Pierre Vogel

Nationalité: Swiss

EPFL SB-DO
CH F0 494 (Bâtiment CH)
Station 6
1015 Lausanne

Textbooks

Vogel, P. Sustainable Development; The Role of Carbon and Bio-carbon. An Introduction to Molecular Sciences.. Foreword by Bertrand Piccard. World Scientific Publishers, Singapore 2022, pp. 1-612. ISBN 9789811 (hardcover)., ISBN 9789811240492 (ebook for institutions); ISBN 9789811240508 (ebook for individuals).

Vogel, P.; Houk, K. N. Organic Chemistry; Theory, Reactivity and Mechanisms in Modern Synthesis, Foreword by Grubbs, Robert H. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2019, pp 1-1352. ISBN 978-3-527-34532-8 (hardcover); ISBN 978-3-527-81925-6 (ePDF), ISBN 978-3-527-81927-0 (ePub) "C:\Users\pvogel\OneDrive - epfl.ch\Bureau\CD15651-Vogel Flyer-Wiley-GlobalA4-2pp-Final print Ready-Nomarks.pdf"

Vogel, P. Chimie Organique. Méthodes et Modèles. Préface de Prof.Jean-Marie Lehn. DeBoeck Univerité, Bruxelles,Paris, 1997, pp. 1-1432, ISBN 2-8041-2620-X.
 
Vogel, P.  Carbocation Chemistry, Elsevier, Amsterdam, 1985, pp. 1-610 . ISBN 1: 444425225/ISBN 13: 9780444425225

Patents

Medicinal chemistry in collaboration with the European FP7 health program on pancreatic cancers, with the Ludwig Institute and the CHUV (Prof. Olivier Michielin) on skin cancer

1.              Preparation of 4-amino-1-alkoxynaphthalene IDO inhibitors for cancer treatment. Roehrig, Ute; Loay, Awad; Michielin, Olivier; Van Den Eynde, Benoit; Pilotte, Luc; Stroobant, Vincent; Larrieu, Pierre; Vogel, Pierre; Zoete, Vincent; Assignee: Ludwig Institute for Cancer Research Ltd, USA, Patent  Apr 21, 2011, WO 2011045340 A1.

2.              Preparation of 4-iminonaphthalenones as IDO inhibitors. Roehrig, Ute; Loay, Awad; Michielin, Olivier; Van Den Eynde, Benoit; Pilotte, Luc; Stroobant, Vincent; Larrieu, Pierre; Vogel, Pierre Zoete, Vincent; Assignee: Ludwig Institute for Cancer Research Ltd, USA, Patent Apr 21, 2011, WO 2011045341 A1.

3.              Preparation of piperidine derivatives for the treatment of pancreatic cancers. Vogel, Pierre; Duchosal, Michel; Aimable, Nahimana; Robina, Inmaculada; Mollinedo, Faustino; Nencioni, Alessio. Assignee: Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland; Consejo Superior de Investigaciones Cientificas (CSIC), Spain. Patent Feb 8, 2018, WO 2018024907 A1.

 
Professional positions: P. Vogel was born in Cully (Switzerland) Oct. 23, 1944. In 1969, he did his Ph.D Award under supervision of Prof. H. Prinzbach at the Institute of Organic Chemistry, University of Lausanne. After finishing his Ph.D in 1969, he did post-doctoral research at Yale University, New Haven, Connecticut, USA with Prof. Martin Saunders; research associate with Prof. J. A. Berson, K. A. Wiberg and P.v.R. Schleyer (Princeton Universtiy). From 1971 he worked as a Research chemist at Syntex S.A., in Mexico with Prof. P.Crabbé before he returned to the University of Lausanne in 1972. As of 1977 he became Professor of organic chemistry at the University of Lausanne. In 1991 he was Vice-Chairman of the Institute of organic Chemistry, University of Lausanne until 2001. Then he was Part-time grad.school teacher at the Universitites of Rouen and Caen from 1991 to 1993 and Part-time professor at Ecole Polytechnique de Palaiseau from 1993-2000. From 2000-2001 he was reviewer of the "Institut Universitaire de France" and as of 2001 Professor of organic chemistry at the EPFL. Degrees and distincions 1969 Ph.D, University of Lausanne 1976 Swiss Chemical Society Award, Werner Medal 1973-now Member of the Swiss Chemical Society, of the American Chemical Society and "Société Française de Chimie" 1984-1989 IOCD adviser 1988-1989 Associate Professor of Organic Chemistry at Ecole Normale Supérieure, Paris 1989-2000 Member of the Swiss National Council of Research 1991-1992 Associate Professor of Organic Chemistry, University of Paris VI 1992 Pacific Coast Lecturer (USA) 1992-1993 Associate Professor at the Université de Montpellier, France 1993 Associate Professor, Université Paris Sud, Orsay 1993-1997 Swiss co-ordinator of the European COST D2 research program 1994 (spring) Associate Professor, ESPCI, Paris 1997 President of the european COST D2 management committee 1999 Coordinator of the european COSRD13 2001-now Member of the "Conseil Scientifique du Département des Sciences Chimiques", CNRS 2002-2003 Novartis Lectureship 2004-2005 Boehringer Ingelheim Distinguished Lecturer. Honoary Professeor since 2010. Head of a laboratry of medicinal chemistry at the EPFL form 2010 to 2021. Collaboration with the CHUV (Univerity hospital of Lausanne, skin cancer) and with the European Health 7 programm (pancreac cancers). More than 550 piblications in referred journals, 11 patents, 5 textbooks. Invited editor of Catalysts.

Publications représentatives

Polysulfones: solid organic catalysts for the chemoselective cleavage of methyl-substituted allyl ethers under neutral conditions.

Markovic, D.; Steunenberg, P.; Ekstrand, M.; Vogel, P.
Published in J. Chem. Soc., Chem. Commun. 2004, 2444. in

First Asymmetric Synthesis of the Cyclohexanone Subunit of Baconipyrones A and B. Revision of Its Structure.

Turks,M.; Murcia, M. C.; Scopelliti,R.; Vogel, P.
Published in Organic Letters, 2004, 6(18), 3031-3034. in

Synthesis of D- and L-2,3-trans-3,4-cis-4,5-trans-3,4-Dihydroxy-5-hydroxymethylproline and Tripeptides Containing Them.

Moreno Vargas, A. J.; Robina, I.; Petricci, E.; Vogel, P.
Published in Journal of Organic Chemistry, 2004, 69(13), 4487-4491. in

Synthesis of Long-Chain Polyketide Fragments by Reaction of 1,3-Dioxy-1,3-dienes with Allylsilanes: Umpolung with Sulfur Dioxide.

Turks, M.; Fonquerne, F.; Vogel, P.
Published in Organic Letters, 2004, 6(6), 1053-1056 in

Palladium-Catalyzed Stille Cross-Couplings of Sulfonyl Chlorides and Organostannanes.

Dubbaka, S. R.; Vogel, P.
Published in Journal of the American Chemical Society. 2004, 125(59), 15292-15293. in

An expeditous, on-iterative, and asymmetric synthesis of 3,5,7,9,11,13,15-heptahydroxypentadecanals.

Gerber, S.; Vogel, P.
Published in European Journal of Organic Chemistry, 2003, (15), 2959-2963. in

Total Asymmetric Synthesis of a New 9,12-Anhydroerythronolide Aglycone.

Gerber-Lemaire, S.; Ainge, S. W.; Glanzmann, C.; Vogel, P.
Published in Helv. Chim. Acta. 2002, 85, 417-430. in

An efficient Combinatorial Method for the discovery of Glycosidase Inhibitors.

Gerber-Lemaire, S.; Poposycz, F.; Rodriguez-Garcia, E.; Carmona-Asenjo, A. T.; Robina, I.; Vogel, P.
Published in ChemBioChem, 2002, 3(5), 466-470. in

A New, Non-Iterative Asymmetric Synthesis of Long.Chain, 1,3-Polyols.

Schwenter, M.-E.; Vogel, P.
Published in Chem. Eur. J., 2000, 6, 4091-4103. in

The C-Disaccharide α-C(1→3)-Mannopyranoside of N-Acetylgalactosamine is an Inhibitor of Glycohydrolases and of Human α-1, 3-Fucosyltransferase VI. Its Epimer α- (1→3)-Mannopyranoside of N-Acetylosamine Is Not.

Pasquarello, C.; Picasso, S.; Demange, R.; Malissard, M.; Berger, E.G.; Vogel, P.
Published in The Journal of Organic Chemistry, 2000, 65(14), 4251-4260. in

Synthesis of a C29-C51 Subunit of Spongistatin 1(Altohyrtin A) Starting from (R)-3-Benzyloxy-2-methylpropan-1-ol.

Lemaire-Audoire, S.; Vogel, P.
Published in J. Org. Chem., 2000, 65, 3346-3356. in

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity,

Borcard, Francoise; Baud, Matthias; Bello, Claudia; Dal Bello, Giovanna; Grossi, Francesco; Pronzato, Paolo; Cea, Michele; Nencioni, Alessio; Vogel, Pierre
Published in Bioorg. Med. Chem. Letters 2010, 20, 5353-5356 in 2010

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

Roehrig, Ute F.; Awad, Loay; Grosdidier, Aurelien; Larrieu, Pierre; Stroobant, Vincent; Colau, Didier; Cerundolo, Vincenzo; Simpson, Andrew J.; Vogel, Pierre; Van den Eynde, Benoit J.; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2010, 53, 1172-1189 in 2010

Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Bello, Claudia; Dal Bello, Giovanna; Cea, Michele; Nahimana, Aimable; Aubry, Dominique; Garuti, Anna; Motta, Giulia; Moran, Eva; Fruscione, Floriana; Pronzato, Paolo; Grossi, Francesco; Patrone, Franco; Ballestrero, Alberto; Dupuis, Marc; Sordat, Bernard; Zimmermann, Kaspar; Loretan, Jacqueline; Wartmann, Markus; Duchosal, Michel A.; Nencioni, Alessio; Vogel, Pierre.
Published in Bioorg. Med. Chem. 2011, 19, 7720-7727. https://doi.org/10.1016/j.bmc.2011.07.053 in 2011

A C-Linked Disaccharide Analogue of Thomsen-Friedenreich Epitope Induces a Strong Immune Response in Mice.

Awad, Loay; Madani, Rime; Gillig, Annabelle; Kolympadi, Maria; Philgren, Maria; Muhs, Andreas; Gerard, Catherine; Vogel, Pierre.
Published in Chem. Eur. J. 2012, 18, 8578-8582. https://doi.org/10.1002/chem.201200364 in 2012

Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors.

Li, Hongqing; Zhang, Yongmin; Favre, Sylvain; Vogel, Pierre; Sollogoub, Matthieu; Bleriot, Yves.
Published in Carbohydrate Research 2012, 356, 110-114. https://doi.org/10.1016/j.carres.2011.10.039 in 2012

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Roehrig, Ute F.; Majjigapu, Somi Reddy; Grosdidier, Aurelien; Bron, Sylvian; Stroobant, Vincent; Pilotte, Luc; Colau, Didier; Vogel, Pierre; Van den Eynde, Benoit J.; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2012, 55, 5270-5290. httpds://doi.org/10.1021/jm300260v in 2026

Synthesis of 2-(1-aminocyclopropyl)pyrrolidine-3,4-diol derivatives applying titanium-mediated reaction conditions.

Declerck, Delphine; Nhien, Albert Nguyen Van; Josse, Solen; Szymoniak, Jan; Bertus, Philippe; Bello, Claudia; Vogel, Pierre; Postel, Denis.
Published in Tetrahedron 2012, 68, 1802-1809. https://doi.org/10.1016/j.tet.2011.12.024 in 2012

Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866.

Gillig, Annabelle; Majjigapu, Somi Reddy; Sordat, Bernard; Vogel, Pierre.
Published in Helv. Chim. Acta 2012, 95, 34-42. https://doi.org/10.1002/hlca.201100415 in 2012

Amide Formation in One Pot from Carboxylic Acids and Amines via Carboxyl and Sulfinyl Mixed Anhydrides.

Zambron, Bartosz K.; Dubbaka, Srinivas R.; Markovic, Dean; Moreno-Clavijo, Elena; Vogel, Pierre.
Published in Org. Letters 2013, 15, 2550-2553. https://doi.org/10.1021/ol401053y in 2013

Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides.

Bai, Jianfei; Zambron, Bartosz K.; Vogel, Pierre.
Published in Org. Letters 2014, 16 (2), 604-607. https://doi.org/10.1021/ol403508j in 2014

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Roehrig, Ute F.; Majjigapu, Somi Reddy; Chambon, Marc; Bron, Sylvian; Pilotte, Luc; Colau, Didier; Van den Eynde, Benoit J.; Turcatti, Gerardo; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in Eur. J. Med. Chem. 2014, 84, 284-301. https://doi.org/10.1016/j.ejmech.2014.06.078 in 2014

Synthesis of pyrrolidine 3,4-diol derivatives with anticancer activity on pancreatic tumor cells.

Steimer, Frederic; Carmona, Ana T.; Moreno-Vargas, Antonio J.; Caffa, Irene; Cea, Michele; Montecucco, Fabrizio; Nencioni, Alessio;Vogel, Pierre; Robina, Inmaculada.
Published in Heterocycles 2014, 88 (2), 1445-1464. in 2014

A critical role of autophagy in antileukemia/ lymphoma effects of APO866, an inhibitor of NAD biosynthesis.

Ginet, Vanessa; Puyal, Julien; Rummel, Coralie; Aubry, Dominique; Breton, Caroline; Cloux, Anne-Julie; Majjigapu, Somi R.; Sordat, Bernard; Vogel, Pierre; Bruzzone, Santina; Nencioni, Alessio; Duchosal, Miechel A.; Nahimana, Aimable.
Published in Autophagy, 2014, 10(4), 603–617. https://doi.org/10.4161/auto.27722 in 2014

The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody

Nahimana, Aimable; Aubry, Dominique; Breton, Caroline S.; Majjigapu, Somi R.; Sordat, Bernard; Vogel, Pierre; Duchosal, Michel A.
Published in Leukemia & Lymphoma 2014, 55 (9), 2141-2150. https://doi.org/10.3109/10428194.2013.869325 in 2014

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.

Roehrig, Ute F.; Majjigapu, Somi Reddy; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in J. Med. Chem. 2015, 58 (24), 9421-9437. https://doi.ord/10.1021/acs.jmedchem.5b00326 in 2015

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).

Roehrig, Ute F.; Majjigapu, Somi Reddy; Caldelari, Daniela; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier.
Published in Bioorg. Med. Chem. Lett. 2016, 26 (17), 4330-4333. https://doi.org/10.1016/j.bmcl.2016.07.031 in 2016

Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells

Bello, Claudia; Bai, Jianfei; Zambron, Bartosz K.; Elias-Rodriguez, Pilar; Gajate, Consuelo; Robina, Inmaculada; Caffa, Irene; Cea, Michele; Montecucco, Fabrizio; Nencioni, Alessio; Nahimana, Aimable; Aubry, Dominique; Breton, Caroline; Duchosal, Michel A.; Mollinedo, Faustino; Vogel, Pierre
Published in Eur. J. Med. Chem. 2018, 150, 457-478. https://doi.org/10.1016/j.ejmech.2018.02.086 in 2018

Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).

Roehrig, Ute F.; Reynaud, Aline; Majjigapu, Somi Reddy; Vogel, Pierre; Pojer, Florence; Zoete, Vincent.
Published in J. Med. Chem. 2019, 62 (19), 8784-8795. https://doi.org/10.1021/acs.jmedchem.9b00942 in 2019

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.

Röhrig, Ute; Majjigapu, Somi Reddy; Reynaud, Aline; Pojer, Florence; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Michielin, Oliver; Zoete, Vincent.
Published in .J. Med. Chem. 2021, 64(4), 2205-2227. https://doi.org/10.1021/acs.jmedchem.0c01968 in 2021

Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.

Bai, Jianfei; Majjigapu, Sordat, Bernard; Poty, Sophie; Vogel, Pierre; Elias-Rodriguez, Pilar; Moreno-Vargas, Antonio, J.; Carmona, Ana. T.; Caffa, Irene; Ghanem, Moustafa; Khalifa, Amr; Robina, Inmaculada; Cajate, Consuelo; Mollinedo, Faustino; Nahimana, Aimable; Duchosal, Michel; Nencioni, Alessio.
Published in Eur. J. Med. Chem. 2022, 239, article no. 114504, pp. 1-11. https://doi.org/10.1016/j.ejmech.2022.114504 in 2022

Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Röhrig, Ute, F.; Majjigapu, Somi, R.; Vogel, Pierre; Reynaud, Aline; Pojer, Florence; Dilek, Nahzli; Reichenbach, Patrick; Ascenção, Kelly; Irving, Melita; Coukos, George; Michielin, Olivier; Zoete, Vincent.
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1), 1773-1811, https://doi.org/10.1080/14756366.2022.2089665. in 2022

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies.

Biniecka, P.; Matsumoto, S.; Belotti, A.; Joussot, J.; Bai, J. F.; Majjigapu, S. R.; Thoueille, P.; Spaggiari, D.; Desfontaine, V.; Piacente, F.; Bruzzone, S.; Cea, M.; Decosterd, L. A.; Vogel, P.; Nencioni, A.; Duchosal, M. A.; Nahimana, A.
Published in Molecules 2023, 28, article nb. 1897, pp. 1-23. https://doi.org/10.3390/molecules28041897 in 2023

Organocatalysis: fundamentals and comparisons to metal and enzyme catalysis,

Vogel, Pierre; Lam, Yu-hong; Simon, Adam; Houk, Kendall N.
Published in Catalysts 2016, 6 (9), article nb, 128, pp. 1-65. https://doi.org/10.3390/catal6090128 in 2016

Expeditious Asymmetric Synthesis of Polypropionates Relying on Sulfur Dioxide-Induced C-C Bond Forming Reactions

Vogel, Pierre; Sordo Gonzalo, Jose Angel.
Published in Catalysts 2021, 11(11), article nb. 1267, pp.1-20. https://doi.org/10.3390/catal11111267 in 2021

Organic Chemistry and Synthesis Rely More and More upon Catalysts.

Vogel, Pierre; Houk, Kendall N.
Published in Catalysts 2022, 12(7), article no. 758, pp. 1-31. https://doi.org/10.3390/catal12070758 in 2022

Asymmetric Bio- and Organocatalysis: Historical Aspects and Concepts.

Vogel, Pierre.
Published in Catalysts 2026, 6, article nb. 131, pp. 1-142. https://doi.org/10.3390/catal16020131. Link: https://www.mdpi.com/2073-4344/16/2/131 in 2026

Total Synthei and Determinaion f the Absolte Configuration of (-)-Dolabriferol

Laclef, S.; Turk, M.; Vogel, P.
Published in Angew. Chem. Int. Ed. 2010, 49(4), 8525-8527 in 2010

Synthesis and Applications of Silyl 2-Methylprop-2-ene-1-sulfinates in Preparative Silylation and GC-Derivatization actions of Polyols and Carbohydrates s

Markovic, D.; Tchawou, W. A.; Novosjolova, I.; LaClef, S.; Stepanovs, D.; Turks, M.; Vogel. P.
Published in Chem. Eur. J. 2016, 22(12), 4196-4205 in 2016

The norbornene mistery revealed

Steinmann, S. N.; Vogel, P.; Mo, Y.; Corminboeuf, C.
Published in Chem. Commun. 2011, 47(1), 227-229 in 2011