Sylvie Roke

Nationality: Dutch

EPFL STI IBI-STI LBP
BM 4112 (Bâtiment BM)
Station 17
1015 Lausanne

EPFL STI IMX-GE
BM 4112 (Bâtiment BM)
Station 17
1015 Lausanne

Expertise

Water
Aqueous interfaces and systems
Nonlinear optics
Ultrafast spectroscopy
Light scattering
Nonlinear and multiphoton imaging
Soft matter and membrane systems

Mission

Approximately sixty percent of the mass of the human body is composed of water. Water is not the passive background against which biology unfolds, but an active participator in change. The structural and dynamical properties of water determine the outcome of biological and chemical change. This change occurs at interfaces and in solution. To understand the molecular level details of water-related biological, chemical and physical processes, and to harness them for tomorrow's technology, we investigate the structure and dynamics of water on various length scales and with varying degrees of complexity.
Our strategy is to develop novel optical technology, geared to obtaining molecular level details of nanoscale and microscopic systems in aqueous environments as well as other complex 3D environments such as pores. We have focused on ultrafast nonlinear optical methods as they are non-invasive and label-free and inherently interface specific or sensitive to polar structures. We apply these tools to fundamental questions that have important implications for biology, chemistry or technology.
Topics of interest:
• Water, aqueous solutions
• Aqueous interfaces and nanoscopic systems
• Nonlinear optics, ultrafast spectroscopy, light scattering
• Multiphoton imaging
• Soft systems: Interfaces, membranes, electric double layers
• Structure and dynamics in living systems
• Neuroimaging and neurological activity

2011 – present: Julia Jacobi Chair in photomedicine, école Polytechnique Fédérale Lausanne (EPFL), CH.
2005 – 2012: Max Planck Research Group Leader (W2 /C3) of a centrally announced open theme independent research group. Host: The Max-Planck Institute for Metals Research, Stuttgart, DE.
2005 – 2005: Alexander von Humboldt Fellow, dept. of Applied Physical Chemistry, Heidelberg University, DE.
2004 – 2005: Postdoctoral Fellow, FOM-Institute for Plasma Physics, NL.

Awards and Distinctions

2022 - Elected Member of the Swiss Academy of Engineering Sciences (SATW)
2021 - Elected Fellow of Optica (formerly Optical Society of America)
2020 - Winner of an ERC Synergy Grant
2020 - Elected Fellow of the American Physical Society
2020 - ERC Proof of Concept Grant
2019 - Featured for OSA living stories2014 - Winner of an ERC Consolidator Grant.
2013 - Cover and Featured Professional in the 2013-2014 SPIE Monthly Planner.
2011 - Julia Jacobi Chair in photomedicine.
2010 - Fellow of the Young Academy of the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW) and the German Academy of Natural Scientists, Leopoldina.
2010 - Young member Werner von Siemens Ring (DE).
2010 - Selection for the Excellence Network of the Robert-Bosch Foundation (DE).
2009 - Winner of an ERC Startup Grant.
2008 - Hertha-Sponer-Preis awarded by the German Physical Society (DPG)
2007 - Young Researcher prize, ESF conference on Bio-interfaces, Saint Feliu, ES.
2006 - Minerva Prize awarded biyearly by the Dutch Foundation for Fundamental Research on Matter (FOM).
2006 - Featured Professional in «Brilliant Minds» for Germany's international broadcaster Deutsche Welle's Tomorrow Today (broadcast on television worldwide 06/2006).
2005 - Recipient of a Max Planck Research Group Leader position.
2005 - Recipient of an Alexander von Humboldt Fellowship.
2005 - Prize winner in a Dutch science writing contest of the Dutch Physical Society.
2004 - Ph. D. degree with highest honors, awarded to <5% of all candidates.
2003 - L. J. Oosterhoff prize, awarded by the University of Leiden.
2002 - Young Researcher prize of the «Holland Research School for Molecular Chemistry».
2001 - Young Researcher prize at the Gordon Research Conference on Surface Dynamics, New Hampshire, USA.
2000 - Cum Laude, M. Sc. in chemistry with highest honors, <10% of all candidates.
2000 - Cum Laude, M. Sc. in physics with highest honors, <10% of all candidates.

Education

PhD

| Natural Sciences

2000 – 2004 Leiden University

M.Sc.

| Physics

1997 – 2000 Utrecht University

M. Sc.

| Chemistry

1995 – 2000 Utrecht University

Awards

Holland Research School for Molecular Chemistry Young Researcher prize

2002

L. J. Oosterhoff prize

2003

Alexander von Humboldt Fellowship

2005

Minerva Prize (Dutch Foundation for Fundamental Research on Matter

2006

Hertha-Sponer-Preis

DPG

2008

ERC Starting Grant

European Research Council

2009

Fellow of Leopoldina and BBAW

2010

ERC Consolidator Grant (2013). Julia Jacobi Chair in photomedicine@EPFL

European Research Council

2011

Holland Research School for Molecular Chemistry Young Researcher prize

2002

L. J. Oosterhoff prize

2003

Alexander von Humboldt Fellowship

2005

Minerva Prize (Dutch Foundation for Fundamental Research on Matter

2006

Hertha-Sponer-Preis

DPG

2008

ERC Starting Grant

European Research Council

2009

Fellow of Leopoldina and BBAW

2010

ERC Consolidator Grant (2013). Julia Jacobi Chair in photomedicine@EPFL

European Research Council

2011

Fellowship to the American Physical Society

American Physical Society

2020

Publications

Quantifying Inter- and Intramolecular Interactions in Liquids with Correlated Vibrational Spectroscopy: Case Study of CCl <sub>4</sub> and CH <sub>3</sub> CN

M. FlórV. VorobevA. BouchezA. MarchioroD. M. Wilkins  et al.

The Journal of Physical Chemistry B. 2026. DOI : 10.1021/acs.jpcb.5c03893.

Correlated vibrational spectroscopy: A new window into molecular interactions

M. S. Flór

Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-11607.

Droplets inside out: Molecular level studies of water at nanoscale aqueous interfaces

L. Zhang

Lausanne, EPFL, 2025. DOI : 10.5075/epfl-thesis-11488.

Method, computer readable medium and apparatus for determining an aggregation state of a solute in a solvent

O. B. TarunN. DupertuisS. Roke

WO2025082878 ; EP4542204 . 2025.

Unraveling the Molecular Pathways for Structure “Making” and “Breaking” by Ions in Water

M. FlórV. VorobevV. MandalaparthyN. F. A. van der VegtP. S. Cremer  et al.

Journal of the American Chemical Society. 2025. DOI : 10.1021/jacs.5c10984.

Interfacial Self-Assembly of Sugars at Nanoscale Membranes Leads to Micron-Scale, Spectroscopically Ice-Like Chiral Suprastructures of Water

L. ZhangJ. LiuK. VoïtchovskyC. E. RaniS. Pullanchery  et al.

Journal of the American Chemical Society. 2025. DOI : 10.1021/jacs.5c05215.

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

O. B. TarunN. DupertuisD. M. WilkinsS. Roke

The Journal of Physical Chemistry B. 2025. DOI : 10.1021/acs.jpcb.5c03073.

Sum-Frequency Scattering Spectroscopy Reveals the Charging Mechanism and Surface Structure of hBN Nanoflakes in Solution

B. RehlN. RoncerayL. ZhangA. RađenovićS. Roke

ACS Nano. 2025. DOI : 10.1021/acsnano.5c03589.

Finite Volume Effects in Water Nanodroplets: A Molecular Level Investigation

L. ZhangS. PullancheryP. S. CremerS. Roke

ACS Nano. 2025. DOI : 10.1021/acsnano.5c04422.

Membrane Potential Fluctuations and Water Asymmetry on Plasma Cell and Model Lipid Membranes: Origins, Implications and Properties

Z. LiI. SwiderskaL. DalifoskiS. LeeN. A. Correa-Rojas  et al.

FARADAY DISCUSSIONS. 2025. DOI : 10.1039/d4fd00197d.

Dissecting the hydrogen bond network of water: Charge transfer and nuclear quantum effects

M. FlórD. M. WilkinsM. de la PuenteD. LaageG. Cassone  et al.

Science. 2024. DOI : 10.1126/science.ads4369.

pH drives electron density fluctuations that enhance electric field-induced liquid flow

S. PullancheryS. KulikT. SchönfeldováC. K. EganG. Cassone  et al.

Nature Communications. 2024. DOI : 10.1038/s41467-024-50030-8.

Does the ionic distribution in the electrical double layer modify second harmonic scattering?

B. ChuS. RokeA. Marchioro

The Journal of Chemical Physics. 2024. DOI : 10.1063/5.0198247.

Dissecting the membrane association mechanism of aerolysin pore at femtomolar concentrations using water as a probe

T. RoeselC. CaoJ. F. Bada JuarezM. Dal PeraroS. Roke

2024.

Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes

S. LeeC. S. PoojariA. MaznichenkoD. RoeselI. Swiderska  et al.

Journal of the American Chemical Society. 2024. DOI : 10.1021/jacs.4c02810.

Optical imaging of molecules and their dynamics from surfaces to nanoscale confinement

N. Ronceray

Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-11003.

Second harmonic scattering of nanoparticles: A journey into the electrical double layer

B. Chu

Lausanne, EPFL, 2024. DOI : 10.5075/epfl-thesis-10850.

Quantified interface chemistry and biophysics via water imaging

S. Roke

2024. Conference on Advanced Chemical Microscopy for Life Science and Translational Medicine, San Francisco, CA, JAN 27-29, 2024. DOI : 10.1117/12.3003675.

Liposomes and Lipid Droplets Display a Reversal of Charge-Induced Hydration Asymmetry

S. PullancheryN. DupertuisT. RoeselS. Roke

Nano Letters. 2023. DOI : 10.1021/acs.nanolett.3c02653.

Dynamic second-harmonic imaging of divalent cation translocation through giant vesicle membranes

D. RoeselM. EremchevC. S. PoojariJ. S. HubS. Roke

2023. p. S203 - S203.

Minimum dataset for "Liquid-activated quantum emission from pristine hexagonal boron nitride for nanofluidic sensing"

N. RoncerayA. RadenovicY. YouE. GlushkovM. Lihter  et al.

2023.

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

S. Lee

Lausanne, EPFL, 2023. DOI : 10.5075/epfl-thesis-10176.

Evolution of the electrical double layer with electrolyte concentration probed by second harmonic scattering

B. ChuD. BiriukovM. BischoffM. PredotaS. Roke  et al.

Faraday Discussions. 2023. DOI : 10.1039/d3fd00036b.

Interfacial Inversion, Interference, and IR Absorption in Vibrational Sum Frequency Scattering Experiments

S. PullancheryL. ZhangS. KulikS. Roke

The Journal of Physical Chemistry B. 2023. DOI : 10.1021/acs.jpcb.3c02727.

High throughput wide field second harmonic imaging of giant unilamellar vesicles

M. EremchevD. RoeselP. -m. DansetteA. MichailovasS. Roke

Biointerphases. 2023. DOI : 10.1116/6.0002640.

A discrepancy of 10(7) in experimental and theoretical density detection limits of aerosol particles by surface nonlinear light scattering

A. MarchioroT. W. GolbekA. S. ChatterleyT. WeidnerS. Roke

Communications Chemistry. 2023. DOI : 10.1038/s42004-023-00903-8.

Lysozyme Interaction with Phospholipid Nanodroplets Probed by Sum Frequency Scattering Vibrational Spectroscopy

T. W. GolbekH. I. OkurS. KulikJ. DedicS. Roke  et al.

Langmuir. 2023. DOI : 10.1021/acs.langmuir.3c00276.

Size dependence of second-harmonic scattering from nanoparticles: Disentangling surface and electrostatic contributions

B. ChuA. MarchioroS. Roke

Journal Of Chemical Physics. 2023. DOI : 10.1063/5.0135157.

Passive transport of Ca2+ ions through lipid bilayers imaged by widefield second harmonic microscopy

M. EremchevD. RoeselC. S. PoojariA. RouxJ. S. Hub  et al.

Biophysical Journal. 2023. DOI : 10.1016/j.bpj.2023.01.018.

Ion-Induced Transient Potential Fluctuations Facilitate Pore Formation and Cation Transport through Lipid Membranes

D. RoeselM. EremchevC. S. PoojariJ. S. HubS. Roke

Journal of the American Chemical Society. 2022. DOI : 10.1021/jacs.2c08543.

Second harmonic scattering of water in a biological context

T. Schönfeldová

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9937.

Water as a contrast agent for imaging interfacial structure and ion transport in giant vesicles

D. Roesel

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9860.

Three-Dimensional Confinement of Water: H2O Exhibits Long-Range (> 50 nm) Structure while D2O Does Not

N. DupertuisO. B. TarunC. LutgebaucksS. Roke

Nano Letters. 2022. DOI : 10.1021/acs.nanolett.2c02206.

Charge Gradients around Dendritic Voids Cause Nanoscale Inhomogeneities in Liquid Water

T. SchoenfeldovaN. DupertuisY. ChenN. AnsariE. Poli  et al.

The Journal of Physical Chemistry Letters. 2022. DOI : 10.1021/acs.jpclett.2c01872.

Tribute to Dor Ben-Amotz

A. Vila VerdeP. CremerS. KaisK. MochizukiS. Roke

The Journal of Physical Chemistry B. 2022. DOI : 10.1021/acs.jpcb.2c01804.

Water Structure at the Hydrophobic Nanodroplet Surface Revealedby Vibrational Sum Frequency Scattering Using Isotopic Dilution br

S. PullancheryS. KulikS. Roke

The Journal of Physical Chemistry B. 2022. DOI : 10.1021/acs.jpcb.2c01987.

Water as a contrast agent to quantify surface chemistry and physics using second harmonic scattering and imaging: A perspective

D. RoeselM. EremchevT. SchoenfeldovaS. LeeS. Roke

Applied Physics Letters. 2022. DOI : 10.1063/5.0085807.

Resolving the charging paradox of neat oil droplets in water

S. Kulik

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9113.

Ultrasensitive Label-Free Detection of Protein–Membrane Interaction Exemplified by Toxin-Liposome Insertion

T. SchönfeldováH. I. OkurV. VezočnikM. I. IacovacheC. Cao  et al.

The Journal of Physical Chemistry Letters. 2022. DOI : 10.1021/acs.jpclett.1c04011.

Molecular insights into the electrical double layer of colloidal oxide particles obtained through second harmonic scattering

M. Bischoff

Lausanne, EPFL, 2022. DOI : 10.5075/epfl-thesis-9448.

Lipid Melting Transitions Involve Structural Redistribution of Interfacial Water

T. SchoenfeldovaP. PillerF. KovacikG. PabstH. Okur  et al.

The Journal of Physical Chemistry B. 2021. DOI : 10.1021/acs.jpcb.1c06868.

Charge transfer across C-H center dot center dot center dot O hydrogen bonds stabilizes oil droplets in water

S. PullancheryS. KulikB. RehlA. HassanaliS. Roke

Science. 2021. DOI : 10.1126/science.abj3007.

Imaging Cu2+ binding to charged phospholipid membranes by high-throughput second harmonic wide-field microscopy

S. LeeD. RoeselS. Roke

Journal Of Chemical Physics. 2021. DOI : 10.1063/5.0063362.

Passive and active ion permeation through lipid bilayers investigated by second harmonic water imaging

M. Eremchev

Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-9105.

Dynamic second-harmonic imaging of lipid membrane hydration induced by copper ions

S. LeeD. RoeselS. Roke

2021. p. 141 - 141.

A water window on membrane biochemistry: Quantifying surface potential, free energy and binding constants

S. Roke

2021. p. 41 - 41.

Molecular ordering effects in bulk and at lipid/water nanoscopic interfaces: A story of water, light, and order

N. Dupertuis

Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8657.

A tunable femtosecond fiber laser source for multiphoton emission microscopy

P.-M. J. M. Dansette

Lausanne, EPFL, 2021. DOI : 10.5075/epfl-thesis-8839.

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

A. Y. SonayK. KalyviotisS. YaganogluA. UnsalM. Konantz  et al.

Acs Nano. 2021. DOI : 10.1021/acsnano.0c10634.

Molecular Mechanism for the Interactions of Hofmeister Cations with Macromolecules in Aqueous Solution

E. E. BruceH. OkurS. StegmaierC. DrexlerB. A. Rogers  et al.

Journal Of The American Chemical Society. 2020. DOI : 10.1021/jacs.0c07214.

Hyaluronan orders water molecules in its nanoscale extended hydration shells

J. DedicH. OkurS. Roke

Science Advances. 2021. DOI : 10.1126/sciadv.abf2558.

Handy water: Chiral superstructures around peptide beta-sheets

S. PullancheryS. Roke

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2021. DOI : 10.1073/pnas.2024376118.

Vibrational Sum Frequency Scattering in Absorptive Media: A Theoretical Case Study of Nano-objects in Water

S. KulikS. PullancheryS. Roke

Journal Of Physical Chemistry C. 2020. DOI : 10.1021/acs.jpcc.0c05196.

Mapping Electrochemical Heterogeneity at Gold Surfaces: A Second Harmonic Imaging Study

I. NahalkaG. ZwaschkaR. K. CampenA. MarchioroS. Roke

Journal Of Physical Chemistry C. 2020. DOI : 10.1021/acs.jpcc.0c02740.

Mapping of Chemical Heterogeneity at Surfaces with High-Throughput Wide-Field Second Harmonic Microscopy

I. Nahálka

Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-8201.

Self-Assembly at Water Nanodroplet Interfaces Quantified with Nonlinear Light Scattering

N. SmolentsevS. Roke

Langmuir. 2020. DOI : 10.1021/acs.langmuir.0c01887.

On the stability and necessary electrophoretic mobility of bare oil nanodroplets in water

S. PullancheryS. KulikH. I. OkurH. B. de AguiarS. Roke

Journal Of Chemical Physics. 2020. DOI : 10.1063/5.0009640.

Imaging the Heterogeneity of the Oxygen Evolution Reaction on Gold Electrodes Operando: Activity is Highly Local

G. ZwaschkaI. NahalkaA. MarchioroY. TongS. Roke  et al.

Acs Catalysis. 2020. DOI : 10.1021/acscatal.0c01177.

Surface Potential and Interfacial Water Order at the Amorphous TiO2 Nanoparticle/Aqueous Interface

M. BischoffD. BiriukovM. PredotaS. RokeA. Marchioro

Journal of Physical Chemistry C. 2020. DOI : 10.1021/acs.jpcc.0c01158.

Water window on membrane biochemistry

S. Roke

2019. Fall National Meeting and Exposition of the American-Chemical-Society (ACS), San Diego, CA, Aug 25-29, 2019.

Long-range interactions of ions with water determine the Jones-Ray effect

S. Roke

2019. Fall National Meeting and Exposition of the American-Chemical-Society (ACS), San Diego, CA, Aug 25-29, 2019.

Water perspective on neuronal activity using wide field second harmonic imaging

S. Roke

2019. Fall National Meeting and Exposition of the American-Chemical-Society (ACS), San Diego, CA, Aug 25-29, 2019.

Second harmonic imaging of real-time spatially resolved chemical reaction constants

S. Roke

2019. Fall National Meeting and Exposition of the American-Chemical-Society (ACS), San Diego, CA, Aug 25-29, 2019.

Membrane-protein-hydration interaction of alpha-synuclein with anionic vesicles in solution probed via angle-resolved second harmonic scattering

J. DedicS. RochaP. W. StafshedeS. Roke

2019. ACS Fall National Meeting and Exposition, San Diego, CA, Aug 25-29, 2019.

Surface chemistry of silica particles in aqueous solution

A. MarchioroS. Roke

2019. ACS Fall National Meeting and Exposition, San Diego, CA, Aug 25-29, 2019.

Endogenous second harmonic and two photon coherence imaging of substructures in neurons in 3D

S. Roke

2019. ACS Fall National Meeting and Exposition, San Diego, CA, Aug 25-29, 2019.

Dynamic Imaging of Membrane Hydration

S. Roke

2020. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, Feb 15-19, 2020. p. 4A - 4A. DOI : 10.1016/j.bpj.2019.11.214.

Transient domains of ordered water induced by divalent ions lead to lipid membrane curvature fluctuations

O. B. TarunH. I. OkurP. RangamaniS. Roke

Communications Chemistry. 2020. DOI : 10.1038/s42004-020-0263-8.

Mapping of real-time morphological changes in the neuronal cytoskeleton with label-free wide-field second-harmonic imaging: a case study of nocodazole

M. E. P. DidierC. Macias-RomeroC. TeulonP. JourdainS. Roke

Neurophotonics. 2019. DOI : 10.1117/1.NPh.6.4.045006.

Soft matter probed by nonlinear scattering: self-assembly, interfaces, hydration, and long-range order

J. Dedic

Lausanne, EPFL, 2020. DOI : 10.5075/epfl-thesis-9977.

Polyelectrolytes induce water-water correlations that result in dramatic viscosity changes and nuclear quantum effects

J. DedicH. I. OkurS. Roke

Science Advances. 2019. DOI : 10.1126/sciadv.aay1443.

Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces

Z. LuoA. MurelloD. M. WilkinsF. KovacikJ. Kohlbrecher  et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2019. DOI : 10.1073/pnas.1916180116.

Surface Characterization of Colloidal Silica Nanoparticles by Second Harmonic Scattering: Quantifying the Surface Potential and Interfacial Water Order

A. MarchioroM. BischoffC. LütgebaucksD. BiriukovM. Předota  et al.

Journal of Physical Chemistry C. 2019. DOI : 10.1021/acs.jpcc.9b05482.

Chemistry of Lipid Membranes from Models to Living Systems: A Perspective of Hydration, Surface Potential, Curvature, Confinement and Heterogeneity

H. I. OkurO. B. TarunS. Roke

Journal of the American Chemical Society. 2019. DOI : 10.1021/jacs.9b02820.

The interfacial structure of nano-and micron-sized oil and water droplets stabilized with SDS and Span80

E. ZdraliG. EtienneN. SmolentsevE. AmstadS. Roke

Journal Of Chemical Physics. 2019. DOI : 10.1063/1.5083844.

Specific Ion Effects at the Interface of Nanometer-Sized Droplets in Water: Structure and Stability

E. ZdraliH. I. OkurS. Roke

The Journal of Physical Chemistry C. 2019. DOI : 10.1021/acs.jpcc.9b01001.

The Diverse Nature of Ion Speciation at the Nanoscale Hydrophobic/Water Interface

E. ZdraliM. D. BaerH. I. OkurC. J. MundyS. Roke

The Journal of Physical Chemistry B. 2019. DOI : 10.1021/acs.jpcb.8b10207.

Dynamic Imaging of Lipid Membranes by Means of Water

O. B. Tarun

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9270.

Molecular Level Interfacial Studies of Nanoemulsions: Surface Structure, Specific Ion Effects and Stability

E. Zdrali

Lausanne, EPFL, 2019. DOI : 10.5075/epfl-thesis-9037.

Hydration mediated interfacial transitions on mixed hydrophobic/hydrophilic nanodroplet interfaces

F. KovacikH. I. OkurN. SmolentsevR. ScheuS. Roke

Journal Of Chemical Physics. 2018. DOI : 10.1063/1.5035161.

Comment on "Water- water correlations in electrolyte solutions probed by hyper-Rayleigh scattering" [J. Chem. Phys. 147, 214505 (2017)]

Y. ChenH. I. OkurN. DupertuisJ. DedicD. M. Wilkins  et al.

Journal Of Chemical Physics. 2018. DOI : 10.1063/1.5023579.

Nanoemulsions of lipid droplets - a new model lipid system

V. VezocnikV. HodnikH. I. OkurS. SitarM. Tusek-Znidaric  et al.

2018. p. 473 - 473.

The interfacial structure of water droplets in a hydrophobic liquid

N. SmolentsevW. SmitH. BakkerS. Roke

2018. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA, Mar 18-22, 2018.

Low photodamage label-free imaging of single cell activity aimed at mapping neuronal activity

M. DidierO. TarunS. Roke

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Lipid membranes probed label-free with nonlinear light scattering and imaging: Direct probes of surface chemistry

S. Roke

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Label-free dynamic imaging of free standing lipid membranes and their hydration

O. TarunS. Roke

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Hydration mediated interfacial transitions on mixed hydrophobic/hydrophilic nanodroplet interfaces

F. KovacikH. OkurS. Roke

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Optical label- and model-free probing of the surface potential of nanoscale silica particles in aqueous solution

A. MarchioroC. LuetgebaucksS. Roke

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Nonlinear microscopy for temporally and spatially resolved label-free imaging of living cells

M. E. P. Didier

Lausanne, EPFL, 2018. DOI : 10.5075/epfl-thesis-8891.

Optical imaging of surface chemistry and dynamics in confinement

C. Macias-RomeroI. NahalkaH. OkurS. Roke

2018. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA, Mar 18-22, 2018.

Intermolecular headgroup interaction and hydration as driving forces for lipid transmembrane asymmetry

N. SmolentsevC. LuetgebaucksH. OkurS. Roke

2018. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA, Mar 18-22, 2018.

Jones-Ray effect reinterpreted: Surface tension minima of low ionic strength electrolyte solutions are caused by electric field induced water-water correlations

H. OkurY. ChenD. WilkinsS. Roke

2018. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA, Mar 18-22, 2018.

Temperature dependence of water-water and ion-water correlations in bulk water and electrolyte solutions probed by femtosecond elastic second harmonic scattering

Y. ChenN. DupertuisH. I. OkurS. Roke

The Journal of Chemical Physics. 2018. DOI : 10.1063/1.5023343.

Zwitterionic and Charged Lipids Form Remarkably Different Structures on Nanoscale Oil Droplets in Aqueous Solution

Y. ChenH. I. OkurC. LütgebaucksS. Roke

Langmuir. 2018. DOI : 10.1021/acs.langmuir.7b02896.

Molecular-level characterization of curved water interfaces with sum frequency and second harmonic scattering

N. Smolentsev

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-8100.

Solvent fluctuations and nuclear quantum effects modulate the molecular hyperpolarizability of water

C. LiangG. TocciD. M. WilkinsA. GrisafiS. Roke  et al.

Physical Review B. 2017. DOI : 10.1103/PhysRevB.96.041407.

Optical imaging of surface chemistry and dynamics in confinement

C. Macias-RomeroI. NahalkaH. I. OkurS. Roke

Science. 2017. DOI : 10.1126/science.aal4346.

Aqueous Nanoscale Systems

S. Roke

Chimia. 2017. DOI : 10.2533/chimia.2017.278.

The Jones-Ray Effect Reinterpreted: Surface Tension Minima of Low Ionic Strength Electrolyte Solutions are caused by Electric Field Induced Water-Water Correlations

H. OkurY. ChenD. WilkinsS. Roke

Chemical Physics Letters. 2017. DOI : 10.1016/j.cplett.2017.06.018.

Device and method for measuring and imaging second harmonic and multi-photon generation scattered radiation

S. RokeC. Macias Romero

US9778177 ; US2015233820 ; WO2014012848 . 2015.

Communication: Mean-field theory of water-water correlations in electrolyte solutions

D. M. WilkinsD. E. ManolopoulosS. RokeM. Ceriotti

The Journal of Chemical Physics. 2017. DOI : 10.1063/1.4983221.

The interfacial structure of water droplets in a hydrophobic liquid

N. SmolentsevW. J. SmitH. J. BakkerS. Roke

Nature Communications. 2017. DOI : 10.1038/ncomms15548.

Molecular insights in aqueous systems : from electrolyte solutions to aqueous nanoscale interfaces

Y. Chen

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7646.

Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution

H. I. OkurY. ChenN. SmolentsevE. ZdraliS. Roke

The Journal of Physical Chemistry B. 2017. DOI : 10.1021/acs.jpcb.7b00609.

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

C. U. Lütgebaucks

Lausanne, EPFL, 2017. DOI : 10.5075/epfl-thesis-7626.

Characterization of the interface of binary mixed DOPC:DOPS liposomes in water: The impact of charge condensation

C. LütgebaucksC. Macias-RomeroS. Roke

The Journal of Chemical Physics. 2017. DOI : 10.1063/1.4974084.

Optical label-free and model-free probe of the surface potential of nanoscale and microscopic objects in aqueous solution

C. LütgebaucksG. GonellaS. Roke

Physical Review B. 2016. DOI : 10.1103/PhysRevB.94.195410.

Second-Harmonic Scattering as a Probe of Structural Correlations in Liquids

G. TocciC. LiangD. M. WilkinsS. RokeM. Ceriotti

The Journal of Physical Chemistry Letters. 2016. DOI : 10.1021/acs.jpclett.6b01851.

Freezing effects of oil-in-water emulsions studied by sum-frequency scattering spectroscopy

W. J. SmitN. SmolentsevJ. VersluisS. RokeH. J. Bakker

Journal Of Chemical Physics. 2016. DOI : 10.1063/1.4959128.

What interactions can distort the orientational distribution of interfacial water molecules as probed by second harmonic and sum frequency generation?

A. G. F. De BeerS. Roke

Journal Of Chemical Physics. 2016. DOI : 10.1063/1.4959033.

Water-Mediated Ion Pairing: Occurrence and Relevance

N. F. A. Van Der VegtK. HaldrupS. RokeJ. ZhengM. Lund  et al.

Chemical Reviews. 2016. DOI : 10.1021/acs.chemrev.5b00742.

Protons and Hydroxide Ions in Aqueous Systems

N. AgmonH. J. BakkerR. K. CampenR. H. HenchmanP. Pohl  et al.

Chemical Reviews. 2016. DOI : 10.1021/acs.chemrev.5b00736.

Second Harmonic and Sum-Frequency Generation from Aqueous Interfaces Is Modulated by Interference

G. GonellaC. LuetgebaucksA. G. F. De BeerS. Roke

Journal Of Physical Chemistry C. 2016. DOI : 10.1021/acs.jpcc.5b12453.

Electrolytes induce long-range orientational order and free energy changes in the H-bond network of bulk water

Y. ChenH. I. OkurN. GomopoulosC. Macias-RomeroP. S. Cremer  et al.

Science Advances. 2016. DOI : 10.1126/sciadv.1501891.

Wide-field medium-repetition-rate multiphoton microscopy reduces photodamage of living cells

C. Macias-RomeroV. ZubkovsS. WangS. Roke

Biomedical Optics Express. 2016. DOI : 10.1364/BOE.7.001458.

Intermolecular Headgroup Interaction and Hydration as Driving Forces for Lipid Transmembrane Asymmetry

N. SmolentsevC. LütgebaucksH. I. OkurA. G. F. De BeerS. Roke

Journal of the American Chemical Society. 2016. DOI : 10.1021/jacs.5b11776.

Three Dimensional Nano "Langmuir Trough" for Lipid Studies

Y. ChenK. C. JenaC. LuetgebaucksH. I. OkurS. Roke

Nano Letters. 2015. DOI : 10.1021/acs.nanolett.5b02143.

From Hydrophobic to Hydrophilic: The Structure and Density of the Hexadecane Droplet/Alkanol/Water Interface

Y. ChenK. C. JenaS. Roke

Journal Of Physical Chemistry C. 2015. DOI : 10.1021/acs.jpcc.5b04904.

Electric double layer formation: A molecular level study

S. Roke

2014. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, AUG 10-14, 2014.

Sum frequency and second harmonic generation from the surface of a liquid microjet

N. SmolentsevY. ChenK. C. JenaM. A. BrownS. Roke

Journal Of Chemical Physics. 2014. DOI : 10.1063/1.4896996.

Sum frequency spectroscopy of the hydrophobic nanodroplet/water interface: Absence of hydroxyl ion and dangling OH bond signatures

J.-S. SamsonR. ScheuN. SmolentsevS. W. RickS. Roke

Chemical Physics Letters. 2014. DOI : 10.1016/j.cplett.2014.09.034.

High throughput second harmonic imaging for label-free biological applications

C. Macias-RomeroM. E. P. DidierP. JourdainP. MarquetP. Magistretti  et al.

Optics Express. 2014. DOI : 10.1364/OE.22.031102.

Charge Asymmetry at Aqueous Hydrophobic Interfaces and Hydration Shells

R. ScheuB. M. RankinY. ChenK. C. JenaD. Ben-Amotz  et al.

Angewandte Chemie International Edition. 2014. DOI : 10.1002/anie.201310266.

Probing Rotational and Translational Diffusion of Nanodoublers in Living Cells on Microsecond Time Scales

C. Macias-RomeroM. E. P. DidierV. ZubkovsL. DelannoyF. Dutto  et al.

Nano Letters. 2014. DOI : 10.1021/nl500356u.

Toward Vibrational Dynamics at Liquid-Liquid and Nano-Interfaces: Time-Resolved Sum-Frequency Scattering

R. ScheuS. Roke

The Journal of Physical Chemistry B. 2014. DOI : 10.1021/jp411798s.

Specific Ion Effects in Amphiphile Hydration and Interface Stabilization

R. ScheuY. ChenH. B. de AguiarB. M. RankinD. Ben-Amotz  et al.

Journal of the American Chemical Society. 2014. DOI : 10.1021/ja4120117.

Stern Layer Formation Induced by Hydrophobic Interactions: A Molecular Level Study

R. ScheuY. ChenM. SubinyaS. Roke

Journal Of The American Chemical Society. 2013. DOI : 10.1021/ja4102858.

Specific ion effects and the molecular structure of water, ions and amphiphiles on nanoscopic hydrophobic interfaces

R. Scheu

Lausanne, EPFL, 2014. DOI : 10.5075/epfl-thesis-6060.

Analysis of Complex Spectra Using Fourier Filtering

A. G. F. de BeerR. ScheuY. ChenJ. C. ConboyS. Roke

Journal Of Physical Chemistry C. 2013. DOI : 10.1021/jp406161n.

The Presence of Ultralow Densities of Nanocrystallites in Amorphous Poly(lactic acid) Microspheres

H. B. de AguiarA. G. F. de BeerS. Roke

The Journal of Physical Chemistry B. 2013. DOI : 10.1021/jp4034497.

Vesicle Photonics

A. E. VasdekisE. A. ScottS. RokeJ. A. HubbellD. Psaltis

Annual Review of Materials Research. 2013. DOI : 10.1146/annurev-matsci-071312-121724.

Label-Free Hyper Rayleigh and Second Harmonic Scattering with High Efficiency

N. GomopoulosC. LütgebauksQ. SunM. RomeroC. Alberto  et al.

Optics Express. 2013. DOI : 10.1364/OE.21.000815.

Interface-solvent effects during colloidal phase transitions

S. RokeJ. BuitenhuisJ. C. Van MiltenburgM. BonnA. Van Blaaderen

Journal of Physics: Condensed Matter. 2005. DOI : 10.1088/0953-8984/17/45/036.

A molecular view of cholesterol-induced condensation in a lipid monolayer

M. BonnS. RokeO. BergL. B. F. JuurlinkA. Stamouli  et al.

The Journal of Physical Chemistry B. 2004. DOI : 10.1021/jp0452249.

Nonlinear light scattering spectroscopy from polymorph microspheres: Ultrasensitive detection of buried nanoscopic domains

S. Roke

Abstracts of Papers of the American Chemical Society. 2009.

Cascading second-order versus direct third-order nonlinear optical processes in a uniaxial crystal

E. H. G. BackusS. RokeA. W. KleynM. Bonn

Optics Communications. 2004. DOI : 10.1016/j.optcom.2004.01.070.

Surface and bulk structure of poly-(lactic acid) films studied by vibrational sum frequency generation spectroscopy

C. M. JohnsonA. B. SugihartoS. Roke

Chemical Physics Letters. 2007. DOI : 10.1016/j.cplett.2007.10.061.

Vibrational sum frequency scattering from a submicron suspension

S. RokeW. G. RoeterdinkJ. E. WijnhovenA. V. PetukhovA. W. Kleyn  et al.

Physical Review Letters. 2003. DOI : 10.1103/PhysRevLett.91.258302.

Vibrational spectroscopic investigation of the phase diagram of a biomimetic lipid monolayer

S. RokeJ. SchinsM. MullerM. Bonn

Physical Review Letters. 2003. DOI : 10.1103/PhysRevLett.90.128101.

The Interfacial Tension of Nanoscopic Oil Droplets in Water Is Hardly Affected by SDS Surfactant

H. B. de AguiarA. G. F. de BeerM. L. StraderS. Roke

Journal Of The American Chemical Society. 2010. DOI : 10.1021/ja9095158.

Generation and application of high power femtosecond pulses in the vibrational fingerprint region

A. B. SugihartoC. M. JohnsonH. B. De AguiarL. AlloattiS. Roke

Applied Physics B: Lasers and Optics. 2008. DOI : 10.1007/s00340-008-2993-7.

ANYL 82-Vibrational sum frequency scattering from vesicles in solution

M. L. StraderH. de AguiarA. G. F. de BeerS. Roke

Abstracts of Papers of the American Chemical Society. 2009.

Nonlinear light scattering from clusters and single particles

J. I. DadapH. B. de AguiarS. Roke

Journal Of Chemical Physics. 2009. DOI : 10.1063/1.3141383.

COLL 182-Local surface structure of surfactant on emulsion droplets probed by nonlinear light scattering spectroscopy

H. B. de AguiarM. L. StraderA. G. F. de BeerS. Roke

Abstracts of Papers of the American Chemical Society. 2009.

Time- vs. frequency-domain femtosecond surface sum frequency generation

S. RokeA. W. KleynM. Bonn

Chemical Physics Letters. 2003. DOI : 10.1016/S0009-2614(03)00085-X.

Femtosecond time-resolved vibrational SFG spectroscopy of CO/Ru(0 0 1)

C. HessM. WolfS. RokeM. Bonn

Surface Science. 2002. DOI : 10.1016/S0039-6028(01)01968-9.

Probing nanoscopic droplet interfaces in aqueous solution with vibrational sum-frequency scattering: A study of the effects of path length, droplet density and pulse energy

H. B. De AguiarJ.-S. SamsonS. Roke

Chemical Physics Letters. 2011. DOI : 10.1016/j.cplett.2011.06.081.

Reorganization of adsorbed films by coadsorbing species

S. RokeJ. M. CoquelA. W. Kleyn

Journal Of Chemical Physics. 2000. DOI : 10.1063/1.1309529.

Nonlinear Mie theory for second-harmonic and sum-frequency scattering

A. G. F. de BeerS. Roke

Physical Review B. 2009. DOI : 10.1103/PhysRevB.79.155420.

Sodium dodecyl sulfate at water-hydrophobic interfaces: A simulation study

R. VáchaS. Roke

The Journal of Physical Chemistry B. 2012. DOI : 10.1021/jp304900z.

Surface molecular view of colloidal gelation

S. RokeO. BergJ. BuitenhuisA. van BlaaderenM. Bonn

Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2006. DOI : 10.1073/pnas.0606116103.

ANYL 369-Separating charge and structure of interfaces by angular-resolved vibrational sum-frequency scattering

A. G. F. de BeerH. de AguiarM. L. StraderS. Roke

Abstracts of Papers of the American Chemical Society. 2009.

Delocalized surface modes reveal three-dimensional structures of complex biomolecules

A. B. SugihartoC. M. JohnsonI. E. DunlopS. Roke

Journal of Physical Chemistry C. 2008. DOI : 10.1021/jp801254y.

Sum frequency generation for studying plasma-wall interactions

S. Roke

2010. 14th International Symposium on Laser-Aided Plasma Diagnostics (LAPD14), Castelbrando, Treviso, Italy, 21–24 September 2009. DOI : 10.1088/1742-6596/227/1/012009.

Nonlinear Light Scattering and Spectroscopy of Particles and Droplets in Liquids

S. RokeG. Gonella

Annual Review Of Physical Chemistry; Annual Reviews, 2012. p. 353 - 378.

Sum frequency generation scattering from the interface of an isotropic particle: Geometrical and chiral effects

A. G. F. de BeerS. Roke

Physical Review B. 2007. DOI : 10.1103/PhysRevB.75.245438.

Continuous Photobleaching to Study the Growth Modes of Focal Adhesions

A. G. F. de BeerG. MajerS. RokeJ. P. Spatz

Journal of Adhesion Science and Technology. 2010. DOI : 10.1163/016942410x508046.

ANYL 279-Vibrational sum frequency generation scattering from the interface of an isotropic particle: Geometrical and chiral effects

A. G. F. de BeerS. Roke

Abstracts of Papers of the American Chemical Society. 2007.

Nonlinear Optical Spectroscopy of Soft Matter Interfaces

S. Roke

Chemphyschem. 2009. DOI : 10.1002/cphc.200900138.

Surface-Specific Interaction of the Extracellular Domain of Protein L1 with Nitrilotriacetic Acid-Terminated Self-Assembled Monolayers

J. FickT. WolframF. BelzS. Roke

Langmuir. 2010. DOI : 10.1021/la902320b.

Ultrafast surface dynamics studied with femtosecond sum frequency generation

S. RokeA. W. KleynM. Bonn

The Journal of Physical Chemistry A. 2001. DOI : 10.1021/jp004167q.

Nonlinear spectroscopy of bio-interfaces

S. Roke

International Journal of Materials Research. 2011. DOI : 10.3139/146.110535.

Obtaining molecular orientation from second harmonic and sum frequency scattering experiments in water: angular distribution and polarization dependence

A. G. de BeerS. Roke

The Journal of Chemical Physics. 2010. DOI : 10.1063/1.3429969.

Detection of buried microstructures by nonlinear light scattering spectroscopy

A. G. F. De BeerH. B. De AguiarJ. F. W. NijsenS. Roke

Physical Review Letters. 2009. DOI : 10.1103/PhysRevLett.102.095502.

ANYL 185-Molecular view of a colloidal gelation

S. RokeM. BonnA. van Blaaderen

Abstracts of Papers of the American Chemical Society. 2007.

Surface Impurities Are Not Responsible For the Charge on the Oil/Water Interface: A Comment

K. C. JenaR. ScheuS. Roke

Angewandte Chemie International Edition. 2012. DOI : 10.1002/anie.201204662.

The adsorption behaviour of isobutane on Pt(533): A combined RAIRS and TPD study

S. RokeJ. M. CoquelA. W. Kleyn

Chemical Physics Letters. 2000. DOI : 10.1016/S0009-2614(00)00528-5.

Phase transitions in a lipid monolayer observed with vibrational sum-frequency generation

M. MullerJ. M. SchinsS. RokeM. Bonn

2003. p. 90 - 97. DOI : 10.1117/12.499817.

ANYL 416-Vibrational sum frequency scattering from biodegradable polymer particles

S. RokeA. B. SugihartoC. M. Johnson

Abstracts of Papers of the American Chemical Society. 2007.

Nonlinear optical scattering: The concept of effective susceptibility

S. RokeM. BonnA. V. Petukhov

Physical Review B. 2004. DOI : 10.1103/PhysRevB.70.115106.

Separating surface structure and surface charge with second-harmonic and sum-frequency scattering

A. G. F. de BeerR. K. CampenS. Roke

Physical Review B. 2010. DOI : 10.1103/PhysRevB.82.235431.

ANYL 370-Surface binding of transmembrane proteins to nitrilotriacetic acid (NTA)-terminated self-assembled monolayers

S. RokeT. WolframJ. FickF. Belz

Abstracts of Papers of the American Chemical Society. 2009.

ANYL 466-3-D Structure of biomolecules at interfaces: Femtosecond vibrational sum frequency generation in the fingerprint region

S. Roke

Abstracts of Papers of the American Chemical Society. 2007.

Femtosecond sum frequency generation at the metal-liquid interface

S. RokeA. W. KleynM. Bonn

Surface Science. 2005. DOI : 10.1016/j.susc.2005.06.049.

Comparison of scattering and reflection SFG: a question of phase-matching

H. B. de AguiarR. ScheuK. C. JenaA. G. F. de BeerS. Roke

Physical Chemistry Chemical Physics. 2012. DOI : 10.1039/c2cp40324b.

Direct comparison of phase-sensitive vibrational sum frequency generation with maximum entropy method: Case study of water

A. G. F. de BeerJ.-S. SamsonW. HuaZ. HuangX. Chen  et al.

Journal Of Chemical Physics. 2011. DOI : 10.1063/1.3662469.

Sodium dodecyl sulfate at water/hydrophobic interfaces

R. VachaP. JungwirthS. RokeD. Frenkel

2011. 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO, Aug 28-Sep 01, 2011. p. 63 - PHYS.

Erratum: Probing nanoscopic droplet interfaces in aqueous solution with vibrational sum-frequency scattering: A study of the effects of path length, droplet density and pulse energy (Chemical Physics Letters (2011) 512 (7680))

H. B. de AguiarJ.-S. SamsonS. Roke

Chemical Physics Letters. 2012. DOI : 10.1016/j.cplett.2012.01.055.

Laser-Heating-Induced Displacement of Surfactants on the Water Surface

E. H. G. BackusD. BonnS. CantinS. RokeM. Bonn

The Journal of Physical Chemistry B. 2012. DOI : 10.1021/jp2074545.

Label-free spectroscopic detection of vesicles in water using vibrational sum frequency scattering

M. L. StraderH. B. de AguiarA. G. F. de BeerS. Roke

Soft Matter. 2011. DOI : 10.1039/c0sm01358g.

Surface Structure of Sodium Dodecyl Sulfate Surfactant and Oil at the Oil-in-Water Droplet Liquid/Liquid Interface: A Manifestation of a Nonequilibrium Surface State

H. B. de AguiarM. L. StraderA. G. F. de BeerS. Roke

The Journal of Physical Chemistry B. 2011. DOI : 10.1021/jp200536k.

Theory of optical second-harmonic and sum-frequency scattering from arbitrarily shaped particles

A. G. F. de BeerS. RokeJ. I. Dadap

Journal Of The Optical Society Of America B-Optical Physics. 2011. DOI : 10.1364/JOSAB.28.001374.

The Orientation and Charge of Water at the Hydrophobic Oil Droplet-Water Interface

R. VachaS. W. RickP. JungwirthA. G. F. de BeerH. B. de Aguiar  et al.

Journal of the American Chemical Society. 2011. DOI : 10.1021/ja202081x.

Vibrational Sum-Frequency Scattering Studies of Oil-in-Water Emulsions

H. Barbosa de Aguiar

Lausanne, EPFL, 2011. DOI : 10.5075/epfl-thesis-5074.

Research

Research Highlights

We develop novel optical technology, geared to obtaining molecular level details of nanoscale and microscopic systems in aqueous environments as well as other complex 3D environments such as pores. We have focused on ultrafast nonlinear optical methods as they are non-invasive and label-free and inherently interface specific or sensitive to polar structures. We apply these tools to fundamental questions that have important implications for biology, chemistry or technology.
Topics of interest:
• Water, aqueous solutions
• Aqueous interfaces and nanoscopic systems
• Nonlinear optics, ultrafast spectroscopy, light scattering
• Multiphoton imaging
• Soft systems: Interfaces, membranes, electric double layers
• Structure and dynamics in living systems
• Neuroimaging and neurological activity
10 Research Highlights (anti-chronological)
• Surface electrostatic potentials and reaction constants can be optically imaged in real time and display heterogeneities of respectively a factor of 3 x the average and 8 orders of magnitude on a glass micro-capillary surface immersed in water.
• Electrolytes induce changes in the hydrogen bond network of water that range over ~77 hydration shells and are subject to quantum effects. These changes lead to energy changes on the order of kT per ion, which lead to surface tension anomalies, better known as the controversial Jones-Ray effect (discovered in the 1930's).
• Discovery that (~50-150 nm) liposomes exhibit trans-membrane asymmetry in their hydration shells rather than the lipid composition. Specific interactions may induce membrane asymmetry.
• Development of a nanodroplet platform to study the molecular structure of lipid droplets and biological monolayer phenomena in solution.
• Discovery that various molecular properties of nanoscale / submicron droplets of oil and water behave differently than extended planar interfaces composed of the same chemicals; reasons can be found in the difference in hydrogen bond network configurations and a different balance of electrostatic interactions.
• Development of wide field medium repetition rate second harmonic and multiphoton imaging instruments with ~5000 x better efficiency than scanning confocal microscopy.
• Angle resolved second harmonic scattering can be used to measure unique surface potential values on particles in solution.
• Development of second harmonic scattering instrumentation with an improved efficiency of ~1000.
• Invention of vibrational sum frequency scattering, and subsequent development into a reliable interfacial molecular probe of buried interfaces of nano- and microscale materials.
• Development of nonlinear optical theories to understand nonlinear light scattering.

Teaching & PhD

PhD Students

Lena Dalifoski, Chaudhary Eksha Rani, Nelson Alonso Correa Rojas, Zhi Li, Iwona Swiderska, Kshitij Vivek Goyal, Viktor Vorobev, Angela Natalie Moskal

Past EPFL PhD Students

Hilton Barbosa De Aguiar, Rüdiger Scheu, Yixing Chen, Cornelis Lütgebaucks, Nikolay Smolentsev, Marie Eve Pascale Didier, Evangelia Zdrali, Orly Bagunu Tarun, Jan Dedic, Igor Nahálka, Nathan Dupertuis, Maksim Eremchev, Pierre-Marc Jean Marie Dansette, Sergey Kulik, Marie Bischoff, David Roesel, Tereza Schönfeldová, Seonwoo Lee, Bingxin Chu, Li Zhang, Mischa Flór

Past EPFL PhD Students as codirector

Nathan Ronceray

Courses

Light, liquids and interfaces

MICRO-390

This course provides an overview of relevant interactions in liquids, combining thermodynamics, statistical physics and pair potetnials. Water and aqueos systm,es will be considered in detail. Optical techniques to investigate liquid and liquid interfacial structure will treated.

Nonlinear Optics

PHYS-501

Basic principles of optics

Nonlinear Spectroscopy

PHYS-613

To provide an introduction into the field of nonlinear spectroscopy, and focus in particular on linear and nonlinear light scattering