Priscilla Turelli
priscilla.turelli@epfl.ch +41 21 693 18 11
Nationalité : Française/French
Date de naissance : 29.11.1970
EPFL SV GHI LVG
AI 3151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
EPFL VPRHO DSPS COSEC-SV
AI 3151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
Biographie
Positions
2005-présent: Chercheur, Ecole Polytechnique Fédérale de Lausanne, Laboratoire de virologie et génétique, Suisse.
2001-2004: Chercheur dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse.
1997-2001: Etudiante Post-doctorante dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse.
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Honneurs et prix
2004: Bristol-Myers Squibb AIDS AWARD
1997-1999: Human Frontier Science Program fellowship
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Education
June 1997:
PhD in cellular biology.
Final mark:jury congratulations.
Université de la Méditerranée, France.
June 1993:
Post-graduate diploma in cellular biology and microbiology.
INSERM U372, Marseille-Luminy, université de Provence, France.
June 1992:
Master in cellular biology Specialty: genetic.
Final mark: Best master student of this year.
Université de la Méditerranée, France.
June 1987:
Scientific baccalaureate, France.
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Enseignement
2009-présent: co-directeur de thèses, Ecole Polytechnique Fédérale de Lausanne, Suisse
2002: Tuteur en virologie pour les étudiants de médecine, Ecole de Médecine de Genève, Suisse.
1996-1997: Tuteur en biologie moléculaire et biochimie, Université de la Méditerranée, Aix Marseille II
Publications Infoscience
Publications
P. Helleboid; M. Heusel; J. Duc; C. Piot; C. W. Thorball et al. : The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification; The EMBO Journal. 2019-08-12. DOI : 10.15252/embj.2018101220.
Y. Sun; J. R. Keown; M. M. Black; C. Raclot; N. Demarais et al. : A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family; Journal of Molecular Biology. 2019-06-28. DOI : 10.1016/j.jmb.2019.05.002.
J. Pontis; E. Planet; S. Offner; P. Turelli; J. Duc et al. : Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs; Cell Stem Cell. 2019-03-27. DOI : 10.1016/j.stem.2019.03.012.
P.-Y. J. L. Helleboid : Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins. Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9388.
N. Takahashi; A. Coluccio; C. W. Thorball; E. Planet; H. Shi et al. : ZNF445 is a primary regulator of genomic imprinting; Genes & Development. 2019-01-01. DOI : 10.1101/gad.320069.118.
G. C. Pereira; L. Sanchez; P. M. Schaughency; A. Rubio-Roldan; J. A. Choi et al. : Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis; Mobile Dna. 2018-12-15. DOI : 10.1186/s13100-018-0138-z.
A. Iouranova; A. Coudray; J. Duc; M. Imbeault; P. Turelli et al. : KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks. 2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, October 16-19, 2018. p. A150-A150.
Y. Ariumi; K. Kawano; M. Yasuda-Inoue; M. Kuroki; H. Fukuda et al. : DNA repair protein Rad18 restricts LINE-1 mobility; Scientific Reports. 2018-10-26. DOI : 10.1038/s41598-018-34288-9.
K. Kawano; A. J. Doucet; M. Ueno; R. Kariya; W. An et al. : HIV-1 Vpr and p21 restrict LINE-1 mobility; Nucleic Acids Research. 2018-07-31. DOI : 10.1093/nar/gky688.
S. M. Jang; A. Kauzlaric; J.-P. Quivy; J. Pontis; B. Rauwel et al. : KAP1 facilitates reinstatement of heterochromatin after DNA replication; Nucleic Acids Research. 2018-06-28. DOI : 10.1093/nar/gky580.
A. Coluccio; G. Ecco; J. Duc; S. Offner; P. Turelli et al. : Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells; Epigenetics & Chromatin. 2018-02-26. DOI : 10.1186/s13072-018-0177-1.
A. Coluccio : KRAB'n'KAP, DNA methylation and epigenetic memory. Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8070.
G. Ecco; M. Cassano; A. Kauzlaric; J. Duc; A. Coluccio et al. : Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues; Developmental Cell. 2016. DOI : 10.1016/j.devcel.2016.02.024.
G. Ecco : Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells. Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7020.
F. Marzetta : Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6842.
N. Pennese : Evolutionally dynamic control of LINE-1 elements in embryonic stem cells. Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6511.
L. Fasching; A. Kapopoulou; R. Sachdeva; R. Petri; M. Jönsson et al. : TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells; Cell Reports. 2015. DOI : 10.1016/j.celrep.2014.12.004.
N. Castro-Diaz; G. Ecco; A. Coluccio; A. Kapopoulou; B. Yazdanpanah et al. : Evolutionally dynamic L1 regulation in embryonic stem cells; Genes & development. 2014. DOI : 10.1101/gad.241661.114.
P. Turelli; N. Castro-Diaz; F. Marzetta; A. Kapopoulou; C. Raclot et al. : Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements; Genome research. 2014. DOI : 10.1101/gr.172833.114.
M. Friedli; P. Turelli; A. Kapopoulou; B. Rauwel; N. Castro-Díaz et al. : Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency; Genome research. 2014. DOI : 10.1101/gr.172809.114.
S. Quenneville; P. Turelli; K. Bojkowska; C. Raclot; S. Offner et al. : The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development; Cell Reports. 2012. DOI : 10.1016/j.celrep.2012.08.043.
Y. Bulliard; I. Narvaiza; A. Bertero; S. Peddi; U. F. Röhrig et al. : Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities; Journal of virology. 2010. DOI : 10.1128/JVI.01651-10.
Y. Bulliard; P. Turelli; U. Röhrig; V. Zoete; B. Mangeat et al. : Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition; Journal of Virology. 2009. DOI : 10.1128/JVI.01491-09.
P. Turelli; A. Liagre-Quazzola; B. Mangeat; S. Verp; S. Jost et al. : APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice; Journal of Virology. 2008. DOI : 10.1128/JVI.00216-08.
P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono : Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha; PLOS Pathogens. 2007. DOI : 10.1371/journal.ppat.0030200.
S. Jost; P. Turelli; B. Mangeat; U. Protzer; D. Trono : Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons; Journal of Virology. 2007. DOI : 10.1128/JVI.02489-06.
Y. Ariumi; F. Serhan; P. Turelli; A. Telenti; D. Trono : The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription; Retrovirology. 2006.
P. Turelli; D. Trono : Editing at the crossroad of innate and adaptive immunity; Science. 2005. DOI : 10.1126/science.1105964.
Y. Ariumi; P. Turelli; M. Masutani; D. Trono : DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration; Journal of Virology. 2005. DOI : 10.1128/JVI.79.5.2973-2978.2005.
B. Mangeat; P. Turelli; S. Liao; D. Trono : A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action; Journal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400060200.
P. Turelli; B. Mangeat; S. Jost; S. Vianin; D. Trono : author reply on comment on: Inhibition of hepatitis B virus replication by APOBEC3G; science. 2004.
P. Turelli; S. Jost; B. Mangeat; D. Trono : Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"; Science. 2004.
P. Turelli; B. Mangeat; S. Jost; S. Vianin; D. Trono : Inhibition of hepatitis B virus replication by APOBEC3G; Science. 2004. DOI : 10.1126/science.1092066.
P. Turelli; S. Vianin; D. Trono : The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay; Journal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400334200.
B. Mangeat; P. Turelli; G. Caron; M. Friedli; L. Perrin et al. : Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts; Nature. 2003. DOI : 10.1038/nature01709.
M. Guyader; E. Kiyokawa; L. Abrami; P. Turelli; D. Trono : Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization; Journal of Virology. 2002. DOI : 10.1128/JVI.76.20.10356-10364.2002.
P. Turelli; V. Doucas; E. Craig; B. Mangeat; N. Klages et al. : Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication; Mol Cell. 2001. DOI : 10.1016/S1097-2765(01)00255-6.
M. Berton; P. Turelli; D. Trono; C. A. Stein; E. Allémann et al. : Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles; Pharm Res. 2001. DOI : 10.1023/A:1010962507273.
G. Petursson; P. Turelli; S. Matthiasdottir; G. Georgsson; O. Andresson et al. : Visna virus dUTPase is dispensable for neuropathogenicity; Journal of Virology. 1998.
P. Turelli; F. Guiguen; J. Mornex; R. Vigne; G. Querat : dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.; Journal of Virology. 1997.
P. Turelli; G. Petursson; F. Guiguen; J. Mornex; R. Vigne et al. : Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses; Journal of Virology. 1996.
