Jacques Fellay
EPFL SV GHI GR-FE
SV 3824 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Mission
Human genetic variation plays a key role in determining individual outcomes after exposure to infectious agents.
The mission of our laboratory is to contribute to a better understanding of inter-individual differences in response to infections, using a range of contemporary genomic tools. Approaches include genome-wide genotyping and association analysis, exome/genome sequencing and transcriptomics.
Biography
Jacques Fellay is a medical scientist with expertise in infectious diseases and human genomics. He obtained his MD from the University of Lausanne in 2002 and his PhD from University of Utrecht. After a clinical training in infectious diseases in Switzerland and a 4-years postdoctoral fellowship at Duke University, he joined the EPFL in April 2011 with an SNF Professorship.
On top of his EPFL affiliation, Jacques is also Head of Precision Medicine at the University Hospital (CHUV) in Lausanne, Group Leader at the Swiss Institute of Bioinformatics, and Co-director of the Health2030 Genome Center at Campus Biotech in Geneva.
Compétences
Human genomics of infectious diseases - Immunogenetics - Virus-host interactions - Translational genomics - Personalized health
Publications
Infoscience
Infoscience
Les données en-ligne ne sont pas accessiblesD. E. Geraghty; C. W. Thorball; J. Fellay; R. Thomas : Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis; Frontiers In Immunology. 2019-05-09. DOI : 10.3389/fimmu.2019.00970.
S. Asgari; N. Chaturvedi; P. Scepanovic; C. Hammer; N. Semmo et al. : Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients; Journal Of Viral Hepatitis. 2019-02-01. DOI : 10.1111/jvh.13019.
P. Maffucci; B. Bigio; F. Rapaport; A. Cobat; A. Borghesi et al. : Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1808403116.
J. Arora; P. J. McLare; N. Chaturvedi; M. Carrington; J. Fellay et al. : HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1812548116.
S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.) : A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.
S. Langer; C. Hammer; K. Hopfensperger; L. Klein; D. Hotter et al. : HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses; eLife. 2019. DOI : 10.7554/eLife.41930.
Ö. Kocabiyik / F. Stellacci (Dir.) : Virucidal nanomaterials against influenza. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9114.
S. Bibert; A. Wojtowicz; P. Taffe; P. E. Tarr; E. Bernasconi et al. : Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma; Aids. 2018-11-28. DOI : 10.1097/QAD.0000000000002004.
P. Scepanovic; C. Alanio; C. Hammer; F. Hodel; J. Bergstedt et al. : Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines; Genome Medicine. 2018-07-27. DOI : 10.1186/s13073-018-0568-8.
C. Wymant; F. Blanquart; T. Golubchik; A. Gall; M. Bakker et al. : Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver; Virus Evolution. 2018-05-18. DOI : 10.1093/ve/vey007.
M. P. Martin; V. Naranbhai; P. R. Shea; Y. Qi; V. Ramsuran et al. : Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1; Journal of Clinical Investigation. 2018-05-01. DOI : 10.1172/JCI98463.
E. Patin; M. Hasan; J. Bergstedt; V. Rouilly; V. Libri et al. : Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors; Nature Immunology. 2018-03-19. DOI : 10.1038/s41590-018-0049-7.
S. Cordey; M.-A. Hartley; K. Keitel; F. Laubscher; F. Brito et al. : Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children; Emerging Microbes & Infections. 2018-03-14. DOI : 10.1038/s41426-018-0025-1.
J.-L. Raisaro; P. J. McLaren; J. Fellay; M. Cavassini; C. Klersy et al. : Are privacy-enhancing technologies for genomic data ready for the clinic? A survey of medical experts of the Swiss HIV Cohort Study; Journal of Biomedical Informatics. 2018-03-01. DOI : 10.1016/j.jbi.2017.12.013.
V. Ramsuran; V. Naranbhai; A. Horowitz; Y. Qi; M. P. Martin et al. : Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells; Science. 2018-01-05. DOI : 10.1126/science.aam8825.
F. Hodel; A. Shaqiri; M. Roinishvili; E. Chkonia; A. Brand et al. : Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype. 2018. Annual meeting of the American Society of Human Genetics (ASHG), San Diego, USA, October 16-20, 2018.
P. Scepanovic / J. Fellay; B. Deplancke (Dir.) : Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8955.
O. Naret; N. Chaturvedi; I. Bartha; C. Hammer; J. Fellay : Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes; Frontiers in Genetics. 2018. DOI : 10.3389/fgene.2018.00266.
A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.) : Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8748.
C. Avanzi / S. Cole (Dir.) : Genomics: a Swiss army knife to fight leprosy. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8482.
Z. Huang / J.-P. Hubaux; J. Fellay (Dir.) : On Secure Cloud Computing for Genomic Data: From Storage to Analysis. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8367.
F. Bertels; A. Marzel; G. Leventhal; V. Mitov; J. Fellay et al. : Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity; Molecular biology and evolution. 2018. DOI : 10.1093/molbev/msx246.
E. Adland; M. Hill; N. Lavandier; A. Csala; A. Edwards et al. : Differential immunodominance hierarchy of CD8+ T cell responses in HLA-B*27:05 and B*27:02-mediated control of HIV-1 infection; Journal of virology. 2018. DOI : 10.1128/JVI.01685-17.
Enseignement & Phd
Enseignement
- Life Sciences Engineering,
Programmes doctoraux
- Doctoral Program in Molecular Life Sciences
- Doctoral Program in Biotechnology and Bioengineering
- Doctoral Program in Computational and Quantitative Biology
Doctorants
Hodel Flavia Aurelia ShokoNaret Olivier Noël Marie
Thorball Christian Axel Wandall
Xu Zhi Ming
A dirigé les thèses de
Asgari Samira ...Huang Zhicong ...
Scepanovic Petar ...
Cours
Génétique et génomique
Ce cours couvre d'abord la génétique classique et après les techniques et les avancées de la génomique contemporaine. Le cours comporte aussi une introduction au langage de programmation « R », suivie d'analyses bioinformatiques de base pour l'analyse des... 
New tools & research strategies in personalized health
Nous allons définir le concept de santé personnalisée, décrire les technologies sous-jacentes, les défis technologiques, juridiques et éthiques auxquels ce champ est confronté aujourd'hui, et comment ils sont pris en compte.
Landmark Papers in Cancer and Infection
The topics will cover all the fields in which the GHI and ISREC PIs work.
Practical - Fellay Lab
Exploration of human genetic variation in large-scale sequencing data.