Jacques Fellay
Maître d'enseignement et de recherche
jacques.fellay@epfl.ch +41 21 69 31849 http://fellay-lab.epfl.ch
EPFL SV GHI GR-FE
SV 3824 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Mission
Human genetic variation plays a key role in determining individual outcomes after exposure to infectious agents.
The mission of our laboratory is to contribute to a better understanding of inter-individual differences in response to infections, using a range of contemporary genomic tools. Approaches include genome-wide genotyping and association analysis, exome/genome sequencing and transcriptomics.
Biography
Jacques Fellay is a medical scientist with expertise in infectious diseases and human genomics. He obtained his MD from the University of Lausanne in 2002 and his PhD from University of Utrecht. After a clinical training in infectious diseases in Switzerland and a 4-years postdoctoral fellowship at Duke University, he joined the EPFL in April 2011 with an SNF Professorship.
On top of his EPFL affiliation, Jacques is also Head of Precision Medicine at the University Hospital (CHUV) in Lausanne, Group Leader at the Swiss Institute of Bioinformatics, and Co-director of the Health2030 Genome Center at Campus Biotech in Geneva.
Publications
Infoscience
P. Maffucci; B. Bigio; F. Rapaport; A. Cobat; A. Borghesi et al. : Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1808403116.
J. Arora; P. J. McLare; N. Chaturvedi; M. Carrington; J. Fellay et al. : HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1812548116.
S. Bibert; A. Wojtowicz; P. Taffe; P. E. Tarr; E. Bernasconi et al. : Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma; Aids. 2018-11-28. DOI : 10.1097/QAD.0000000000002004.
P. Scepanovic; C. Alanio; C. Hammer; F. Hodel; J. Bergstedt et al. : Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines; Genome Medicine. 2018-07-27. DOI : 10.1186/s13073-018-0568-8.
C. Wymant; F. Blanquart; T. Golubchik; A. Gall; M. Bakker et al. : Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver; Virus Evolution. 2018-05-18. DOI : 10.1093/ve/vey007.
M. P. Martin; V. Naranbhai; P. R. Shea; Y. Qi; V. Ramsuran et al. : Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1; Journal of Clinical Investigation. 2018-05-01. DOI : 10.1172/JCI98463.
E. Patin; M. Hasan; J. Bergstedt; V. Rouilly; V. Libri et al. : Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors; Nature Immunology. 2018-03-19. DOI : 10.1038/s41590-018-0049-7.
S. Cordey; M.-A. Hartley; K. Keitel; F. Laubscher; F. Brito et al. : Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children; Emerging Microbes & Infections. 2018-03-14. DOI : 10.1038/s41426-018-0025-1.
J.-L. Raisaro; P. J. McLaren; J. Fellay; M. Cavassini; C. Klersy et al. : Are privacy-enhancing technologies for genomic data ready for the clinic? A survey of medical experts of the Swiss HIV Cohort Study; Journal of Biomedical Informatics. 2018-03-01. DOI : 10.1016/j.jbi.2017.12.013.
V. Ramsuran; V. Naranbhai; A. Horowitz; Y. Qi; M. P. Martin et al. : Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells; Science. 2018-01-05. DOI : 10.1126/science.aam8825.
F. Hodel; A. Shaqiri; M. Roinishvili; E. Chkonia; A. Brand et al. : Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype. 2018. Annual meeting of the American Society of Human Genetics (ASHG), San Diego, USA, October 16-20, 2018.
P. Scepanovic / J. Fellay; B. Deplancke (Dir.) : Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8955.
F. Bertels; A. Marzel; G. Leventhal; V. Mitov; J. Fellay et al. : Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+T-Cell Decline, and Per-Parasite Pathogenicity; MOLECULAR BIOLOGY AND EVOLUTION. 2018. DOI : 10.1093/molbev/msx246.
E. Adland; M. Hill; N. Lavandier; A. Csala; A. Edwards et al. : Differential Immunodominance Hierarchy of CD8(+) T-Cell Responses in HLA-B*27:05-and -B*27:02-Mediated Control of HIV-1 Infection; JOURNAL OF VIROLOGY. 2018. DOI : 10.1128/JVI.01685-17.
O. Naret; N. Chaturvedi; I. Bartha; C. Hammer; J. Fellay : Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes; FRONTIERS IN GENETICS. 2018. DOI : 10.3389/fgene.2018.00266.
A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.) : Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8748.
C. Avanzi / S. Cole (Dir.) : Genomics: a Swiss army knife to fight leprosy. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8482.
Z. Huang / J.-P. Hubaux; J. Fellay (Dir.) : On Secure Cloud Computing for Genomic Data: From Storage to Analysis. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8367.
L. Abel; J. Fellay; D. W. Haas; E. Schurr; G. Srikrishna et al. : Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives; The Lancet. Infectious Diseases. 2018. DOI : 10.1016/S1473-3099(17)30623-0.
E. M. Leitman; C. B. Willberg; M.-H. Tsai; H. Chen; S. Buus et al. : HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection; Journal of virology. 2017. DOI : 10.1128/JVI.00544-17.
P. J. McLaren; S. L. Pulit; D. Gurdasani; I. Bartha; P. R. Shea et al. : Evaluating the Impact of Functional Genetic Variation on HIV-1 Control; The Journal of infectious diseases. 2017. DOI : 10.1093/infdis/jix470.
F. Bertels; A. Marzel; G. Leventhal; V. Mitov; J. Fellay et al. : Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity; Molecular biology and evolution. 2017. DOI : 10.1093/molbev/msx246.
E. Adland; M. Hill; N. Lavandier; A. Csala; A. Edwards et al. : Differential immunodominance hierarchy of CD8+ T cell responses in HLA-B*27:05 and B*27:02-mediated control of HIV-1 infection; Journal of virology. 2017. DOI : 10.1128/JVI.01685-17.
B. Piasecka; D. Duffy; A. Urrutia; H. Quach; E. Patin et al. : Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges; Proceedings of the National Academy of Sciences of the United States of America. 2017. DOI : 10.1073/pnas.1714765115.
F. Blanquart; C. Wymant; M. Cornelissen; A. Gall; M. Bakker et al. : Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe; Plos Biology. 2017. DOI : 10.1371/journal.pbio.2001855.
S. Asgari; L. J. Schlapbach; S. Anchisi; C. Hammer; I. Bartha et al. : Severe viral respiratory infections in children with IFIH1 loss-of-function mutations; Proceedings of the National Academy of Sciences of the United States of America. 2017. DOI : 10.1073/pnas.1704259114.
Z. Huang; H. Lin; J. Fellay; Z. Kutalik; J.-P. Hubaux : SQC: Secure Quality Control for Meta-Analysis of Genome-Wide Association Studies; Bioinformatics. 2017. DOI : 10.1093/bioinformatics/btx193.
M. A. Ansari; V. Pedergnana; C. L. C. Ip; A. Magri; A. Von Delft et al. : Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus; Nature Genetics. 2017. DOI : 10.1038/ng.3835.
I. Bartha; P. J. Mclaren; C. Brumme; R. Harrigan; A. Telenti et al. : Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control; PLoS Computational Biology. 2017. DOI : 10.1371/journal.pcbi.1005339.
A. Borghesi; M. Stronati; J. Fellay : Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses; Frontiers In Immunology. 2017. DOI : 10.3389/fimmu.2017.00215.
R. Abujaber; P. R. Shea; P. J. Mclaren; S. Lakhi; J. Gilmour et al. : No Evidence for Association of beta-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS; Annals Of Human Genetics. 2017. DOI : 10.1111/ahg.12182.
E. Ayday; J. P. Hubaux; J. L. Raisaro; A. Telenti; J. Fellay et al. ; Privacy-enhancing technologies for medical tests using genomic data. US9536047 ; US2016224735 ; US9270446 ; US2015236849 ; EP2895980 ; WO2014040964 ; EP2709028 . 2016.
T. Junier; M. Rotger; E. Biver; B. Ledergerber; C. Barcelo et al. : Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study; Open Forum Infectious Diseases. 2016. DOI : 10.1093/ofid/ofw101.
S. Asgari; P. J. Mclaren; J. Peake; M. Wong; R. Wong et al. : Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis; Frontiers In Immunology. 2016. DOI : 10.3389/fimmu.2016.00357.
N. Chaturvedi; R. K. Chodavarapu; E. S. Svarovskaia; H. Mo; A. O. Osinusi et al. : Multiple HCV Amino Acid Variants Associate with Interferon Lambda Polymorphism in Genotype 1a, 1b and 3a Infections. 2016. 67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston, MA, NOV 11-15, 2016. p. 33A-33A.
F. Licciardi; D. Montin; A. Versace; G. Migliore; C. Tzialla et al. : Familial segregation of group B streptococcal infection in a consanguineous kindred; International Journal Of Infectious Diseases. 2016. DOI : 10.1016/j.ijid.2016.08.010.
P. Rusert; R. D. Kouyos; C. Kadelka; H. Ebner; M. Schanz et al. : Determinants of HIV-1 broadly neutralizing antibody induction; Nature Medicine. 2016. DOI : 10.1038/nm.4187.
Z. Huang; E. Ayday; H. Lin; R. S. Aiyar; A. Molyneaux et al. : A privacy-preserving solution for compressed storage and selective retrieval of genomic data; Genome Research. 2016. DOI : 10.1101/gr.206870.116.
S. Asgari; P. J. Mclaren; J. Peake; M. Wong; R. Wong et al. : Corrigendum: Exome Sequencing reveals Primary immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis (vol 7, 357, 2016); Frontiers In Immunology. 2016. DOI : 10.3389/fimmu.2016.00447.
J. Martinez-Picado; P. J. Mclaren; I. Erkizia; M. P. Martin; S. Benet et al. : Identification of Siglec-1 null individuals infected with HIV-1; Nature Communications. 2016. DOI : 10.1038/ncomms12412.
M. Bou Sleiman / B. Lemaitre; B. Deplancke (Dir.) : The Drosophila gut response to infection. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7151.
P. An; S. Penugonda; C. W. Thorball; I. Bartha; J. J. Goedert et al. : Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia; Plos Genetics. 2016. DOI : 10.1371/journal.pgen.1005921.
P. J. McLaren; J. L. Raisaro; M. Aouri; M. Rotger; E. Ayday et al. : Privacy-preserving genomic testing in the clinic: a model using HIV treatment; Genetics in medicine : official journal of the American College of Medical Genetics. 2016. DOI : 10.1038/gim.2015.167.
S. Asgari / J. Fellay (Dir.) : Host and pathogen genomics of severe pediatric infections. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6656.
C. Hammer; M. Begemann; P. J. Mclaren; I. Bartha; A. Michel et al. : Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses; American Journal Of Human Genetics. 2015. DOI : 10.1016/j.ajhg.2015.09.008.
P. J. Mclaren; C. Coulonges; I. Bartha; T. L. Lenz; A. J. Deutsch et al. : Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2015. DOI : 10.1073/pnas.1514867112.
I. Bartha; A. Rausell; P. J. Mclaren; P. Mohammadi; M. Tardaguila et al. : The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome; Plos Computational Biology. 2015. DOI : 10.1371/journal.pcbi.1004647.
M. R. Perkins; I. Bartha; J. K. Timmer; J. C. Liebner; D. Wollinsky et al. : The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals; The Journal of infectious diseases. 2015. DOI : 10.1093/infdis/jiv089.
M. Naveed; E. Ayday; E. Clayton; J. Fellay; C. Gunter et al. : Privacy in the Genomic Era; ACM Computing Surveys. 2015. DOI : 10.1145/2767007.
I. Bartha; J. Fellay : Adaptation on a genomic scale; eLife. 2015. DOI : 10.7554/eLife.06193.
P. J. McLaren; J. Fellay : Human genetic variation in HIV disease: beyond genome-wide association studies; Current opinion in HIV and AIDS. 2015. DOI : 10.1097/COH.0000000000000133.
S. Samani; Z. Huang; E. Ayday; M. Elliot; J. Fellay et al. : Quantifying Genomic Privacy via Inference Attack with High-Order SNV Correlations. 2015. 2nd International Workshop on Genome Privacy and Security (in conjunction with IEEE S&P 2015), San Jose, CA, USA, May 21, 2015.
Z. Huang; E. Ayday; J. Fellay; J.-P. Hubaux; A. Juels : GenoGuard: Protecting Genomic Data against Brute-Force Attacks. 2015. 36th IEEE Symposium on Security and Privacy (S&P 2015), San Jose, CA, USA, May 18-20, 2015.
M. Humbert / J.-P. Hubaux (Dir.) : When Others Impinge upon Your Privacy. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6515.
Z. Huang; E. Ayday; J. Fellay; J.-P. Hubaux; A. Juels : GenoGuard: Protecting Genomic Data Against Brute-Force Attacks. 2015.
M. Fellay : Valparaíso en 02h01. Promenade d'un port à l'autre ; 2014.
J. Fellay : Médecine génomique et Maladies infectieuses; Praxis. 2014. DOI : 10.1024/1661-8157/a001658.
D. L. Braun; R. Kouyos; C. Oberle; C. Grube; B. Joos et al. : A Novel Acute Retroviral Syndrome Severity Score Predicts the Key Surrogate Markers for HIV-1 Disease Progression; Plos One. 2014. DOI : 10.1371/journal.pone.0114111.
J. Fellay : [Genomic medicine and infectious diseases]; Praxis. 2014. DOI : 10.1024/1661-8157/a001658.
N. Vince; A. A. Bashirova; A. Lied; X. Gao; L. Dorrell et al. : HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A; The Journal of infectious diseases. 2014. DOI : 10.1093/infdis/jiu214.
R. R. Regoes; P. J. McLaren; M. Battegay; E. Bernasconi; A. Calmy et al. : Disentangling human tolerance and resistance against HIV; PLoS biology. 2014. DOI : 10.1371/journal.pbio.1001951.
J. Fellay; J. L. Raisaro; Z. Huang; M. Humbert; E. Ayday et al. : Practical Solutions for Protecting Individual Genomic Privacy ; American Society of Human Genetics (ASHG), San Diego, CA, USA, October 2014.
P. Mohammadi; J. Di Iulio; M. Munoz; R. Martinez; I. Bartha et al. : Dynamics of HIV Latency and Reactivation in a Primary CD4+T Cell Model; Plos Pathogens. 2014. DOI : 10.1371/journal.ppat.1004156.
A. Rausell; P. Mohammadi; P. J. Mclaren; I. Bartha; I. Xenarios et al. : Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes; Plos Computational Biology. 2014. DOI : 10.1371/journal.pcbi.1003757.
A. A. Bashirova; E. Martin-Gayo; D. C. Jones; Y. Qi; R. Apps et al. : LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection; Plos Genetics. 2014. DOI : 10.1371/journal.pgen.1004196.
B. Lechartier / S. Cole; L. P. Nicod (Dir.) : Benzothiazinones: from a new lead to new combination therapies against Mycobacterium tuberculosis. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6239.
I. Bartha; P. J. Mclaren; A. Ciuffi; J. Fellay; A. Telenti : GuavaH: a compendium of host genomic data in HIV biology and disease; Retrovirology. 2014. DOI : 10.1186/1742-4690-11-6.
P. J. McLaren; J. Fellay; A. Telenti : European genetic diversity and susceptibility to pathogens; Human heredity. 2013. DOI : 10.1159/000357758.
I. Bartha; J. M. Carlson; C. J. Brumme; P. J. Mclaren; Z. L. Brumme et al. : A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control; Elife. 2013. DOI : 10.7554/eLife.01123.
S. Kulkarni; Y. Qi; C. O'Huigin; F. Pereyra; V. Ramsuran et al. : Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013. DOI : 10.1073/pnas.1312237110.
C. Fellay / K. Johnsson (Dir.) : Detection of Drug-Protein Interactions with an Improved Yeast Three-Hybrid System. Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5944.
E. Ayday; J. L. Raisaro; M. Laren; P. Jack; J. Fellay et al. : Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data (poster version) ; USENIX Security Workshop on Health Information Technologies (HealthTech '13), Washington, DC, USA, August, 2013.
J. Lane; P. J. Mclaren; L. Dorrell; K. V. Shianna; A. Stemke et al. : A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A; Human Molecular Genetics. 2013. DOI : 10.1093/hmg/ddt033.
M. Rotger; T. R. Glass; T. Junier; J. Lundgren; J. D. Neaton et al. : Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons; Clinical Infectious Diseases. 2013. DOI : 10.1093/cid/cit196.
P. J. Mclaren; C. Coulonges; S. Ripke; L. Van Den Berg; S. Buchbinder et al. : Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls; PLoS Pathogens. 2013. DOI : 10.1371/journal.ppat.1003515.
E. Ayday; J. L. Raisaro; M. Laren; P. Jack; J. Fellay et al. : Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data. 2013. USENIX Security Workshop on Health Information Technologies (HealthTech '13), Washington, DC, USA, August.
R. Apps; Y. Qi; J. M. Carlson; H. Chen; X. Gao et al. : Influence of HLA-C Expression Level on HIV Control; Science. 2013. DOI : 10.1126/science.1232685.
S. K. Pillai; M. Abdel-Mohsen; J. Guatelli; M. Skasko; A. Monto et al. : Role of retroviral restriction factors in the interferon- -mediated suppression of HIV-1 in vivo; Proceedings of the National Academy of Sciences. 2012. DOI : 10.1073/pnas.1111573109.
M. Stern; K. Czaja; A. Rauch; M. Rickenbach; H. F. Günthard et al. : HLA-Bw4 identifies a population of HIV-infected patients with an increased capacity to control viral replication after structured treatment interruption; HIV Medicine. 2012. DOI : 10.1111/j.1468-1293.2012.01019.x.
P. J. Clark; A. J. Thompson; M. Zhu; D. M. Vock; Q. Zhu et al. : Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response; Journal of viral hepatitis. 2012. DOI : 10.1111/j.1365-2893.2011.01553.x.
P. J. Clark; A. J. Thompson; Q. Zhu; D. M. Vock; M. Zhu et al. : The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection; Digestive diseases and sciences. 2012. DOI : 10.1007/s10620-012-2171-y.
E. Elamparuthi; C. Fellay; M. Neuburger; K. Gademann : Total Synthesis of Cyrneine A; Angewandte Chemie-International Edition. 2012. DOI : 10.1002/anie.201200515.
K. Pelak; A. C. Need; J. Fellay; K. V. Shianna; S. Feng et al. : Copy Number Variation of KIR Genes Influences HIV-1 Control; Plos Biology. 2011. DOI : 10.1371/journal.pbio.1001208.
J. Snoeck; J. Fellay; I. Bartha; D. C. Douek; A. Telenti : Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints; Retrovirology. 2011. DOI : 10.1186/1742-4690-8-87.
C. Chidley; H. Haruki; M. G. Pedersen; C. Fellay; S. Moser et al. : Searching for the Protein Targets of Bioactive Molecules; Chimia. 2011. DOI : 10.2533/chimia.2011.720.
G. J. Vanasse; J.-Y. Jeong; J. Tate; H. Bathulapalli; D. Anderson et al. : A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease; Blood. 2011. DOI : 10.1182/blood-2011-06-362194.
M. Rotger; J. Dalmau; A. Rauch; P. McLaren; S. Bosinger et al. : Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque; The Journal of clinical investigation. 2011. DOI : 10.1172/JCI45235.
A. Rauch; J. Fellay : Personalized hepatitis C therapy: opportunities and pitfalls; Expert review of molecular diagnostics. 2011. DOI : 10.1586/erm.10.116.
Y. Hitomi; E. T. Cirulli; J. Fellay; J. G. McHutchison; A. J. Thompson et al. : Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function; Gastroenterology. 2011. DOI : 10.1053/j.gastro.2010.12.038.
S. Petrovski; J. Fellay; K. V. Shianna; N. Carpenetti; J. Kumwenda et al. : Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population; AIDS. 2011. DOI : 10.1097/QAD.0b013e328343817b.
S. M. Bol; P. D. Moerland; S. Limou; Y. van Remmerden; C. Coulonges et al. : Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages; PloS one. 2011. DOI : 10.1371/journal.pone.0017190.
J. Fellay; N. Frahm; K. V. Shianna; E. T. Cirulli; D. R. Casimiro et al. : Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial; The Journal of infectious diseases. 2011. DOI : 10.1093/infdis/jiq125.
J. di Iulio; A. Ciuffi; K. Fitzmaurice; D. Kelleher; M. Rotger et al. : Estimating the net contribution of IL28B variation to spontaneous hepatitis C virus clearance; Hepatology. 2011. DOI : 10.1002/hep.24263.
E. Evangelou; J. Fellay; S. Colombo; J. Martinez-Picado; N. Obel et al. : Impact of Phenotype Definition on Genome-Wide Association Signals: Empirical Evaluation in Human Immunodeficiency Virus Type 1 Infection; American Journal of Epidemiology. 2011. DOI : 10.1093/aje/kwr024.
A. J. Thompson; J. Fellay; J. G. McHutchison : How the human genome can predict response to Hepatitis C therapy; Current Hepatitis Reports. 2010. DOI : 10.1007/s11901-010-0029-3.
D. H. Barouch; T. Ndung’u; G. Alter; T. Cardozo; B. Chohan et al. : Young and Early Career Investigators: Report from a Global HIV Vaccine Enterprise Working Group; Nature Precedings. 2010. DOI : 10.1038/npre.2010.4800.2.
J. Fellay; K. V. Shianna; A. Telenti; D. B. Goldstein : Host genetics and HIV-1: the final phase?; PLoS pathogens. 2010. DOI : 10.1371/journal.ppat.1001033.
W. Yoon; B.-J. Ma; J. Fellay; W. Huang; S.-M. Xia et al. : A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro; AIDS. 2010. DOI : 10.1097/QAD.0b013e32833202f5.
A. J. Thompson; A. J. Muir; M. S. Sulkowski; K. Patel; H. L. Tillmann et al. : Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype; Hepatology. 2010. DOI : 10.1002/hep.23826.
S. Gheuens; J. Fellay; D. B. Goldstein; I. J. Koralnik : Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy; Journal of neurovirology. 2010. DOI : 10.3109/13550280903552438.
Enseignement & Phd
Enseignement
- Life Sciences Engineering,
Programmes doctoraux
- Doctoral Program in Molecular Life Sciences
- Doctoral Program in Biotechnology and Bioengineering
- Doctoral Program in Computational and Quantitative Biology
Doctorants
Hodel Flavia Aurelia Shoko
Naret Olivier Noël Marie
Thorball Christian Axel Wandall
Huang Zhicong ...
Scepanovic Petar ...
Naret Olivier Noël Marie
Thorball Christian Axel Wandall
A dirigé les thèses de
Asgari Samira ...Huang Zhicong ...
Scepanovic Petar ...
Cours
Génétique et génomique
Ce cours couvre d'abord la génétique classique et après les techniques et les avancées de la génomique contemporaine. Le cours comporte aussi une introduction au langage de programmation « R », suivie d'analyses bioinformatiques de base pour l'analyse des... 
Landmark Papers in Cancer and Infection
The topics will cover all the fields in which the GHI and ISREC PIs work.
New tools & research strategies in personalized health
Practical - Fellay Lab
Exploration of human genetic variation in large-scale sequencing data.