688.
Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIVScientific Reports. 2022-01-12. DOI : 10.1038/s41598-021-04308-2.
The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidityLausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9518.
Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk GroupClinical Infectious Diseases. 2022. DOI : 10.1093/cid/ciab628.
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infectionNature Immunology. 2022. DOI : 10.1038/s41590-021-01030-z.
Telomere Length Declines in Persons With Human Immunodeficiency Virus Before Antiretroviral Therapy Start but Not After Viral Suppression: A Longitudinal Study Over >17 YearsJournal Of Infectious Diseases. 2021-12-16. DOI : 10.1093/infdis/jiab603.
Human genomics of the humoral immune response against polyomavirusesVirus Evolution. 2021-12-01. DOI : 10.1093/ve/veab058.
Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort StudyClinical Infectious Diseases. 2021-11-01. DOI : 10.1093/cid/ciab521.
Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failureNature Communications. 2021-10-20. DOI : 10.1038/s41467-021-25649-6.
Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryptionNature Communications. 2021-10-11. DOI : 10.1038/s41467-021-25972-y.
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host responseNature Genetics. 2021-10-01. DOI : 10.1038/s41588-021-00935-7.
Immunological lessons from genome-wide association studies of infectionsCurrent Opinion In Immunology. 2021-10-01. DOI : 10.1016/j.coi.2021.03.017.
Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deathsScience Immunology. 2021-08-01. DOI : 10.1126/sciimmunol.abl4340.
Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphomaHaematologica. 2021-08-01. DOI : 10.3324/haematol.2020.247023.
HIV-1 and human genetic variationNature Reviews Genetics. 2021-06-24. DOI : 10.1038/s41576-021-00378-0.
Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk ScoresJournal Of Infectious Diseases. 2021-06-15. DOI : 10.1093/infdis/jiaa695.
Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape linkElife. 2021-06-01. DOI : 10.7554/eLife.67388.
Revolutionizing Medical Data Sharing Using Advanced Privacy-Enhancing Technologies: Technical, Legal, and Ethical SynthesisJournal Of Medical Internet Research. 2021-02-25. DOI : 10.2196/25120.
The influence of human genetic variation on Epstein–Barr virus sequence diversityScientific Reports. 2021-02-25. DOI : 10.1038/s41598-021-84070-7.
Blood virosphere in febrile Tanzanian childrenEmerging Microbes & Infections. 2021-01-01. DOI : 10.1080/22221751.2021.1925161.
The genetic architecture of complex human traits at the dawn of genomic medicineLausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8464.
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesiclesJournal Of Extracellular Vesicles. 2021-01-01. DOI : 10.1002/jev2.12046.
On the use of applied machine learning and digital infrastructure to leverage social media data in health and epidemiologyLausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8283.
Genome-to-genome analysis identifies an Asian-specific variant in the gene encoding NTCP that leads to specific HBV escape mutations during chronic infection2020-12-01. p. 316-317.
Human genomics of the humoral response against polyomaviruses2020-12-01. p. 312-313.
An indel in the promoter region of NFKB1 confers protection against infection but increases risk of allergy2020-12-01. p. 311-312.
Using reference-fixed principal components to improve polygenic risk score prediction2020-12-01. p. 134-135.
Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral TreatmentJaids-Journal Of Acquired Immune Deficiency Syndromes. 2020-12-01. DOI : 10.1097/QAI.0000000000002473.
Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort StudyClinical Infectious Diseases. 2020-11-15. DOI : 10.1093/cid/ciaa290.
HLA tapasin independence: broader peptide repertoire and HIV controlProceedings Of The National Academy Of Sciences Of The United States Of America. 2020-11-10. DOI : 10.1073/pnas.2013554117.
Heritability of the HIV-1 reservoir size and decay under long-term suppressive ARTNature Communications. 2020-11-02. DOI : 10.1038/s41467-020-19198-7.
Virosaurus A Reference to Explore and Capture Virus Genetic DiversityViruses-Basel. 2020-11-01. DOI : 10.3390/v12111248.
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19Science. 2020-10-23. DOI : 10.1126/science.abd4570.
Designing a Tanzanian Specific SNP Array Add-On to Capture Population-Specific Genetic Variations and to Improve Genotype Imputation2020-07-01. 48th European Mathematical Genetics Meeting (EMGM), Lausanne, SWITZERLAND, Apr 16-17, 2020. p. 227-227. DOI : 10.1159/000507248.
Susceptibility to infection in early life: a growing role for human geneticsHuman Genetics. 2020-06-01. DOI : 10.1007/s00439-019-02109-2.
Exploring the interactions between the human and viral genomesHuman Genetics. 2020-06-01. DOI : 10.1007/s00439-019-02089-3.
Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in SwitzerlandSwiss Medical Weekly. 2020-05-30. DOI : 10.4414/smw.20295.
COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolationSwiss Medical Weekly. 2020-03-19. DOI : 10.4414/smw.2020.20225.
HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide PresentationMolecular Biology And Evolution. 2020-03-01. DOI : 10.1093/molbev/msz249.
Contribution of Genetic Background and Data Collection on Adverse Events of Anti-human Immunodeficiency Virus (HIV) Drugs (D:A:D) Clinical Risk Score to Chronic Kidney Disease in Swiss HIV-infected Persons With Normal Baseline Estimated Glomerular Filtration RateClinical Infectious Diseases. 2020-03-01. DOI : 10.1093/cid/ciz280.
SPHN/PHRT - MedCo in Action: Empowering the Swiss Molecular Tumor Board with Privacy-Preserving and Real-Time Patient Discovery2020-01-01. 30th Medical Informatics Europe (MIE) Conference, Geneva, SWITZERLAND, Apr, 2020. p. 1161-1162. DOI : 10.3233/SHTI200345.
GenoShare: Supporting Privacy-Informed Decisions for Sharing Individual-Level Genetic Data2020-01-01. 30th Medical Informatics Europe (MIE) Conference, Geneva, SWITZERLAND, Apr, 2020. p. 238-241. DOI : 10.3233/SHTI200158.
Data protection and ethics requirements for multisite research with health data: a comparative examination of legislative governance frameworks and the role of data protection technologiesJournal Of Law And The Biosciences. 2020-01-01. DOI : 10.1093/jlb/lsaa010.
Contact networks across ages: computational analysis of epidemiological dynamicsLausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7482.
Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral TherapyOpen Forum Infectious Diseases. 2020-01-01. DOI : 10.1093/ofid/ofz464.
HIV host genomics in the era of effective antiretroviral therapyLausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-10132.
Gender medicine and oncology: report and consensus of an ESMO workshopAnnals Of Oncology. 2019-12-01. DOI : 10.1093/annonc/mdz414.
Systems Biology in 874 Patients with Primary Sjogren's Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA2019-10-01.
Genome-to-genome analysis of Epstein-Barr virus infection2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1365-1365.
Rare variants in antiviral response genes drive severe viral respiratory infections in children2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1374-1375.
Human genetic determinants of chronic low-grade inflammation in the general population2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1747-1748.
Predicting the Occurrence of Variants in RAG1 and RAG2Journal Of Clinical Immunology. 2019-10-01. DOI : 10.1007/s10875-019-00670-z.
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individualsMicrobiome. 2019-09-13. DOI : 10.1186/s40168-019-0747-x.
Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypesElife. 2019-09-03. DOI : 10.7554/eLife.42542.
HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly ExpectedJaids-Journal Of Acquired Immune Deficiency Syndromes. 2019-08-15. DOI : 10.1097/QAI.0000000000002077.
Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ARTNature Communications. 2019-07-19. DOI : 10.1038/s41467-019-10884-9.
Effect of Fc Receptor Genetic Diversity on HIV-1 Disease PathogenesisFrontiers In Immunology. 2019-05-09. DOI : 10.3389/fimmu.2019.00970.
Associations between usual diet and gut microbiota composition: results from the Milieu Interieur cross-sectional studyAmerican Journal Of Clinical Nutrition. 2019-05-01. DOI : 10.1093/ajcn/nqz029.
Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipientsJournal Of Viral Hepatitis. 2019-02-01. DOI : 10.1111/jvh.13019.
Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysisProceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1808403116.
HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV controlProceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1812548116.
A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathologyLausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.
Exploring on Protein-DNA interactionsLausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9426.
HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responseseLife. 2019. DOI : 10.7554/eLife.41930.
Virucidal nanomaterials against influenzaLausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9114.
Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcomaAids. 2018-11-28. DOI : 10.1097/QAD.0000000000002004.
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccinesGenome Medicine. 2018-07-27. DOI : 10.1186/s13073-018-0568-8.
Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiverVirus Evolution. 2018-05-18. DOI : 10.1093/ve/vey007.
Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1Journal of Clinical Investigation. 2018-05-01. DOI : 10.1172/JCI98463.
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factorsNature Immunology. 2018-03-19. DOI : 10.1038/s41590-018-0049-7.
Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian childrenEmerging Microbes & Infections. 2018-03-14. DOI : 10.1038/s41426-018-0025-1.
Are privacy-enhancing technologies for genomic data ready for the clinic? A survey of medical experts of the Swiss HIV Cohort StudyJournal of Biomedical Informatics. 2018-03-01. DOI : 10.1016/j.jbi.2017.12.013.
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cellsScience. 2018-01-05. DOI : 10.1126/science.aam8825.
Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype2018. Annual meeting of the American Society of Human Genetics (ASHG), San Diego, USA, October 16-20, 2018.
Genetic determinants of healthy human immune variance: from humoral response to microbiome diversityLausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8955.
Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen GenomesFrontiers in Genetics. 2018. DOI : 10.3389/fgene.2018.00266.
Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing DataLausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8748.
Genomics: a Swiss army knife to fight leprosyLausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8482.
On Secure Cloud Computing for Genomic Data: From Storage to AnalysisLausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8367.
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