Joerg Huelsken
EPFL SV ISREC UPHUELSKEN
SV 2823 (Bâtiment SV)
Station 19
1015 Lausanne
+41 21 693 07 51
+41 21 693 07 52
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Publications
Publications Infoscience
Infoscience
Lat-based nk cars and their use
WO2024153707 . 2024.Metabolic dependencies of metastasis-initiating cells in female breast cancer
Nature Communications. 2023. DOI : 10.1038/s41467-023-42748-8.Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma
Journal Of Experimental & Clinical Cancer Research. 2023. DOI : 10.1186/s13046-023-02650-z.Metabolic dependencies of metastasis-initiating cells in breast cancer
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8855.Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8912.Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-9093.Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Iscience. 2022. DOI : 10.1016/j.isci.2022.105171.Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo
2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62 - S62.The role of eosinophils in breast cancer
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8575.High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109026.Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes
Cancers. 2021. DOI : 10.3390/cancers13061267.Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen
Journal Of Immunology. 2021. DOI : 10.4049/jimmunol.2001066.Intestinal stem cells differentiation and its application in cancer therapy
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8868.The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
Stem Cell Reports. 2020. DOI : 10.1016/j.stemcr.2020.06.022.γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia
Cancer Cell. 2019. DOI : 10.1016/j.ccell.2019.03.005.Comprehensive analysis of cancer stemness
2018. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.Targeting cancer stem cells by T cell engineering
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
Stem Cells. 2017. DOI : 10.1002/stem.2719.Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue
Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation
Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Nature Communications. 2016. DOI : 10.1038/ncomms13500.Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host
2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity
Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.Development of microfluidic devices for chemotaxis of primary stem cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.Microfluidic co-culture platform to quantify chemotaxis of primary stem cells
Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host
2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167 - S168.Complex metastatic niches: already a target for therapy?
Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer
Oncogene. 2014. DOI : 10.1038/onc.2013.140.Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation
2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42 - S42. DOI : 10.1016/j.exphem.2014.07.156.Identification of tumor-stroma interactions crucial for the establishment of liver metastasis
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.The niche under siege: novel targets for metastasis therapy
Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.Metastasis: New insights into organ-specific extravasation and metastatic niches
Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.Putting cancer stem cells in context
2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7 - S7.Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung
2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15 - S15.Interactions between cancer stem cells and their niche govern metastatic colonization
Nature. 2012. DOI : 10.1038/nature10694.Lrig1: a new master regulator of epithelial stem cells
The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.Identification of a Novel Wnt Inhibitor
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.Asymmetric Cell Division in the Skin
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.Targeting extracellular matrix molecules for the treatment of cancer
WO2011024114 . 2011.β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2010. DOI : 10.1073/pnas.0914127107.Cancer stem cells: never Wnt away from the niche
Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1
Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.Tissue-specific stem cells: friend or foe?
Cell Res. 2009. DOI : 10.1038/cr.2009.24.Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction
Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.Canonical Wnt signalling plays essential roles
European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.Differential requirement for beta-catenin in epithelial and fiber cells during lens development
Developmental Biology. 2008. DOI : 10.1016/j.ydbio.2008.07.002.Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood. 2008. DOI : 10.1182/blood-2007-07-102558.T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin
Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels
Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature. 2008. DOI : 10.1038/nature06835.Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. DOI : 10.1073/pnas.0702555104.Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology. 2006. DOI : 10.1038/ni1387.Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks
Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival
Blood. 2005. DOI : 10.1182/blood-2005-01-0337.beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology. 2004. DOI : 10.1083/jcb.200402096.Deletion of beta-catenin impairs T cell development
Nature Immunology. 2003. DOI : 10.1038/ni1008.Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development. 2003. DOI : 10.1101/gad.263003.Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development. 2003. DOI : 10.1242/dev.00859.The Wnt signalling pathway
Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development. 2002. DOI : 10.1101/gad.230402.Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling
Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development. 2002.beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development. 2001.New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.150.6.1375.Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.148.3.567.Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines
Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117 - 135.E-cadherin as an invasion suppressor
Ciba Found Symp. 1995.Adherens junction proteins in tumour progression
Cancer Surveys. 1995.E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology. 1994. DOI : 10.1083/jcb.127.6.2061.Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development
Genomics. 1994. DOI : 10.1006/geno.1994.1493.Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology. 1993.Articles de journaux
2023
Metabolic dependencies of metastasis-initiating cells in female breast cancer
Nature Communications. 2023. DOI : 10.1038/s41467-023-42748-8.Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma
Journal Of Experimental & Clinical Cancer Research. 2023. DOI : 10.1186/s13046-023-02650-z.2022
Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
Iscience. 2022. DOI : 10.1016/j.isci.2022.105171.2021
High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
Cell Reports. 2021. DOI : 10.1016/j.celrep.2021.109026.Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes
Cancers. 2021. DOI : 10.3390/cancers13061267.Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen
Journal Of Immunology. 2021. DOI : 10.4049/jimmunol.2001066.2020
The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
Stem Cell Reports. 2020. DOI : 10.1016/j.stemcr.2020.06.022.2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia
Cancer Cell. 2019. DOI : 10.1016/j.ccell.2019.03.005.2017
Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
Stem Cells. 2017. DOI : 10.1002/stem.2719.Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue
Cell Reports. 2017. DOI : 10.1016/j.celrep.2017.05.051.Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation
Cell Stem Cell. 2017. DOI : 10.1016/j.stem.2017.07.004.2016
Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Nature Communications. 2016. DOI : 10.1038/ncomms13500.Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity
Cell Stem Cell. 2016. DOI : 10.1016/j.stem.2015.09.019.Microfluidic co-culture platform to quantify chemotaxis of primary stem cells
Lab On A Chip. 2016. DOI : 10.1039/c6lc00236f.Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem. 2016. DOI : 10.1002/cmdc.201500557.Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology. 2016. DOI : 10.1021/acschembio.5b00963.2015
HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Cancer Cell. 2015. DOI : 10.1016/j.ccell.2015.11.001.2014
SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer
Oncogene. 2014. DOI : 10.1038/onc.2013.140.2013
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
The EMBO Journal. 2013. DOI : 10.1038/emboj.2013.123.2012
Interactions between cancer stem cells and their niche govern metastatic colonization
Nature. 2012. DOI : 10.1038/nature10694.β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
British Journal of Cancer. 2012. DOI : 10.1038/bjc.2012.430.2011
β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
Gut. 2011. DOI : 10.1136/gutjnl-2011-300817.Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
European Journal of Neuroscience. 2011. DOI : 10.1111/j.1460-9568.2011.07632.x.2010
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
PLoS genetics. 2010. DOI : 10.1371/journal.pgen.1000816.SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
PLoS One. 2010. DOI : 10.1371/journal.pone.0008960.Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2010. DOI : 10.1073/pnas.0914127107.2009
Cancer stem cells: never Wnt away from the niche
Current Opinion in Oncology. 2009. DOI : 10.1097/CCO.0b013e32831d1faf.Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1
Drug Metab Dispos. 2009. DOI : 10.1124/dmd.108.026179.Tissue-specific stem cells: friend or foe?
Cell Res. 2009. DOI : 10.1038/cr.2009.24.Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction
Developmental Cell. 2009. DOI : 10.1016/j.devcel.2009.05.011.Canonical Wnt signalling plays essential roles
European Journal of Immunology. 2009. DOI : 10.1002/eji.200838982.2008
Differential requirement for beta-catenin in epithelial and fiber cells during lens development
Developmental Biology. 2008. DOI : 10.1016/j.ydbio.2008.07.002.Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood. 2008. DOI : 10.1182/blood-2007-07-102558.Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels
Molecular genetics and metabolism. 2008. DOI : 10.1016/j.ymgme.2008.01.013.Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature. 2008. DOI : 10.1038/nature06835.2007
Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research. 2007. DOI : 10.1161/01.RES.0000266605.63681.5a.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2007. DOI : 10.1073/pnas.0702555104.Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
Molecular and Cellular Biology. 2007. DOI : 10.1128/MCB.01034-07.beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters. 2007. DOI : 10.1016/j.febslet.2007.01.053.2006
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology. 2006. DOI : 10.1038/ni1387.2005
Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
Current Biology. 2005. DOI : 10.1016/j.cub.2005.08.037.Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks
Nucleic Acids Res. 2005. DOI : 10.1093/nar/gni104.Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival
Blood. 2005. DOI : 10.1182/blood-2005-01-0337.2004
beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology. 2004. DOI : 10.1128/MCB.24.19.8649-8661.2004.Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology. 2004. DOI : 10.1083/jcb.200402096.2003
Deletion of beta-catenin impairs T cell development
Nature Immunology. 2003. DOI : 10.1038/ni1008.Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
Neuron. 2003. DOI : 10.1016/S0896-6273(03)00718-9.beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry. 2003. DOI : 10.1074/jbc.M305892200.beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology. 2003. DOI : 10.1016/S0012-1606(03)00123-4.Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development. 2003. DOI : 10.1101/gad.263003.Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development. 2003. DOI : 10.1242/dev.00859.2002
The Wnt signalling pathway
Journal of Cell Science. 2002. DOI : 10.1242/jcs.00089.The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development. 2002. DOI : 10.1101/gad.230402.Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling
Journal of Biological Chemistry. 2002. DOI : 10.1074/jbc.M200184200.Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development. 2002.2001
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell. 2001. DOI : 10.1016/S0092-8674(01)00336-1.Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development. 2001.2000
Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.150.6.1375.Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology. 2000. DOI : 10.1083/jcb.148.3.567.1997
Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines
Cancer Lett. 1997. DOI : 10.1016/S0304-3835(97)00308-X.1994
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology. 1994. DOI : 10.1083/jcb.127.6.2061.Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development
Genomics. 1994. DOI : 10.1006/geno.1994.1493.Papiers de conférences
2022
Role Of Outside-In Integrin Signaling In Hematopoietic Development Of Mouse Embryo
2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S62 - S62.2018
Comprehensive analysis of cancer stemness
2018. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, Apr 14-18, 2018. DOI : 10.1158/1538-7445.AM2018-LB-373.2016
Successful immunotherapy of cancer stem cells requires memory and the adaptive immune system of the host
2016. DOI : 10.1158/2326-6074.Cricimteatiaacr15-B067.2015
Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host
2015. 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), New Orleans, LA, MAY 13-16, 2015. p. S167 - S168.2014
Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation
2014. 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Montreal, CANADA, AUG 21-24, 2014. p. S42 - S42. DOI : 10.1016/j.exphem.2014.07.156.2013
Putting cancer stem cells in context
2013. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam, NETHERLANDS, SEP 27-OCT 01, 2013. p. S7 - S7.2012
Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung
2012. 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, JUL 07-10, 2012. p. S15 - S15.Reviews
2014
Complex metastatic niches: already a target for therapy?
Current Opinion in Cell Biology. 2014. DOI : 10.1016/j.ceb.2014.06.012.2013
The niche under siege: novel targets for metastasis therapy
Journal of internal medicine. 2013. DOI : 10.1111/joim.12024.Metastasis: New insights into organ-specific extravasation and metastatic niches
Experimental Cell Research. 2013. DOI : 10.1016/j.yexcr.2013.02.012.2012
Lrig1: a new master regulator of epithelial stem cells
The EMBO Journal. 2012. DOI : 10.1038/emboj.2012.73.2001
New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development. 2001. DOI : 10.1016/S0959-437X(00)00231-8.1995
E-cadherin as an invasion suppressor
Ciba Found Symp. 1995.Adherens junction proteins in tumour progression
Cancer Surveys. 1995.1994
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology. 1994. DOI : 10.1016/0955-0674(94)90098-1.1993
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology. 1993.Thèses
2023
Metabolic dependencies of metastasis-initiating cells in breast cancer
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8855.Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-8912.Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond
Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-9093.2022
The role of eosinophils in breast cancer
Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-8575.2021
Intestinal stem cells differentiation and its application in cancer therapy
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8868.2017
Targeting cancer stem cells by T cell engineering
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7960.2016
Development of microfluidic devices for chemotaxis of primary stem cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7071.2014
The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6143.Identification of tumor-stroma interactions crucial for the establishment of liver metastasis
Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6148.2012
Identification of a Novel Wnt Inhibitor
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5431.Asymmetric Cell Division in the Skin
Lausanne, EPFL, 2012. DOI : 10.5075/epfl-thesis-5024.Chapitres de livres
1996
Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II: Regulatory Factors; 1996. p. 117 - 135.Présentations
2008
T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin
Annual Joint Meeting of the Swiss Societies for Pneumology, Paediatric Pneumology, Allergology and Immunology, Thoracic Surgery, Fribourg, April 17-18, 2008.Brevets
2024
Lat-based nk cars and their use
WO2024153707 . 2024.2011
Targeting extracellular matrix molecules for the treatment of cancer
WO2011024114 . 2011.Enseignement & Phd
Enseignement
Life Sciences Engineering
Doctorants
Gajera Krishna Rasik, Hernandez Lopez Pablo, Wyss Laura Fabienne,A dirigé les thèses EPFL de
Abbühl Jean-Paul , Dafflon Caroline , Desbaillets Nicolas Pierre , Evelyn Evelyn , Fan Wan-Hung , Girardin Mathieu , Madurga Alonso Angela , Norkin Maxim , Spisak Luisa , Tatárová Zuzana , Young Candice Megan T ,Cours
Cancer biology II
The course covers in detail the interactions of cancer cells with their environment with an emphasis on tumor-angiogenesis, inflammation, adaptive and innate immunity and cancer-induced immune suppression. Additional topics are cancer metabolism, cancer stem cells and metastasis.
Practical - Huelsken Lab
Assessment of signaling mechanisms in cancer.
The objectives of the course are:
- to understand the importance of signaling and cell-cell interactions in cancer stroma interactions
- to learn techniques involved in assessing the function of such interactions in vitro and in vivo.