Sylvie Roke

EPFL STI IBI-STI LBP
BM 4112 (Bâtiment BM)
Station 17
CH-1015 Lausanne

EPFL STI IMX IMX-GE
BM 4112 (Bâtiment BM)
Station 17
CH-1015 Lausanne

+41 21 69 31191
Unité: IMX-GE
Local: BM 4112

EPFL SV IBI-SV IBI-SV-GE
BM 4112 (Bâtiment BM)
Station 17
CH-1015 Lausanne

EPFL STI IBI-STI IBI-STI-GE
BM 4112 (Bâtiment BM)
Station 17
CH-1015 Lausanne

Données administratives


Education

PhD Natural Sciences Leiden University 2000-2004 (highest honors)
M.Sc. Physics Utrecht University 1997 - 2000 (highest honors)
M. Sc. Chemistry Utrecht University 1995 - 2000 (highest honors)

Enseignement & Phd

Enseignement

  • Life Sciences Engineering,

Programmes doctoraux

  • Doctoral Program in Photonics
  • Doctoral Program in Biotechnology and Bioengineering
  • Doctoral Program in Materials Science and Engineering

Doctorants

Cours

Nonlinear Optics

Basic principles of optics goto

MINEUR, 2018-2019, Semestre automne, language : anglais
Manufacturing (edoc), 2018-2019, language : anglais
Microtechnique, 2018-2019, Master semestre 1, language : anglais
Microtechnique, 2018-2019, Master semestre 3, language : anglais
Photonique (edoc), 2018-2019, language : anglais

Nonlinear Spectroscopy

Molecular properties relevant for spectroscopy
Symmetry properties, space, time induced
Susceptibility: Relation between molecular properties and macroscopic
Optical properties
Overview of nonlinear optical spectroscopies: SHG / SFG... goto

Photonique (edoc), 2018-2019, language : anglais

Recherche

Research Highlights

We develop novel optical technology, geared to obtaining molecular level details of nanoscale and microscopic systems in aqueous environments as well as other complex 3D environments such as pores. We have focused on ultrafast nonlinear optical methods as they are non-invasive and label-free and inherently interface specific or sensitive to polar structures. We apply these tools to fundamental questions that have important implications for biology, chemistry or technology. Topics of interest: • Water, aqueous solutions • Aqueous interfaces and nanoscopic systems • Nonlinear optics, ultrafast spectroscopy, light scattering • Multiphoton imaging • Soft systems: Interfaces, membranes, electric double layers • Structure and dynamics in living systems • Neuroimaging and neurological activity 10 Research Highlights (anti-chronological) • Surface electrostatic potentials and reaction constants can be optically imaged in real time and display heterogeneities of respectively a factor of 3 x the average and 8 orders of magnitude on a glass micro-capillary surface immersed in water. • Electrolytes induce changes in the hydrogen bond network of water that range over ~77 hydration shells and are subject to quantum effects. These changes lead to energy changes on the order of kT per ion, which lead to surface tension anomalies, better known as the controversial Jones-Ray effect (discovered in the 1930’s). • Discovery that (~50-150 nm) liposomes exhibit trans-membrane asymmetry in their hydration shells rather than the lipid composition. Specific interactions may induce membrane asymmetry. • Development of a nanodroplet platform to study the molecular structure of lipid droplets and biological monolayer phenomena in solution. • Discovery that various molecular properties of nanoscale / submicron droplets of oil and water behave differently than extended planar interfaces composed of the same chemicals; reasons can be found in the difference in hydrogen bond network configurations and a different balance of electrostatic interactions. • Development of wide field medium repetition rate second harmonic and multiphoton imaging instruments with ~5000 x better efficiency than scanning confocal microscopy. • Angle resolved second harmonic scattering can be used to measure unique surface potential values on particles in solution. • Development of second harmonic scattering instrumentation with an improved efficiency of ~1000. • Invention of vibrational sum frequency scattering, and subsequent development into a reliable interfacial molecular probe of buried interfaces of nano- and microscale materials. • Development of nonlinear optical theories to understand nonlinear light scattering.