Jacques Fellay
Professeur associé
jacques.fellay@epfl.ch +41 21 693 18 49 http://fellay-lab.epfl.ch
EPFL SV GHI GR-FE
SV 3824 (Bâtiment SV)
Station 19
CH-1015 Lausanne
+41 21 693 18 49
+41 21 693 72 32
Local: SV 3824
EPFL > SV > GHI > GR-FE
Web site: Site web: https://fellay-lab.epfl.ch
Domaines de compétences
Human genomics of infectious diseases - Immunogenetics - Virus-host interactions - Translational genomics - Personalized health
Mission
Human genetic variation plays a key role in determining individual outcomes after exposure to infectious agents.The mission of our laboratory is to contribute to a better understanding of inter-individual differences in response to infections, using a range of contemporary genomic tools. Approaches include genome-wide genotyping and association analysis, exome/genome sequencing and transcriptomics.
Biography
Jacques Fellay is a medical scientist with expertise in infectious diseases and human genomics. He obtained his MD from the University of Lausanne in 2002 and his PhD from University of Utrecht. After a clinical training in infectious diseases in Switzerland and a 4-years postdoctoral fellowship at Duke University, he joined the EPFL in April 2011 with an SNF Professorship.On top of his EPFL affiliation, Jacques is also Head of Precision Medicine at the University Hospital (CHUV) in Lausanne, Group Leader at the Swiss Institute of Bioinformatics, and Co-director of the Health2030 Genome Center at Campus Biotech in Geneva.
Publications
Publications Infoscience
Infoscience
A. Borghesi; A. Marzollo; A. Michev; J. Fellay : Susceptibility to infection in early life: a growing role for human genetics; Human Genetics. 2020-06-01. DOI : 10.1007/s00439-019-02109-2.
J. Fellay; V. Pedergnana : Exploring the interactions between the human and viral genomes; Human Genetics. 2020-06-01. DOI : 10.1007/s00439-019-02089-3.
L. C. Joseph; P.-S. Javier; A. S. Andrew; R. Andrea; F. Jacques : Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland; Swiss Medical Weekly. 2020-05-30. DOI : 10.4414/smw.20295.
S. Marcel; A. L. Christian; N. Richard; S. Silvia; H. Emma et al. : COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation; Swiss Medical Weekly. 2020-03-19. DOI : 10.4414/smw.2020.20225.
J. Arora; F. Pierini; P. J. McLaren; M. Carrington; J. Fellay et al. : HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation; Molecular Biology And Evolution. 2020-03-01. DOI : 10.1093/molbev/msz249.
L. G. Dietrich; C. Barcelo; C. W. Thorball; L. Ryom; F. Burkhalter et al. : Contribution of Genetic Background and Data Collection on Adverse Events of Anti-human Immunodeficiency Virus (HIV) Drugs (D:A:D) Clinical Risk Score to Chronic Kidney Disease in Swiss HIV-infected Persons With Normal Baseline Estimated Glomerular Filtration Rate; Clinical Infectious Diseases. 2020-03-01. DOI : 10.1093/cid/ciz280.
G. Lazzari / M. Salathé (Dir.) : Contact networks across ages: computational analysis of epidemiological dynamics. Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-7482.
C. Barcelo; M. Guidi; C. W. Thorball; C. Hammer; A. Chaouch et al. : Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy; Open Forum Infectious Diseases. 2020-01-01. DOI : 10.1093/ofid/ofz464.
C. A. W. Thorball / J. Fellay; D. Trono (Dir.) : HIV host genomics in the era of effective antiretroviral therapy. Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-10132.
A. D. Wagner; S. Oertelt-Prigione; A. Adjei; T. Buclin; V. Cristina et al. : Gender medicine and oncology: report and consensus of an ESMO workshop; Annals Of Oncology. 2019-12-01. DOI : 10.1093/annonc/mdz414.
P. Bost; X. Mariette; V. Bondet; A. Llibre; C. Posseme et al. : Systems Biology in 874 Patients with Primary Sjogren's Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA. 2019-10-01.
S. Rueger; C. Hammer; A. Loetscher; E. Zdobnov; J. Fellay : Genome-to-genome analysis of Epstein-Barr virus infection. 2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1365-1365.
D. Lawless; S. Asgari; L. Schlapbach; J. Fellay : Rare variants in antiviral response genes drive severe viral respiratory infections in children. 2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1374-1375.
F. Hodel; P. Marques-Vidal; P. Vollenweider; J. Fellay : Human genetic determinants of chronic low-grade inflammation in the general population. 2019-10-01. 52nd Conference of the European-Society-of-Human-Genetics (ESHG), Gothenburg, SWEDEN, Jun 15-18, 2019. p. 1747-1748.
D. Lawless; H. L. Allen; J. Thaventhiran; F. Hodel; R. Anwar et al. : Predicting the Occurrence of Variants in RAG1 and RAG2; Journal Of Clinical Immunology. 2019-10-01. DOI : 10.1007/s10875-019-00670-z.
P. Scepanovic; F. Hodel; S. Mondot; V. Partula; A. Byrd et al. : A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals; Microbiome. 2019-09-13. DOI : 10.1186/s40168-019-0747-x.
N. Chaturvedi; E. S. Svarovskaia; H. Mo; A. O. Osinusi; D. M. Brainard et al. : Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes; Elife. 2019-09-03. DOI : 10.7554/eLife.42542.
Huyen Nguyen; C. W. Thorball; J. Fellay; J. Boni; S. Yerly et al. : HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected; Jaids-Journal Of Acquired Immune Deficiency Syndromes. 2019-08-15. DOI : 10.1097/QAI.0000000000002077.
N. Bachmann; C. von Siebenthal; V. Vongrad; T. Turk; K. Neumann et al. : Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART; Nature Communications. 2019-07-19. DOI : 10.1038/s41467-019-10884-9.
D. E. Geraghty; C. W. Thorball; J. Fellay; R. Thomas : Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis; Frontiers In Immunology. 2019-05-09. DOI : 10.3389/fimmu.2019.00970.
V. Partula; S. Mondot; M. J. Torres; E. Kesse-Guyot; M. Deschasaux et al. : Associations between usual diet and gut microbiota composition: results from the Milieu Interieur cross-sectional study; American Journal Of Clinical Nutrition. 2019-05-01. DOI : 10.1093/ajcn/nqz029.
S. Asgari; N. Chaturvedi; P. Scepanovic; C. Hammer; N. Semmo et al. : Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients; Journal Of Viral Hepatitis. 2019-02-01. DOI : 10.1111/jvh.13019.
P. Maffucci; B. Bigio; F. Rapaport; A. Cobat; A. Borghesi et al. : Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1808403116.
J. Arora; P. J. McLare; N. Chaturvedi; M. Carrington; J. Fellay et al. : HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019-01-15. DOI : 10.1073/pnas.1812548116.
S. M. K. Nazeeruddin / B. Schneider; P. Aebischer (Dir.) : A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9532.
S. Langer; C. Hammer; K. Hopfensperger; L. Klein; D. Hotter et al. : HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses; eLife. 2019. DOI : 10.7554/eLife.41930.
Ö. Kocabiyik / F. Stellacci (Dir.) : Virucidal nanomaterials against influenza. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9114.
S. Bibert; A. Wojtowicz; P. Taffe; P. E. Tarr; E. Bernasconi et al. : Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma; Aids. 2018-11-28. DOI : 10.1097/QAD.0000000000002004.
P. Scepanovic; C. Alanio; C. Hammer; F. Hodel; J. Bergstedt et al. : Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines; Genome Medicine. 2018-07-27. DOI : 10.1186/s13073-018-0568-8.
C. Wymant; F. Blanquart; T. Golubchik; A. Gall; M. Bakker et al. : Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver; Virus Evolution. 2018-05-18. DOI : 10.1093/ve/vey007.
M. P. Martin; V. Naranbhai; P. R. Shea; Y. Qi; V. Ramsuran et al. : Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1; Journal of Clinical Investigation. 2018-05-01. DOI : 10.1172/JCI98463.
E. Patin; M. Hasan; J. Bergstedt; V. Rouilly; V. Libri et al. : Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors; Nature Immunology. 2018-03-19. DOI : 10.1038/s41590-018-0049-7.
S. Cordey; M.-A. Hartley; K. Keitel; F. Laubscher; F. Brito et al. : Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children; Emerging Microbes & Infections. 2018-03-14. DOI : 10.1038/s41426-018-0025-1.
J.-L. Raisaro; P. J. McLaren; J. Fellay; M. Cavassini; C. Klersy et al. : Are privacy-enhancing technologies for genomic data ready for the clinic? A survey of medical experts of the Swiss HIV Cohort Study; Journal of Biomedical Informatics. 2018-03-01. DOI : 10.1016/j.jbi.2017.12.013.
V. Ramsuran; V. Naranbhai; A. Horowitz; Y. Qi; M. P. Martin et al. : Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells; Science. 2018-01-05. DOI : 10.1126/science.aam8825.
F. Hodel; A. Shaqiri; M. Roinishvili; E. Chkonia; A. Brand et al. : Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype. 2018. Annual meeting of the American Society of Human Genetics (ASHG), San Diego, USA, October 16-20, 2018.
P. Scepanovic / J. Fellay; B. Deplancke (Dir.) : Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8955.
O. Naret; N. Chaturvedi; I. Bartha; C. Hammer; J. Fellay : Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes; Frontiers in Genetics. 2018. DOI : 10.3389/fgene.2018.00266.
A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.) : Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8748.
C. Avanzi / S. Cole (Dir.) : Genomics: a Swiss army knife to fight leprosy. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8482.
Z. Huang / J.-P. Hubaux; J. Fellay (Dir.) : On Secure Cloud Computing for Genomic Data: From Storage to Analysis. Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8367.
F. Bertels; A. Marzel; G. Leventhal; V. Mitov; J. Fellay et al. : Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity; Molecular biology and evolution. 2018. DOI : 10.1093/molbev/msx246.
E. Adland; M. Hill; N. Lavandier; A. Csala; A. Edwards et al. : Differential immunodominance hierarchy of CD8+ T cell responses in HLA-B*27:05 and B*27:02-mediated control of HIV-1 infection; Journal of virology. 2018. DOI : 10.1128/JVI.01685-17.
L. Abel; J. Fellay; D. W. Haas; E. Schurr; G. Srikrishna et al. : Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives; The Lancet. Infectious Diseases. 2018. DOI : 10.1016/S1473-3099(17)30623-0.
E. M. Leitman; C. B. Willberg; M.-H. Tsai; H. Chen; S. Buus et al. : HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection; Journal of virology. 2017. DOI : 10.1128/JVI.00544-17.
P. J. McLaren; S. L. Pulit; D. Gurdasani; I. Bartha; P. R. Shea et al. : Evaluating the Impact of Functional Genetic Variation on HIV-1 Control; The Journal of infectious diseases. 2017. DOI : 10.1093/infdis/jix470.
B. Piasecka; D. Duffy; A. Urrutia; H. Quach; E. Patin et al. : Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges; Proceedings of the National Academy of Sciences of the United States of America. 2017. DOI : 10.1073/pnas.1714765115.
F. Blanquart; C. Wymant; M. Cornelissen; A. Gall; M. Bakker et al. : Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe; Plos Biology. 2017. DOI : 10.1371/journal.pbio.2001855.
S. Asgari; L. J. Schlapbach; S. Anchisi; C. Hammer; I. Bartha et al. : Severe viral respiratory infections in children with IFIH1 loss-of-function mutations; Proceedings of the National Academy of Sciences of the United States of America. 2017. DOI : 10.1073/pnas.1704259114.
Z. Huang; H. Lin; J. Fellay; Z. Kutalik; J.-P. Hubaux : SQC: Secure Quality Control for Meta-Analysis of Genome-Wide Association Studies; Bioinformatics. 2017. DOI : 10.1093/bioinformatics/btx193.
M. A. Ansari; V. Pedergnana; C. L. C. Ip; A. Magri; A. Von Delft et al. : Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus; Nature Genetics. 2017. DOI : 10.1038/ng.3835.
I. Bartha; P. J. Mclaren; C. Brumme; R. Harrigan; A. Telenti et al. : Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control; PLoS Computational Biology. 2017. DOI : 10.1371/journal.pcbi.1005339.
A. Borghesi; M. Stronati; J. Fellay : Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses; Frontiers In Immunology. 2017. DOI : 10.3389/fimmu.2017.00215.
R. Abujaber; P. R. Shea; P. J. Mclaren; S. Lakhi; J. Gilmour et al. : No Evidence for Association of beta-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS; Annals Of Human Genetics. 2017. DOI : 10.1111/ahg.12182.
Z. Huang; E. Ayday; H. Lin; R. S. Aiyar; A. Molyneaux et al. : A privacy-preserving solution for compressed storage and selective retrieval of genomic data; Genome Research. 2016-10-27. DOI : 10.1101/gr.206870.116.
T. Junier; M. Rotger; E. Biver; B. Ledergerber; C. Barcelo et al. : Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study; Open Forum Infectious Diseases. 2016-04-01. DOI : 10.1093/ofid/ofw101.
E. Ayday; J. P. Hubaux; J. L. Raisaro; A. Telenti; J. Fellay et al. ; Privacy-enhancing technologies for medical tests using genomic data. EP2895980 ; US9536047 ; US2016224735 ; US9306443 ; US9270446 ; US2015236849 ; EP2895980 ; CN103677065 ; WO2014040964 ; US2014077757 ; EP2709028 ; TW201411310 . 2016.
S. Asgari; P. J. Mclaren; J. Peake; M. Wong; R. Wong et al. : Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis; Frontiers In Immunology. 2016. DOI : 10.3389/fimmu.2016.00357.
N. Chaturvedi; R. K. Chodavarapu; E. S. Svarovskaia; H. Mo; A. O. Osinusi et al. : Multiple HCV Amino Acid Variants Associate with Interferon Lambda Polymorphism in Genotype 1a, 1b and 3a Infections. 2016. 67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston, MA, NOV 11-15, 2016. p. 33A-33A.
F. Licciardi; D. Montin; A. Versace; G. Migliore; C. Tzialla et al. : Familial segregation of group B streptococcal infection in a consanguineous kindred; International Journal Of Infectious Diseases. 2016. DOI : 10.1016/j.ijid.2016.08.010.
P. Rusert; R. D. Kouyos; C. Kadelka; H. Ebner; M. Schanz et al. : Determinants of HIV-1 broadly neutralizing antibody induction; Nature Medicine. 2016. DOI : 10.1038/nm.4187.
S. Asgari; P. J. Mclaren; J. Peake; M. Wong; R. Wong et al. : Corrigendum: Exome Sequencing reveals Primary immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis (vol 7, 357, 2016); Frontiers In Immunology. 2016. DOI : 10.3389/fimmu.2016.00447.
J. Martinez-Picado; P. J. Mclaren; I. Erkizia; M. P. Martin; S. Benet et al. : Identification of Siglec-1 null individuals infected with HIV-1; Nature Communications. 2016. DOI : 10.1038/ncomms12412.
M. Bou Sleiman / B. Lemaitre; B. Deplancke (Dir.) : The Drosophila gut response to infection. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7151.
P. An; S. Penugonda; C. W. Thorball; I. Bartha; J. J. Goedert et al. : Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia; Plos Genetics. 2016. DOI : 10.1371/journal.pgen.1005921.
P. J. McLaren; J. L. Raisaro; M. Aouri; M. Rotger; E. Ayday et al. : Privacy-preserving genomic testing in the clinic: a model using HIV treatment; Genetics in medicine : official journal of the American College of Medical Genetics. 2016. DOI : 10.1038/gim.2015.167.
S. Asgari / J. Fellay (Dir.) : Host and pathogen genomics of severe pediatric infections. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-6656.
C. Hammer; M. Begemann; P. J. Mclaren; I. Bartha; A. Michel et al. : Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses; American Journal Of Human Genetics. 2015. DOI : 10.1016/j.ajhg.2015.09.008.
P. J. Mclaren; C. Coulonges; I. Bartha; T. L. Lenz; A. J. Deutsch et al. : Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2015. DOI : 10.1073/pnas.1514867112.
I. Bartha; A. Rausell; P. J. Mclaren; P. Mohammadi; M. Tardaguila et al. : The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome; Plos Computational Biology. 2015. DOI : 10.1371/journal.pcbi.1004647.
M. R. Perkins; I. Bartha; J. K. Timmer; J. C. Liebner; D. Wollinsky et al. : The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals; The Journal of infectious diseases. 2015. DOI : 10.1093/infdis/jiv089.
M. Naveed; E. Ayday; E. Clayton; J. Fellay; C. Gunter et al. : Privacy in the Genomic Era; ACM Computing Surveys. 2015. DOI : 10.1145/2767007.
I. Bartha; J. Fellay : Adaptation on a genomic scale; eLife. 2015. DOI : 10.7554/eLife.06193.
P. J. McLaren; J. Fellay : Human genetic variation in HIV disease: beyond genome-wide association studies; Current opinion in HIV and AIDS. 2015. DOI : 10.1097/COH.0000000000000133.
S. Samani; Z. Huang; E. Ayday; M. Elliot; J. Fellay et al. : Quantifying Genomic Privacy via Inference Attack with High-Order SNV Correlations. 2015. 2nd International Workshop on Genome Privacy and Security (in conjunction with IEEE S&P 2015), San Jose, CA, USA, May 21, 2015.
Z. Huang; E. Ayday; J. Fellay; J.-P. Hubaux; A. Juels : GenoGuard: Protecting Genomic Data against Brute-Force Attacks. 2015. 36th IEEE Symposium on Security and Privacy (S&P 2015), San Jose, CA, USA, May 18-20, 2015.
Z. Huang; E. Ayday; J. Fellay; J.-P. Hubaux; A. Juels : GenoGuard: Protecting Genomic Data Against Brute-Force Attacks. 2015.
M. Fellay : Valparaíso en 02h01. Promenade d'un port à l'autre ; 2014.
J. Fellay : Médecine génomique et Maladies infectieuses; Praxis. 2014. DOI : 10.1024/1661-8157/a001658.
D. L. Braun; R. Kouyos; C. Oberle; C. Grube; B. Joos et al. : A Novel Acute Retroviral Syndrome Severity Score Predicts the Key Surrogate Markers for HIV-1 Disease Progression; Plos One. 2014. DOI : 10.1371/journal.pone.0114111.
J. Fellay : [Genomic medicine and infectious diseases]; Praxis. 2014. DOI : 10.1024/1661-8157/a001658.
N. Vince; A. A. Bashirova; A. Lied; X. Gao; L. Dorrell et al. : HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A; The Journal of infectious diseases. 2014. DOI : 10.1093/infdis/jiu214.
R. R. Regoes; P. J. McLaren; M. Battegay; E. Bernasconi; A. Calmy et al. : Disentangling human tolerance and resistance against HIV; PLoS biology. 2014. DOI : 10.1371/journal.pbio.1001951.
J. Fellay; J. L. Raisaro; Z. Huang; M. Humbert; E. Ayday et al. : Practical Solutions for Protecting Individual Genomic Privacy ; American Society of Human Genetics (ASHG), San Diego, CA, USA, October 2014.
P. Mohammadi; J. Di Iulio; M. Munoz; R. Martinez; I. Bartha et al. : Dynamics of HIV Latency and Reactivation in a Primary CD4+T Cell Model; Plos Pathogens. 2014. DOI : 10.1371/journal.ppat.1004156.
A. Rausell; P. Mohammadi; P. J. Mclaren; I. Bartha; I. Xenarios et al. : Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes; Plos Computational Biology. 2014. DOI : 10.1371/journal.pcbi.1003757.
A. A. Bashirova; E. Martin-Gayo; D. C. Jones; Y. Qi; R. Apps et al. : LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection; Plos Genetics. 2014. DOI : 10.1371/journal.pgen.1004196.
B. Lechartier / S. Cole; L. P. Nicod (Dir.) : Benzothiazinones: from a new lead to new combination therapies against Mycobacterium tuberculosis. Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6239.
I. Bartha; P. J. Mclaren; A. Ciuffi; J. Fellay; A. Telenti : GuavaH: a compendium of host genomic data in HIV biology and disease; Retrovirology. 2014. DOI : 10.1186/1742-4690-11-6.
P. J. McLaren; J. Fellay; A. Telenti : European genetic diversity and susceptibility to pathogens; Human heredity. 2013. DOI : 10.1159/000357758.
I. Bartha; J. M. Carlson; C. J. Brumme; P. J. Mclaren; Z. L. Brumme et al. : A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control; Elife. 2013. DOI : 10.7554/eLife.01123.
S. Kulkarni; Y. Qi; C. O'Huigin; F. Pereyra; V. Ramsuran et al. : Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease; Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013. DOI : 10.1073/pnas.1312237110.
C. Fellay / K. Johnsson (Dir.) : Detection of Drug-Protein Interactions with an Improved Yeast Three-Hybrid System. Lausanne, EPFL, 2013. DOI : 10.5075/epfl-thesis-5944.
E. Ayday; J. L. Raisaro; M. Laren; P. Jack; J. Fellay et al. : Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data (poster version) ; USENIX Security Workshop on Health Information Technologies (HealthTech '13), Washington, DC, USA, August, 2013.
J. Lane; P. J. Mclaren; L. Dorrell; K. V. Shianna; A. Stemke et al. : A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A; Human Molecular Genetics. 2013. DOI : 10.1093/hmg/ddt033.
M. Rotger; T. R. Glass; T. Junier; J. Lundgren; J. D. Neaton et al. : Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons; Clinical Infectious Diseases. 2013. DOI : 10.1093/cid/cit196.
P. J. Mclaren; C. Coulonges; S. Ripke; L. Van Den Berg; S. Buchbinder et al. : Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls; PLoS Pathogens. 2013. DOI : 10.1371/journal.ppat.1003515.
E. Ayday; J. L. Raisaro; M. Laren; P. Jack; J. Fellay et al. : Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data. 2013. USENIX Security Workshop on Health Information Technologies (HealthTech '13), Washington, DC, USA, August.
R. Apps; Y. Qi; J. M. Carlson; H. Chen; X. Gao et al. : Influence of HLA-C Expression Level on HIV Control; Science. 2013. DOI : 10.1126/science.1232685.
S. K. Pillai; M. Abdel-Mohsen; J. Guatelli; M. Skasko; A. Monto et al. : Role of retroviral restriction factors in the interferon- -mediated suppression of HIV-1 in vivo; Proceedings of the National Academy of Sciences. 2012. DOI : 10.1073/pnas.1111573109.
Enseignement & Phd
Enseignement
Life Sciences Engineering