Priscilla Turelli

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priscilla.turelli@epfl.ch +41 21 693 18 11

Nationalité: Française/French

Date de naissance: 29.11.1970

EPFL SV GHI LVG
AI 3151 (Bâtiment AI)
Station 19
CH-1015 Lausanne

+41 21 693 18 11
Local: AI 3151
EPFL > SV > GHI > LVG

Web site: Site web: https://tronolab.epfl.ch/

+41 21 693 18 11
EPFL > VPO > VPO-SE > OHS > COSEC-SV

+41 21 693 18 11
EPFL > VPA > VPA-AVP-PGE > AVP-PGE-EDOC > EDMS-ENS

Web site: Site web: https://go.epfl.ch/edms

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Biographie

Positions 2005-présent: Chercheur, Ecole Polytechnique Fédérale de Lausanne, Laboratoire de virologie et génétique, Suisse. 2001-2004: Chercheur dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse. 1997-2001: Etudiante Post-doctorante dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse. ________________________________________________________________________ Honneurs et prix 2004: Bristol-Myers Squibb AIDS AWARD 1997-1999: Human Frontier Science Program fellowship ________________________________________________________________________ Education June 1997: PhD in cellular biology. Final mark:jury congratulations. Université de la Méditerranée, France. June 1993: Post-graduate diploma in cellular biology and microbiology. INSERM U372, Marseille-Luminy, université de Provence, France. June 1992: Master in cellular biology Specialty: genetic. Final mark: Best master student of this year. Université de la Méditerranée, France. June 1987: Scientific baccalaureate, France. ------------------------------------------------------------------------------------------------------------------------ Enseignement 2009-présent: co-directeur de thèses, Ecole Polytechnique Fédérale de Lausanne, Suisse 2002: Tuteur en virologie pour les étudiants de médecine, Ecole de Médecine de Genève, Suisse. 1996-1997: Tuteur en biologie moléculaire et biochimie, Université de la Méditerranée, Aix Marseille II

Publications

Publications Infoscience

Publications

De novo design of protein interactions with learned surface fingerprints

P. Gainza Cirauqui; S. Wehrle; A. K. Van Hall-Beauvais; A. Marchand; A. Scheck et al.

Nature. 2023-04-26. DOI : 10.1038/s41586-023-05993-x.

Priscilla Turelli

Biographie

Publications

Publications Infoscience

Publications

De novo design of protein interactions with learned surface fingerprints

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Genetic features and genomic targets of human KRAB-zinc finger proteins

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Krab-containing zinc finger protein and cancer

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Cell-free method for the quantitative measurement of virus neutralizing antibodies

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

A highly potent antibody effective against SARS-CoV-2 variants of concern

A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

ZNF445 is a primary regulator of genomic imprinting

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks

DNA repair protein Rad18 restricts LINE-1 mobility

HIV-1 Vpr and p21 restrict LINE-1 mobility

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

KRAB'n'KAP, DNA methylation and epigenetic memory

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

Evolutionally dynamic L1 regulation in embryonic stem cells

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons

The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription

Editing at the crossroad of innate and adaptive immunity

DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action

Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

Inhibition of hepatitis B virus replication by APOBEC3G

The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles

Visna virus dUTPase is dispensable for neuropathogenicity

dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.

Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses

Enseignement & Phd

A dirigé les thèses EPFL de

Cours

Practical - Trono Lab

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