Lijing Xin
lijing.xin@epfl.ch +41 21 693 05 97 https://www.epfl.ch/labs/metmrs/
Citizenship: P.R. China
EPFL CIBM-AIT
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 05 97
Office:
CH F1 532
EPFL
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VPA-AVP-CP
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CIBM
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CIBM-AIT
Web site: Web site: https://www.cibm.ch/
EPFL CIBM-AIT
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne
EPFL CIBM-AIT
CH F1 532 (Bâtiment CH)
Station 6
1015 Lausanne
+41 21 693 05 97
EPFL
>
SB
>
IPHYS
>
IPHYS-GE
Fields of expertise
Magnetic resonance spectroscopy (1H, 13C and 31P)
Spin physics
Brain energy metabolism
Schizophrenia
Mood disorders
MRI instrumentation
Spin physics
Brain energy metabolism
Schizophrenia
Mood disorders
MRI instrumentation
Biography
Lijing Xin is an assistant professor at the Institute of Physics (IPHYS) and research staff scientist at the Center for Biomedical Imaging (CIBM), Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland. Her research interests focus on developing cutting-edge magnetic resonance spectroscopy and imaging methods for better understanding the brain function and the pathophysiology of neurological diseases. Her journey on magnetic resonance imaging (MRI) started from her master project during 2002-2005, where she developed a gradient unit with eddy current compensation and a pulse sequence generator for MRI spectrometer, which enhanced her knowledge in MR instrumentation. Later, she obtained her PhD in physics from Ecole polytechnique fédérale de Lausanne (EPFL) in 2010, where she focused on developing various novel 1H and 13C magnetic resonance spectroscopy (MRS) acquisition and quantification methods as well as RF coils on high field preclinical MR scanners. Afterwards, she started working on the clinical MR platforms including both 3 and 7T and continued to improve and develop novel acquisition and quantification methods for 1H, 13C and 31P nuclei. She carries on interdisciplinary collaborations with different partners, particularly with clinical partners where translational strategies are performed to explore the pathophysiology of psychiatric disorders and disease biomarkers for early diagnosis and intervention.Publications
Infoscience publications
Main Publications from infoscience
Neurochemical characteristics of pathological tissues in epilepsy: A preliminary <sup>1</sup>H MR spectroscopy study at 7 T
European Journal of Radiology Open. 2025. DOI : 10.1016/j.ejro.2025.100640.Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility
Human Brain Mapping. 2025. DOI : 10.1002/hbm.70176.Fast 3D <sup>31</sup>P B1+ mapping with a weighted stack of spiral trajectory at 7 T
Magnetic resonance in medicine. 2025. DOI : 10.1002/mrm.30321.CEST imaging combined with <SUP>1</SUP>H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice
ALZHEIMERS RESEARCH & THERAPY. 2025. DOI : 10.1186/s13195-025-01672-3.A graphical pipeline platform for MRS data processing and analysis: MRSpecLAB
Frontiers in neuroimaging. 2025. DOI : 10.3389/fnimg.2025.1610658.Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity
Human Brain Mapping. 2024. DOI : 10.1002/hbm.70057.Five percent CO<inf>2</inf> inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats
Neuroprotection. 2024. DOI : 10.1002/nep3.53.A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making
Molecular Psychiatry. 2024. DOI : 10.1038/s41380-024-02726-y.Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study
Molecular Psychiatry. 2024. DOI : 10.1038/s41380-024-02631-4.NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection
Nature Communications. 2024. DOI : 10.1038/s41467-024-46837-0.Twisted pair transmission line coil - a flexible, self-decoupled and robust element for 7 T MRI
Magnetic Resonance Imaging. 2024. DOI : 10.1016/j.mri.2024.02.007.MRI characterization of in vitro clots at 3T and 7T: A technical note
Journal Of Neuroradiology. 2024. DOI : 10.1016/j.neurad.2023.06.003.NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages
International Journal of Cancer. 2024. DOI : 10.1002/ijc.35273.Effect of circadian rhythm on NAD and other metabolites in human brain
Frontiers In Physiology. 2023. DOI : 10.3389/fphys.2023.1285776.Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel
Nmr In Biomedicine. 2023. DOI : 10.1002/nbm.5056.Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia
Translational Psychiatry. 2023. DOI : 10.1038/s41398-023-02568-2.Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting
Nmr In Biomedicine. 2023. DOI : 10.1002/nbm.4998.High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study
Analytical Biochemistry. 2023. DOI : 10.1016/j.ab.2023.115212.Dipolectric antenna for high-field MRI
Magnetic Resonance in Medicine. 2023. DOI : 10.1002/mrm.29719.Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential
International Journal Of Neuropsychopharmacology. 2023. DOI : 10.1093/ijnp/pyad012.Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Molecular Psychiatry. 2023. DOI : 10.1038/s41380-023-01991-7.Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T
Magnetic Resonance Materials In Physics Biology And Medicine. 2023. DOI : 10.1007/s10334-023-01065-3.Bridging structural MRI with cognitive function for individual level classification of early psychosis via deep learning
Frontiers In Psychiatry. 2023. DOI : 10.3389/fpsyt.2022.1075564.In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN
Magnetic Resonance in Medicine. 2022. DOI : 10.1002/mrm.29446.gamma-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing
Nmr In Biomedicine. 2022. DOI : 10.1002/nbm.4706.Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort
eLife. 2022. DOI : 10.7554/eLife.77791.Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis
Schizophrenia Bulletin. 2021. DOI : 10.1093/schbul/sbab066.Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
Acta Neuropathologica Communications. 2021. DOI : 10.1186/s40478-021-01232-4.In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times
Magnetic Resonance in Medicine. 2021. DOI : 10.1002/mrm.28910.Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans
Frontiers In Aging Neuroscience. 2020. DOI : 10.3389/fnagi.2020.609517.Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4393.In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment
Scientific Reports. 2020. DOI : 10.1038/s41598-020-72492-8.Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations
Nmr In Biomedicine. 2020. DOI : 10.1002/nbm.4325.Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations
NMR in Biomedicine. 2020. DOI : 10.1002/nbm.4236.MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
Molecular Psychiatry. 2020. DOI : 10.1038/s41380-019-0393-5.Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans
Neuropsychopharmacology. 2020. DOI : 10.1038/s41386-020-0760-6.Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times
Magnetic Resonance in Medicine. 2020. DOI : 10.1002/mrm.28066.N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study
International Journal of Neuropsychopharmacology. 2019. DOI : 10.1093/ijnp/pyz022.Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism
Neurochemical research. 2019. DOI : 10.1007/s11064-018-2521-z.Improved off‐resonance phase behavior using a phase‐inverted adiabatic half‐passage pulse for 13 C MRS in humans at 7 T
NMR in Biomedicine. 2019. DOI : 10.1002/nbm.4171.Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study
Eur Neuropsychopharmacol. 2019. DOI : 10.1016/j.euroneuro.2018.12.015.Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla
Journal of Cerebral Blood Flow & Metabolism. 2019. DOI : 10.1177/0271678X19831022.Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS
Nutrients. 2019. DOI : 10.3390/nu11071649.Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex
Psychopharmacology. 2018. DOI : 10.1007/s00213-017-4745-z.MP2RAGE and Susceptibility-Weighted Imaging in Lesional Epilepsy at 7T
Journal of Neuroimaging. 2018. DOI : 10.1111/jon.12523.Clinical Neuroimaging Using 7 T MRI: Challenges and Prospects
Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2018. DOI : 10.1111/jon.12481.N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial
Translational Psychiatry. 2018. DOI : 10.1038/s41398-018-0266-8.Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
Frontiers in Nutrition. 2018. DOI : 10.3389/fnut.2018.00062.A practical guide to in vivo proton magnetic resonance spectroscopy at high magnetic fields
Analytical biochemistry. 2017. DOI : 10.1016/j.ab.2016.10.019.Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis
Schizophrenia bulletin. 2016. DOI : 10.1093/schbul/sbw038.A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T
Magnetic Resonance in Medicine. 2015. DOI : 10.1002/mrm.25171.Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla
Journal of Cerebral Blood Flow & Metabolism. 2015. DOI : 10.1038/jcbfm.2014.251.Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients
Molecular Psychiatry. 2015. DOI : 10.1038/mp.2014.88.In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T
Journal of Neurochemistry (JNC). 2014. DOI : 10.1111/jnc.12479.Is the macromolecule signal tissue-specific in healthy human brain? A 1H MRS study at 7 tesla in the occipital lobe
Magnetic Resonance in Medicine. 2014. DOI : 10.1002/mrm.24995.Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla
NeuroImage. 2014. DOI : 10.1016/j.neuroimage.2014.02.016.Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia
Journal of Cerebral Blood Flow & Metabolism. 2014. DOI : 10.1038/jcbfm.2014.155.Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences
Neuroimage. 2013. DOI : 10.1016/j.neuroimage.2013.02.042.Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain
Magma (New York, N.Y.). 2013. DOI : 10.1007/s10334-013-0378-3.Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T
NMR in biomedicine. 2013. DOI : 10.1002/nbm.2896.Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
Journal of neuroscience research. 2013. DOI : 10.1002/jnr.23194.Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T
Magnetic Resonance in Medicine. 2013. DOI : 10.1002/mrm.24352.Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7 T
Journal of Cerebral Blood Flow & Metabolism. 2012. DOI : 10.1038/jcbfm.2012.33.Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata
Nmr In Biomedicine. 2010. DOI : 10.1002/nbm.1537.H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T
Magnetic Resonance in Medicine. 2010. DOI : 10.1002/mrm.22359.Quantification of brain glycogen concentration and turnover through localized C-13 NMR of both the C1 and C6 resonances
Nmr In Biomedicine. 2010. DOI : 10.1002/nbm.1460.Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla
Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.22022.In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T
Magnetic Resonance Materials In Physics Biology And Medicine. 2009. DOI : 10.1007/s10334-008-0152-0.Selective Resonance Suppression H-1-[C-13] NMR Spectroscopy With Asymmetric Adiabatic RF Pulses
Magnetic Resonance in Medicine. 2009. DOI : 10.1002/mrm.21829.Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum
Measurement Science & Technology. 2009. DOI : 10.1088/0957-0233/20/10/104034.Proton T-2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4T
Nmr In Biomedicine. 2008. DOI : 10.1002/nbm.1205.H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
Journal of Magnetic Resonance. 2008. DOI : 10.1016/j.jmr.2008.06.019.Non-invasive quantification of brain glycogen absolute concentration
Journal of Neurochemistry (JNC). 2008. DOI : 10.1111/j.1471-4159.2008.05717.x.In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time
Magnetic Resonance in Medicine. 2008. DOI : 10.1002/mrm.21695.Other publications
Profile on
google scholarSelected peer-reviewed conference proceedings
ISMRM 2022M. Widmaier, S-I. Lim, L. Xin. Super-fast and accurate estimation of relaxation and chemical exchange rate using 31P-MT-MR fingerprinting at 7T in the human brain. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
M. Widmaier, S-I. Lim, L. Xin. Time-efficient and reproducible relaxation measurements by 31P MR fingerprinting in human brain at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
S-I. Lim, M. Widmaier, L. Xin. Frequency sweep 31P MR spectroscopic imaging at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Z Huang, B. Cuenoud, M. Hartweg, D. Wenz, L. Xin. Effect of circadian rhythm on brain NAD: an MRS study at 7 T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Xiao, I. Tkac, L. Xin. Investigating the influences of spectral lineshape and linewidth in LCModel basis-sets on 1H MRS quantification at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Xiao, D. Wenz, L. Xin. STEAM-based proton observed carbon edited (POCE) 13C magnetic resonance Spectroscopy without decoupling at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Y. Wen, C. Zhou, L. Chen, Y. Deng, M. Cleusix, R. Jenni, P. Conus, K. Do, L. Xin. Bridging Structural MRI with Cognitive Function for Individual Level Classification of Early Psychosis via Deep Learning. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
Z. Wang, M. Cleusix, R. Jenni, P. Conus, K. Do, L. Xin. Structural abnormalities in patients with early psychosis: a MP2RAGE-based morphometric study at 7T. ISMRM-ESMRMB, London, UK, 07-12 May 2022.
ISMRM 2021M. Widmaier, S-I. Lim, L. Xin. Fast acquisition of 31-P creatin kinease chemical exchange rate and relaxation rates of g-ATP and PCr in vivo human brain at 7T using MRS-FP. ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
S-I. Lim, L. Xin. GABA measurement at 7T: short-TE or MEGA editing? ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
S-I. Lim, M. Widmaier, Y. Jiang, L. Xin. Rapid T1, T2 measurements and SNR evaluation by 31P MR fingerprinting in human brain at 7T. ISMRM & SMRT Virtual Conference & Exhibition, 15-20 May 2021.
ISMRM 2020
B. Lanz, R. Skupienski, K. Q. Do, L. Xin. Cerebral energy metabolism and neurotransmission in a schizophrenia mouse model: a combined 1H-[13C] MRS and 13C MRS study at 14.1T. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.
S-I. Lim, L. Xin. Improved GABA editing and macromolecule suppression with adiabatic and highly selective Gaussian pulses at 7T. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.
R. Skupienski, K. Q. Do, L. Xin. NAD /NADH dysregulation and brain homeostasis in the gclm-KO mouse: towards biomarker identification for schizophrenia. ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020.
Teaching & PhD
Courses
Fundamentals of biomedical imaging
The goal of this course is to illustrate how modern principles of basic science approaches are integrated into the major
biomedical imaging modalities of importance to biology and medicine, with an emphasis on those of interest to in vivo.
CIBM translational MR neuroimaging & spectroscopy
This course's purpose is to provide students with a solid theoretical and practical knowledge in magnetic resonance imaging (MRI) and spectroscopy (MRS). This course will cover all of the core aspects that a PhD candidate or a post-doc would require to design and carry out their own (neuro)imaging experiment in order to accomplish specific research goals. These include fundamentals of experimen