Maria Josefina Marcaida Lopez

maria.marcaidalopez@epfl.ch +41 21 693 14 93

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Nationality: Spanish

EPFL SV IBI-SV UPDALPE
AI 2351.F (Bâtiment AI)
Station 19
1015 Lausanne

+41 21 693 14 93
Office: AI 2351.D
EPFL › SV › IBI-SV › UPDALPE

Website: https://lbm.epfl.ch/

Expertise

Protein crystallography Protein-nucleic acid complexes Kinase-small molecule interactions

Biography Publications

FELLOWSHIPS & AWARDS

• Marie Heim-Vögtlin Postdoctoral Fellowship SNSF March 2012-August 2014 • CRUS Dual career couples, September 2011 & January 2012 • Human Frontiers Short Term Fellowship, September- December 2009 • Juan de la Cierva Postdoctoral Fellowship 2009-2011 • EMBO Long term Fellowship 2007-2008 • Wellcome Trust Prize Studentship 2001-2005 • Final Year Project Award, Imperial College, 2001

Education

M.Sci.

| Physics

1997 – 2001 Imperial College London, U.K.

Ph.D.

| Biochemistry and protein crystallography

2001 – 2005 University of Cambridge, U.K.
Directed by Supervisor: Ben Luisi

Professionals experiences

Scientist

2014–2014

EPFL

Postdoctoral Fellow

2006–2010

CNIO (Spanish National Cancer Research Centre), Spain

JOURNAL ARTICLES

Structural characterization of Prolyl endopeptidase-like, a mitochondrial protein involved in congenital myasthenic syndrome-22

A. Theodoropoulou; E. Cavani; Y. Monnens; M. Marcaida; J. Creemers et al.

2023-07-01. p. S109-S109.

Maria Josefina Marcaida Lopez

Expertise

FELLOWSHIPS & AWARDS

Education

M.Sci.

Ph.D.

Professionals experiences

JOURNAL ARTICLES

Structural characterization of Prolyl endopeptidase-like, a mitochondrial protein involved in congenital myasthenic syndrome-22

Using integrative structural biology for the identification of novel aerolysin-like pore forming toxins for nanopore sensing

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Structural and functional divergence of duplicated mosquito Toll and Spz compared to Drosophila

Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores

KAP1 is an antiparallel dimer with a functional asymmetry

Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability

Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor

Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01

Visualizing phosphodiester-bond hydrolysis by an endonuclease

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Homing endonucleases: from basics to therapeutic applications

Molecular basis of histone H3K4me3 recognition by ING4

Complementing structural information of modular proteins with small angle neutron scattering and contrast variation

The crystal structure of the Escherichia coli RNase E apoprotein and a mechanism for RNA degradation

Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering

Modulation of heme redox potential in the cytochrome c6 family

The RNA degradosome: life in the fast lane of adaptive molecular evolution

Structure of cytochrome c6A, a novel dithio-cytochrome of Arabidopsis thaliana, and its reactivity with plastocyanin: implications for function

Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover