Michele De Palma

EPFL
B25A (Bâtiment Agora)
Rue du Bugnon 25a
1005 Lausanne

EPFLSVSV-DECSV-DIR

Expertise

My research program leverages new cell engineering technologies and preclinical trials in genetically engineered mouse models of cancer to advance the conceptual understanding of the tumor microenvironment and its role in modulating tumor response or resistance to anti-cancer therapies.

Mission

A key goal of our team is to identify novel or poorly understood mechanisms and therapeutic vulnerabilities in tumors that can be exploited to enhance the efficacy and expand the reach of cancer immunotherapies. Lead strategies include reprogramming the immunosuppressive and pro-angiogenic features of the tumor microenvironment, using cancer models stratified by clinical parameters and refined through genetics to test new drug combinations and define more effective therapeutic windows. In parallel, our research program aims to revitalize the clinical potential of dendritic cell therapies via innovative, antigen-agnostic biotechnological platforms.
Michele (Miki) De Palma is a tenured associate professor in the School of Life Sciences at EPFL, where he teaches cancer biology. Miki trained as a postdoctoral researcher and later became group leader at the Telethon Institute for Gene Therapy in Milan, where he developed gene transfer strategies to engineer monocytes into anti-tumoral immune cells – work that led to a first-in-kind clinical trial in brain cancer. He has received two ERC programme grants and, in 2017, the Robert Wenner Prize for cancer research. Research in the De Palma lab focuses on tumor resistance to immunotherapy mediated by myeloid cells and the angiogenic vasculature, and on developing novel platforms of engineered dendritic cell therapies. In his spare time, Miki studies the taxonomy of Scarab beetles in the family Cetoniinae.

Awards

Robert Wenner Prize

Swiss Cancer League

2017

Leenaards Prize

Leenaards Foundation

2013

Highly Cited Researcher

Web of Science-Clarivate

2023

Polysphère-SV Teaching Award

AGEPoly

2024

Teaching & PhD

PhD Students

Eleni Lamprou, Haohua Li, Elodie Anaïs Pauline Marcandalli, Simge Yücel, Luqing Li, Yuchen Liu

Past EPFL PhD Students

Caroline Maïté Monnard, Ece Kadioglu, Tim Beltraminelli, Agnieszka Alicja Chryplewicz, Yahya Mohammadzadeh, Ali Ghasemi

Past EPFL PhD Students as codirector

Ingrid Maria van Mier, Morgane Marie Lecointre

Courses

Cancer biology II

BIO-472

The course covers in detail the interactions of cancer cells with their environment with an emphasis on tumor-angiogenesis, inflammation, adaptive and innate immunity and cancer-induced immune suppression. Additional topics are cancer metabolism, cancer stem cells and metastasis.

Oncology

BIO-392

This course provides a comprehensive overview of the biology of cancer, including common mechanisms that cancer cells use to grow and disseminate in humans and in animal models.

Practical - De Palma Lab

BIO-680

Cell heterogeneity in the tumor microenvironment.

Scientific project design in translational oncology

BIO-488

The theme of the course is the role of inflammation in cancer. It focuses on the regulation and multifaceted functions of tumor-associated inflammatory cells, and how they promote or oppose cancer.