Lijing Xin

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lijing.xin@epfl.ch +41 21 693 05 97 https://www.epfl.ch/labs/metmrs/

Nationalité: P.R. China

EPFL CIBM-AIT
CH F0 542 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 05 97
Local: CH F0 542
EPFL > VPA-AVP-CP > CIBM > CIBM-AIT

Web site: Site web: https://www.cibm.ch/

EPFL CIBM-AIT
CH F0 542 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 05 97
EPFL > VPA-AVP-DLE > AVP-DLE-EDOC > EDPY-ENS

EPFL CIBM-AIT
CH F0 542 (Bâtiment CH)
Station 6
1015 Lausanne

+41 21 693 05 97
EPFL > SB > IPHYS > IPHYS-GE

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Données administratives

Domaines de compétences

Magnetic resonance spectroscopy (1H, 13C and 31P)
Spin physics
brain energy metabolism
Schizophrenia
Mood disorders
MRI instrumentation

Biographie

Lijing Xin is an assistant professor at the Institute of Physics (IPHYS) and research staff scientist at the Center for Biomedical Imaging (CIBM), Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland. Her research interests focus on developing cutting-edge magnetic resonance spectroscopy and imaging methods for better understanding the brain function and the pathophysiology of neurological diseases. Her journey on magnetic resonance imaging (MRI) started from her master project during 2002-2005, where she developed a gradient unit with eddy current compensation and a pulse sequence generator for MRI spectrometer, which enhanced her knowledge in MR instrumentation. Later, she obtained her PhD in physics from Ecole polytechnique fédérale de Lausanne (EPFL) in 2010, where she focused on developing various novel 1H and 13C magnetic resonance spectroscopy (MRS) acquisition and quantification methods as well as RF coils on high field preclinical MR scanners. Afterwards, she started working on the clinical MR platforms including both 3 and 7T and continued to improve and develop novel acquisition and quantification methods for 1H, 13C and 31P nuclei. She carries on interdisciplinary collaborations with different partners, particularly with clinical partners where translational strategies are performed to explore the pathophysiology of psychiatric disorders and disease biomarkers for early diagnosis and intervention.

Publications

Publications Infoscience

infoscience

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T

L. Xin; P. Reymond; J. Boto; F. Grouiller; S. Vulliemoz et al.

European Journal of Radiology Open. 2025. DOI : 10.1016/j.ejro.2025.100640.

Lijing Xin

Domaines de compétences

Biographie

Publications

Publications Infoscience

infoscience

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary <sup>1</sup>H MR spectroscopy study at 7 T

Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility

Fast 3D <sup>31</sup>P B1+ mapping with a weighted stack of spiral trajectory at 7 T

CEST imaging combined with <SUP>1</SUP>H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity

Five percent CO<inf>2</inf> inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Twisted pair transmission line coil - a flexible, self-decoupled and robust element for 7 T MRI

MRI characterization of in vitro clots at 3T and 7T: A technical note

NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

Effect of circadian rhythm on NAD and other metabolites in human brain

Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel

Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

Dipolectric antenna for high-field MRI

Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T

Bridging structural MRI with cognitive function for individual level classification of early psychosis via deep learning

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

gamma-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans

Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla

Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study

Improved off‐resonance phase behavior using a phase‐inverted adiabatic half‐passage pulse for 13 C MRS in humans at 7 T

Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

MP2RAGE and Susceptibility-Weighted Imaging in Lesional Epilepsy at 7T

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Clinical Neuroimaging Using 7 T MRI: Challenges and Prospects

A practical guide to in vivo proton magnetic resonance spectroscopy at high magnetic fields

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

Is the macromolecule signal tissue-specific in healthy human brain? A 1H MRS study at 7 tesla in the occipital lobe

Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences

Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7 T

Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata

Quantification of brain glycogen concentration and turnover through localized C-13 NMR of both the C1 and C6 resonances

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T

Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

Selective Resonance Suppression H-1-[C-13] NMR Spectroscopy With Asymmetric Adiabatic RF Pulses

Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

Non-invasive quantification of brain glycogen absolute concentration

Proton T-2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4T

H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

Enseignement & Phd

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary <sup>1</sup>H MR spectroscopy study at 7 T