Priscilla Turelli

priscilla.turelli@epfl.ch +41 21 693 18 11
Nationalité: Française/French
Date de naissance: 29.11.1970
EPFL SV GHI LVG
AI 3151 (Bâtiment AI)
Station 19
CH-1015 Lausanne
Web site: Site web: https://tronolab.epfl.ch/
EPFL AVP-PGE EDMS-ENS
SV 2515 (Bâtiment SV)
Station 19
CH-1015 Lausanne
+41 21 693 18 11
Local:
SV 2515
EPFL
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VPA
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VPA-AVP-PGE
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AVP-PGE-EDOC
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EDMS-ENS
Web site: Site web: https://go.epfl.ch/edms
Biographie
Positions 2005-présent: Chercheur, Ecole Polytechnique Fédérale de Lausanne, Laboratoire de virologie et génétique, Suisse. 2001-2004: Chercheur dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse. 1997-2001: Etudiante Post-doctorante dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse. ________________________________________________________________________ Honneurs et prix 2004: Bristol-Myers Squibb AIDS AWARD 1997-1999: Human Frontier Science Program fellowship ________________________________________________________________________ Education June 1997: PhD in cellular biology. Final mark:jury congratulations. Université de la Méditerranée, France. June 1993: Post-graduate diploma in cellular biology and microbiology. INSERM U372, Marseille-Luminy, université de Provence, France. June 1992: Master in cellular biology Specialty: genetic. Final mark: Best master student of this year. Université de la Méditerranée, France. June 1987: Scientific baccalaureate, France. ------------------------------------------------------------------------------------------------------------------------ Enseignement 2009-présent: co-directeur de thèses, Ecole Polytechnique Fédérale de Lausanne, Suisse 2002: Tuteur en virologie pour les étudiants de médecine, Ecole de Médecine de Genève, Suisse. 1996-1997: Tuteur en biologie moléculaire et biochimie, Université de la Méditerranée, Aix Marseille IIPublications
Publications Infoscience
Publications
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Life Science Alliance. 2022-02-01. DOI : 10.26508/lsa.202101270.KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences
Mobile Dna. 2022-01-18. DOI : 10.1186/s13100-021-00260-0.S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity
Developmental Cell. 2021-10-25. DOI : 10.1016/j.devcel.2021.09.016.A highly potent antibody effective against SARS-CoV-2 variants of concern
Cell Reports. 2021-10-12. DOI : 10.1016/j.celrep.2021.109814.A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
Science Translational Medicine. 2021-08-04. DOI : 10.1126/scitranslmed.abi8452.KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos
Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-10621.Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression
Science Advances. 2020-10-01. DOI : 10.1126/sciadv.abc3020.Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
Science Advances. 2020-08-28. DOI : 10.1126/sciadv.aba3200.The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
The EMBO Journal. 2019-08-12. DOI : 10.15252/embj.2018101220.A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family
Journal of Molecular Biology. 2019-06-28. DOI : 10.1016/j.jmb.2019.05.002.Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Cell Stem Cell. 2019-03-27. DOI : 10.1016/j.stem.2019.03.012.Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins
Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9388.ZNF445 is a primary regulator of genomic imprinting
Genes & Development. 2019-01-01. DOI : 10.1101/gad.320069.118.Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
Mobile Dna. 2018-12-15. DOI : 10.1186/s13100-018-0138-z.KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks
2018-12-01. Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, October 16-19, 2018. p. A150-A150.DNA repair protein Rad18 restricts LINE-1 mobility
Scientific Reports. 2018-10-26. DOI : 10.1038/s41598-018-34288-9.HIV-1 Vpr and p21 restrict LINE-1 mobility
Nucleic Acids Research. 2018-07-31. DOI : 10.1093/nar/gky688.KAP1 facilitates reinstatement of heterochromatin after DNA replication
Nucleic Acids Research. 2018-06-28. DOI : 10.1093/nar/gky580.Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells
Epigenetics & Chromatin. 2018-02-26. DOI : 10.1186/s13072-018-0177-1.KRAB'n'KAP, DNA methylation and epigenetic memory
Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8070.Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues
Developmental Cell. 2016. DOI : 10.1016/j.devcel.2016.02.024.Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells
Lausanne, EPFL, 2016. DOI : 10.5075/epfl-thesis-7020.Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6842.Evolutionally dynamic control of LINE-1 elements in embryonic stem cells
Lausanne, EPFL, 2015. DOI : 10.5075/epfl-thesis-6511.TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
Cell Reports. 2015. DOI : 10.1016/j.celrep.2014.12.004.Evolutionally dynamic L1 regulation in embryonic stem cells
Genes & development. 2014. DOI : 10.1101/gad.241661.114.Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
Genome research. 2014. DOI : 10.1101/gr.172833.114.Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency
Genome research. 2014. DOI : 10.1101/gr.172809.114.The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development
Cell Reports. 2012. DOI : 10.1016/j.celrep.2012.08.043.Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities
Journal of virology. 2010. DOI : 10.1128/JVI.01651-10.Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition
Journal of Virology. 2009. DOI : 10.1128/JVI.01491-09.APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice
Journal of Virology. 2008. DOI : 10.1128/JVI.00216-08.Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha
PLOS Pathogens. 2007. DOI : 10.1371/journal.ppat.0030200.Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons
Journal of Virology. 2007. DOI : 10.1128/JVI.02489-06.The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription
Retrovirology. 2006. DOI : 10.1186/1742-4690-3-47.Editing at the crossroad of innate and adaptive immunity
Science. 2005. DOI : 10.1126/science.1105964.DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration
Journal of Virology. 2005. DOI : 10.1128/JVI.79.5.2973-2978.2005.A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action
Journal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400060200.Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"
Science. 2004. DOI : 10.1126/science.1101974.Inhibition of hepatitis B virus replication by APOBEC3G
Science. 2004. DOI : 10.1126/science.1092066.The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay
Journal of Biological Chemistry. 2004. DOI : 10.1074/jbc.C400334200.Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Nature. 2003. DOI : 10.1038/nature01709.Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization
Journal of Virology. 2002. DOI : 10.1128/JVI.76.20.10356-10364.2002.Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication
Molecular Cell. 2001. DOI : 10.1016/S1097-2765(01)00255-6.Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles
Pharm Res. 2001. DOI : 10.1023/A:1010962507273.Visna virus dUTPase is dispensable for neuropathogenicity
Journal of Virology. 1998. DOI : 10.1128/JVI.72.2.1657-1661.1998.dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.
Journal of Virology. 1997. DOI : 10.1128/jvi.71.6.4522-4530.1997.Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses
Journal of Virology. 1996. DOI : 10.1128/jvi.70.2.1213-1217.1996.Enseignement & Phd
Programmes doctoraux
Doctoral Program in Molecular Life Sciences